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The map label for this gene is tpm [H]

Identifier: 73540141

GI number: 73540141

Start: 478834

End: 479457

Strand: Direct

Name: tpm [H]

Synonym: Reut_A0435

Alternate gene names: 73540141

Gene position: 478834-479457 (Clockwise)

Preceding gene: 73540140

Following gene: 73540142

Centisome position: 12.58

GC content: 69.39

Gene sequence:

>624_bases
ATGACCGCCGACAAGGCTCCGACTCCGCCTTCATTTACCACGCGCGATGCGGCGGATCCGGCATTCTGGGACGAGCGCTT
CGAGCAGGACTTCACGCCGTGGGACATGCATGGCGTGCCTGAGGAGTTCCAGCAATTCATCGCCGGCCGGGCACCATGCC
CGACGCTGGTGCCGGGCTGCGGCAACGGATGGGAGGCTGGCTGGTTGTTCGAGCGCGGCTGGCCGGTCACCGCCATCGAC
TTCTCGCCGCAGGCAGTCGCGTCGGCCAAGCGCGCATTGGGCCCCGCCGGCGCCATCGTGCGCGAGGCGGATTTCTTCGC
CTTCACGCCCGAGCCGGCCTGCGAACTGATCTACGAGCGCGCTTTCCTGTGCGCGCTGCCGCCGCCTCTGCGCGAATCCT
ATGCGGAGCGTGTGGCGGCGATGCTGCCGCCGGGTGGCCTGCTGGCCGGCTACTTCTTTCTGGGTGAAAAGCGTGGCGGG
CCGCCGTTCGCCATGCCGGCGTCCGAGCTAGATGCCCTGCTGGAACCCGCGTTCGAGCGGATCGATGACCGTCCTTCCGC
CGCGCCGCTGCCCGTCTTCGAAGGGCAGGAGCGCTGGCAGGTCTGGCGCCGCCGGGCTGGCTGA

Upstream 100 bases:

>100_bases
CGGCTTTGTCGCCGGTATCGTGCTCACGCATGTGCTCGGCTGGATCGGCTACTGGTAAGCGGCTGAAGCGGCAGTTCTGC
GCTTTCGAAGGAGATACGAC

Downstream 100 bases:

>100_bases
CGCGAACGCAGGCCACACAGGTGGCGCGCCGACGCAACAGGTTTGCGAGGCGCGGTGCCGGCCAGGATGCACGCCAGCGT
GAATTCACGAGGGCCGGGGG

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MTADKAPTPPSFTTRDAADPAFWDERFEQDFTPWDMHGVPEEFQQFIAGRAPCPTLVPGCGNGWEAGWLFERGWPVTAID
FSPQAVASAKRALGPAGAIVREADFFAFTPEPACELIYERAFLCALPPPLRESYAERVAAMLPPGGLLAGYFFLGEKRGG
PPFAMPASELDALLEPAFERIDDRPSAAPLPVFEGQERWQVWRRRAG

Sequences:

>Translated_207_residues
MTADKAPTPPSFTTRDAADPAFWDERFEQDFTPWDMHGVPEEFQQFIAGRAPCPTLVPGCGNGWEAGWLFERGWPVTAID
FSPQAVASAKRALGPAGAIVREADFFAFTPEPACELIYERAFLCALPPPLRESYAERVAAMLPPGGLLAGYFFLGEKRGG
PPFAMPASELDALLEPAFERIDDRPSAAPLPVFEGQERWQVWRRRAG
>Mature_206_residues
TADKAPTPPSFTTRDAADPAFWDERFEQDFTPWDMHGVPEEFQQFIAGRAPCPTLVPGCGNGWEAGWLFERGWPVTAIDF
SPQAVASAKRALGPAGAIVREADFFAFTPEPACELIYERAFLCALPPPLRESYAERVAAMLPPGGLLAGYFFLGEKRGGP
PFAMPASELDALLEPAFERIDDRPSAAPLPVFEGQERWQVWRRRAG

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 22830; Mature: 22699

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADKAPTPPSFTTRDAADPAFWDERFEQDFTPWDMHGVPEEFQQFIAGRAPCPTLVPGC
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
GNGWEAGWLFERGWPVTAIDFSPQAVASAKRALGPAGAIVREADFFAFTPEPACELIYER
CCCCCCCEEEECCCCEEEECCCHHHHHHHHHHCCCHHHHHHHCCCEEECCCHHHHHHHHH
AFLCALPPPLRESYAERVAAMLPPGGLLAGYFFLGEKRGGPPFAMPASELDALLEPAFER
HHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IDDRPSAAPLPVFEGQERWQVWRRRAG
HCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TADKAPTPPSFTTRDAADPAFWDERFEQDFTPWDMHGVPEEFQQFIAGRAPCPTLVPGC
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
GNGWEAGWLFERGWPVTAIDFSPQAVASAKRALGPAGAIVREADFFAFTPEPACELIYER
CCCCCCCEEEECCCCEEEECCCHHHHHHHHHHCCCHHHHHHHCCCEEECCCHHHHHHHHH
AFLCALPPPLRESYAERVAAMLPPGGLLAGYFFLGEKRGGPPFAMPASELDALLEPAFER
HHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IDDRPSAAPLPVFEGQERWQVWRRRAG
HCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA