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The map label for this gene is can [H]

Identifier: 73539843

GI number: 73539843

Start: 163870

End: 164541

Strand: Direct

Name: can [H]

Synonym: Reut_A0137

Alternate gene names: 73539843

Gene position: 163870-164541 (Clockwise)

Preceding gene: 73539842

Following gene: 73539844

Centisome position: 4.3

GC content: 65.33

Gene sequence:

>672_bases
ATGAGTGACGCTATCGCCCAGCTGTTCCGCAACAACCGCGAATGGGTCGACCGCGTCAACGCGGAAGATCCGACCTTCTT
CATGCGCCTGGCCAACCAGCAGGCGCCGGAATACCTGTGGATCGGCTGCTCCGATTCCCGCGTGCCCGCCAACCAGATCC
TTGGCCTGGCGCCGGGCGAGGTCTTCGTCCACCGCAATATCGCCAACGTGATCGCGCACAGCGACCTGAACGCGCTGTCG
GTAATCCAGTTCGCCGTGGAAGTGCTCAAGGTGCGCCACATCACCGTGGTCGGCCACTATGGCTGCGGCGGCGTGAAGGT
CGCACTCAAGCGCGAGCGCATCGGCCTGGCCGACAACTGGCTGCGCCATGTGCGCGATGTGGCCGACAAGCACGAGGCCT
ATCTCGGCACCATCCTGCGCGAGGAAGATGCGCACACGCGGCTGTGCGAGCTCAATGTCATCGAGCAGGTCAGCAACATC
TGCCAGACCACCGTGCTGCAGGACGCGTGGTCGCGCGGACAGGCTGTGACGGTGCACGGCTGGATCTATGGCGTCTCCGA
CGGCCTGCTGCGCGACCTCGGCATGGCTGCGAGCAACAACGACGAACTGCACGAGCAGCTCGCCGCGGCCTACCGACAGT
TCGGCGATCCGCCGCAGGCCTCCATCCGCTGA

Upstream 100 bases:

>100_bases
TTCATGACTTCTTTGCCTATCCCATTTCTGAACGCTTCATCAACCGCTACGGCACGGCTGCGCACGGCACGCCCGTCGCC
AGTTTCGCAAGGAGAGTCGC

Downstream 100 bases:

>100_bases
ACGTGCGCGGCATCATGTAGTCATCGAATCAAACACCGTCGTTTCCGTGCGCGTACCCTTACCCGCACGGAGCGACGGTG
GTGAAGCATACCGATATCAG

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSDAIAQLFRNNREWVDRVNAEDPTFFMRLANQQAPEYLWIGCSDSRVPANQILGLAPGEVFVHRNIANVIAHSDLNALS
VIQFAVEVLKVRHITVVGHYGCGGVKVALKRERIGLADNWLRHVRDVADKHEAYLGTILREEDAHTRLCELNVIEQVSNI
CQTTVLQDAWSRGQAVTVHGWIYGVSDGLLRDLGMAASNNDELHEQLAAAYRQFGDPPQASIR

Sequences:

>Translated_223_residues
MSDAIAQLFRNNREWVDRVNAEDPTFFMRLANQQAPEYLWIGCSDSRVPANQILGLAPGEVFVHRNIANVIAHSDLNALS
VIQFAVEVLKVRHITVVGHYGCGGVKVALKRERIGLADNWLRHVRDVADKHEAYLGTILREEDAHTRLCELNVIEQVSNI
CQTTVLQDAWSRGQAVTVHGWIYGVSDGLLRDLGMAASNNDELHEQLAAAYRQFGDPPQASIR
>Mature_222_residues
SDAIAQLFRNNREWVDRVNAEDPTFFMRLANQQAPEYLWIGCSDSRVPANQILGLAPGEVFVHRNIANVIAHSDLNALSV
IQFAVEVLKVRHITVVGHYGCGGVKVALKRERIGLADNWLRHVRDVADKHEAYLGTILREEDAHTRLCELNVIEQVSNIC
QTTVLQDAWSRGQAVTVHGWIYGVSDGLLRDLGMAASNNDELHEQLAAAYRQFGDPPQASIR

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=202, Percent_Identity=54.4554455445545, Blast_Score=241, Evalue=2e-65,
Organism=Escherichia coli, GI1786534, Length=194, Percent_Identity=27.8350515463918, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324292, Length=192, Percent_Identity=34.8958333333333, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24918; Mature: 24787

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIAQLFRNNREWVDRVNAEDPTFFMRLANQQAPEYLWIGCSDSRVPANQILGLAPGE
CCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCC
VFVHRNIANVIAHSDLNALSVIQFAVEVLKVRHITVVGHYGCGGVKVALKRERIGLADNW
EEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEHHHCCHHHHH
LRHVRDVADKHEAYLGTILREEDAHTRLCELNVIEQVSNICQTTVLQDAWSRGQAVTVHG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
WIYGVSDGLLRDLGMAASNNDELHEQLAAAYRQFGDPPQASIR
EEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDAIAQLFRNNREWVDRVNAEDPTFFMRLANQQAPEYLWIGCSDSRVPANQILGLAPGE
CHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCC
VFVHRNIANVIAHSDLNALSVIQFAVEVLKVRHITVVGHYGCGGVKVALKRERIGLADNW
EEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEHHHCCHHHHH
LRHVRDVADKHEAYLGTILREEDAHTRLCELNVIEQVSNICQTTVLQDAWSRGQAVTVHG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
WIYGVSDGLLRDLGMAASNNDELHEQLAAAYRQFGDPPQASIR
EEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]