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The map label for this gene is livM [H]

Identifier: 73541095

GI number: 73541095

Start: 1515269

End: 1516588

Strand: Direct

Name: livM [H]

Synonym: Reut_A1401

Alternate gene names: 73541095

Gene position: 1515269-1516588 (Clockwise)

Preceding gene: 73541094

Following gene: 73541096

Centisome position: 39.81

GC content: 63.56

Gene sequence:

>1320_bases
ATGAGAATCGAATCGACAATGGAACAACGCCGCGGGCCGGTCGTGACCGGCCGTACCATGCGCTACAAGCCGCTCAACCT
TGCGCGCTGGGTGATCTGGAGCCTGACCATACTGGTCATGCTGGTGCTGCCGCTGATCTTTACCGGCGGGTTTGCGATCA
CGCTGATGTCCCAGATGGGCATCATGATCATCTTTGCGCTGTCGTACAACATGCTGCTCGGCCAGACCGGCATGCTGTCG
TTCGGGCACGCCGTGTATTCGGGCCTCGGCGCCTTCATTGCCGTGCACGTGCTCAATATGCTGGGCGCGGGCAAGGTGTG
GCTGCCCGTGTCGATGCTGCCGCTTGTGGGCGGCCTGGCCGGCGCATTCTTCGGCGTGCTGTTCGGCTACGTGACCACCA
AGAAGTCGGGCACGACGTTCGCCATGATCACCATGGGCATCGGCGAGATGGTGTTTGCCAGTTCGCTGATGTTCCCCGAG
TTCTTCGGCGGCGAAGGCGGCATCTCTACCAACCGCGTGGTGGGTGACCCATTCCTTGGCATCACGTTCGGTCCCGGCCG
TCAGGTCTACTACCTGATCGCCGCGTGGTGCCTGGTGTCGATGGTGGCGATGTATGCGTGGACGCAGACGCCGCTTGGCC
GCATTGCCAACGCGGTACGCGATAACCCTGAACGTGTCGAGTTCATCGGGTACAACACGCAGCGTGTGCGCTACCTCGTG
CTGATCCTGTCGGCGTTCTTCGCCGGCATCTCGGGCGCGCTGTCGGCGATCAACTTCGAGATCGTATCGGCCGAAAATGT
GAGCGCCGTACGCTCGGGCGGCGTGCTGCTCGCGGCGTTCATCGGTGGCGCCGGCGTGTTCTTCGGGCCGATCATCGGCG
CGGTGGTATTCATGCTGTTCGCGGTTGCACTGTCGGACCTGACCAAGGCGTGGCTGCTGTACCTGGGCCTGTTCTTCGTG
CTGATGGTGATGTTCGTACCGGGCGGCATCGCGAGCCTGCTGCTGATGCAGATGCCGCTGGTGGCCAAAGGCAAGTTCAA
ACAGATGCTGCCGTCCTACGGGCGTGCCGCAGCGGCAGGCGTGGTGCTGCTCGCAGCCATGATCCTGACCGTGGAACTGG
TCTACAAGGTTCAGGTCGACAGCGCCAACGGCACCGACATGTCGCTGTTCGGCATCGCTTTCGATGCCGGCAAGCCTATG
GCCTGGGCGGTCGCGGCCGCCCTGTGGGTGGCCGGGTTGTTGGCGTGGCGCATGGCGGCGGCGCGCGTGCGCACGGCATG
GGACAAGGTGCACGGTGAAATCGCGGGAGGCAGGGCATGA

Upstream 100 bases:

>100_bases
GACCGTGGCCCAGGTGGCGCCGGTGCTACCTTATCTGCTGCTGGTGCTGATGCTGATCTTCCGGCCGCGAGGTCTGATGG
GAACCCGGGAGAGCTGAGCC

Downstream 100 bases:

>100_bases
CAGCGGCACTGGAACTGACCGATGTACGCAAGAAGTTCGGCCAGACGGAAATCATCCGTGGCGTGAACCTGTCGATTGGC
AAGGGCGAGCGCCACGCGCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MRIESTMEQRRGPVVTGRTMRYKPLNLARWVIWSLTILVMLVLPLIFTGGFAITLMSQMGIMIIFALSYNMLLGQTGMLS
FGHAVYSGLGAFIAVHVLNMLGAGKVWLPVSMLPLVGGLAGAFFGVLFGYVTTKKSGTTFAMITMGIGEMVFASSLMFPE
FFGGEGGISTNRVVGDPFLGITFGPGRQVYYLIAAWCLVSMVAMYAWTQTPLGRIANAVRDNPERVEFIGYNTQRVRYLV
LILSAFFAGISGALSAINFEIVSAENVSAVRSGGVLLAAFIGGAGVFFGPIIGAVVFMLFAVALSDLTKAWLLYLGLFFV
LMVMFVPGGIASLLLMQMPLVAKGKFKQMLPSYGRAAAAGVVLLAAMILTVELVYKVQVDSANGTDMSLFGIAFDAGKPM
AWAVAAALWVAGLLAWRMAAARVRTAWDKVHGEIAGGRA

Sequences:

>Translated_439_residues
MRIESTMEQRRGPVVTGRTMRYKPLNLARWVIWSLTILVMLVLPLIFTGGFAITLMSQMGIMIIFALSYNMLLGQTGMLS
FGHAVYSGLGAFIAVHVLNMLGAGKVWLPVSMLPLVGGLAGAFFGVLFGYVTTKKSGTTFAMITMGIGEMVFASSLMFPE
FFGGEGGISTNRVVGDPFLGITFGPGRQVYYLIAAWCLVSMVAMYAWTQTPLGRIANAVRDNPERVEFIGYNTQRVRYLV
LILSAFFAGISGALSAINFEIVSAENVSAVRSGGVLLAAFIGGAGVFFGPIIGAVVFMLFAVALSDLTKAWLLYLGLFFV
LMVMFVPGGIASLLLMQMPLVAKGKFKQMLPSYGRAAAAGVVLLAAMILTVELVYKVQVDSANGTDMSLFGIAFDAGKPM
AWAVAAALWVAGLLAWRMAAARVRTAWDKVHGEIAGGRA
>Mature_439_residues
MRIESTMEQRRGPVVTGRTMRYKPLNLARWVIWSLTILVMLVLPLIFTGGFAITLMSQMGIMIIFALSYNMLLGQTGMLS
FGHAVYSGLGAFIAVHVLNMLGAGKVWLPVSMLPLVGGLAGAFFGVLFGYVTTKKSGTTFAMITMGIGEMVFASSLMFPE
FFGGEGGISTNRVVGDPFLGITFGPGRQVYYLIAAWCLVSMVAMYAWTQTPLGRIANAVRDNPERVEFIGYNTQRVRYLV
LILSAFFAGISGALSAINFEIVSAENVSAVRSGGVLLAAFIGGAGVFFGPIIGAVVFMLFAVALSDLTKAWLLYLGLFFV
LMVMFVPGGIASLLLMQMPLVAKGKFKQMLPSYGRAAAAGVVLLAAMILTVELVYKVQVDSANGTDMSLFGIAFDAGKPM
AWAVAAALWVAGLLAWRMAAARVRTAWDKVHGEIAGGRA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=309, Percent_Identity=28.1553398058252, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46997; Mature: 46997

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIESTMEQRRGPVVTGRTMRYKPLNLARWVIWSLTILVMLVLPLIFTGGFAITLMSQMG
CCCHHHHHHHCCCEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
IMIIFALSYNMLLGQTGMLSFGHAVYSGLGAFIAVHVLNMLGAGKVWLPVSMLPLVGGLA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GAFFGVLFGYVTTKKSGTTFAMITMGIGEMVFASSLMFPEFFGGEGGISTNRVVGDPFLG
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCHHHCCCCCCCCCCCEECCCCEE
ITFGPGRQVYYLIAAWCLVSMVAMYAWTQTPLGRIANAVRDNPERVEFIGYNTQRVRYLV
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
LILSAFFAGISGALSAINFEIVSAENVSAVRSGGVLLAAFIGGAGVFFGPIIGAVVFMLF
HHHHHHHHHHHHHHHHHEEEEEECCCHHHHHCCCEEEEHHHCCCHHHHHHHHHHHHHHHH
AVALSDLTKAWLLYLGLFFVLMVMFVPGGIASLLLMQMPLVAKGKFKQMLPSYGRAAAAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHCCCHHHHHHHHHCHHHHHH
VVLLAAMILTVELVYKVQVDSANGTDMSLFGIAFDAGKPMAWAVAAALWVAGLLAWRMAA
HHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ARVRTAWDKVHGEIAGGRA
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRIESTMEQRRGPVVTGRTMRYKPLNLARWVIWSLTILVMLVLPLIFTGGFAITLMSQMG
CCCHHHHHHHCCCEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
IMIIFALSYNMLLGQTGMLSFGHAVYSGLGAFIAVHVLNMLGAGKVWLPVSMLPLVGGLA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GAFFGVLFGYVTTKKSGTTFAMITMGIGEMVFASSLMFPEFFGGEGGISTNRVVGDPFLG
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCHHHCCCCCCCCCCCEECCCCEE
ITFGPGRQVYYLIAAWCLVSMVAMYAWTQTPLGRIANAVRDNPERVEFIGYNTQRVRYLV
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
LILSAFFAGISGALSAINFEIVSAENVSAVRSGGVLLAAFIGGAGVFFGPIIGAVVFMLF
HHHHHHHHHHHHHHHHHEEEEEECCCHHHHHCCCEEEEHHHCCCHHHHHHHHHHHHHHHH
AVALSDLTKAWLLYLGLFFVLMVMFVPGGIASLLLMQMPLVAKGKFKQMLPSYGRAAAAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHCCCHHHHHHHHHCHHHHHH
VVLLAAMILTVELVYKVQVDSANGTDMSLFGIAFDAGKPMAWAVAAALWVAGLLAWRMAA
HHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ARVRTAWDKVHGEIAGGRA
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]