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The map label for this gene is ubiB [H]

Identifier: 73540140

GI number: 73540140

Start: 477214

End: 478791

Strand: Direct

Name: ubiB [H]

Synonym: Reut_A0434

Alternate gene names: 73540140

Gene position: 477214-478791 (Clockwise)

Preceding gene: 73540139

Following gene: 73540141

Centisome position: 12.54

GC content: 64.83

Gene sequence:

>1578_bases
ATGACCCGCCTTCTGCGCCTCGGCAAGATCCTTTTCGTCATCCTGTACTACGGGCTCGATGAGCTCGTGCTGTCCGGCTT
CCAGAACCGCAAGATCCGCTTCCTGGTCCGCGTCATGACCATCGGGCGCAAGCTCGATATGCCGCGCGGCGAGCGGCTGC
GGCTCGCGCTGACCAAGCTCGGGCCGATCTTCGTCAAGTTCGGCCAGGTGCTGTCGACGCGGCGCGACCTGATGCCGCCG
GACATCGCCGATGAGTTGGCGTTGCTGCAGGACCAGGTGCCGCCGTTCGACTCGGCCGTCGCCGTGAAGATCATCGAGCG
TTCGCTCGGCCGCACGCTTGCGGATCTGTTCGAAACCTTCGAGCACCAGCCGGTCGCGAGCGCCTCGATCGCGCAGGTGC
ACTTCGCCACGCTGAAAGGGGGCCCGAACCACGGCCGCGAAGTTGCGGTGAAGGTGCTGCGCCCCGGCATGCTGCCGGTG
ATCGACAGCGACCTGGCCCTGATGCGCGACCTGGCCACCTGGCTCGAGCGCTTCTGGGCTGACGGCAAGCGTCTCAAGCC
GCGCGAGGTCGTGGCGGAGTTCGACAAGTACCTGCACGACGAACTCGATCTGATGATCGAGGCGGCCAACGCCAGCCAGC
TCCGGCGCAATTTCGCCGATACCAACCTGCTGCTGGTGCCCGAGGTGTTCTGGGACTGGTGCAGCAGCACGGTGTTCGTG
ATGGAACGCATGCATGGCATCCCGATCTCGCGCACCGAATCGCTGAAGGCGGCCGGCGTCGACATGCACCAGTTAGCGGA
AGAGGGCGTCGAGATCTTCTTCACGCAGGTGTTCCGTGACGGCTTTTTCCATGCCGATATGCACCCCGGCAACATCCTGG
TGTCGGTCCAGCCCGAGACCTTCGGCCGCTATATTGCGCTGGATTTTGGCATCGTGGGCGCGCTGTCGGAGTTCGACAAG
AACTACCTCGCGCAAAACTTCATCGCGTTCTTCCGCCGCGACTACCACCGCGTGGCCTTGCTGCACGTGGAATCGGGCTG
GGTGCCGCCCGACACGCGCGTCGAGGAACTGGAGAGCGCGGTGCGCGCCTGCTGCGAGCCCTATTTCGACAAGCCGCTCA
AGGAAATCTCGCTGGGCATGGTGCTGATGCGCCTGTTCCAGACCTCGCGCCGTTTCAACGTCGAGATCCAGCCGCAGCTG
GTGCTGCTGCAGAAGACGCTGCTCAATATCGAAGGCCTGGGCCGCCAGCTCGACCCGGACCTGGACCTGTGGAAAACCGC
GAAGCCGTTCCTCGAGCGCTGGATGCACGAGCAGGTTGGCTGGAAGGGCGCGTGGGAACGGATCAAGGTCGAGGCGCCGC
TGTGGGCCAAGATGCTGCCCGATTTCCCGCGCCTCGCGCACCAGTTCCTGGAGCGCCGTGCGCTCAATACCAACGGCGAG
CAGGAACGGCTGCTCGCGCAGCTGGTCACGGAGCAGCGGCGCACCAACCGGCTGGTCGGCACGGCATTGCTGCTGGTGGG
CGGCTTTGTCGCCGGTATCGTGCTCACGCATGTGCTCGGCTGGATCGGCTACTGGTAA

Upstream 100 bases:

>100_bases
CGGCATTGCCGTCCGCCCATCGCTGAGCGCACCGCCGCATGACGCCATCTTTCGCTGCTGCCCGCGTCGCGCAGCACCAC
CGTTCCCTGAATACCGCCGC

Downstream 100 bases:

>100_bases
GCGGCTGAAGCGGCAGTTCTGCGCTTTCGAAGGAGATACGACATGACCGCCGACAAGGCTCCGACTCCGCCTTCATTTAC
CACGCGCGATGCGGCGGATC

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTRLLRLGKILFVILYYGLDELVLSGFQNRKIRFLVRVMTIGRKLDMPRGERLRLALTKLGPIFVKFGQVLSTRRDLMPP
DIADELALLQDQVPPFDSAVAVKIIERSLGRTLADLFETFEHQPVASASIAQVHFATLKGGPNHGREVAVKVLRPGMLPV
IDSDLALMRDLATWLERFWADGKRLKPREVVAEFDKYLHDELDLMIEAANASQLRRNFADTNLLLVPEVFWDWCSSTVFV
MERMHGIPISRTESLKAAGVDMHQLAEEGVEIFFTQVFRDGFFHADMHPGNILVSVQPETFGRYIALDFGIVGALSEFDK
NYLAQNFIAFFRRDYHRVALLHVESGWVPPDTRVEELESAVRACCEPYFDKPLKEISLGMVLMRLFQTSRRFNVEIQPQL
VLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLERWMHEQVGWKGAWERIKVEAPLWAKMLPDFPRLAHQFLERRALNTNGE
QERLLAQLVTEQRRTNRLVGTALLLVGGFVAGIVLTHVLGWIGYW

Sequences:

>Translated_525_residues
MTRLLRLGKILFVILYYGLDELVLSGFQNRKIRFLVRVMTIGRKLDMPRGERLRLALTKLGPIFVKFGQVLSTRRDLMPP
DIADELALLQDQVPPFDSAVAVKIIERSLGRTLADLFETFEHQPVASASIAQVHFATLKGGPNHGREVAVKVLRPGMLPV
IDSDLALMRDLATWLERFWADGKRLKPREVVAEFDKYLHDELDLMIEAANASQLRRNFADTNLLLVPEVFWDWCSSTVFV
MERMHGIPISRTESLKAAGVDMHQLAEEGVEIFFTQVFRDGFFHADMHPGNILVSVQPETFGRYIALDFGIVGALSEFDK
NYLAQNFIAFFRRDYHRVALLHVESGWVPPDTRVEELESAVRACCEPYFDKPLKEISLGMVLMRLFQTSRRFNVEIQPQL
VLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLERWMHEQVGWKGAWERIKVEAPLWAKMLPDFPRLAHQFLERRALNTNGE
QERLLAQLVTEQRRTNRLVGTALLLVGGFVAGIVLTHVLGWIGYW
>Mature_524_residues
TRLLRLGKILFVILYYGLDELVLSGFQNRKIRFLVRVMTIGRKLDMPRGERLRLALTKLGPIFVKFGQVLSTRRDLMPPD
IADELALLQDQVPPFDSAVAVKIIERSLGRTLADLFETFEHQPVASASIAQVHFATLKGGPNHGREVAVKVLRPGMLPVI
DSDLALMRDLATWLERFWADGKRLKPREVVAEFDKYLHDELDLMIEAANASQLRRNFADTNLLLVPEVFWDWCSSTVFVM
ERMHGIPISRTESLKAAGVDMHQLAEEGVEIFFTQVFRDGFFHADMHPGNILVSVQPETFGRYIALDFGIVGALSEFDKN
YLAQNFIAFFRRDYHRVALLHVESGWVPPDTRVEELESAVRACCEPYFDKPLKEISLGMVLMRLFQTSRRFNVEIQPQLV
LLQKTLLNIEGLGRQLDPDLDLWKTAKPFLERWMHEQVGWKGAWERIKVEAPLWAKMLPDFPRLAHQFLERRALNTNGEQ
ERLLAQLVTEQRRTNRLVGTALLLVGGFVAGIVLTHVLGWIGYW

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=30.6569343065693, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI40254938, Length=261, Percent_Identity=30.6513409961686, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI32261307, Length=316, Percent_Identity=28.1645569620253, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI217035081, Length=216, Percent_Identity=31.0185185185185, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34147522, Length=323, Percent_Identity=25.6965944272446, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27363457, Length=282, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217416386, Length=224, Percent_Identity=27.6785714285714, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=514, Percent_Identity=53.1128404669261, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17559152, Length=278, Percent_Identity=28.0575539568345, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=328, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=26.3038548752834, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=28.5140562248996, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=289, Percent_Identity=24.5674740484429, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI22024280, Length=255, Percent_Identity=30.9803921568627, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24662575, Length=275, Percent_Identity=30.1818181818182, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 60180; Mature: 60049

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLLRLGKILFVILYYGLDELVLSGFQNRKIRFLVRVMTIGRKLDMPRGERLRLALTKL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GPIFVKFGQVLSTRRDLMPPDIADELALLQDQVPPFDSAVAVKIIERSLGRTLADLFETF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EHQPVASASIAQVHFATLKGGPNHGREVAVKVLRPGMLPVIDSDLALMRDLATWLERFWA
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
DGKRLKPREVVAEFDKYLHDELDLMIEAANASQLRRNFADTNLLLVPEVFWDWCSSTVFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
MERMHGIPISRTESLKAAGVDMHQLAEEGVEIFFTQVFRDGFFHADMHPGNILVSVQPET
HHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHH
FGRYIALDFGIVGALSEFDKNYLAQNFIAFFRRDYHRVALLHVESGWVPPDTRVEELESA
HCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEEEEECCCCCCCCHHHHHHHH
VRACCEPYFDKPLKEISLGMVLMRLFQTSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCC
LDLWKTAKPFLERWMHEQVGWKGAWERIKVEAPLWAKMLPDFPRLAHQFLERRALNTNGE
CHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCHHHHHCCCHHHHHHHHHHHHHCCCCCH
QERLLAQLVTEQRRTNRLVGTALLLVGGFVAGIVLTHVLGWIGYW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRLLRLGKILFVILYYGLDELVLSGFQNRKIRFLVRVMTIGRKLDMPRGERLRLALTKL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GPIFVKFGQVLSTRRDLMPPDIADELALLQDQVPPFDSAVAVKIIERSLGRTLADLFETF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EHQPVASASIAQVHFATLKGGPNHGREVAVKVLRPGMLPVIDSDLALMRDLATWLERFWA
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
DGKRLKPREVVAEFDKYLHDELDLMIEAANASQLRRNFADTNLLLVPEVFWDWCSSTVFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
MERMHGIPISRTESLKAAGVDMHQLAEEGVEIFFTQVFRDGFFHADMHPGNILVSVQPET
HHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHH
FGRYIALDFGIVGALSEFDKNYLAQNFIAFFRRDYHRVALLHVESGWVPPDTRVEELESA
HCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEEEEECCCCCCCCHHHHHHHH
VRACCEPYFDKPLKEISLGMVLMRLFQTSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCC
LDLWKTAKPFLERWMHEQVGWKGAWERIKVEAPLWAKMLPDFPRLAHQFLERRALNTNGE
CHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCHHHHHCCCHHHHHHHHHHHHHCCCCCH
QERLLAQLVTEQRRTNRLVGTALLLVGGFVAGIVLTHVLGWIGYW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]