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The map label for this gene is ispD [H]

Identifier: 73541055

GI number: 73541055

Start: 1465887

End: 1466771

Strand: Direct

Name: ispD [H]

Synonym: Reut_A1361

Alternate gene names: 73541055

Gene position: 1465887-1466771 (Clockwise)

Preceding gene: 73541049

Following gene: 73541056

Centisome position: 38.51

GC content: 67.12

Gene sequence:

>885_bases
GTGCGCCGCTTGCCGGATTGGCAAGGCGGCATGGCGGCAAACAAGGGCCGTATTATAGAATGCGCTCCGGCCACGGCGCA
GGCCATCGCCGTGACGTTTTCAACGCATTTTCCATTTCATCCCGACCCTGTGTCCGACCGCCGCTTCGCCTTGATTCCCT
GTGCCGGTACCGGCAGCCGCGCGGGTGGCTCCGTGCCCAAGCAATACCAGCCCGTCGCGGGCCGGCCCATGATCTGGTAC
GCGCTGGCAGCGTTTTCGGCCTGTGACGCGATCAGTGCCACCGCGCTGGTGCTGGCGCCCGACGACATGCCGCTGGAGTC
GCGCTTCGGCGCCGATATCTTTGCCGGCTTGCGCTTCGATACCGCTTTTGTCGGCGGCGACACGCGCCACGCGTCGGTGC
TCGCCGGCCTACATCACCTGGCGCAGCTCGGCGCTACCGACACTGACTGGGTGCTGGTGCACGATGCGGCACGACCGGGC
CTGACGCCCGCGATGATCCATAACCTGGTGCGCGCCGTCGAAAGCGATAACGACGATGATCCCGATGCGGCAATCGGCGG
CATCCTGGCCGTGCCCGTCCCCGATACGCTGAAGCGTGCCGATGCCGGCGAGCGCATCGGCACCACAGTGCCGCGCGACG
GACTGTGGCAGGCCCAGACCCCGCAGATGTTTCGCGTCGGCGTATTGCGCCAGGCCTTGCAGGACGCCCTGGCCGCGGGC
GCGGTGGTGACCGACGAAGCCAGCGCGATCGAACGGCTGGGCCTGCATCCGCGGCTCGTCAACGGTTCGCTGCGCAATTT
CAAAGTGACATATCCGGAAGACTTCGCGCTGGCCGAAGTGCTGCTCGGCACCGGGCCGGCCAGGTCTGCCGATTCAGGAG
CCTGA

Upstream 100 bases:

>100_bases
TTGGCGAACGGGAAGGCGGGTGCGGCGTCAGGCATCGGGCAGCGGTCGGAATCAACGACAACGAACGACAACGCCCCGCC
GGCAGCGCGGGCGGGGGTGC

Downstream 100 bases:

>100_bases
TCAATGATGCCTTTTGATATCCGCGTGGGGCAGGGCTATGACGTCCACGCACTTGTGCCCGGCCGCAAGCTGATCCTCGG
CGGCGTGCATATTCCACACG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRRLPDWQGGMAANKGRIIECAPATAQAIAVTFSTHFPFHPDPVSDRRFALIPCAGTGSRAGGSVPKQYQPVAGRPMIWY
ALAAFSACDAISATALVLAPDDMPLESRFGADIFAGLRFDTAFVGGDTRHASVLAGLHHLAQLGATDTDWVLVHDAARPG
LTPAMIHNLVRAVESDNDDDPDAAIGGILAVPVPDTLKRADAGERIGTTVPRDGLWQAQTPQMFRVGVLRQALQDALAAG
AVVTDEASAIERLGLHPRLVNGSLRNFKVTYPEDFALAEVLLGTGPARSADSGA

Sequences:

>Translated_294_residues
MRRLPDWQGGMAANKGRIIECAPATAQAIAVTFSTHFPFHPDPVSDRRFALIPCAGTGSRAGGSVPKQYQPVAGRPMIWY
ALAAFSACDAISATALVLAPDDMPLESRFGADIFAGLRFDTAFVGGDTRHASVLAGLHHLAQLGATDTDWVLVHDAARPG
LTPAMIHNLVRAVESDNDDDPDAAIGGILAVPVPDTLKRADAGERIGTTVPRDGLWQAQTPQMFRVGVLRQALQDALAAG
AVVTDEASAIERLGLHPRLVNGSLRNFKVTYPEDFALAEVLLGTGPARSADSGA
>Mature_294_residues
MRRLPDWQGGMAANKGRIIECAPATAQAIAVTFSTHFPFHPDPVSDRRFALIPCAGTGSRAGGSVPKQYQPVAGRPMIWY
ALAAFSACDAISATALVLAPDDMPLESRFGADIFAGLRFDTAFVGGDTRHASVLAGLHHLAQLGATDTDWVLVHDAARPG
LTPAMIHNLVRAVESDNDDDPDAAIGGILAVPVPDTLKRADAGERIGTTVPRDGLWQAQTPQMFRVGVLRQALQDALAAG
AVVTDEASAIERLGLHPRLVNGSLRNFKVTYPEDFALAEVLLGTGPARSADSGA

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Escherichia coli, GI1789104, Length=234, Percent_Identity=42.7350427350427, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 30989; Mature: 30989

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00370 PEP_ENZYMES_PHOS_SITE ; PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLPDWQGGMAANKGRIIECAPATAQAIAVTFSTHFPFHPDPVSDRRFALIPCAGTGSR
CCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCC
AGGSVPKQYQPVAGRPMIWYALAAFSACDAISATALVLAPDDMPLESRFGADIFAGLRFD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCHHHHCCEEE
TAFVGGDTRHASVLAGLHHLAQLGATDTDWVLVHDAARPGLTPAMIHNLVRAVESDNDDD
EEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCC
PDAAIGGILAVPVPDTLKRADAGERIGTTVPRDGLWQAQTPQMFRVGVLRQALQDALAAG
CCHHHCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
AVVTDEASAIERLGLHPRLVNGSLRNFKVTYPEDFALAEVLLGTGPARSADSGA
CEEECHHHHHHHHCCCCEEECCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRRLPDWQGGMAANKGRIIECAPATAQAIAVTFSTHFPFHPDPVSDRRFALIPCAGTGSR
CCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCC
AGGSVPKQYQPVAGRPMIWYALAAFSACDAISATALVLAPDDMPLESRFGADIFAGLRFD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCHHHHCCEEE
TAFVGGDTRHASVLAGLHHLAQLGATDTDWVLVHDAARPGLTPAMIHNLVRAVESDNDDD
EEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCC
PDAAIGGILAVPVPDTLKRADAGERIGTTVPRDGLWQAQTPQMFRVGVLRQALQDALAAG
CCHHHCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
AVVTDEASAIERLGLHPRLVNGSLRNFKVTYPEDFALAEVLLGTGPARSADSGA
CEEECHHHHHHHHCCCCEEECCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA