Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 73540296

GI number: 73540296

Start: 641617

End: 642282

Strand: Reverse

Name: adk [H]

Synonym: Reut_A0590

Alternate gene names: 73540296

Gene position: 642282-641617 (Counterclockwise)

Preceding gene: 73540297

Following gene: 73540295

Centisome position: 16.87

GC content: 62.61

Gene sequence:

>666_bases
ATGCGTTTGATCCTGTTGGGCGCACCCGGCGCTGGCAAAGGCACGCAAGCCAAGTTCATCTGCGAGAAGTTCGGCATTCC
GCAAATCTCCACGGGCGACATGCTGCGCGCCGCGGTGAAGGCCGGTACACCGCTTGGCGTGGAAGCCAAGAAGGTCATGG
ATGCGGGCGGACTTGTGTCGGATGACATCATTATCGGCTTGGTCAAGGACCGTCTTAAGGACGCCGATTGCAAGAACGGC
TACCTGTTCGATGGCTTCCCGCGCACCATTCCGCAGGCCGAGGCCATGAAGGAAGCCGGCGTGGCGATCGACTACGTGCT
GGAAATCGACGTGCCGTTCGACGCCATCATCGAGCGCATGAGCGGCCGCCGCGTGCACGTGGCCTCGGGCCGGACCTACC
ACGTCAAGTACAACCCGCCCAAAACGGAAGGCGTCGACGATGAAACCGGCGAAGCGCTGATCCAGCGCGACGACGACAAG
GAAGACACCGTCCGCAAGCGCCTGGACGTGTATTCGCAGCAAACCCGCCCGCTGGTGGACTATTACTCGGACTGGGCCGC
CAAGGGCGATGCCACGGCCAAGGTGTCCCCGCCGAAGTACCGCAAGATCGCCGGCGTGGGCGATGTGGACAGCATCACTG
CCCGCGTGTTCGAAGCGCTCAAGTAA

Upstream 100 bases:

>100_bases
ACCTGATTCATGCGCGCGCAGTAAGTCCTGCGTCAAGTTACGGCGTTACCCTCCTTCTTGTCTCCCGCTACACAAGATTC
AAAACTCTGAGGACCCGTAA

Downstream 100 bases:

>100_bases
GCCTCGATCCTGGCAGCCCAACAAAAAGCGACCTTCGGGTCGCTTTTTGCGTTCTGGGATCCTTATCGCTTTCCCCCTTG
CCAGTCAGGCTACCGTCCGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVSDDIIIGLVKDRLKDADCKNG
YLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKTEGVDDETGEALIQRDDDK
EDTVRKRLDVYSQQTRPLVDYYSDWAAKGDATAKVSPPKYRKIAGVGDVDSITARVFEALK

Sequences:

>Translated_221_residues
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVSDDIIIGLVKDRLKDADCKNG
YLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKTEGVDDETGEALIQRDDDK
EDTVRKRLDVYSQQTRPLVDYYSDWAAKGDATAKVSPPKYRKIAGVGDVDSITARVFEALK
>Mature_221_residues
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVSDDIIIGLVKDRLKDADCKNG
YLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKTEGVDDETGEALIQRDDDK
EDTVRKRLDVYSQQTRPLVDYYSDWAAKGDATAKVSPPKYRKIAGVGDVDSITARVFEALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=48.3870967741936, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=48.3870967741936, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI19923437, Length=204, Percent_Identity=45.0980392156863, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI310110345, Length=204, Percent_Identity=37.2549019607843, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832003, Length=204, Percent_Identity=37.2549019607843, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI8051579, Length=204, Percent_Identity=37.2549019607843, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832001, Length=204, Percent_Identity=37.2549019607843, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=30.2197802197802, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502011, Length=219, Percent_Identity=26.9406392694064, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI7706497, Length=203, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI28144897, Length=197, Percent_Identity=25.8883248730964, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI28144899, Length=197, Percent_Identity=25.8883248730964, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=62.6168224299065, Blast_Score=274, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=47.3118279569892, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=33.953488372093, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=220, Percent_Identity=31.3636363636364, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=28.2608695652174, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=27.1739130434783, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=51.0309278350515, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321018, Length=200, Percent_Identity=42, Blast_Score=151, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=28.4153005464481, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=50.2732240437158, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17737899, Length=201, Percent_Identity=40.7960199004975, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645822, Length=201, Percent_Identity=40.7960199004975, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=30.4147465437788, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24663208, Length=217, Percent_Identity=30.4147465437788, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=28.1081081081081, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24091; Mature: 24091

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DDIIIGLVKDRLKDADCKNGYLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERM
CHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRVHVASGRTYHVKYNPPKTEGVDDETGEALIQRDDDKEDTVRKRLDVYSQQTRPLVD
CCCEEEEECCEEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCHHH
YYSDWAAKGDATAKVSPPKYRKIAGVGDVDSITARVFEALK
HHHHHCCCCCCCEECCCCHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DDIIIGLVKDRLKDADCKNGYLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERM
CHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRVHVASGRTYHVKYNPPKTEGVDDETGEALIQRDDDKEDTVRKRLDVYSQQTRPLVD
CCCEEEEECCEEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCHHH
YYSDWAAKGDATAKVSPPKYRKIAGVGDVDSITARVFEALK
HHHHHCCCCCCCEECCCCHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA