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The map label for this gene is pcp [H]

Identifier: 73541448

GI number: 73541448

Start: 1914794

End: 1916449

Strand: Reverse

Name: pcp [H]

Synonym: Reut_A1759

Alternate gene names: 73541448

Gene position: 1916449-1914794 (Counterclockwise)

Preceding gene: 73541449

Following gene: 73541447

Centisome position: 50.35

GC content: 66.61

Gene sequence:

>1656_bases
ATGGCGGACACACACGTACAGCTTGCTGGCAGTCGCCGGCCGCTGCCGCACAACGCCATCCGGGTGCGCGACGTGGATCC
GCACGCGATCGTCGACGTCACGGTCACGCTCAAGGGTCCCGATCTTCCCGCACCGGAACAGATGCCCGACAAGGCGTTGT
CGCGCGAAGAGATCGTGCAGCGTTTCGGCGTGCCCGCGGAAACGGTGCGCAAGGTCGAGGACGTGCTCCGGGGCTATGGC
CTCCAGGTCGTCGAGGTGAAGCAAGGCGGCCGCAGCATACGGGTGCGCGGAACGGCGTCGGCGATGATCGCCGCGTTCAA
GCCCGAACTTGGCATCTACCATGTGCCCGGGCAGGGTCAGATCCGCGCGCGCCACGGCGTGCTGATGGTGCCGGGCGAGA
TCGCCGACGTCGTGGAGGGTGTGTTCGGCCTGGACCAGCGGCAGATGGCGAAGCGTCATGCGCAAGCCGCGGCATTGGTG
CGCACGCTGGTCCCGCTGACCCCCGCAGACCTTGTGAAGCGATACCACTTTCCTGATGGCGATGGCGCAGACCGGACGAT
CGCCATCGCCGAATTCGGCCAGAACATCGGCAATGGGCAGGTACTGCCGCCCGCGTATCTTCCTTCGGACGTATCCCTGT
TCTGCAAGCGGCAAGGGTTGCCGGTGCCTGTGGTGCGGATCGAAAGCGTTGGCCTGTCTCCGCTCAGCGAACAGCAGTTC
CGGGCCGAGATTCAGGAACTTCCCAAGGACCTGCAGGACCTGCTGTTCGTGCAGACCGCCGAGACGATGATGGATATCGA
GATCGTCGCCGGACTTTGTCCGAAGGCGGATATCGGCGTGTATTTCGCGACGTGGGGAGAGAGCGGCTGGATCAACCTGC
TCGATGAAGTCACTTCGGGGAAAGGGCCCGTGCCCGTGGCGCTGTCCATCAGCTACGGTCTCGCCGAAGAGGCCACGGAC
TGGAGCCATGGTGCGATGGCATCGATCAACCAGCGGCTTCAGATTGCAGCGATGCAGGGCGTGACCGTGTGCGTATCGTC
GGGCGATGACGGCAGCGGCTGCAATCAACCGGGCAAGCGCTGTCATGTCGCATTCCCGACCTCGAGTCCCTATGTGCTGA
GCGTGGGCGGCACCATGCTTGTCACACATGCGGACGGGAAGTCCGAGGAAGTGGCGTGGTGGGAAGCGCCGGGCGAGCGC
ACACAGCAGGGCGGCGGCTCGACCGGTGGTGGCGTGAGCGTGCTGAATCCGCGGCCGCCGTGGCAGAACGTCTCGGTGGC
GTCTCTGAATCCCGGCGCCGCAAACGGGCGCGTGGTGCCTGACGTGGCCGCATTGGCGGGGCCGCCGCTCTACGACCTGC
TGCTCGATGGCCACGCATTGCCCGATGGCGGCACGAGCGCCGCCGCGCCGTTGTGGGCGGCGCTGGTGGCGCGTATCGAT
GCGGCGTTGCCGGCCGGCAAGCGGCAGCGATTCCTTGCGCCGCTGCTCTACAAGGGCGATGTGGGACGCGCGGGCTTCAG
CGACGTCGTTTCGGGCCAGAACACCTCGCGTCCGAGCCCCGGCAAGGGCTATACGGCCAAGGCGGGCTTTGATGCGGTCA
CCGGCTGGGGCGTGCCCAACGGGCAGGGATTGCTCGCCGCGCTGGCTGCGGTCTGA

Upstream 100 bases:

>100_bases
ACACGCTCAGCAGCGGCATTTTGACGAATGGCCCCGCAATACCTAAGCTCGTTTGAGCCTGCCGCCAAAGCCGCAGGCAA
CGTCAGTGCGGGAGGAAAAC

Downstream 100 bases:

>100_bases
CGATCTGGCGCCAGCGGACTTCACCATTTCGCACACGGAGGACAATGCAATGAGCCCGACGACACGAAAGGAAGTTCCGT
CCGATGAGCCGCTTATCGAC

Product: kumamolisin

Products: NA

Alternate protein names: Pepstatin-insensitive carboxyl proteinase; Pseudomonapepsin [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MADTHVQLAGSRRPLPHNAIRVRDVDPHAIVDVTVTLKGPDLPAPEQMPDKALSREEIVQRFGVPAETVRKVEDVLRGYG
LQVVEVKQGGRSIRVRGTASAMIAAFKPELGIYHVPGQGQIRARHGVLMVPGEIADVVEGVFGLDQRQMAKRHAQAAALV
RTLVPLTPADLVKRYHFPDGDGADRTIAIAEFGQNIGNGQVLPPAYLPSDVSLFCKRQGLPVPVVRIESVGLSPLSEQQF
RAEIQELPKDLQDLLFVQTAETMMDIEIVAGLCPKADIGVYFATWGESGWINLLDEVTSGKGPVPVALSISYGLAEEATD
WSHGAMASINQRLQIAAMQGVTVCVSSGDDGSGCNQPGKRCHVAFPTSSPYVLSVGGTMLVTHADGKSEEVAWWEAPGER
TQQGGGSTGGGVSVLNPRPPWQNVSVASLNPGAANGRVVPDVAALAGPPLYDLLLDGHALPDGGTSAAAPLWAALVARID
AALPAGKRQRFLAPLLYKGDVGRAGFSDVVSGQNTSRPSPGKGYTAKAGFDAVTGWGVPNGQGLLAALAAV

Sequences:

>Translated_551_residues
MADTHVQLAGSRRPLPHNAIRVRDVDPHAIVDVTVTLKGPDLPAPEQMPDKALSREEIVQRFGVPAETVRKVEDVLRGYG
LQVVEVKQGGRSIRVRGTASAMIAAFKPELGIYHVPGQGQIRARHGVLMVPGEIADVVEGVFGLDQRQMAKRHAQAAALV
RTLVPLTPADLVKRYHFPDGDGADRTIAIAEFGQNIGNGQVLPPAYLPSDVSLFCKRQGLPVPVVRIESVGLSPLSEQQF
RAEIQELPKDLQDLLFVQTAETMMDIEIVAGLCPKADIGVYFATWGESGWINLLDEVTSGKGPVPVALSISYGLAEEATD
WSHGAMASINQRLQIAAMQGVTVCVSSGDDGSGCNQPGKRCHVAFPTSSPYVLSVGGTMLVTHADGKSEEVAWWEAPGER
TQQGGGSTGGGVSVLNPRPPWQNVSVASLNPGAANGRVVPDVAALAGPPLYDLLLDGHALPDGGTSAAAPLWAALVARID
AALPAGKRQRFLAPLLYKGDVGRAGFSDVVSGQNTSRPSPGKGYTAKAGFDAVTGWGVPNGQGLLAALAAV
>Mature_550_residues
ADTHVQLAGSRRPLPHNAIRVRDVDPHAIVDVTVTLKGPDLPAPEQMPDKALSREEIVQRFGVPAETVRKVEDVLRGYGL
QVVEVKQGGRSIRVRGTASAMIAAFKPELGIYHVPGQGQIRARHGVLMVPGEIADVVEGVFGLDQRQMAKRHAQAAALVR
TLVPLTPADLVKRYHFPDGDGADRTIAIAEFGQNIGNGQVLPPAYLPSDVSLFCKRQGLPVPVVRIESVGLSPLSEQQFR
AEIQELPKDLQDLLFVQTAETMMDIEIVAGLCPKADIGVYFATWGESGWINLLDEVTSGKGPVPVALSISYGLAEEATDW
SHGAMASINQRLQIAAMQGVTVCVSSGDDGSGCNQPGKRCHVAFPTSSPYVLSVGGTMLVTHADGKSEEVAWWEAPGERT
QQGGGSTGGGVSVLNPRPPWQNVSVASLNPGAANGRVVPDVAALAGPPLYDLLLDGHALPDGGTSAAAPLWAALVARIDA
ALPAGKRQRFLAPLLYKGDVGRAGFSDVVSGQNTSRPSPGKGYTAKAGFDAVTGWGVPNGQGLLAALAAV

Specific function: Unknown

COG id: COG4934

COG function: function code O; Predicted protease

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S53 family [H]

Homologues:

Organism=Homo sapiens, GI5729770, Length=277, Percent_Identity=31.7689530685921, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015366
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8; PF09286 Pro-kuma_activ [H]

EC number: =3.4.21.100 [H]

Molecular weight: Translated: 57952; Mature: 57820

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTHVQLAGSRRPLPHNAIRVRDVDPHAIVDVTVTLKGPDLPAPEQMPDKALSREEIVQ
CCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCHHHHHH
RFGVPAETVRKVEDVLRGYGLQVVEVKQGGRSIRVRGTASAMIAAFKPELGIYHVPGQGQ
HHCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECHHHHHEEECCCCCEEECCCCCC
IRARHGVLMVPGEIADVVEGVFGLDQRQMAKRHAQAAALVRTLVPLTPADLVKRYHFPDG
EEECCCEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
DGADRTIAIAEFGQNIGNGQVLPPAYLPSDVSLFCKRQGLPVPVVRIESVGLSPLSEQQF
CCCCCEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCHHHH
RAEIQELPKDLQDLLFVQTAETMMDIEIVAGLCPKADIGVYFATWGESGWINLLDEVTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCC
KGPVPVALSISYGLAEEATDWSHGAMASINQRLQIAAMQGVTVCVSSGDDGSGCNQPGKR
CCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHEEEEEECCEEEEEECCCCCCCCCCCCCE
CHVAFPTSSPYVLSVGGTMLVTHADGKSEEVAWWEAPGERTQQGGGSTGGGVSVLNPRPP
EEEECCCCCCEEEEECCEEEEEECCCCCCCEEEECCCCHHHHCCCCCCCCCEEECCCCCC
WQNVSVASLNPGAANGRVVPDVAALAGPPLYDLLLDGHALPDGGTSAAAPLWAALVARID
CCCCEEEECCCCCCCCEECCCHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AALPAGKRQRFLAPLLYKGDVGRAGFSDVVSGQNTSRPSPGKGYTAKAGFDAVTGWGVPN
HHCCCCCHHHHHHHHEECCCCCCCCHHHHHCCCCCCCCCCCCCCEECCCCCCEECCCCCC
GQGLLAALAAV
CCHHHHHHHCC
>Mature Secondary Structure 
ADTHVQLAGSRRPLPHNAIRVRDVDPHAIVDVTVTLKGPDLPAPEQMPDKALSREEIVQ
CCCEEEECCCCCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCHHHHHH
RFGVPAETVRKVEDVLRGYGLQVVEVKQGGRSIRVRGTASAMIAAFKPELGIYHVPGQGQ
HHCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECHHHHHEEECCCCCEEECCCCCC
IRARHGVLMVPGEIADVVEGVFGLDQRQMAKRHAQAAALVRTLVPLTPADLVKRYHFPDG
EEECCCEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
DGADRTIAIAEFGQNIGNGQVLPPAYLPSDVSLFCKRQGLPVPVVRIESVGLSPLSEQQF
CCCCCEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCHHHH
RAEIQELPKDLQDLLFVQTAETMMDIEIVAGLCPKADIGVYFATWGESGWINLLDEVTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCC
KGPVPVALSISYGLAEEATDWSHGAMASINQRLQIAAMQGVTVCVSSGDDGSGCNQPGKR
CCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHEEEEEECCEEEEEECCCCCCCCCCCCCE
CHVAFPTSSPYVLSVGGTMLVTHADGKSEEVAWWEAPGERTQQGGGSTGGGVSVLNPRPP
EEEECCCCCCEEEEECCEEEEEECCCCCCCEEEECCCCHHHHCCCCCCCCCEEECCCCCC
WQNVSVASLNPGAANGRVVPDVAALAGPPLYDLLLDGHALPDGGTSAAAPLWAALVARID
CCCCEEEECCCCCCCCEECCCHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AALPAGKRQRFLAPLLYKGDVGRAGFSDVVSGQNTSRPSPGKGYTAKAGFDAVTGWGVPN
HHCCCCCHHHHHHHHEECCCCCCCCHHHHHCCCCCCCCCCCCCCEECCCCCCEECCCCCC
GQGLLAALAAV
CCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929375; 8576087; 10488127; 11747435; 11323721 [H]