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The map label for this gene is moeA [H]

Identifier: 73541679

GI number: 73541679

Start: 2180722

End: 2181963

Strand: Reverse

Name: moeA [H]

Synonym: Reut_A1991

Alternate gene names: 73541679

Gene position: 2181963-2180722 (Counterclockwise)

Preceding gene: 73541680

Following gene: 73541678

Centisome position: 57.32

GC content: 67.87

Gene sequence:

>1242_bases
ATGACCCAAGCTGCAGCGTCTTCCCGCCCCCCGATGCTGACCATGGCCCAGGCGCTCGACGCCTTGCTGGCCGCCGCCCG
CCCGCTGGCGCAGTTCGAGCAGGTCGATACCCTGGCCGCCAACGGCCGCGTGCTGGCCACGCCGGTCACCAGTTCCCTGC
AGGTGCCGCCCGCCGACAATACGTCGATGGATGGCTACGTGATGCGTGCCGCGGACGTACCCGCAGCCGGTACACGCTTG
CCGGTGTCGCAGCGTATTCCGGCCGGCCATGTCGGTACGGAACTGGCGCCGGGCACCGCCGCACGCATTTTCACCGGCGG
GCTGATCCCGCCGGGCGCCGACGCGGTGGTGATGCAGGAACAGTGCGTGGCCGATGGCAATGACGTGATCGTCAACCACG
TGCCGCAGTCCGGCGAGTGGATCCGCCGCGCCGGCGAGGACATCGAAGCCGGTAGTGTGATCCTGCCCGCCGGTACGCGG
CTGACACCGCAGGCGTTGGGTCTGGCTGCTTCCGTGGGCCAGGCACGGCTGGAGGTGGTGCGGCGTGTACGCGTCGCAGT
GTTCTTCACGGGCGACGAGCTGGCCATGCCTGGCGAGCCGCTGAAGCCGGGTGCCATCTACAACTCGAATCGCTTCACGC
TGCGTGGACTGCTCGAGAACCTCGGTTGCGAAGTCAGCGACCTTGGCATCGTCCCCGATACGCTGGCTGCCACGCGAGAG
ACCCTGCGCAAGGCTGCGCAGGGCCACGACCTGATCATCACGTCGGGCGGTGTCTCGGTCGGCGAAGAGGACCACATCAA
GCCCGCGGTCGAAGCCGAAGGGCGTCTCGACATGTGGCAGATCGCTATCAAGCCAGGCAAGCCACTGGCGTTCGGGCACG
TGAACCATGGCAGCAGCGATGCGGCGTTCTTCCTTGGGCTGCCGGGCAACCCGGTGTCGAGCTTCGTCACGTTCCTGCTG
TTCGTGCGGCCATTCATCCTGCGCCTGCAAGGCGTGGCCGACGTGGCGCCGCGGCGCCTGCCGCTGCGAGCGGACTTCGA
ACTGAAGAAGGGCGACCGCCGCAACGAGTTCCTGCGCGCGCGCATCAACGCCAATGGCGGCCTGGACCTGTTCCCGAACC
AGAGTTCGGGCGTGCTGACCTCCACGGTGTGGGGCGACGGCTTGATCGACAACCCGCCCGACCGGGCGATCGCGCACGGC
GATACCGTGCAGTTCATTCCGTTCGACGGCCTGCTCGCATAG

Upstream 100 bases:

>100_bases
CCCAGTCGCGGCCCCCGGATTGCCCGCCAGGTCGAATGACCCAGTGCGACGCAATGCGCGGGCCGTTTTTCATGGGCGCC
CAGAAATCACACATCCCACC

Downstream 100 bases:

>100_bases
TGGGCCATAAGGTGCAAGAAGTCGCGATGAACATCGAACTACGTTTCTTTGCCAGCGTGCGCGAACAACTGGGCGTTGCC
GGGGAGCGCGCCGAAGTCCC

Product: molybdopterin binding domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTQAAASSRPPMLTMAQALDALLAAARPLAQFEQVDTLAANGRVLATPVTSSLQVPPADNTSMDGYVMRAADVPAAGTRL
PVSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQCVADGNDVIVNHVPQSGEWIRRAGEDIEAGSVILPAGTR
LTPQALGLAASVGQARLEVVRRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVSDLGIVPDTLAATRE
TLRKAAQGHDLIITSGGVSVGEEDHIKPAVEAEGRLDMWQIAIKPGKPLAFGHVNHGSSDAAFFLGLPGNPVSSFVTFLL
FVRPFILRLQGVADVAPRRLPLRADFELKKGDRRNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPDRAIAHG
DTVQFIPFDGLLA

Sequences:

>Translated_413_residues
MTQAAASSRPPMLTMAQALDALLAAARPLAQFEQVDTLAANGRVLATPVTSSLQVPPADNTSMDGYVMRAADVPAAGTRL
PVSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQCVADGNDVIVNHVPQSGEWIRRAGEDIEAGSVILPAGTR
LTPQALGLAASVGQARLEVVRRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVSDLGIVPDTLAATRE
TLRKAAQGHDLIITSGGVSVGEEDHIKPAVEAEGRLDMWQIAIKPGKPLAFGHVNHGSSDAAFFLGLPGNPVSSFVTFLL
FVRPFILRLQGVADVAPRRLPLRADFELKKGDRRNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPDRAIAHG
DTVQFIPFDGLLA
>Mature_412_residues
TQAAASSRPPMLTMAQALDALLAAARPLAQFEQVDTLAANGRVLATPVTSSLQVPPADNTSMDGYVMRAADVPAAGTRLP
VSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQCVADGNDVIVNHVPQSGEWIRRAGEDIEAGSVILPAGTRL
TPQALGLAASVGQARLEVVRRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVSDLGIVPDTLAATRET
LRKAAQGHDLIITSGGVSVGEEDHIKPAVEAEGRLDMWQIAIKPGKPLAFGHVNHGSSDAAFFLGLPGNPVSSFVTFLLF
VRPFILRLQGVADVAPRRLPLRADFELKKGDRRNEFLRARINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPDRAIAHGD
TVQFIPFDGLLA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=33.75, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=33.75, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=43.3333333333333, Blast_Score=279, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI25147659, Length=346, Percent_Identity=32.3699421965318, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=362, Percent_Identity=25.1381215469613, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136978, Length=423, Percent_Identity=32.6241134751773, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24638841, Length=423, Percent_Identity=32.6241134751773, Blast_Score=147, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43578; Mature: 43447

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAAASSRPPMLTMAQALDALLAAARPLAQFEQVDTLAANGRVLATPVTSSLQVPPADN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCC
TSMDGYVMRAADVPAAGTRLPVSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQE
CCCCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEHEEECCCCCCCCCEEEEHH
QCVADGNDVIVNHVPQSGEWIRRAGEDIEAGSVILPAGTRLTPQALGLAASVGQARLEVV
HHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH
RRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVSDLGIVPDTLAATRE
HHEEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHH
TLRKAAQGHDLIITSGGVSVGEEDHIKPAVEAEGRLDMWQIAIKPGKPLAFGHVNHGSSD
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCC
AAFFLGLPGNPVSSFVTFLLFVRPFILRLQGVADVAPRRLPLRADFELKKGDRRNEFLRA
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEECCCCCCCCEEEE
RINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPDRAIAHGDTVQFIPFDGLLA
EECCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCCEECCCEEEEECCCCCCC
>Mature Secondary Structure 
TQAAASSRPPMLTMAQALDALLAAARPLAQFEQVDTLAANGRVLATPVTSSLQVPPADN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCC
TSMDGYVMRAADVPAAGTRLPVSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQE
CCCCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEHEEECCCCCCCCCEEEEHH
QCVADGNDVIVNHVPQSGEWIRRAGEDIEAGSVILPAGTRLTPQALGLAASVGQARLEVV
HHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH
RRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVSDLGIVPDTLAATRE
HHEEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHH
TLRKAAQGHDLIITSGGVSVGEEDHIKPAVEAEGRLDMWQIAIKPGKPLAFGHVNHGSSD
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCC
AAFFLGLPGNPVSSFVTFLLFVRPFILRLQGVADVAPRRLPLRADFELKKGDRRNEFLRA
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCEECCCCCCCCEEEE
RINANGGLDLFPNQSSGVLTSTVWGDGLIDNPPDRAIAHGDTVQFIPFDGLLA
EECCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCCEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]