Click here to switch to the map view.

The map label for this gene is ycgO [H]

Identifier: 73540142

GI number: 73540142

Start: 479779

End: 481215

Strand: Direct

Name: ycgO [H]

Synonym: Reut_A0436

Alternate gene names: 73540142

Gene position: 479779-481215 (Clockwise)

Preceding gene: 73540141

Following gene: 73540143

Centisome position: 12.6

GC content: 63.47

Gene sequence:

>1437_bases
ATGCTGATCTGGTTCGTCATCATCTACTGGGTAATTTCGGTCGGCATCGGCCTGTGGGCGGCGCTGCGCGTGCGCAACAC
GACCGATTTCGCCGTCGCCGGGCGCAGCCTGCCGTTCTACGTCGTTACCGCCACCGTCTTTGCCACCTGGTTCGGTTCCG
AAACCGTGCTGGGCATTCCCGCGGTATTCCTGAAAGAGGGCCTGTCCGGGGTCGTATCCGACCCGTTCGGCTCTTCGCTG
TGCCTGATCCTGGTGGGCCTGTTCTTTGCGCGGCCGCTGTACCGGATGAACCTGCTCACCATCGGCGACTACTACCACAA
CCGCTACGGGCGGCTGGCCGAGGTGCTGACCACCCTGTGCATCGTGGTGTCCTACCTGGGCTGGGTGGCGGCGCAGATCA
AGGCGCTTGGTCTCGTGTTCTATACGGTTTCCGACGGCGCGCTGTCGCAGGACGCCGGCATGATGATCGGCGCGGCCAGC
GTGCTGGTGTACACGCTGTTCGGCGGCATGTGGTCGGTCGCGGTGACGGACTTCATCCAGATGATCATCATCGTGGTCGG
CATGCTCTATATCGGCTACGAGGTCAGCGGCCAGGCCGGCGGCGTGACGGCGGTGGTGTCGCACGCGGCGGCGGCCGGCA
AGTTCGAGTTCCTGCCGTCGTTGGACCTGGTGCAGATCGTTGGGTTTGCCGCGGCGCTGTTCACCATGATGCTCGGCTCG
ATCCCACAGCAGGATGTGTTCCAGCGGGTGACATCGTCGCGCACCGAGCAGATCGCCGGCCGCGCGTCGGTGCTCGGCGG
CGTGCTGTATTTCTTCTTCGCCTTCATCCCGATGTTCCTCGCCTATTCGGCCACGCTGATCGATCCGGGCATGGTGGAAA
AGTACATCAACGCGGATTCCCAGCTCATCCTGCCGCAGCTGATCCTGCAACACGCTCCGATGTTCGCGCAGGTGATGTTC
TTCGGCGCGCTGCTGTCGGCCATCAAGAGCTGCGCGTCGGCGACGCTGCTGGCACCGTCCGTCACCTTTGCCGAGAACAT
CCTGCGGCCGTATTTCCGCCACCTCGTAGACAAGCAGTTCCTGCGTGTGATGCAGACGGTCGTGCTGGTATTCACCGCCA
CCGTGACGCTGTTCGCCCTGAACTCGCACCTTTCGATCTTCCATATGGTCGAAAATGCCTATAAGGTCACACTGGTGTCG
TCGTTCGTGCCGCTCGCCTTCGGCATGTTCTGGAAGCCGGCGACGCGGCAGGGCGGCCTGTCCGCCATCCTGCTGGGCCT
GGCCTCGTGGCTGACGTGCGAGATCGCGTTTGCCGATGCGACCGTGCCGCCGCAGATGGTCGGCCTGACGTTCTCGATCA
GCGGCATGGTGGTCGGTTCGCTGCTGCCGCAGTGGATTGCGGATCACGCGCCGGTCAAGGAAGTGCATATCGCCTGA

Upstream 100 bases:

>100_bases
GACCGATGAATTGGACTCCGGGCAGACAGGCGCCAGATTCAGCCGCCAGCCCGGCATTCGGTTTTTCGCCACAAGGGCAA
TTTCTGCATAGGGCAGCGGC

Downstream 100 bases:

>100_bases
CCGCCTGACCGCCTTCCCGGCGCGGCGACGCCTGGACTGCCCGATCCTGGCCCCCGGCGGCCAGGTGTGCCGCTTTGTGC
CCGCATTTCCTCCCGTCAGG

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MLIWFVIIYWVISVGIGLWAALRVRNTTDFAVAGRSLPFYVVTATVFATWFGSETVLGIPAVFLKEGLSGVVSDPFGSSL
CLILVGLFFARPLYRMNLLTIGDYYHNRYGRLAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGALSQDAGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVVGMLYIGYEVSGQAGGVTAVVSHAAAAGKFEFLPSLDLVQIVGFAAALFTMMLGS
IPQQDVFQRVTSSRTEQIAGRASVLGGVLYFFFAFIPMFLAYSATLIDPGMVEKYINADSQLILPQLILQHAPMFAQVMF
FGALLSAIKSCASATLLAPSVTFAENILRPYFRHLVDKQFLRVMQTVVLVFTATVTLFALNSHLSIFHMVENAYKVTLVS
SFVPLAFGMFWKPATRQGGLSAILLGLASWLTCEIAFADATVPPQMVGLTFSISGMVVGSLLPQWIADHAPVKEVHIA

Sequences:

>Translated_478_residues
MLIWFVIIYWVISVGIGLWAALRVRNTTDFAVAGRSLPFYVVTATVFATWFGSETVLGIPAVFLKEGLSGVVSDPFGSSL
CLILVGLFFARPLYRMNLLTIGDYYHNRYGRLAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGALSQDAGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVVGMLYIGYEVSGQAGGVTAVVSHAAAAGKFEFLPSLDLVQIVGFAAALFTMMLGS
IPQQDVFQRVTSSRTEQIAGRASVLGGVLYFFFAFIPMFLAYSATLIDPGMVEKYINADSQLILPQLILQHAPMFAQVMF
FGALLSAIKSCASATLLAPSVTFAENILRPYFRHLVDKQFLRVMQTVVLVFTATVTLFALNSHLSIFHMVENAYKVTLVS
SFVPLAFGMFWKPATRQGGLSAILLGLASWLTCEIAFADATVPPQMVGLTFSISGMVVGSLLPQWIADHAPVKEVHIA
>Mature_478_residues
MLIWFVIIYWVISVGIGLWAALRVRNTTDFAVAGRSLPFYVVTATVFATWFGSETVLGIPAVFLKEGLSGVVSDPFGSSL
CLILVGLFFARPLYRMNLLTIGDYYHNRYGRLAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGALSQDAGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVVGMLYIGYEVSGQAGGVTAVVSHAAAAGKFEFLPSLDLVQIVGFAAALFTMMLGS
IPQQDVFQRVTSSRTEQIAGRASVLGGVLYFFFAFIPMFLAYSATLIDPGMVEKYINADSQLILPQLILQHAPMFAQVMF
FGALLSAIKSCASATLLAPSVTFAENILRPYFRHLVDKQFLRVMQTVVLVFTATVTLFALNSHLSIFHMVENAYKVTLVS
SFVPLAFGMFWKPATRQGGLSAILLGLASWLTCEIAFADATVPPQMVGLTFSISGMVVGSLLPQWIADHAPVKEVHIA

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=399, Percent_Identity=29.5739348370927, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI14140236, Length=482, Percent_Identity=21.9917012448133, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4507035, Length=394, Percent_Identity=25.8883248730964, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI87082237, Length=436, Percent_Identity=24.0825688073394, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787251, Length=452, Percent_Identity=25, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=405, Percent_Identity=24.6913580246914, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648033, Length=439, Percent_Identity=25.5125284738041, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356865, Length=439, Percent_Identity=25.5125284738041, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51849; Mature: 51849

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHEEEEECCCCCCHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHEEEEECCCCCCHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]