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The map label for this gene is hit [H]

Identifier: 73539960

GI number: 73539960

Start: 284513

End: 284950

Strand: Direct

Name: hit [H]

Synonym: Reut_A0254

Alternate gene names: 73539960

Gene position: 284513-284950 (Clockwise)

Preceding gene: 73539959

Following gene: 73539961

Centisome position: 7.47

GC content: 63.93

Gene sequence:

>438_bases
ATGAACAGCCCGTACGACACGAACAACATTTTCGCGAAGATCCTGCGCGGGGAAATTCCGTGCCACAAGGTCTATGAAGA
TGCCGAGACCATCGCCTTCATGGACATCATGCCGCAATCGGATGGCCACACGCTGGTAGTGCCCAAGGAGGCCGCCGTCA
ATCTGTTCGATTTGTCGGAAGCCGGCGCCCAGGCCGCCATCCGCACCACGCAGCGCGTCGCGCGCGCGGTGCGCCAGGCG
TTCAATCCGGACGGGCTGTCGATTGGCCAGTTCAACGGCGCGGCAGCCGGCCAGACCGTACCGCACATCCATTTCCATAT
CGTGCCGCGCTATGCCGACCAGACGCTGCGCGGCCACGCGCGTGACATGCAGGACCCGGACCTGCTCAAGAAGCACGCGG
AGCGCATTATCGCCGCGCTGCGCGAACAGGCAGCCTGA

Upstream 100 bases:

>100_bases
CCGAAATCGGGGGGCGGAGGGTGGCTGTCACATCCATGGCGGCCCTCGTGCGGTAAACTCGGAGGCTCGCCGGATTCCGG
AACCACCGCCGCACCCGACC

Downstream 100 bases:

>100_bases
TCTGGCACGAACCCCAAACATATAACCAGCAAAGAGGAAGAAGAGATGGCAATCAGGACAGTGGGCATCGTGGGTGCCGG
CACCATGGGCAACGGCATCG

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MNSPYDTNNIFAKILRGEIPCHKVYEDAETIAFMDIMPQSDGHTLVVPKEAAVNLFDLSEAGAQAAIRTTQRVARAVRQA
FNPDGLSIGQFNGAAAGQTVPHIHFHIVPRYADQTLRGHARDMQDPDLLKKHAERIIAALREQAA

Sequences:

>Translated_145_residues
MNSPYDTNNIFAKILRGEIPCHKVYEDAETIAFMDIMPQSDGHTLVVPKEAAVNLFDLSEAGAQAAIRTTQRVARAVRQA
FNPDGLSIGQFNGAAAGQTVPHIHFHIVPRYADQTLRGHARDMQDPDLLKKHAERIIAALREQAA
>Mature_145_residues
MNSPYDTNNIFAKILRGEIPCHKVYEDAETIAFMDIMPQSDGHTLVVPKEAAVNLFDLSEAGAQAAIRTTQRVARAVRQA
FNPDGLSIGQFNGAAAGQTVPHIHFHIVPRYADQTLRGHARDMQDPDLLKKHAERIIAALREQAA

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17556280, Length=101, Percent_Identity=35.6435643564356, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320078, Length=145, Percent_Identity=32.4137931034483, Blast_Score=81, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320511, Length=112, Percent_Identity=33.9285714285714, Blast_Score=70, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24581222, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28574010, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: NA

Molecular weight: Translated: 15983; Mature: 15983

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPYDTNNIFAKILRGEIPCHKVYEDAETIAFMDIMPQSDGHTLVVPKEAAVNLFDLSE
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEHEEECCCCCCCEEEECHHHHCEEHHCHH
AGAQAAIRTTQRVARAVRQAFNPDGLSIGQFNGAAAGQTVPHIHFHIVPRYADQTLRGHA
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHH
RDMQDPDLLKKHAERIIAALREQAA
CCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSPYDTNNIFAKILRGEIPCHKVYEDAETIAFMDIMPQSDGHTLVVPKEAAVNLFDLSE
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEHEEECCCCCCCEEEECHHHHCEEHHCHH
AGAQAAIRTTQRVARAVRQAFNPDGLSIGQFNGAAAGQTVPHIHFHIVPRYADQTLRGHA
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHH
RDMQDPDLLKKHAERIIAALREQAA
CCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]