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The map label for this gene is aaeR [H]

Identifier: 73541173

GI number: 73541173

Start: 1602618

End: 1603532

Strand: Direct

Name: aaeR [H]

Synonym: Reut_A1480

Alternate gene names: 73541173

Gene position: 1602618-1603532 (Clockwise)

Preceding gene: 73541172

Following gene: 73541175

Centisome position: 42.1

GC content: 61.2

Gene sequence:

>915_bases
ATGGATCGGATGGCCAGTCTTACCGCCTTTGTCCGCGTCGTCGAGAGCGGGGGCTTTACCGCGGCGGCGCGTCGCCTGGA
CCTGTCGACAACGACGGTCAGCAACCACGTCCAGGCGCTCGAAGACAGCCTTGGTGTGCGCCTGTTGAACCGCACCACAC
GCCATGTGAGTCTAACCGAGATCGGCCGCGAGTATTACGAGCGCTGCTCACATATCTTGCAGGAGTTGGCGGAAGCCGAC
GAGATTACCAGCGCGTTGCAGGTGACTCCGCGCGGCCGGCTTCGCCTCCGTTGCCATCAATCACTGGACCGGTTCATCGC
GCCGGTCGTCACCCGCTTCTTGGGCAATTACCCGGAAGTCTCGCTAGATTTCGAGACCGACGTCATGATCGACCCCGTGC
GGGAGGGCTTCGACCTATCGATCATGCCGGCATCACCTCCTGACTCGACCCTGATCAGACGGACCCTGGCGAAATGGCAT
TACCTATTGTGCTGTGCGCCGGCTTACCTCGAGACGCATTCCGTGCCCCACAGCCCAGCCGACCTGGTCGACCATAACTG
CCTGCTTTACGCCTATTCGATCTTCCGCAACGAGTTTCATTTCGTCGATCCTGCCGGCAATCCGATGAGCACTCGCGTTT
CGGGCAACATGGTCACCGCCAGCATTACCGTAATGCGCGCAGCTGCCGCAGCCGGACTCGGATTGTGGCTGTGCCCCCCG
TTTCTCGTATCAGACCTTCTCGCCTCCGGTGCGCTGGTGCCGCTGCTGCCCGATTACCGAACACAGGAGTTGGAGATCGT
CGCGCTCTACCCCCATCGGCGTCAGGTAAGCACCAAGGTCCGGTTGCTCCTCGATATGCTGGTCGACCGGTTCGCCGAAG
AGCAGCGCTGGCTTGATGCCATGCCTGATCGGTAA

Upstream 100 bases:

>100_bases
AGCAATTCGCTTAACGTGACGCGTCAATTACGTTGACAAACGCCGGTTTGGCGCTCCAGTATTGACGTGACTCTCAACTG
TGACTTAATTGGTGGAACGC

Downstream 100 bases:

>100_bases
GACCGGAGTAGCTGCTTTCCGGCAGCGCCACGATTCGGTGAACGCAGCCCAGCCAGAGATCGGCGTATCGAGGCTTTCCA
TTACGTTCATCAGGTTCATG

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDRMASLTAFVRVVESGGFTAAARRLDLSTTTVSNHVQALEDSLGVRLLNRTTRHVSLTEIGREYYERCSHILQELAEAD
EITSALQVTPRGRLRLRCHQSLDRFIAPVVTRFLGNYPEVSLDFETDVMIDPVREGFDLSIMPASPPDSTLIRRTLAKWH
YLLCCAPAYLETHSVPHSPADLVDHNCLLYAYSIFRNEFHFVDPAGNPMSTRVSGNMVTASITVMRAAAAAGLGLWLCPP
FLVSDLLASGALVPLLPDYRTQELEIVALYPHRRQVSTKVRLLLDMLVDRFAEEQRWLDAMPDR

Sequences:

>Translated_304_residues
MDRMASLTAFVRVVESGGFTAAARRLDLSTTTVSNHVQALEDSLGVRLLNRTTRHVSLTEIGREYYERCSHILQELAEAD
EITSALQVTPRGRLRLRCHQSLDRFIAPVVTRFLGNYPEVSLDFETDVMIDPVREGFDLSIMPASPPDSTLIRRTLAKWH
YLLCCAPAYLETHSVPHSPADLVDHNCLLYAYSIFRNEFHFVDPAGNPMSTRVSGNMVTASITVMRAAAAAGLGLWLCPP
FLVSDLLASGALVPLLPDYRTQELEIVALYPHRRQVSTKVRLLLDMLVDRFAEEQRWLDAMPDR
>Mature_304_residues
MDRMASLTAFVRVVESGGFTAAARRLDLSTTTVSNHVQALEDSLGVRLLNRTTRHVSLTEIGREYYERCSHILQELAEAD
EITSALQVTPRGRLRLRCHQSLDRFIAPVVTRFLGNYPEVSLDFETDVMIDPVREGFDLSIMPASPPDSTLIRRTLAKWH
YLLCCAPAYLETHSVPHSPADLVDHNCLLYAYSIFRNEFHFVDPAGNPMSTRVSGNMVTASITVMRAAAAAGLGLWLCPP
FLVSDLLASGALVPLLPDYRTQELEIVALYPHRRQVSTKVRLLLDMLVDRFAEEQRWLDAMPDR

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=308, Percent_Identity=34.4155844155844, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI145693193, Length=296, Percent_Identity=32.0945945945946, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=33.5664335664336, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1786401, Length=286, Percent_Identity=31.8181818181818, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081978, Length=300, Percent_Identity=32.3333333333333, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1787128, Length=306, Percent_Identity=27.1241830065359, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787589, Length=292, Percent_Identity=30.1369863013699, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787601, Length=174, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790262, Length=243, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790011, Length=286, Percent_Identity=22.3776223776224, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI157672245, Length=117, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=264, Percent_Identity=26.5151515151515, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786448, Length=271, Percent_Identity=26.5682656826568, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787879, Length=142, Percent_Identity=33.0985915492958, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34153; Mature: 34153

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRMASLTAFVRVVESGGFTAAARRLDLSTTTVSNHVQALEDSLGVRLLNRTTRHVSLTE
CCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHH
IGREYYERCSHILQELAEADEITSALQVTPRGRLRLRCHQSLDRFIAPVVTRFLGNYPEV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCE
SLDFETDVMIDPVREGFDLSIMPASPPDSTLIRRTLAKWHYLLCCAPAYLETHSVPHSPA
EECCCCCEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCH
DLVDHNCLLYAYSIFRNEFHFVDPAGNPMSTRVSGNMVTASITVMRAAAAAGLGLWLCPP
HHHCCCHHHHHHHHHHCCCEEECCCCCCCCEEECCCEEEHHHHHHHHHHHHCCHHHHCCH
FLVSDLLASGALVPLLPDYRTQELEIVALYPHRRQVSTKVRLLLDMLVDRFAEEQRWLDA
HHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPDR
CCCC
>Mature Secondary Structure
MDRMASLTAFVRVVESGGFTAAARRLDLSTTTVSNHVQALEDSLGVRLLNRTTRHVSLTE
CCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHH
IGREYYERCSHILQELAEADEITSALQVTPRGRLRLRCHQSLDRFIAPVVTRFLGNYPEV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCE
SLDFETDVMIDPVREGFDLSIMPASPPDSTLIRRTLAKWHYLLCCAPAYLETHSVPHSPA
EECCCCCEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCH
DLVDHNCLLYAYSIFRNEFHFVDPAGNPMSTRVSGNMVTASITVMRAAAAAGLGLWLCPP
HHHCCCHHHHHHHHHHCCCEEECCCCCCCCEEECCCEEEHHHHHHHHHHHHCCHHHHCCH
FLVSDLLASGALVPLLPDYRTQELEIVALYPHRRQVSTKVRLLLDMLVDRFAEEQRWLDA
HHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPDR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]