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The map label for this gene is envZ [H]

Identifier: 73540097

GI number: 73540097

Start: 428253

End: 429590

Strand: Direct

Name: envZ [H]

Synonym: Reut_A0391

Alternate gene names: 73540097

Gene position: 428253-429590 (Clockwise)

Preceding gene: 73540096

Following gene: 73540098

Centisome position: 11.25

GC content: 68.46

Gene sequence:

>1338_bases
ATGCGGATCGGGCTGCCGCGTTCGCTGCTGGCGCGCAATATCGCGCTGCTGCTCGCGCTGGTGGCGCTCACGCAGGCGTG
TTCGCTCACCGTGCTGCTGCATTACGTGCAGCGTCCGCGCCTCGAGCGTGCGGCCATCATCTTTGCGGACTATGTGAAGA
TGCTCGACGGCGTTCTCGGTGCCATGCCCGCCGGTACGAGCGGTGCCGTGGTCCAGCGGTTAGGCGCACAGTTGGAGGAT
CCCGACCACGCTACGCCGCAGGCCGACCCCAACCCGCTGCAGCTTTTCCGCACTTACCAGCGCGACGTGTTCCTCGAAGC
GCTGCAGCGCCACCTGCCATCCGACATGCCCGTGCGCTGGCAGTCCGGCGACGAAGAGCGGTTATGGATCCGCCTGCACG
TCGCCGATACCGCGCGCTGGGTCGCCATGCCGATGACCGAGGATGCGCGTGCGGGCGGCATCACCACGGCGTTGATCTTA
TCGACAGCGCTCGCCTTGCTGGCCGCTCTGACCGGCTACCTGATCCAGCTTCACCTGAACCGTCCGTTGCGGGACCTCGC
AGACGCCGCGCGCCAGATCTGCGCGGGCGATTCGCCGCCGCCGCTGCCGACCAACGGCCCTACGGAGATCGCCCAGGTCA
GCAGCGCTTTCAACCAGATGACGCAGGCGCTGCAGCAGGCCGAGCAGACGCGCGCACTGATGCTCGCAGGCGTCTCGCAC
GACATCCGCACGCCGCTGACCAAGCTGCGCCTGGCGATGGCCATGTCGATCCCGCGCGGCGCCGACGATGCGTTCGTGGC
GTCCGCGGAAGGCTATCTCGATCACATCGAGACCATCCTGCAGCAGTTCATGGACTATGCGGGCAGCGGCGAGAAGGAGC
AGCCGCAGCCCGGCGACATCAATGCGCTCGTCGGCCAGCTTGCGTCGGACTTCGCGGGGCTCGGCCATGAGTTCGATCTT
TCCCTCGGCGATCTGCCTCCGGTTCCGTTCCGCCCGGTCAGCCTGCTCCGCCTGCTGATGAACCTGATGCAGAACGCCGT
CGTCTACGGCAAGACGGGCCTGGCCGTGCGCACGTGGCGCGATGGCGAGCGCGCGTGCATTGCCGTGGGCGATCGCGGCA
CGGGCATGGCGGCGGCCGAGCTCGAACAGCTCAAAGCGCCGTTCAGCCGCGGCCCGAATGCGCGAACGCATTCGGGCGGC
ACGGGCCTGGGTCTCGCGATCGTCGATCGCATCGCGCGCCTGCATGGCGGCTCGCTGCAGTTCCGCGCGCGCGAGGGCGG
CGGCCTGGAGGCCGTGGTATCGCTGCCGCTCCACGCGCAAGGCGTGCAGCACATCTGA

Upstream 100 bases:

>100_bases
TGCGCCTGCGCCAGATCGTCGAGGACGATCCGTCCAAGCCGCGCTTCATCAAGACCGTTTGGGGAATCGGTTACATGCTG
GTGGCCGGCGTCGAATCGTG

Downstream 100 bases:

>100_bases
GCACCTGAGAACGCCAGGGCCTCGCGCCGTGACATCGCGCGAAATATTTGATGCATGGCGATTCGGGCGGGCACTTCCCA
TACTTTGGTCACCGCGACGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MRIGLPRSLLARNIALLLALVALTQACSLTVLLHYVQRPRLERAAIIFADYVKMLDGVLGAMPAGTSGAVVQRLGAQLED
PDHATPQADPNPLQLFRTYQRDVFLEALQRHLPSDMPVRWQSGDEERLWIRLHVADTARWVAMPMTEDARAGGITTALIL
STALALLAALTGYLIQLHLNRPLRDLADAARQICAGDSPPPLPTNGPTEIAQVSSAFNQMTQALQQAEQTRALMLAGVSH
DIRTPLTKLRLAMAMSIPRGADDAFVASAEGYLDHIETILQQFMDYAGSGEKEQPQPGDINALVGQLASDFAGLGHEFDL
SLGDLPPVPFRPVSLLRLLMNLMQNAVVYGKTGLAVRTWRDGERACIAVGDRGTGMAAAELEQLKAPFSRGPNARTHSGG
TGLGLAIVDRIARLHGGSLQFRAREGGGLEAVVSLPLHAQGVQHI

Sequences:

>Translated_445_residues
MRIGLPRSLLARNIALLLALVALTQACSLTVLLHYVQRPRLERAAIIFADYVKMLDGVLGAMPAGTSGAVVQRLGAQLED
PDHATPQADPNPLQLFRTYQRDVFLEALQRHLPSDMPVRWQSGDEERLWIRLHVADTARWVAMPMTEDARAGGITTALIL
STALALLAALTGYLIQLHLNRPLRDLADAARQICAGDSPPPLPTNGPTEIAQVSSAFNQMTQALQQAEQTRALMLAGVSH
DIRTPLTKLRLAMAMSIPRGADDAFVASAEGYLDHIETILQQFMDYAGSGEKEQPQPGDINALVGQLASDFAGLGHEFDL
SLGDLPPVPFRPVSLLRLLMNLMQNAVVYGKTGLAVRTWRDGERACIAVGDRGTGMAAAELEQLKAPFSRGPNARTHSGG
TGLGLAIVDRIARLHGGSLQFRAREGGGLEAVVSLPLHAQGVQHI
>Mature_445_residues
MRIGLPRSLLARNIALLLALVALTQACSLTVLLHYVQRPRLERAAIIFADYVKMLDGVLGAMPAGTSGAVVQRLGAQLED
PDHATPQADPNPLQLFRTYQRDVFLEALQRHLPSDMPVRWQSGDEERLWIRLHVADTARWVAMPMTEDARAGGITTALIL
STALALLAALTGYLIQLHLNRPLRDLADAARQICAGDSPPPLPTNGPTEIAQVSSAFNQMTQALQQAEQTRALMLAGVSH
DIRTPLTKLRLAMAMSIPRGADDAFVASAEGYLDHIETILQQFMDYAGSGEKEQPQPGDINALVGQLASDFAGLGHEFDL
SLGDLPPVPFRPVSLLRLLMNLMQNAVVYGKTGLAVRTWRDGERACIAVGDRGTGMAAAELEQLKAPFSRGPNARTHSGG
TGLGLAIVDRIARLHGGSLQFRAREGGGLEAVVSLPLHAQGVQHI

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=450, Percent_Identity=32.2222222222222, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=30, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI145693157, Length=249, Percent_Identity=29.718875502008, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=27.5092936802974, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=238, Percent_Identity=26.4705882352941, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786783, Length=323, Percent_Identity=25.3869969040248, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=26.530612244898, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=348, Percent_Identity=26.4367816091954, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=32.034632034632, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47934; Mature: 47934

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGLPRSLLARNIALLLALVALTQACSLTVLLHYVQRPRLERAAIIFADYVKMLDGVLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMPAGTSGAVVQRLGAQLEDPDHATPQADPNPLQLFRTYQRDVFLEALQRHLPSDMPVRW
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
QSGDEERLWIRLHVADTARWVAMPMTEDARAGGITTALILSTALALLAALTGYLIQLHLN
CCCCCCEEEEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPLRDLADAARQICAGDSPPPLPTNGPTEIAQVSSAFNQMTQALQQAEQTRALMLAGVSH
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DIRTPLTKLRLAMAMSIPRGADDAFVASAEGYLDHIETILQQFMDYAGSGEKEQPQPGDI
HHHHHHHHHHHHHHHCCCCCCCCHHEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
NALVGQLASDFAGLGHEFDLSLGDLPPVPFRPVSLLRLLMNLMQNAVVYGKTGLAVRTWR
HHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEC
DGERACIAVGDRGTGMAAAELEQLKAPFSRGPNARTHSGGTGLGLAIVDRIARLHGGSLQ
CCCEEEEEECCCCCCHHHHHHHHHHCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
FRAREGGGLEAVVSLPLHAQGVQHI
EEECCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRIGLPRSLLARNIALLLALVALTQACSLTVLLHYVQRPRLERAAIIFADYVKMLDGVLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMPAGTSGAVVQRLGAQLEDPDHATPQADPNPLQLFRTYQRDVFLEALQRHLPSDMPVRW
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
QSGDEERLWIRLHVADTARWVAMPMTEDARAGGITTALILSTALALLAALTGYLIQLHLN
CCCCCCEEEEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPLRDLADAARQICAGDSPPPLPTNGPTEIAQVSSAFNQMTQALQQAEQTRALMLAGVSH
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DIRTPLTKLRLAMAMSIPRGADDAFVASAEGYLDHIETILQQFMDYAGSGEKEQPQPGDI
HHHHHHHHHHHHHHHCCCCCCCCHHEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
NALVGQLASDFAGLGHEFDLSLGDLPPVPFRPVSLLRLLMNLMQNAVVYGKTGLAVRTWR
HHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEC
DGERACIAVGDRGTGMAAAELEQLKAPFSRGPNARTHSGGTGLGLAIVDRIARLHGGSLQ
CCCEEEEEECCCCCCHHHHHHHHHHCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEE
FRAREGGGLEAVVSLPLHAQGVQHI
EEECCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]