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The map label for this gene is fabG2 [H]

Identifier: 73540295

GI number: 73540295

Start: 640688

End: 641446

Strand: Reverse

Name: fabG2 [H]

Synonym: Reut_A0589

Alternate gene names: 73540295

Gene position: 641446-640688 (Counterclockwise)

Preceding gene: 73540296

Following gene: 73540293

Centisome position: 16.85

GC content: 67.59

Gene sequence:

>759_bases
ATGGACATTCAGGACAATGTATTCATCGTCACGGGCGGCGCGTCTGGCTTGGGAGAAGGCACCGCGCGCATGCTGGCCGA
GGCTGGCGGCAAGGTCGTCATCGCCGACCTGAACGAGGCTGCGGGCACCGCGCTCGCGCAGGAGTTGGGCGGGACCTTCG
TCAAGTGCGATGTCTCGTCGGAAGCCGACGGCCAGGCGGCGGTCGCCGCCGCACAGGCGCTCGGCCGCGTGTCCGGGCTG
GTCAATTGCGCCGGCATCGCCACGGCCAACAAGACCGTGGGCAAGAACGGCCCGCATCCGCTCGACGCGTTCGACAAGAC
CATCCGCGTCAATTTGATCGGCACCTTCAACATGATTCGCCTGGCCGCTGCGGCGATGGTGCAGAACACGCCCGACGCCG
AAGGCGAGCGCGGCGTGATCATCAACACCGCGTCGGTGGCCGCGTTCGACGGCCAGATCGGACAGGCCGCCTATGCCGCG
TCCAAGGGCGGCGTGGTCGGCATGACGCTGGCCATTGCGCGCGACCTGTCTCGTGACGGCGTGCGCTGCGTGACGATCGC
CCCCGGCCTGTTCGAAACGCCGATGCTGCTCGGCATGCCGCAGGAAGTGCAGGACGCTCTCGGCAGGATGGTGCCGTTCC
CCCCGCGTCTGGGCCGCCCGGCGGAATACGCCAAGCTGGCCAAGGCCATCATCGGCAATACCATGCTCAACGGCGAAGTG
ATCCGCCTCGACGGCGCGATCCGGATGCAGCCCAAGTAA

Upstream 100 bases:

>100_bases
TTCCCCCTTGCCAGTCAGGCTACCGTCCGTACAATAGCGCCAGAGTTGACGTTTACGTAAACGGCAGTCGCCACGCGACT
GATCACCGAGGAGACAGCAA

Downstream 100 bases:

>100_bases
GGGACCGCTTTGCCTGCTGCCGCTGCTTCACGCCGGCAGCAGCATCACCAGCATCAAACCCGGCGCCGCCGCCGGCCACA
GCGTGAGCTGCTCGAACTGC

Product: Short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MDIQDNVFIVTGGASGLGEGTARMLAEAGGKVVIADLNEAAGTALAQELGGTFVKCDVSSEADGQAAVAAAQALGRVSGL
VNCAGIATANKTVGKNGPHPLDAFDKTIRVNLIGTFNMIRLAAAAMVQNTPDAEGERGVIINTASVAAFDGQIGQAAYAA
SKGGVVGMTLAIARDLSRDGVRCVTIAPGLFETPMLLGMPQEVQDALGRMVPFPPRLGRPAEYAKLAKAIIGNTMLNGEV
IRLDGAIRMQPK

Sequences:

>Translated_252_residues
MDIQDNVFIVTGGASGLGEGTARMLAEAGGKVVIADLNEAAGTALAQELGGTFVKCDVSSEADGQAAVAAAQALGRVSGL
VNCAGIATANKTVGKNGPHPLDAFDKTIRVNLIGTFNMIRLAAAAMVQNTPDAEGERGVIINTASVAAFDGQIGQAAYAA
SKGGVVGMTLAIARDLSRDGVRCVTIAPGLFETPMLLGMPQEVQDALGRMVPFPPRLGRPAEYAKLAKAIIGNTMLNGEV
IRLDGAIRMQPK
>Mature_252_residues
MDIQDNVFIVTGGASGLGEGTARMLAEAGGKVVIADLNEAAGTALAQELGGTFVKCDVSSEADGQAAVAAAQALGRVSGL
VNCAGIATANKTVGKNGPHPLDAFDKTIRVNLIGTFNMIRLAAAAMVQNTPDAEGERGVIINTASVAAFDGQIGQAAYAA
SKGGVVGMTLAIARDLSRDGVRCVTIAPGLFETPMLLGMPQEVQDALGRMVPFPPRLGRPAEYAKLAKAIIGNTMLNGEV
IRLDGAIRMQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=59.2, Blast_Score=269, Evalue=2e-72,
Organism=Homo sapiens, GI83715985, Length=251, Percent_Identity=57.3705179282869, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI15277342, Length=232, Percent_Identity=37.5, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=29.8387096774194, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI59889578, Length=215, Percent_Identity=31.6279069767442, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI31542939, Length=233, Percent_Identity=29.6137339055794, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4504505, Length=213, Percent_Identity=30.0469483568075, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI5031737, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=31.0734463276836, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=27.5590551181102, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082100, Length=232, Percent_Identity=28.0172413793103, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=30, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=30.3643724696356, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=29.296875, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789057, Length=216, Percent_Identity=28.7037037037037, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786812, Length=244, Percent_Identity=29.9180327868852, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788459, Length=197, Percent_Identity=29.4416243654822, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=53.6585365853659, Blast_Score=251, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147288, Length=228, Percent_Identity=34.2105263157895, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=224, Percent_Identity=36.1607142857143, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17563726, Length=211, Percent_Identity=26.5402843601896, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=211, Percent_Identity=28.9099526066351, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=28.1853281853282, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=25.4826254826255, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=218, Percent_Identity=30.2752293577982, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=256, Percent_Identity=26.5625, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=207, Percent_Identity=28.5024154589372, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=201, Percent_Identity=28.3582089552239, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=201, Percent_Identity=30.8457711442786, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320089, Length=203, Percent_Identity=27.0935960591133, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=57.0866141732283, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357041, Length=239, Percent_Identity=33.0543933054393, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571526, Length=242, Percent_Identity=32.6446280991736, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI23397609, Length=238, Percent_Identity=29.8319327731092, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=239, Percent_Identity=28.4518828451883, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=31.7948717948718, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 25759; Mature: 25759

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQDNVFIVTGGASGLGEGTARMLAEAGGKVVIADLNEAAGTALAQELGGTFVKCDVSS
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
EADGQAAVAAAQALGRVSGLVNCAGIATANKTVGKNGPHPLDAFDKTIRVNLIGTFNMIR
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHH
LAAAAMVQNTPDAEGERGVIINTASVAAFDGQIGQAAYAASKGGVVGMTLAIARDLSRDG
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCHHHHHHCCCCEEEHHHHHHHHHCCCC
VRCVTIAPGLFETPMLLGMPQEVQDALGRMVPFPPRLGRPAEYAKLAKAIIGNTMLNGEV
EEEEEECCCCHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEECCEE
IRLDGAIRMQPK
EEECCEEEECCC
>Mature Secondary Structure
MDIQDNVFIVTGGASGLGEGTARMLAEAGGKVVIADLNEAAGTALAQELGGTFVKCDVSS
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCC
EADGQAAVAAAQALGRVSGLVNCAGIATANKTVGKNGPHPLDAFDKTIRVNLIGTFNMIR
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHH
LAAAAMVQNTPDAEGERGVIINTASVAAFDGQIGQAAYAASKGGVVGMTLAIARDLSRDG
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCHHHHHHCCCCEEEHHHHHHHHHCCCC
VRCVTIAPGLFETPMLLGMPQEVQDALGRMVPFPPRLGRPAEYAKLAKAIIGNTMLNGEV
EEEEEECCCCHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEECCEE
IRLDGAIRMQPK
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]