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The map label for this gene is thrC [H]

Identifier: 73541680

GI number: 73541680

Start: 2182143

End: 2183591

Strand: Reverse

Name: thrC [H]

Synonym: Reut_A1992

Alternate gene names: 73541680

Gene position: 2183591-2182143 (Counterclockwise)

Preceding gene: 73541681

Following gene: 73541679

Centisome position: 57.36

GC content: 64.6

Gene sequence:

>1449_bases
ATGAAATACCAGTCGACCCGCGGCCACGAAGTGCCGCAATCGTTCTCTGAAATCCTGCTGGGCGGCCTGGCGCCGGACGG
CGGCCTGTACCTGCCCGTGCAGTACCCACAGGTCACCGCCGACGAGCTGGAGGCCTGGCGCAAGCTGTCGTACGCCGACC
TGGCGTTCGAGATCCTGAGCAAGTTCTGCGACGATATCCCGGCCGAGGACCTGCGCGCGCTGACGCGCAAGACCTATACC
GCCGAGGTGTACTGCAACGCGCGCGCCGGCGATAACACCGCCGACATCACGCCGCTGCGCACGCTGGGCGAGGAAGGCGG
CACGAAGCTGCAACTGCTGGGCCTGTCCAACGGCCCGACGCTGGCCTTCAAGGACATGGCCATGCAACTGCTCGGCAATA
TGTTCGAGTACGCGCTGGGCCGTGCCGGGCTGGAGCTCAACATCCTGGGCGCCACGTCCGGCGATACCGGCAGCGCTGCC
GAATACGCGATGCGCGGCAAGCGCGGCATCCGCGTGTTCATGCTGAGCCCGCACCGCAAGATGAGCGCGTTCCAGACCGC
GCAGATGTTCAGCCTGCAAGATCCGAACATCTTCAACCTGGCGGTGGAAGGTGTGTTCGATGATTGCCAGGACATCGTCA
AGGCGGTCTCGAACGACCTCGAATACAAGGCCCGCCAGCGTATCGGTACGGTCAATTCGATCAACTGGGCGCGTGTGGTG
GCCCAGGTCGTGTACTACTTCAAGGGCTGGCTGCTCGCGACCACGGGCCCAGGCCAGAAGGTGTCGTTCTGCGTGCCGTC
GGGCAACTTCGGCAACGTCTGCGCCGGCCATATCGCGCGCATGATGGGTTTGCCGATCGACAAGCTCGTGGTTGCCACCA
ACGAGAACGACGTACTCGACGAGTTCTTCCGCACAGGCGCCTACCGTGTGCGCAAGTCGGCCGAGACTTACCATACGTCG
AGCCCGAGCATGGATATCTCGAAGGCGTCGAACTTCGAACGCTTCATCTTCGACCTGCTCGGCCAGGACGCCGGCAAGCT
GGCCGCGCTGTTCCGCGATGTGGACGAGAAGGGCGGCTTCGACCTGTCGGGGACGCCCGAGTACGAGCGCATCCGCGGCG
AGTTTGGCTTTGTCTCGGGCCGCAGCACGCACGGGGACCGCGTGGCGACGATCCGCGACATGTCGGCGCGCTATGGCATC
ACGATCGATACCCATACCGCGGATGGCATCAAGGTGGCGCGTGAGCATCTCAGCGCCGACGTGCCGATGGTAGTGCTGGA
AACCGCGCTGCCGGCCAAGTTTGCCGACACCATCCGTGAAGCGCTGGGCCACGAGCCCGAGCGCCCGGCGGCGTTCGAAG
GCATCGAGAAGCTGCCGCAGCGCTTCGAGGTGATGGCCAACGACGCCAGCCAGGTCAAGGCCTTTATCGCTGGTCACACC
GGCCTGTAA

Upstream 100 bases:

>100_bases
TGCCGCCATTGCGAAGATCGAGTCGCTGCCGACTGTGCTGTCGCCGGTCACGCGCCTGCGCATGGAAGAACTGAACTGAT
CGGCAGGATATTCCGGACCC

Downstream 100 bases:

>100_bases
GCGGAGCGGGCGCCAATGTGGCTGCGGCGCCGCCGCATGCCTTGGCGGCGCCAACTCGCTACAATCAGGCTAGCCGTGGC
CCAGTCGCGGCCCCCGGATT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKYQSTRGHEVPQSFSEILLGGLAPDGGLYLPVQYPQVTADELEAWRKLSYADLAFEILSKFCDDIPAEDLRALTRKTYT
AEVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPTLAFKDMAMQLLGNMFEYALGRAGLELNILGATSGDTGSAA
EYAMRGKRGIRVFMLSPHRKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDLEYKARQRIGTVNSINWARVV
AQVVYYFKGWLLATTGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGAYRVRKSAETYHTS
SPSMDISKASNFERFIFDLLGQDAGKLAALFRDVDEKGGFDLSGTPEYERIRGEFGFVSGRSTHGDRVATIRDMSARYGI
TIDTHTADGIKVAREHLSADVPMVVLETALPAKFADTIREALGHEPERPAAFEGIEKLPQRFEVMANDASQVKAFIAGHT
GL

Sequences:

>Translated_482_residues
MKYQSTRGHEVPQSFSEILLGGLAPDGGLYLPVQYPQVTADELEAWRKLSYADLAFEILSKFCDDIPAEDLRALTRKTYT
AEVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPTLAFKDMAMQLLGNMFEYALGRAGLELNILGATSGDTGSAA
EYAMRGKRGIRVFMLSPHRKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDLEYKARQRIGTVNSINWARVV
AQVVYYFKGWLLATTGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGAYRVRKSAETYHTS
SPSMDISKASNFERFIFDLLGQDAGKLAALFRDVDEKGGFDLSGTPEYERIRGEFGFVSGRSTHGDRVATIRDMSARYGI
TIDTHTADGIKVAREHLSADVPMVVLETALPAKFADTIREALGHEPERPAAFEGIEKLPQRFEVMANDASQVKAFIAGHT
GL
>Mature_482_residues
MKYQSTRGHEVPQSFSEILLGGLAPDGGLYLPVQYPQVTADELEAWRKLSYADLAFEILSKFCDDIPAEDLRALTRKTYT
AEVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPTLAFKDMAMQLLGNMFEYALGRAGLELNILGATSGDTGSAA
EYAMRGKRGIRVFMLSPHRKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDLEYKARQRIGTVNSINWARVV
AQVVYYFKGWLLATTGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGAYRVRKSAETYHTS
SPSMDISKASNFERFIFDLLGQDAGKLAALFRDVDEKGGFDLSGTPEYERIRGEFGFVSGRSTHGDRVATIRDMSARYGI
TIDTHTADGIKVAREHLSADVPMVVLETALPAKFADTIREALGHEPERPAAFEGIEKLPQRFEVMANDASQVKAFIAGHT
GL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=449, Percent_Identity=34.2984409799555, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI149193323, Length=474, Percent_Identity=27.8481012658228, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1786185, Length=482, Percent_Identity=28.4232365145228, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319901, Length=474, Percent_Identity=40.084388185654, Blast_Score=313, Evalue=4e-86,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52839; Mature: 52839

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQSTRGHEVPQSFSEILLGGLAPDGGLYLPVQYPQVTADELEAWRKLSYADLAFEILS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KFCDDIPAEDLRALTRKTYTAEVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPT
HHHCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCC
LAFKDMAMQLLGNMFEYALGRAGLELNILGATSGDTGSAAEYAMRGKRGIRVFMLSPHRK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCHH
MSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDLEYKARQRIGTVNSINWARVV
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AQVVYYFKGWLLATTGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLD
HHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHH
EFFRTGAYRVRKSAETYHTSSPSMDISKASNFERFIFDLLGQDAGKLAALFRDVDEKGGF
HHHHCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
DLSGTPEYERIRGEFGFVSGRSTHGDRVATIRDMSARYGITIDTHTADGIKVAREHLSAD
CCCCCCCHHHHCCCCCEECCCCCCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHCCC
VPMVVLETALPAKFADTIREALGHEPERPAAFEGIEKLPQRFEVMANDASQVKAFIAGHT
CCCEEEHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GL
CC
>Mature Secondary Structure
MKYQSTRGHEVPQSFSEILLGGLAPDGGLYLPVQYPQVTADELEAWRKLSYADLAFEILS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KFCDDIPAEDLRALTRKTYTAEVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPT
HHHCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCC
LAFKDMAMQLLGNMFEYALGRAGLELNILGATSGDTGSAAEYAMRGKRGIRVFMLSPHRK
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCHH
MSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDLEYKARQRIGTVNSINWARVV
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AQVVYYFKGWLLATTGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLD
HHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHH
EFFRTGAYRVRKSAETYHTSSPSMDISKASNFERFIFDLLGQDAGKLAALFRDVDEKGGF
HHHHCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
DLSGTPEYERIRGEFGFVSGRSTHGDRVATIRDMSARYGITIDTHTADGIKVAREHLSAD
CCCCCCCHHHHCCCCCEECCCCCCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHCCC
VPMVVLETALPAKFADTIREALGHEPERPAAFEGIEKLPQRFEVMANDASQVKAFIAGHT
CCCEEEHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]