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The map label for this gene is hemF [H]

Identifier: 73542209

GI number: 73542209

Start: 2767212

End: 2768123

Strand: Direct

Name: hemF [H]

Synonym: Reut_A2524

Alternate gene names: 73542209

Gene position: 2767212-2768123 (Clockwise)

Preceding gene: 73542208

Following gene: 73542210

Centisome position: 72.7

GC content: 66.56

Gene sequence:

>912_bases
ATGATCGATTCCCAGGCAGTCCGTGCCTATCTGCTCGGTCTGCAAGACCGCATCACCGACGCCGTCGCTGCCATCGACGG
ACAGCCGTTCCTGACCGACGCCTGGGAAAAGCCGCCCACCGAGCGCCTGCGCGGCAGCGGCCGCACCCGCATCCTGGAAG
GCGGCGCCGTAATGGAGCGTGCCGGCGTGGGCTTTTCGCACGTCATGGGCGACACCCTGCCCCCGTCGGCCAGCGCCAGC
CGGCCCGAACTGGCGGGCCGCAGCTTCGAAGCCATGGGCGTGTCGCTGGTCTTCCATCCGCGCAACCCGTACGTGCCCAC
GGTGCATATGAACGTGCGCTGCTTCATCGCGGTCAAGCCCGATGCCGATCCCGTCTGGTGGTTCGGCGGCGGCATGGACC
TGACGCCGTACTATGGCAATGCCGGCGACTGCACGCATTTCCACCGCACCTGCAAGCAGTCGCTCGCACCGTTCGGCGAT
GACTTGTACCCGCGCTTCAAGCAGTGGTGCGACGAGTACTTCTTCCTCAAGCACCGCGGCGAGGCGCGCGGTATCGGCGG
CATTTTCTTCGACGACTTTTCGGCGCTGGGTTTCGACCGTAGCTTCGAGATGATGCGCAGCGTGGGCGATGCCTTCCTGG
ACGCCTACCTTCCCATCTTGCAGGGCCGCAAGGACACGCCGTTCGGGGCGCGCGAACGCGACTTCCAGGCGTACCGCCGC
GGCCGCTATGTGGAATTCAACCTCGTGTTCGACCGCGGCACGCTGTTCGGACTGCAGTCCGGCGGCCGCGCCGAATCGAT
CCTGATGTCGATGCCGCCGCAGGTGTCATGGCGCTATGACTGGAAGCCGGAGCCCGGCAGCGCGGAAAGCGCGCTGTACA
CCGACTTCCTGCCTGCGCGCGACTGGGCCTGA

Upstream 100 bases:

>100_bases
GGCTCGCCAGCCGTTACAATCGTGACACCCTCATGACGGCCGGGCTGGCCAACTGCCAGCCCGGCCGCCCTTGCATCCGG
GGCTCGCGCCCCTACACGCC

Downstream 100 bases:

>100_bases
CGGCAACCGTATGGCACATACCGACCAAGACGCCGTGCCGGCCGTAGCCGACAAAGACGCCCGCCCCTACCGCCTGGGTA
TCCTCGGCGGCACTTTCGAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIDSQAVRAYLLGLQDRITDAVAAIDGQPFLTDAWEKPPTERLRGSGRTRILEGGAVMERAGVGFSHVMGDTLPPSASAS
RPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKPDADPVWWFGGGMDLTPYYGNAGDCTHFHRTCKQSLAPFGD
DLYPRFKQWCDEYFFLKHRGEARGIGGIFFDDFSALGFDRSFEMMRSVGDAFLDAYLPILQGRKDTPFGARERDFQAYRR
GRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPQVSWRYDWKPEPGSAESALYTDFLPARDWA

Sequences:

>Translated_303_residues
MIDSQAVRAYLLGLQDRITDAVAAIDGQPFLTDAWEKPPTERLRGSGRTRILEGGAVMERAGVGFSHVMGDTLPPSASAS
RPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKPDADPVWWFGGGMDLTPYYGNAGDCTHFHRTCKQSLAPFGD
DLYPRFKQWCDEYFFLKHRGEARGIGGIFFDDFSALGFDRSFEMMRSVGDAFLDAYLPILQGRKDTPFGARERDFQAYRR
GRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPQVSWRYDWKPEPGSAESALYTDFLPARDWA
>Mature_303_residues
MIDSQAVRAYLLGLQDRITDAVAAIDGQPFLTDAWEKPPTERLRGSGRTRILEGGAVMERAGVGFSHVMGDTLPPSASAS
RPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKPDADPVWWFGGGMDLTPYYGNAGDCTHFHRTCKQSLAPFGD
DLYPRFKQWCDEYFFLKHRGEARGIGGIFFDDFSALGFDRSFEMMRSVGDAFLDAYLPILQGRKDTPFGARERDFQAYRR
GRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPQVSWRYDWKPEPGSAESALYTDFLPARDWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=43.7086092715232, Blast_Score=248, Evalue=7e-66,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=61.4617940199336, Blast_Score=391, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=42.2712933753943, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=43.8943894389439, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34058; Mature: 34058

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSQAVRAYLLGLQDRITDAVAAIDGQPFLTDAWEKPPTERLRGSGRTRILEGGAVMER
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCHHHH
AGVGFSHVMGDTLPPSASASRPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKP
CCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEEEEEEEECC
DADPVWWFGGGMDLTPYYGNAGDCTHFHRTCKQSLAPFGDDLYPRFKQWCDEYFFLKHRG
CCCEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EARGIGGIFFDDFSALGFDRSFEMMRSVGDAFLDAYLPILQGRKDTPFGARERDFQAYRR
CCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
GRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPQVSWRYDWKPEPGSAESALYTDFLPAR
CCEEEEEEEEECCEEEEECCCCCHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHCCCCC
DWA
CCC
>Mature Secondary Structure
MIDSQAVRAYLLGLQDRITDAVAAIDGQPFLTDAWEKPPTERLRGSGRTRILEGGAVMER
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCHHHH
AGVGFSHVMGDTLPPSASASRPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKP
CCCCHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEEEEEEEECC
DADPVWWFGGGMDLTPYYGNAGDCTHFHRTCKQSLAPFGDDLYPRFKQWCDEYFFLKHRG
CCCEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EARGIGGIFFDDFSALGFDRSFEMMRSVGDAFLDAYLPILQGRKDTPFGARERDFQAYRR
CCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
GRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPQVSWRYDWKPEPGSAESALYTDFLPAR
CCEEEEEEEEECCEEEEECCCCCHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHCCCCC
DWA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA