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The map label for this gene is fadN [H]

Identifier: 73540153

GI number: 73540153

Start: 491634

End: 494057

Strand: Direct

Name: fadN [H]

Synonym: Reut_A0447

Alternate gene names: 73540153

Gene position: 491634-494057 (Clockwise)

Preceding gene: 73540152

Following gene: 73540154

Centisome position: 12.92

GC content: 65.47

Gene sequence:

>2424_bases
ATGTCCAATTTCATCGTCAAGAAAGTCGCCGTGCTCGGCGCCGGCGTCATGGGAGCGCAGATCGCTGCCCATCTCGTCAA
CGCGCGCGTGCCGGTGGTGCTGTTCGACCTGCCGGCCAAGGAAGGCCCCAAGAGCGGCATTGCGCAGCGTGCGATCGAGA
ACCTCAAGAAGCTGTCGCCCGCGCCGCTGGGCATCAAGGACGAGGCCGGCCTGATCCAGGCCGCCAACTACGAAGACGAT
ATCGCGCTGCTCAAGGAATGCGACGTGGTGATCGAAGCGATCGCTGAACGCATGGACTGGAAGCACGACCTGTACAAGAA
GGTCGCGCCGCACCTGGGCGCGAGCACTATCTTCGCGACCAATACGTCGGGTCTGTCGATCACCGCGCTGTCGGACGGCT
TTGATGCCGAACTGAAGTCACGCTTCTGTGGCGTGCACTTCTTCAATCCGCCGCGCTACATGCATCTGGTCGAGCTGATC
CCGACTGCGACCACGCAGCCGGAAATCCTCGACAAGCTCGAAGCGTTCCTGACCACCACGCTCGGCAAGGGCGTGGTGCG
TGCGAAGGACACGCCGAACTTTATCGCGAACCGCGTTGGCATCTTCTCGATCCTCGCAGTGTTTGCCGAAGCCGAGAAGT
TCGCCATCCCGTTCGATGTGGTCGACGACCTGACCGGCTCGAAGCTCGGCCGCGCGAAGTCTGCCACGTTCCGCACCGCC
GACGTCGTGGGCCTGGACACCATGGCGCACGTGATCAAGACGATGCAGGACAACCTGCATGAGGATCCGTTCGCGCCGGT
GTACAAGACCCCGGCCGTGCTGAAGGGCCTCGTCGATGCGGGCGCGCTGGGCCAGAAGACCGGCGCCGGGTTCTACAAGA
AGGAAGGCAAGGCCATCAAGGTGCTGGATGCCAGGACCGGCCAGTATGTCGAGTCGGGCAAGAAGGCCGACGAGATCGTC
GCGCGCATGCTGAAGAAGGCGCCGGCGGAGCGAATCAAGCTGCTGCGCGAATCGACCAATCCGCAGGCGCAGTTCCTGTG
GGCGATCTTCCGCGACGTGTTCCACTACATCGCCGTGTACCTCGAGCAGATCGCGGGTTCGGCGGCTGACGTCGATCTGG
CGATCCGCTGGGGCTTCGGCTGGAACTCGGGTCCGTTCGAAGACTGGCAGGCCGCCGGGTGGAAGCAGGTCGCCGAATGG
GTGAAGGAAGATATCGACGCCGGCAAGGCACTGTCCAAGGCGGCGCTGCCCGCGTGGGTGTTCGAAGGTCCGGTGGCAGA
GAACCAGGGCGTGCACGCCGCGCAGGGTTCGTGGTCGCCCGCGACGCAGCAGTTCGTCGCGCGCAGCACGCTGCCGGTCT
ACCAGCGCCAGGTGTTCCGCGCCGCGCTGCAGGGCACGGCGGCGCTGGATCCGCGCAAGGCTGGCCGCACCGTCGAAGAG
AACGACGCCGTGCGGATCTGGGTGGCCGAGGGCCAGGACGATGTGCTGGTGGTGTCGTTCAAGAGCAAGATGAACACCAT
CGGGCCGGACGTGATCGACGGCCTGACGCGTGCGATCGACCTTGCCGAAGCTGAATACAAGGGCCTGGTCGTGTGGCAGC
CGACGTCGCTGCAACTTGGCGCGCCCGGTGGTCCGTTCTCGGCGGGCGCCAATCTGGAAGCCGCAATGCCGGCGTTCATG
ATGGGCGGCGCCAAGGGCATCGAACCGTTCGTGAAGAAGTTCCAGGACGGCATGATGCGCGTGAAGTATTCCGCAGTGCC
TGTGGTCTCGGCTGCATCGGGTATTGCGCTGGGCGGCGGCTGCGAGTTGATGCTGCACTCGGCGGCACGCGTGGCCGCGC
TGGAAACCTACGTCGGGCTGGTGGAAGTCGGCGTGGGCCTGGTGCCGGCCGGCGGCGGCCTGAAGGAGGCCGCGCTGGCG
GCAGCGCGCGCAGCACAGGCCGCAGGCAGCACCAACTACCTGCAGTTCCTGACCAGCCGTTTCCAAAGCGCAGCAATGGC
CAAGGTGTCGGCGTCCGCGCTGGAAGCGCGCCAGATGGGCTACCTGCAAGCGTCCGACCGGATCGTCTTCAACGTGCACG
AGCTGCTTCACGTGGCGCAGAACGAAGTGCGTGCGCTGGCCGACGCGGGTTACCGCGCGCCGCTGCCGGCACTGGTGCCG
GTGGCCGGCCGCTCGGGCATCGCGACCATCAAGGCATCGCTGGTCAATATGCGCGACGGCGGCTTTATCTCCGCGCACGA
CTTCCTGATTGCGTCGCGTATTGCCGAAGTGGTGTGCGGCGGTGACGTCGAGGCCGGTTCGCTGGTGAGCGAGGAGTGGC
TGCTCGCGCTCGAGCGCAAGGCTTTCGTCGACCTGCTTGGCACCAGCAAGACGCAGGAACGCATCATGGGCATGCTGCAG
ACCGGCAAGCCCGTCCGCAACTAA

Upstream 100 bases:

>100_bases
ACGCAGACCTGTTCTGACGGCCTGATTGCCGGCCTTCTCTCCTCATGGCAGGAGGGAGGGCCCGCCTCTCTTCAAAACGC
TCAATCCATCAGGAGCGCTC

Downstream 100 bases:

>100_bases
GGCAGCGAGGAAACGACATCATGAAACAACTGCAAGACGCCTACATCGTTGCCGCGACTCGCTCTCCGATCGGCAAGGCG
CCGAAGGGCGCGTTCAAGAA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSNFIVKKVAVLGAGVMGAQIAAHLVNARVPVVLFDLPAKEGPKSGIAQRAIENLKKLSPAPLGIKDEAGLIQAANYEDD
IALLKECDVVIEAIAERMDWKHDLYKKVAPHLGASTIFATNTSGLSITALSDGFDAELKSRFCGVHFFNPPRYMHLVELI
PTATTQPEILDKLEAFLTTTLGKGVVRAKDTPNFIANRVGIFSILAVFAEAEKFAIPFDVVDDLTGSKLGRAKSATFRTA
DVVGLDTMAHVIKTMQDNLHEDPFAPVYKTPAVLKGLVDAGALGQKTGAGFYKKEGKAIKVLDARTGQYVESGKKADEIV
ARMLKKAPAERIKLLRESTNPQAQFLWAIFRDVFHYIAVYLEQIAGSAADVDLAIRWGFGWNSGPFEDWQAAGWKQVAEW
VKEDIDAGKALSKAALPAWVFEGPVAENQGVHAAQGSWSPATQQFVARSTLPVYQRQVFRAALQGTAALDPRKAGRTVEE
NDAVRIWVAEGQDDVLVVSFKSKMNTIGPDVIDGLTRAIDLAEAEYKGLVVWQPTSLQLGAPGGPFSAGANLEAAMPAFM
MGGAKGIEPFVKKFQDGMMRVKYSAVPVVSAASGIALGGGCELMLHSAARVAALETYVGLVEVGVGLVPAGGGLKEAALA
AARAAQAAGSTNYLQFLTSRFQSAAMAKVSASALEARQMGYLQASDRIVFNVHELLHVAQNEVRALADAGYRAPLPALVP
VAGRSGIATIKASLVNMRDGGFISAHDFLIASRIAEVVCGGDVEAGSLVSEEWLLALERKAFVDLLGTSKTQERIMGMLQ
TGKPVRN

Sequences:

>Translated_807_residues
MSNFIVKKVAVLGAGVMGAQIAAHLVNARVPVVLFDLPAKEGPKSGIAQRAIENLKKLSPAPLGIKDEAGLIQAANYEDD
IALLKECDVVIEAIAERMDWKHDLYKKVAPHLGASTIFATNTSGLSITALSDGFDAELKSRFCGVHFFNPPRYMHLVELI
PTATTQPEILDKLEAFLTTTLGKGVVRAKDTPNFIANRVGIFSILAVFAEAEKFAIPFDVVDDLTGSKLGRAKSATFRTA
DVVGLDTMAHVIKTMQDNLHEDPFAPVYKTPAVLKGLVDAGALGQKTGAGFYKKEGKAIKVLDARTGQYVESGKKADEIV
ARMLKKAPAERIKLLRESTNPQAQFLWAIFRDVFHYIAVYLEQIAGSAADVDLAIRWGFGWNSGPFEDWQAAGWKQVAEW
VKEDIDAGKALSKAALPAWVFEGPVAENQGVHAAQGSWSPATQQFVARSTLPVYQRQVFRAALQGTAALDPRKAGRTVEE
NDAVRIWVAEGQDDVLVVSFKSKMNTIGPDVIDGLTRAIDLAEAEYKGLVVWQPTSLQLGAPGGPFSAGANLEAAMPAFM
MGGAKGIEPFVKKFQDGMMRVKYSAVPVVSAASGIALGGGCELMLHSAARVAALETYVGLVEVGVGLVPAGGGLKEAALA
AARAAQAAGSTNYLQFLTSRFQSAAMAKVSASALEARQMGYLQASDRIVFNVHELLHVAQNEVRALADAGYRAPLPALVP
VAGRSGIATIKASLVNMRDGGFISAHDFLIASRIAEVVCGGDVEAGSLVSEEWLLALERKAFVDLLGTSKTQERIMGMLQ
TGKPVRN
>Mature_806_residues
SNFIVKKVAVLGAGVMGAQIAAHLVNARVPVVLFDLPAKEGPKSGIAQRAIENLKKLSPAPLGIKDEAGLIQAANYEDDI
ALLKECDVVIEAIAERMDWKHDLYKKVAPHLGASTIFATNTSGLSITALSDGFDAELKSRFCGVHFFNPPRYMHLVELIP
TATTQPEILDKLEAFLTTTLGKGVVRAKDTPNFIANRVGIFSILAVFAEAEKFAIPFDVVDDLTGSKLGRAKSATFRTAD
VVGLDTMAHVIKTMQDNLHEDPFAPVYKTPAVLKGLVDAGALGQKTGAGFYKKEGKAIKVLDARTGQYVESGKKADEIVA
RMLKKAPAERIKLLRESTNPQAQFLWAIFRDVFHYIAVYLEQIAGSAADVDLAIRWGFGWNSGPFEDWQAAGWKQVAEWV
KEDIDAGKALSKAALPAWVFEGPVAENQGVHAAQGSWSPATQQFVARSTLPVYQRQVFRAALQGTAALDPRKAGRTVEEN
DAVRIWVAEGQDDVLVVSFKSKMNTIGPDVIDGLTRAIDLAEAEYKGLVVWQPTSLQLGAPGGPFSAGANLEAAMPAFMM
GGAKGIEPFVKKFQDGMMRVKYSAVPVVSAASGIALGGGCELMLHSAARVAALETYVGLVEVGVGLVPAGGGLKEAALAA
ARAAQAAGSTNYLQFLTSRFQSAAMAKVSASALEARQMGYLQASDRIVFNVHELLHVAQNEVRALADAGYRAPLPALVPV
AGRSGIATIKASLVNMRDGGFISAHDFLIASRIAEVVCGGDVEAGSLVSEEWLLALERKAFVDLLGTSKTQERIMGMLQT
GKPVRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=302, Percent_Identity=35.0993377483444, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI296179427, Length=317, Percent_Identity=34.0694006309148, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI20127408, Length=404, Percent_Identity=26.4851485148515, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI261878539, Length=399, Percent_Identity=24.0601503759398, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI68989263, Length=399, Percent_Identity=24.0601503759398, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787661, Length=333, Percent_Identity=32.7327327327327, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1790281, Length=368, Percent_Identity=27.7173913043478, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788682, Length=316, Percent_Identity=25.3164556962025, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17549919, Length=302, Percent_Identity=33.112582781457, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17563036, Length=300, Percent_Identity=30.3333333333333, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17553560, Length=302, Percent_Identity=30.1324503311258, Blast_Score=103, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17558304, Length=395, Percent_Identity=27.3417721518987, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508951, Length=388, Percent_Identity=28.6082474226804, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508953, Length=388, Percent_Identity=28.6082474226804, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=31.3793103448276, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=407, Percent_Identity=23.0958230958231, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71985923, Length=409, Percent_Identity=24.4498777506112, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921000, Length=436, Percent_Identity=27.0642201834862, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583077, Length=432, Percent_Identity=26.8518518518519, Blast_Score=84, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24583079, Length=432, Percent_Identity=26.8518518518519, Blast_Score=84, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45549573, Length=198, Percent_Identity=30.8080808080808, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 86221; Mature: 86090

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFIVKKVAVLGAGVMGAQIAAHLVNARVPVVLFDLPAKEGPKSGIAQRAIENLKKLSP
CCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCC
APLGIKDEAGLIQAANYEDDIALLKECDVVIEAIAERMDWKHDLYKKVAPHLGASTIFAT
CCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEE
NTSGLSITALSDGFDAELKSRFCGVHFFNPPRYMHLVELIPTATTQPEILDKLEAFLTTT
CCCCEEEEEECCCCCHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LGKGVVRAKDTPNFIANRVGIFSILAVFAEAEKFAIPFDVVDDLTGSKLGRAKSATFRTA
HCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCEEHH
DVVGLDTMAHVIKTMQDNLHEDPFAPVYKTPAVLKGLVDAGALGQKTGAGFYKKEGKAIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
VLDARTGQYVESGKKADEIVARMLKKAPAERIKLLRESTNPQAQFLWAIFRDVFHYIAVY
EEECCCCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LEQIAGSAADVDLAIRWGFGWNSGPFEDWQAAGWKQVAEWVKEDIDAGKALSKAALPAWV
HHHHCCCCCCEEEEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
FEGPVAENQGVHAAQGSWSPATQQFVARSTLPVYQRQVFRAALQGTAALDPRKAGRTVEE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCC
NDAVRIWVAEGQDDVLVVSFKSKMNTIGPDVIDGLTRAIDLAEAEYKGLVVWQPTSLQLG
CCCEEEEEECCCCCEEEEEECHHCCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCEEEC
APGGPFSAGANLEAAMPAFMMGGAKGIEPFVKKFQDGMMRVKYSAVPVVSAASGIALGGG
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCCCHHHCCCCCEECCC
CELMLHSAARVAALETYVGLVEVGVGLVPAGGGLKEAALAAARAAQAAGSTNYLQFLTSR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
FQSAAMAKVSASALEARQMGYLQASDRIVFNVHELLHVAQNEVRALADAGYRAPLPALVP
HHHHHHHHHHHHHHHHHHHCCEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VAGRSGIATIKASLVNMRDGGFISAHDFLIASRIAEVVCGGDVEAGSLVSEEWLLALERK
CCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AFVDLLGTSKTQERIMGMLQTGKPVRN
HHHHHHCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNFIVKKVAVLGAGVMGAQIAAHLVNARVPVVLFDLPAKEGPKSGIAQRAIENLKKLSP
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCC
APLGIKDEAGLIQAANYEDDIALLKECDVVIEAIAERMDWKHDLYKKVAPHLGASTIFAT
CCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEEE
NTSGLSITALSDGFDAELKSRFCGVHFFNPPRYMHLVELIPTATTQPEILDKLEAFLTTT
CCCCEEEEEECCCCCHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LGKGVVRAKDTPNFIANRVGIFSILAVFAEAEKFAIPFDVVDDLTGSKLGRAKSATFRTA
HCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCEEHH
DVVGLDTMAHVIKTMQDNLHEDPFAPVYKTPAVLKGLVDAGALGQKTGAGFYKKEGKAIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
VLDARTGQYVESGKKADEIVARMLKKAPAERIKLLRESTNPQAQFLWAIFRDVFHYIAVY
EEECCCCHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LEQIAGSAADVDLAIRWGFGWNSGPFEDWQAAGWKQVAEWVKEDIDAGKALSKAALPAWV
HHHHCCCCCCEEEEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
FEGPVAENQGVHAAQGSWSPATQQFVARSTLPVYQRQVFRAALQGTAALDPRKAGRTVEE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCC
NDAVRIWVAEGQDDVLVVSFKSKMNTIGPDVIDGLTRAIDLAEAEYKGLVVWQPTSLQLG
CCCEEEEEECCCCCEEEEEECHHCCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCEEEC
APGGPFSAGANLEAAMPAFMMGGAKGIEPFVKKFQDGMMRVKYSAVPVVSAASGIALGGG
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCCCHHHCCCCCEECCC
CELMLHSAARVAALETYVGLVEVGVGLVPAGGGLKEAALAAARAAQAAGSTNYLQFLTSR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
FQSAAMAKVSASALEARQMGYLQASDRIVFNVHELLHVAQNEVRALADAGYRAPLPALVP
HHHHHHHHHHHHHHHHHHHCCEECCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VAGRSGIATIKASLVNMRDGGFISAHDFLIASRIAEVVCGGDVEAGSLVSEEWLLALERK
CCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AFVDLLGTSKTQERIMGMLQTGKPVRN
HHHHHHCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]