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The map label for this gene is cusR [H]

Identifier: 73542175

GI number: 73542175

Start: 2730316

End: 2731002

Strand: Direct

Name: cusR [H]

Synonym: Reut_A2490

Alternate gene names: 73542175

Gene position: 2730316-2731002 (Clockwise)

Preceding gene: 73542169

Following gene: 73542176

Centisome position: 71.73

GC content: 66.38

Gene sequence:

>687_bases
ATGAAACTGCTAGTAGTGGAAGACGAGGCCAAGACCGGCGAATACCTGCGGCAGGGCCTGACAGAGGCCGGCTTCGTGGT
GGACCTGGCCGCGAATGGACTCGATGGCCACCATCTGGCCATGAGCGAGGCCTACGATCTGATCATCCTCGACGTGATGC
TGCCGGACGTGGACGGCTGGCGCATCGTGCAGACGCTGCGCGCGGCCGGCAACCGCGTGCCGGTGCTGTTCCTGACTGCG
CGCGACAGCGTGGCGGACCGCGTCAAGGGGCTCGAGCTGGGCGCGGACGACTACCTGGTCAAGCCATTCGCGTTCGCCGA
ACTGCTTGCGCGCGTACGCACGTTGCTACGCCGTGGCAGCGTGCAGGCGAGCGTGGATCGCGTACAGGTCGGCGACCTGG
TACTGGATCTGGCGCGCCGGCGTGCGTCGCGCGGCGGGCGCCGCATCGTGCTGACGAGCAAGGAGTTCTCGCTGCTCGAG
CTGCTCGTGCGCCGGCGCGGCGAAGTACTGCCGCGCTCGCTGATTGCGTCGCAAGTCTGGGACATGAACTTCGACAGCGA
CAGTAATGTGATCGACGTCGCCATCCGCCGCCTGCGCGCGAAGATCGACGACGACTTCGACACCAAGCTGATCCAGACGG
TGCGCGGCATGGGCTACGTGCTGGAAGGTCCCGAGGACACGGTGTGA

Upstream 100 bases:

>100_bases
AAATTACAATCCGGTAATCTTGACGTCATCTTGATGTTCATTGCCCTGCGCTACAGTCGCCGCTCGCCTGCGGCGCGGGC
CGGCAACAAGGAAAGTGCAG

Downstream 100 bases:

>100_bases
TGCGCCGGTTCTCGCTGACCACGCGACTGACCGCGCTGTTCTGCCTGTCGTCGGCCGGCGTGCTGCTGGGCCTCGGCATC
CTGATCGCGACGGCCATGGA

Product: heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVVEDEAKTGEYLRQGLTEAGFVVDLAANGLDGHHLAMSEAYDLIILDVMLPDVDGWRIVQTLRAAGNRVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGSVQASVDRVQVGDLVLDLARRRASRGGRRIVLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDTKLIQTVRGMGYVLEGPEDTV

Sequences:

>Translated_228_residues
MKLLVVEDEAKTGEYLRQGLTEAGFVVDLAANGLDGHHLAMSEAYDLIILDVMLPDVDGWRIVQTLRAAGNRVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGSVQASVDRVQVGDLVLDLARRRASRGGRRIVLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDTKLIQTVRGMGYVLEGPEDTV
>Mature_228_residues
MKLLVVEDEAKTGEYLRQGLTEAGFVVDLAANGLDGHHLAMSEAYDLIILDVMLPDVDGWRIVQTLRAAGNRVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGSVQASVDRVQVGDLVLDLARRRASRGGRRIVLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDTKLIQTVRGMGYVLEGPEDTV

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=70.6666666666667, Blast_Score=325, Evalue=1e-90,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=56.1643835616438, Blast_Score=246, Evalue=7e-67,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=43.8914027149321, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1790552, Length=237, Percent_Identity=37.9746835443038, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=36.4864864864865, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.8854625550661, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=38.9140271493213, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=36.1990950226244, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=38.1818181818182, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=34.375, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.1578947368421, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=32.5991189427313, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=31.6017316017316, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=30.6451612903226, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=32.2834645669291, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=31.404958677686, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=30.4347826086957, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25402; Mature: 25402

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDEAKTGEYLRQGLTEAGFVVDLAANGLDGHHLAMSEAYDLIILDVMLPDVDGW
CEEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEEEEEEECCCCCCH
RIVQTLRAAGNRVPVLFLTARDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGS
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
VQASVDRVQVGDLVLDLARRRASRGGRRIVLTSKEFSLLELLVRRRGEVLPRSLIASQVW
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDDFDTKLIQTVRGMGYVLEGPEDTV
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEECCCCCCC
>Mature Secondary Structure
MKLLVVEDEAKTGEYLRQGLTEAGFVVDLAANGLDGHHLAMSEAYDLIILDVMLPDVDGW
CEEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEEEEEEECCCCCCH
RIVQTLRAAGNRVPVLFLTARDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGS
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
VQASVDRVQVGDLVLDLARRRASRGGRRIVLTSKEFSLLELLVRRRGEVLPRSLIASQVW
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDDFDTKLIQTVRGMGYVLEGPEDTV
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]