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The map label for this gene is livH [H]

Identifier: 73541094

GI number: 73541094

Start: 1514237

End: 1515265

Strand: Direct

Name: livH [H]

Synonym: Reut_A1400

Alternate gene names: 73541094

Gene position: 1514237-1515265 (Clockwise)

Preceding gene: 73541093

Following gene: 73541095

Centisome position: 39.78

GC content: 62.78

Gene sequence:

>1029_bases
ATGCCATGCCCGGCAGGATGCGCTCACCCTTGTTCAAACCGGATGGCCGCGCTGTGGCGCAGCCAGATTGAAGGATACGT
TGTGGAATTCTTCGTCATTTCTTTGCTGAACGGCATCAGCTACGGGCTGCTGCTGTTCATGCTCTCGTCTGGCCTCACGC
TGATCTTCAGCATGATGGGTGTGCTCAACTTCGCGCACGCGAGCTTCTACATGCTCGGGGCCTACTTTGCCTACACCGTT
GCCAGCAAGATAGGATTCTGGCCGGCGCTGATCCTGGCGCCGCTGCTGGTGGCATTTGCCGGCGCGCTCGTGGAACGCTT
CGGCCTGCGCGCCGTGCACAAGTACGGGCATGTGGCCGAGCTGCTGTTCACGTTCGGCCTGGCCTACCTGATCGAAGAAG
GGGTCAAGCTCGTCTGGGGCCTGGCTGCCGTGCCATACCGTATTCCGGCCGAACTCGACGGGCCGCTGTTCACGGTATTC
ACGTCGTCGTTCCCGAAATACCGTGCATTCATGATGCTGGTCTCGCTGGGCATGCTCGTGGCGATCTATCTCGTGCTCAC
GCGCACGCGCATCGGCCTCGTGATCCAGGCGGCGCTGACGCATCCGGAGATGGTGGAAGCGCTTGGCCACAATGTGCCGC
GCGTGTTCATGATGGTGTTCGGCGGGGGCGCGGCGCTGGCCGGACTTGCCGGCGTGATCGGTGGCAATGCCTTTGTCACC
GAGCCATCGATGGCGGCGGCAGTCGGGTCGATCGTATTCGTGGTCGCGGTGGTGGGCGGCATGGGTTCACTGGTGGGGGC
GTTTATCGCTTCTATCCTGATCGGCGTGCTGCAGACGTTCGCCGTGACCATCGATGCGTCGCTGGCCGGCCTCTTCAACA
GCATTGGCCTGGCCGTCAGCGACGCCACGCCGTTCTACTCGCTGTGGAAGCTGACCGTGGCCCAGGTGGCGCCGGTGCTA
CCTTATCTGCTGCTGGTGCTGATGCTGATCTTCCGGCCGCGAGGTCTGATGGGAACCCGGGAGAGCTGA

Upstream 100 bases:

>100_bases
GCCGGGCTGATCCTGCCCACGGCGGGCCGGCCGGCAGCATAAAGCCGGCCGCCCGATCCTGCATACTTTCGGTAGAAGAC
CGGGGAGCGTCCGGGCATGC

Downstream 100 bases:

>100_bases
GCCATGAGAATCGAATCGACAATGGAACAACGCCGCGGGCCGGTCGTGACCGGCCGTACCATGCGCTACAAGCCGCTCAA
CCTTGCGCGCTGGGTGATCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MPCPAGCAHPCSNRMAALWRSQIEGYVVEFFVISLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYTV
ASKIGFWPALILAPLLVAFAGALVERFGLRAVHKYGHVAELLFTFGLAYLIEEGVKLVWGLAAVPYRIPAELDGPLFTVF
TSSFPKYRAFMMLVSLGMLVAIYLVLTRTRIGLVIQAALTHPEMVEALGHNVPRVFMMVFGGGAALAGLAGVIGGNAFVT
EPSMAAAVGSIVFVVAVVGGMGSLVGAFIASILIGVLQTFAVTIDASLAGLFNSIGLAVSDATPFYSLWKLTVAQVAPVL
PYLLLVLMLIFRPRGLMGTRES

Sequences:

>Translated_342_residues
MPCPAGCAHPCSNRMAALWRSQIEGYVVEFFVISLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYTV
ASKIGFWPALILAPLLVAFAGALVERFGLRAVHKYGHVAELLFTFGLAYLIEEGVKLVWGLAAVPYRIPAELDGPLFTVF
TSSFPKYRAFMMLVSLGMLVAIYLVLTRTRIGLVIQAALTHPEMVEALGHNVPRVFMMVFGGGAALAGLAGVIGGNAFVT
EPSMAAAVGSIVFVVAVVGGMGSLVGAFIASILIGVLQTFAVTIDASLAGLFNSIGLAVSDATPFYSLWKLTVAQVAPVL
PYLLLVLMLIFRPRGLMGTRES
>Mature_341_residues
PCPAGCAHPCSNRMAALWRSQIEGYVVEFFVISLLNGISYGLLLFMLSSGLTLIFSMMGVLNFAHASFYMLGAYFAYTVA
SKIGFWPALILAPLLVAFAGALVERFGLRAVHKYGHVAELLFTFGLAYLIEEGVKLVWGLAAVPYRIPAELDGPLFTVFT
SSFPKYRAFMMLVSLGMLVAIYLVLTRTRIGLVIQAALTHPEMVEALGHNVPRVFMMVFGGGAALAGLAGVIGGNAFVTE
PSMAAAVGSIVFVVAVVGGMGSLVGAFIASILIGVLQTFAVTIDASLAGLFNSIGLAVSDATPFYSLWKLTVAQVAPVLP
YLLLVLMLIFRPRGLMGTRES

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=328, Percent_Identity=25.3048780487805, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 36437; Mature: 36306

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCPAGCAHPCSNRMAALWRSQIEGYVVEFFVISLLNGISYGLLLFMLSSGLTLIFSMMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VLNFAHASFYMLGAYFAYTVASKIGFWPALILAPLLVAFAGALVERFGLRAVHKYGHVAE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFTFGLAYLIEEGVKLVWGLAAVPYRIPAELDGPLFTVFTSSFPKYRAFMMLVSLGMLV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
AIYLVLTRTRIGLVIQAALTHPEMVEALGHNVPRVFMMVFGGGAALAGLAGVIGGNAFVT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEE
EPSMAAAVGSIVFVVAVVGGMGSLVGAFIASILIGVLQTFAVTIDASLAGLFNSIGLAVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DATPFYSLWKLTVAQVAPVLPYLLLVLMLIFRPRGLMGTRES
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PCPAGCAHPCSNRMAALWRSQIEGYVVEFFVISLLNGISYGLLLFMLSSGLTLIFSMMG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH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CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]