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The map label for this gene is hbd [H]

Identifier: 73539961

GI number: 73539961

Start: 284996

End: 285850

Strand: Direct

Name: hbd [H]

Synonym: Reut_A0255

Alternate gene names: 73539961

Gene position: 284996-285850 (Clockwise)

Preceding gene: 73539960

Following gene: 73539962

Centisome position: 7.49

GC content: 61.99

Gene sequence:

>855_bases
ATGGCAATCAGGACAGTGGGCATCGTGGGTGCCGGCACCATGGGCAACGGCATCGCGCAGGCTTGTGCGGTGGTGGGCCT
GGACGTGGTGATGGTGGATATCAGCGACGCAGCGGTGCAGAAGGGCATCGCCACCGTCGCCGGCAGCCTGGACCGCCTGA
TCAAGAAGGACAAGATCAGCGAAGCCGACAAGATGACTGCGCTCGCGCGCATCCACGGCAGCACCGCGTATGACGACCTG
AAGAAGGCCGATATCGTGATCGAGGCCGCCACCGAGAACTTTGACCTGAAGGTCAAGATCCTCAAGCAGATCGACAGCAT
CGTCGGCGAGAACGTCATCATTGCTTCGAACACGTCGTCGATCTCGATCACCAAGCTGGCCGCCGTGACGAGTCGCCCCG
AGCGCTTCATCGGCATGCACTTCTTCAACCCGGTGCCGGTGATGGCGCTGGTGGAACTGATCCGCGGCCTGCAGACCAGC
GACGCGGCTCACGCCGATGTCGAGGCGCTGGCCAAGGAACTGGGCAAGTACCCGATCACCGTCAAGAACAGCCCGGGCTT
CGTCGTCAACCGCATCCTGTGCCCGATGATCAACGAAGCCTTCTGCGTGCTCGGTGAAGGCCTGGCCTCGCCGGAAGAGA
TCGACGAAGGCATGAAGCTCGGCTGCAACCATCCGATCGGCCCCCTGGCACTGGCCGACATGATCGGCCTGGACACCATG
CTGGCAGTGATGGAAGTGCTGTACACAGAATTTGCCGACCCGAAGTATCGTCCGGCCATGCTGATGCGCGAGATGGTGGC
TGCGGGGTATCTGGGCCGCAAGACTGGCCGTGGCGTGTACGTCTACAGCAAGTAA

Upstream 100 bases:

>100_bases
GCTCAAGAAGCACGCGGAGCGCATTATCGCCGCGCTGCGCGAACAGGCAGCCTGATCTGGCACGAACCCCAAACATATAA
CCAGCAAAGAGGAAGAAGAG

Downstream 100 bases:

>100_bases
TCCCTACCGCCTGCGCGTGTTGCCCTGACGCAACGCGCGATGTGCAGTAATCGCCGGCCGCCTTTCAGGCGGCCGGTTCG
CTTTTGACGTGAATTCGGGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAIRTVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKDKISEADKMTALARIHGSTAYDDL
KKADIVIEAATENFDLKVKILKQIDSIVGENVIIASNTSSISITKLAAVTSRPERFIGMHFFNPVPVMALVELIRGLQTS
DAAHADVEALAKELGKYPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK

Sequences:

>Translated_284_residues
MAIRTVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKDKISEADKMTALARIHGSTAYDDL
KKADIVIEAATENFDLKVKILKQIDSIVGENVIIASNTSSISITKLAAVTSRPERFIGMHFFNPVPVMALVELIRGLQTS
DAAHADVEALAKELGKYPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK
>Mature_283_residues
AIRTVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKDKISEADKMTALARIHGSTAYDDLK
KADIVIEAATENFDLKVKILKQIDSIVGENVIIASNTSSISITKLAAVTSRPERFIGMHFFNPVPVMALVELIRGLQTSD
AAHADVEALAKELGKYPITVKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTML
AVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=39.5833333333333, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=38.0327868852459, Blast_Score=201, Evalue=4e-52,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=35.7894736842105, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI261878539, Length=297, Percent_Identity=30.3030303030303, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI68989263, Length=297, Percent_Identity=30.3030303030303, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI115430219, Length=232, Percent_Identity=30.1724137931034, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=37.7224199288256, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=37.218045112782, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=36.2264150943396, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=41.9243986254296, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=39.7212543554007, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=39.4366197183099, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=39.4366197183099, Blast_Score=190, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=39.4366197183099, Blast_Score=190, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=38.5159010600707, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=35.7388316151203, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=30.6338028169014, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=39.0070921985816, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=39.0070921985816, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=39.0070921985816, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI45549573, Length=237, Percent_Identity=30.379746835443, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129993, Length=226, Percent_Identity=26.9911504424779, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30286; Mature: 30155

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRTVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKDKIS
CCEEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
EADKMTALARIHGSTAYDDLKKADIVIEAATENFDLKVKILKQIDSIVGENVIIASNTSS
HHHHHHHHHHHCCCCHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
ISITKLAAVTSRPERFIGMHFFNPVPVMALVELIRGLQTSDAAHADVEALAKELGKYPIT
EEHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
AIRTVGIVGAGTMGNGIAQACAVVGLDVVMVDISDAAVQKGIATVAGSLDRLIKKDKIS
CEEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
EADKMTALARIHGSTAYDDLKKADIVIEAATENFDLKVKILKQIDSIVGENVIIASNTSS
HHHHHHHHHHHCCCCHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
ISITKLAAVTSRPERFIGMHFFNPVPVMALVELIRGLQTSDAAHADVEALAKELGKYPIT
EEHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCVLGEGLASPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRKTGRGVYVYSK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA