Click here to switch to the map view.

The map label for this gene is bccA [H]

Identifier: 73542137

GI number: 73542137

Start: 2689565

End: 2691295

Strand: Direct

Name: bccA [H]

Synonym: Reut_A2451

Alternate gene names: 73542137

Gene position: 2689565-2691295 (Clockwise)

Preceding gene: 73542136

Following gene: 73542142

Centisome position: 70.66

GC content: 68.05

Gene sequence:

>1731_bases
ATGAAAAAAGTCCTGATTGCCAACCGCGGCGAAATCGCCGTCCGCGTCGTCCGCGCCTGTGCCGACTACGGCGTGCAGTC
CGTTGCCGTGTACGCCAACGCCGACATCGACGCCCTGCACGCGCGCATGGCCGACGAGGCCTACGGGCTCGATGGCGATC
GCCCGGCGGACACTTACCTGAATATCGCCAAGCTGCTGGAGATCGCACGCAAGAGCGGTGCCGATGCCGTGCACCCCGGC
TATGGCTTCCTGTCGGAAAGCGAGGCCTTTGCCCAGGCCGTGATCGACGCGGGCCTGCGCTGGATCGGCCCGTCTCCGGC
CACCATCGCCAAGCTGGGCGACAAGGTCGAAGCGCGCAAGATTGCGCTGCAGGTCGGCGCGCCGCTGGTGGCCGGCACGC
CCGATCCTGTCAAGGATGCCGGTGAGGTACTGGCCTTTGCCGAGCAGCACGGCCTGCCCATCATCATCAAGGCCGCATTC
GGTGGCGGCGGTCGGGGCATGAAGATCGCATGGCGCATGGATGAGGTCGAGGAGCTCTATCACTCGGCGGTACGCGAAGC
CGTTGCCGCATTCGGCCGGGGTGAATGCTTCGTCGAACAGTTTCTCGATAAGCCCCGCCATATCGAGGCCCAGGTGCTGG
CCGACACCCACGGCCATGTCGTGGTGCTCGGCACGCGCGACTGCTCCCTGCAGCGCCGCAACCAGAAGCTCGTGGAAGAA
GCCCCTGCGCCGTTCCTGACCGATGCGCAACGCGCGCGTATCCACATCGCCGCCCGCGACATCTGCGCCGCGGCGGGTTA
CACCAGTGCGGGCACCGTGGAATTCCTGCTTAGCGCGGGAGGCGCGATCTCCTTCCTGGAGGTCAACACCCGCCTGCAGG
TGGAGCATCCGGTGACCGAGCAGACCACCGGCATCGATCTCGTCGTCGAGCAGTTGCGCGTGGCAGACGGCCTGCCGCTC
ACGATCACGGAAACGCCCGCACCGCTGGGCCACTCGATCGAATTCCGCATCAACGCCGAAGATGTCGGCCGTGGCTTTCT
GCCGACGCCGGGCCCGGTACAGTGCTTCGAGCCGCCGTCCGGCCCGGGCGTACGCGTGGACGCGGGCGTGCAATCGGGCT
CCGTCGTACCGGGCACGTTCGATTCGCTGATGGCCAAGCTCATCGTCACCGGGGCCACGCGCGAACAGGCGCTGACCCGT
GCCCGCCGCGCGCTGCGCGAATTCCGGATCGAAGGCGTCGCCTCGGTGCTGCCGTTCCACCGCGCCGTGATCGACAACGC
CGACTTCGTGGGCACCCATGGCTTCAACGTGCACACGCGCTGGATCGAATCCGATTTCGCCGAGCCGCTGGCCGCCGCCG
TCCGTGCGGAGCCCCAGCCCGACAGCAGCCTGCTTCGCACTGCCATCGAGATCGATGGCCGGCGCGTCATGCTGGGCCTG
CCGGCTCAACTGCTGGGCGGACTGGCCAATGCGCAGGCGGCAAGCCCGGCCACTGCGCCGGCCGAGGCCGCCGAAGCCGA
CGTCAGGGATGTGCCGGCCCCGGTCGCCGGCACCGTGCACGCCTGGAAGGTGGCCGACGGCGACGAGGTCAAGGAAGGGG
ATCTCATCGCCGTCATGGAAGCCATGAAGATGGAGATGCAAGTCCACGCGCATCGTGCCGGCCGCATCGTGCTGCGCGCC
GCAGCGGGCATCTTCATGGCCGCGGGCGTGCCGATCGCGACGATTGGCTGA

Upstream 100 bases:

>100_bases
TCCCCGTGGGCGCCTGGCTGCGCTTCAACCCGATCCGCGCGTTTGAAGCACTCTCTCCGGCCGCCGCCCAGCGCGAAGCC
GGCACCTTCCGAGATCTCCG

Downstream 100 bases:

>100_bases
GCCACCGCCGATCCGGTGGACTAGCTCGCCAGCACGTTCACCGCATCCTCCAGCGCCTGGGCCTGCTGCTTCAGCCCTGT
CGCCGCCGCGGCCGATTCCT

Product: carbamoyl-phosphate synthase subunit L

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MKKVLIANRGEIAVRVVRACADYGVQSVAVYANADIDALHARMADEAYGLDGDRPADTYLNIAKLLEIARKSGADAVHPG
YGFLSESEAFAQAVIDAGLRWIGPSPATIAKLGDKVEARKIALQVGAPLVAGTPDPVKDAGEVLAFAEQHGLPIIIKAAF
GGGGRGMKIAWRMDEVEELYHSAVREAVAAFGRGECFVEQFLDKPRHIEAQVLADTHGHVVVLGTRDCSLQRRNQKLVEE
APAPFLTDAQRARIHIAARDICAAAGYTSAGTVEFLLSAGGAISFLEVNTRLQVEHPVTEQTTGIDLVVEQLRVADGLPL
TITETPAPLGHSIEFRINAEDVGRGFLPTPGPVQCFEPPSGPGVRVDAGVQSGSVVPGTFDSLMAKLIVTGATREQALTR
ARRALREFRIEGVASVLPFHRAVIDNADFVGTHGFNVHTRWIESDFAEPLAAAVRAEPQPDSSLLRTAIEIDGRRVMLGL
PAQLLGGLANAQAASPATAPAEAAEADVRDVPAPVAGTVHAWKVADGDEVKEGDLIAVMEAMKMEMQVHAHRAGRIVLRA
AAGIFMAAGVPIATIG

Sequences:

>Translated_576_residues
MKKVLIANRGEIAVRVVRACADYGVQSVAVYANADIDALHARMADEAYGLDGDRPADTYLNIAKLLEIARKSGADAVHPG
YGFLSESEAFAQAVIDAGLRWIGPSPATIAKLGDKVEARKIALQVGAPLVAGTPDPVKDAGEVLAFAEQHGLPIIIKAAF
GGGGRGMKIAWRMDEVEELYHSAVREAVAAFGRGECFVEQFLDKPRHIEAQVLADTHGHVVVLGTRDCSLQRRNQKLVEE
APAPFLTDAQRARIHIAARDICAAAGYTSAGTVEFLLSAGGAISFLEVNTRLQVEHPVTEQTTGIDLVVEQLRVADGLPL
TITETPAPLGHSIEFRINAEDVGRGFLPTPGPVQCFEPPSGPGVRVDAGVQSGSVVPGTFDSLMAKLIVTGATREQALTR
ARRALREFRIEGVASVLPFHRAVIDNADFVGTHGFNVHTRWIESDFAEPLAAAVRAEPQPDSSLLRTAIEIDGRRVMLGL
PAQLLGGLANAQAASPATAPAEAAEADVRDVPAPVAGTVHAWKVADGDEVKEGDLIAVMEAMKMEMQVHAHRAGRIVLRA
AAGIFMAAGVPIATIG
>Mature_576_residues
MKKVLIANRGEIAVRVVRACADYGVQSVAVYANADIDALHARMADEAYGLDGDRPADTYLNIAKLLEIARKSGADAVHPG
YGFLSESEAFAQAVIDAGLRWIGPSPATIAKLGDKVEARKIALQVGAPLVAGTPDPVKDAGEVLAFAEQHGLPIIIKAAF
GGGGRGMKIAWRMDEVEELYHSAVREAVAAFGRGECFVEQFLDKPRHIEAQVLADTHGHVVVLGTRDCSLQRRNQKLVEE
APAPFLTDAQRARIHIAARDICAAAGYTSAGTVEFLLSAGGAISFLEVNTRLQVEHPVTEQTTGIDLVVEQLRVADGLPL
TITETPAPLGHSIEFRINAEDVGRGFLPTPGPVQCFEPPSGPGVRVDAGVQSGSVVPGTFDSLMAKLIVTGATREQALTR
ARRALREFRIEGVASVLPFHRAVIDNADFVGTHGFNVHTRWIESDFAEPLAAAVRAEPQPDSSLLRTAIEIDGRRVMLGL
PAQLLGGLANAQAASPATAPAEAAEADVRDVPAPVAGTVHAWKVADGDEVKEGDLIAVMEAMKMEMQVHAHRAGRIVLRA
AAGIFMAAGVPIATIG

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=46.0176991150442, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=46.0176991150442, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=46.0176991150442, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=42.3423423423423, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI65506442, Length=431, Percent_Identity=43.8515081206497, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI295821183, Length=431, Percent_Identity=43.8515081206497, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI189095269, Length=431, Percent_Identity=43.8515081206497, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI38679974, Length=527, Percent_Identity=30.3605313092979, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679971, Length=527, Percent_Identity=30.3605313092979, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679960, Length=527, Percent_Identity=30.3605313092979, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679977, Length=527, Percent_Identity=30.3605313092979, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679967, Length=527, Percent_Identity=30.3605313092979, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=30.8139534883721, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1789654, Length=441, Percent_Identity=43.5374149659864, Blast_Score=335, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=46.1024498886414, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567343, Length=430, Percent_Identity=43.4883720930233, Blast_Score=350, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=42.5675675675676, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI133931226, Length=457, Percent_Identity=28.6652078774617, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71997168, Length=444, Percent_Identity=29.7297297297297, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71997163, Length=444, Percent_Identity=29.7297297297297, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=43.7641723356009, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=43.7641723356009, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6319685, Length=455, Percent_Identity=38.021978021978, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6323863, Length=480, Percent_Identity=29.7916666666667, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324343, Length=533, Percent_Identity=28.5178236397749, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281363050, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652212, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652210, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652214, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19921944, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652216, Length=440, Percent_Identity=48.4090909090909, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=40.9799554565702, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=40.3892944038929, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=28.8801571709234, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=28.8801571709234, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=28.8801571709234, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=28.8801571709234, Blast_Score=186, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 60986; Mature: 60986

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRVVRACADYGVQSVAVYANADIDALHARMADEAYGLDGDRPADTYL
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHH
NIAKLLEIARKSGADAVHPGYGFLSESEAFAQAVIDAGLRWIGPSPATIAKLGDKVEARK
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCHHHHHHCCHHHHHH
IALQVGAPLVAGTPDPVKDAGEVLAFAEQHGLPIIIKAAFGGGGRGMKIAWRMDEVEELY
EEEEECCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECHHHHHHHH
HSAVREAVAAFGRGECFVEQFLDKPRHIEAQVLADTHGHVVVLGTRDCSLQRRNQKLVEE
HHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
APAPFLTDAQRARIHIAARDICAAAGYTSAGTVEFLLSAGGAISFLEVNTRLQVEHPVTE
CCCCCCCCCCHHEEEEEHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEECCEEEECCCCCC
QTTGIDLVVEQLRVADGLPLTITETPAPLGHSIEFRINAEDVGRGFLPTPGPVQCFEPPS
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEHHHHCCCCCCCCCCCEEECCCC
GPGVRVDAGVQSGSVVPGTFDSLMAKLIVTGATREQALTRARRALREFRIEGVASVLPFH
CCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVIDNADFVGTHGFNVHTRWIESDFAEPLAAAVRAEPQPDSSLLRTAIEIDGRRVMLGL
HHHHCCCCEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEC
PAQLLGGLANAQAASPATAPAEAAEADVRDVPAPVAGTVHAWKVADGDEVKEGDLIAVME
CHHHHCCHHCCCCCCCCCCCHHHHHCCHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
AMKMEMQVHAHRAGRIVLRAAAGIFMAAGVPIATIG
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MKKVLIANRGEIAVRVVRACADYGVQSVAVYANADIDALHARMADEAYGLDGDRPADTYL
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHH
NIAKLLEIARKSGADAVHPGYGFLSESEAFAQAVIDAGLRWIGPSPATIAKLGDKVEARK
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCHHHHHHCCHHHHHH
IALQVGAPLVAGTPDPVKDAGEVLAFAEQHGLPIIIKAAFGGGGRGMKIAWRMDEVEELY
EEEEECCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECHHHHHHHH
HSAVREAVAAFGRGECFVEQFLDKPRHIEAQVLADTHGHVVVLGTRDCSLQRRNQKLVEE
HHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
APAPFLTDAQRARIHIAARDICAAAGYTSAGTVEFLLSAGGAISFLEVNTRLQVEHPVTE
CCCCCCCCCCHHEEEEEHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEECCEEEECCCCCC
QTTGIDLVVEQLRVADGLPLTITETPAPLGHSIEFRINAEDVGRGFLPTPGPVQCFEPPS
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEHHHHCCCCCCCCCCCEEECCCC
GPGVRVDAGVQSGSVVPGTFDSLMAKLIVTGATREQALTRARRALREFRIEGVASVLPFH
CCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVIDNADFVGTHGFNVHTRWIESDFAEPLAAAVRAEPQPDSSLLRTAIEIDGRRVMLGL
HHHHCCCCEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEC
PAQLLGGLANAQAASPATAPAEAAEADVRDVPAPVAGTVHAWKVADGDEVKEGDLIAVME
CHHHHCCHHCCCCCCCCCCCHHHHHCCHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
AMKMEMQVHAHRAGRIVLRAAAGIFMAAGVPIATIG
HHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]