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The map label for this gene is metC [H]

Identifier: 73541049

GI number: 73541049

Start: 1457003

End: 1458256

Strand: Direct

Name: metC [H]

Synonym: Reut_A1355

Alternate gene names: 73541049

Gene position: 1457003-1458256 (Clockwise)

Preceding gene: 73541048

Following gene: 73541055

Centisome position: 38.28

GC content: 67.3

Gene sequence:

>1254_bases
ATGCCAGCCATCAAGGAATCCGCCGTGTCCGATCCCACTTCCGGCAAGCCCGCGTCGGGCTCCGCCAGCCATTACATCCA
GACGGTTGCCGTCCAGCCCGAGTTGGACATCGCGCCAGGCTTTGACTCGTTTTCGCCCGCCACCCATCGCGGCTCCACGG
TTGTCTTCCGCAATCTGGCGGAACTGCGCGCCTATGGGGATCGGGGCACCACATACTGGCGCTATGGCCTGCATGCCACG
CCCACCAGCGAAGCGCTCTGCCAGCACCTGGCGCTGCTCGAAGGCGCGCGGCACACGCTGCTGCTGCCGTCCGGGCTGGC
CGCGATCTCGCTGGTCTACTTCGCGCTGCTCAAAAGCGGCGACGATGTACTGGTGCCCGACAACGTCTACGGCCCGAACC
GCGACCACGGCGAATGGCTCGCGCGCGATTTCGGGGTGACGGTGCGCTATTACGATCCGATGATCGGCGGCGGCATTGCC
GGCATGATTCGCGCCAATACCCGCCTGATCTGGATGGAATCGCCCGGCTCGGTGACGATGGAAGTGCCGGACAGCGAAGC
GATCGTCGCCGCGGCAAAGGCGCGCGGCGTGCTGACCGCCATCGACAATACCTGGTCAGCCGGTCTCTATTTCCGGCCGT
TCGACATGGGCATCGATATCTCGGTGCAAGCGCTGACCAAGTACCAGTCGGGCGGCAGCGATGTCCTGATGGGCGCCGTG
CTGACGCGCGATGACGCCGTGCAGGCTCGCCTGAAGCGCGCGCGCATGCTGATGGGGTGGGGCGTGTCGGCCGACGACTG
CCATCTCGTGCTGCGGTCGTTGCCGAGCCTGCCGGTGCGTTTGGCCGCGCACGACCGCGCCGCGCGCGAGGTCGCGGAGT
GGCTGCACCAGCGCCCGGAAGTCGTGCGGGTACTGCATCCCGCGTTGCCGGACTGCCCGGGCCACGCCAACTGGCGCCGG
GACTTCACCGGCGCAAGCGGCCTGTTCGCGATCATCATGCACGATAGGTATTCGCAGGAGCAGGTGGACGCGTTCGTCGA
AGCGCTGCGCCTGTTCGCGATCGGCTGGTCCTGGGGAGGCGCGCACAGTCTTGCCGTGCCCTACCACGTGCCGACGATGC
GACCGGCAGGCAGCTGGCCGCCTGCTGGCTGGCAGCACGCTGGCGAACTGGTGCGCCTCTACATTGGCCTGGAGGACACG
CGCGACCTTATCGCCGATCTGCGCCAGGCGATGGAGCAGGTGCTGAAGGGCTGA

Upstream 100 bases:

>100_bases
GGGCTGGTAAGCACGCCCGCCGGTGGCGCGGCCGCCATTTGCTGGTAAGCTCGGACGTATATCGCGTCTCTTTTATGCCT
GCCGCGCAACGCGGCGGGGC

Downstream 100 bases:

>100_bases
AGCGCGCTAACTGGCCCGCAATGCGACGTTGAGCTGATCGACCACCTCGGCCCAATCGGCGTCGTCTGCAATCTCGTCTC
GCAGCATGGTTGCCTGTGCA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MPAIKESAVSDPTSGKPASGSASHYIQTVAVQPELDIAPGFDSFSPATHRGSTVVFRNLAELRAYGDRGTTYWRYGLHAT
PTSEALCQHLALLEGARHTLLLPSGLAAISLVYFALLKSGDDVLVPDNVYGPNRDHGEWLARDFGVTVRYYDPMIGGGIA
GMIRANTRLIWMESPGSVTMEVPDSEAIVAAAKARGVLTAIDNTWSAGLYFRPFDMGIDISVQALTKYQSGGSDVLMGAV
LTRDDAVQARLKRARMLMGWGVSADDCHLVLRSLPSLPVRLAAHDRAAREVAEWLHQRPEVVRVLHPALPDCPGHANWRR
DFTGASGLFAIIMHDRYSQEQVDAFVEALRLFAIGWSWGGAHSLAVPYHVPTMRPAGSWPPAGWQHAGELVRLYIGLEDT
RDLIADLRQAMEQVLKG

Sequences:

>Translated_417_residues
MPAIKESAVSDPTSGKPASGSASHYIQTVAVQPELDIAPGFDSFSPATHRGSTVVFRNLAELRAYGDRGTTYWRYGLHAT
PTSEALCQHLALLEGARHTLLLPSGLAAISLVYFALLKSGDDVLVPDNVYGPNRDHGEWLARDFGVTVRYYDPMIGGGIA
GMIRANTRLIWMESPGSVTMEVPDSEAIVAAAKARGVLTAIDNTWSAGLYFRPFDMGIDISVQALTKYQSGGSDVLMGAV
LTRDDAVQARLKRARMLMGWGVSADDCHLVLRSLPSLPVRLAAHDRAAREVAEWLHQRPEVVRVLHPALPDCPGHANWRR
DFTGASGLFAIIMHDRYSQEQVDAFVEALRLFAIGWSWGGAHSLAVPYHVPTMRPAGSWPPAGWQHAGELVRLYIGLEDT
RDLIADLRQAMEQVLKG
>Mature_416_residues
PAIKESAVSDPTSGKPASGSASHYIQTVAVQPELDIAPGFDSFSPATHRGSTVVFRNLAELRAYGDRGTTYWRYGLHATP
TSEALCQHLALLEGARHTLLLPSGLAAISLVYFALLKSGDDVLVPDNVYGPNRDHGEWLARDFGVTVRYYDPMIGGGIAG
MIRANTRLIWMESPGSVTMEVPDSEAIVAAAKARGVLTAIDNTWSAGLYFRPFDMGIDISVQALTKYQSGGSDVLMGAVL
TRDDAVQARLKRARMLMGWGVSADDCHLVLRSLPSLPVRLAAHDRAAREVAEWLHQRPEVVRVLHPALPDCPGHANWRRD
FTGASGLFAIIMHDRYSQEQVDAFVEALRLFAIGWSWGGAHSLAVPYHVPTMRPAGSWPPAGWQHAGELVRLYIGLEDTR
DLIADLRQAMEQVLKG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=337, Percent_Identity=30.2670623145401, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI299473759, Length=237, Percent_Identity=31.6455696202532, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI25453487, Length=336, Percent_Identity=27.3809523809524, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI1789383, Length=377, Percent_Identity=38.4615384615385, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=29.8469387755102, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=346, Percent_Identity=35.2601156069364, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17538055, Length=351, Percent_Identity=34.7578347578348, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=30.5851063829787, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=328, Percent_Identity=40.5487804878049, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6319307, Length=349, Percent_Identity=29.512893982808, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323333, Length=388, Percent_Identity=24.4845360824742, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=328, Percent_Identity=25, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321254, Length=370, Percent_Identity=22.972972972973, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922554, Length=399, Percent_Identity=31.8295739348371, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45496; Mature: 45365

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAIKESAVSDPTSGKPASGSASHYIQTVAVQPELDIAPGFDSFSPATHRGSTVVFRNLA
CCCCCCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ELRAYGDRGTTYWRYGLHATPTSEALCQHLALLEGARHTLLLPSGLAAISLVYFALLKSG
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCC
DDVLVPDNVYGPNRDHGEWLARDFGVTVRYYDPMIGGGIAGMIRANTRLIWMESPGSVTM
CCEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCEEEEECCEEEEEEECCCCEEE
EVPDSEAIVAAAKARGVLTAIDNTWSAGLYFRPFDMGIDISVQALTKYQSGGSDVLMGAV
ECCCCCCEEEHHHHCCEEEEECCCCCCCEEEEEECCCCCEEHHHHHHHCCCCCCEEEHHH
LTRDDAVQARLKRARMLMGWGVSADDCHLVLRSLPSLPVRLAAHDRAAREVAEWLHQRPE
HCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCHH
VVRVLHPALPDCPGHANWRRDFTGASGLFAIIMHDRYSQEQVDAFVEALRLFAIGWSWGG
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCC
AHSLAVPYHVPTMRPAGSWPPAGWQHAGELVRLYIGLEDTRDLIADLRQAMEQVLKG
CCCEEECEECCCCCCCCCCCCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAIKESAVSDPTSGKPASGSASHYIQTVAVQPELDIAPGFDSFSPATHRGSTVVFRNLA
CCCCCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ELRAYGDRGTTYWRYGLHATPTSEALCQHLALLEGARHTLLLPSGLAAISLVYFALLKSG
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCC
DDVLVPDNVYGPNRDHGEWLARDFGVTVRYYDPMIGGGIAGMIRANTRLIWMESPGSVTM
CCEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCEEEEECCEEEEEEECCCCEEE
EVPDSEAIVAAAKARGVLTAIDNTWSAGLYFRPFDMGIDISVQALTKYQSGGSDVLMGAV
ECCCCCCEEEHHHHCCEEEEECCCCCCCEEEEEECCCCCEEHHHHHHHCCCCCCEEEHHH
LTRDDAVQARLKRARMLMGWGVSADDCHLVLRSLPSLPVRLAAHDRAAREVAEWLHQRPE
HCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCHH
VVRVLHPALPDCPGHANWRRDFTGASGLFAIIMHDRYSQEQVDAFVEALRLFAIGWSWGG
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCC
AHSLAVPYHVPTMRPAGSWPPAGWQHAGELVRLYIGLEDTRDLIADLRQAMEQVLKG
CCCEEECEECCCCCCCCCCCCCCHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]