Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 73539785

GI number: 73539785

Start: 97430

End: 99730

Strand: Direct

Name: mrdA [H]

Synonym: Reut_A0079

Alternate gene names: 73539785

Gene position: 97430-99730 (Clockwise)

Preceding gene: 73539784

Following gene: 73539786

Centisome position: 2.56

GC content: 66.71

Gene sequence:

>2301_bases
ATGACCGAAATCCGCAACGTCGAACTGGAAATCGGCCGCTTCCGCCTCCGCGTGGCGGCCGCGGCGCTGTTCACGGTGAT
CTGCTTCGGCTTGCTGTTCACGCGCTTCCTGTGGCTGCAGTGGTACAAGCATGACCAGTACTCGGCCAAGGCCGAGGACA
ACCGCATCTCCGTCGCGCCGATCGAGCCGAACCGCGGCATCATCATGGACCGCAACGGTGTCGTGCTGGCGCGCAATTAC
TCGGCGTACACGCTCGAAATCACGCCGTCCAAGCTGACCGATACGCTCGAAAACACGATCGAGGCACTGTCGTTGCTGGT
CGACATCCAGCCGCGCGACCGGCGCCGCTTCAAGCGCTTGATGGAGGAATCGCGCAGCTTCGAGAGCCTGCCGATCCGCA
GCCAGCTCTCCGATGAAGAGGTGGCGCGCTTCTCCGCGCAGCGTTTCCGCTTCCCGGGCGTAGACGTGCGCGCGCGCCTG
TTCCGGCAATATCCGCTCGGGGAATCGGCGTCGCACGTGATCGGTTACCTGGGACGCATCTCGCAGCGCGACCAGGAGCG
CATCGAGGCCATGGACGAGGCCAACGATGCCGATGGCGCCAAGTACGATCCGCGCAAGGACGCCGACAACTACAAGGGCA
GCAACTACATCGGCAAGATCGGCCTGGAGCAGAGCTACGAGACCGAGCTGCACGGGCTGACCGGCTTCGAGGAGGTCGAG
GTGAGCGCGGGCGGCCGGCCGATCCGCACGCTGTCGACCTCGCCCGCCACGCCGGGCAACAACCTGATCCTGTCGCTCGA
CATCCGCCTGCAGCAACTGGCCGAGGAGCTGTTCGGCGACCGCCGTGGCGCGCTGGTGGCGATCGAGCCGTCGACTGGCG
ACATCCTGGCCTTCGTCTCCAAGCCGACTTTCGACCCGAACCTGTTCGTCGAGGGGATCGACTCCAACACTTGGGGCGAG
CTCAACAATTCGCCCGACAAGCCGCTGCTGAACCGCCCGTTGCGCGGCACCTATCCGCCCGGCTCGACCTACAAGCCGTT
CATGGCGCTGGCGGCGCTGACCACGGGCAAGCGCACGGCCGCGTGGGGCATGCATGACCCGGGTTCGTTCACGCTGGGCA
ACCACACGTTCCGCGACGACAAGCCGGGCGGCCACGGCTGGGTCGACATGCAGACGTCGATCGTGCAGTCGTGCGATACG
TACTACTACGCGCTCGCGCGCGACATGGGCGTCAACGCGATCCACGACTTCATGAAGCCGCTGGGCTTCGGGCAGATCAC
CGGGATCGACATCGAGGGCGAAAGCCGAGGCATCCTGCCGTCCACGGAGTGGAAGCGCAAGGCATACCGCAAGCCCGAGC
AGCAGAAGTGGTATGACGGCGAGACGATTTCGCTGGGTATCGGCCAGGGCTACAACAGCTTCACGATCCTGCAGCTTGCC
AACGCGATCTCGATCATCGTCAACAACGGCGCGGCGATGAAGCCCCACCTGGTCAAGGCCGTGGAGGATTCCGTCACGCG
CAAGCGCACGCTGACCGTGCCCAAGGAAAGCTACCGGCTGGACTTCAAGCAGGCCGACATCGACGTGATCAAGCGCGCGA
TGGTGGCGGTGACGCATTCGGGTACCGCCGCGCGCGTGTTCGCCGGCGCTGCCTACGAGTCGGCCGGCAAGACCGGTACG
GCCCAGACTTACACACTCGGCAAGAACGAGAAGTACAACCACCACGCGCTTGACGAGCGCAAGCGCGACCACTCGCTCTA
CACAGCGTTCGCGCCCGCCGACAACCCGAAGATCGCGCTTGCGCTGATCGTCGAGAACGCGGGCTTCGGCGCCGCGGTGG
CCGCGCCGATCGCACGCAAGGTGATGGACTATTACCTGCTCGGCAAGTGGCCCGCCGAACTGGAAGCCTCGGCACCGCCG
CCGGCTGAACGTCCGCCGGTCGATACGGCGAGCGTGTTCACCACGGGCCAGACTGCGAGCATTGCCAGCGCGACGGTGAT
GTCCGGCGGCGCCAGCGCCGTGGCGGCCAGCGCGGTGGGCGCATCGTCCGCCATGGCGGCGGCATCGTCCGCGACGGCTG
GCGCCTCCATGGCCGCGGCGCTGGATCCGGCCGCCATTGCGCCGGCTTCGGCCGTGCAGACGCTGGATGAACGCATGCTG
CAGGCGCTCGGCCACAGCAAGCCCAAGCCCGTTGCGCCGGGACCGGCGTCTGCCCCTGTTGCGGCCAAGGCGCCTGCACC
GAAACCCCGCGTCAAGCCCGTTGCTGCCACCCCGGCGACTGGCCCCGACGTTACCCGCTGA

Upstream 100 bases:

>100_bases
TTGGCCACGGCAGTGCTGCTCGCGCCGCAGCGCCGCTCGGTCGACGTCGACGAGACGCGCCCGATCTGAGCGCGACCCAC
GCATCCTATCCGGCAGTACC

Downstream 100 bases:

>100_bases
AGGAGACGCGCATGGACAAGCGTCGCGTCCTGTCGCTCATCAAGACGGCGTTTACCGGCTTTGACAAGCCGCTCGCGCTG
ATCGTGTTCCTGTTGTTCGC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MTEIRNVELEIGRFRLRVAAAALFTVICFGLLFTRFLWLQWYKHDQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNY
SAYTLEITPSKLTDTLENTIEALSLLVDIQPRDRRRFKRLMEESRSFESLPIRSQLSDEEVARFSAQRFRFPGVDVRARL
FRQYPLGESASHVIGYLGRISQRDQERIEAMDEANDADGAKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEVE
VSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEELFGDRRGALVAIEPSTGDILAFVSKPTFDPNLFVEGIDSNTWGE
LNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTAAWGMHDPGSFTLGNHTFRDDKPGGHGWVDMQTSIVQSCDT
YYYALARDMGVNAIHDFMKPLGFGQITGIDIEGESRGILPSTEWKRKAYRKPEQQKWYDGETISLGIGQGYNSFTILQLA
NAISIIVNNGAAMKPHLVKAVEDSVTRKRTLTVPKESYRLDFKQADIDVIKRAMVAVTHSGTAARVFAGAAYESAGKTGT
AQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADNPKIALALIVENAGFGAAVAAPIARKVMDYYLLGKWPAELEASAPP
PAERPPVDTASVFTTGQTASIASATVMSGGASAVAASAVGASSAMAAASSATAGASMAAALDPAAIAPASAVQTLDERML
QALGHSKPKPVAPGPASAPVAAKAPAPKPRVKPVAATPATGPDVTR

Sequences:

>Translated_766_residues
MTEIRNVELEIGRFRLRVAAAALFTVICFGLLFTRFLWLQWYKHDQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNY
SAYTLEITPSKLTDTLENTIEALSLLVDIQPRDRRRFKRLMEESRSFESLPIRSQLSDEEVARFSAQRFRFPGVDVRARL
FRQYPLGESASHVIGYLGRISQRDQERIEAMDEANDADGAKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEVE
VSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEELFGDRRGALVAIEPSTGDILAFVSKPTFDPNLFVEGIDSNTWGE
LNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTAAWGMHDPGSFTLGNHTFRDDKPGGHGWVDMQTSIVQSCDT
YYYALARDMGVNAIHDFMKPLGFGQITGIDIEGESRGILPSTEWKRKAYRKPEQQKWYDGETISLGIGQGYNSFTILQLA
NAISIIVNNGAAMKPHLVKAVEDSVTRKRTLTVPKESYRLDFKQADIDVIKRAMVAVTHSGTAARVFAGAAYESAGKTGT
AQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADNPKIALALIVENAGFGAAVAAPIARKVMDYYLLGKWPAELEASAPP
PAERPPVDTASVFTTGQTASIASATVMSGGASAVAASAVGASSAMAAASSATAGASMAAALDPAAIAPASAVQTLDERML
QALGHSKPKPVAPGPASAPVAAKAPAPKPRVKPVAATPATGPDVTR
>Mature_765_residues
TEIRNVELEIGRFRLRVAAAALFTVICFGLLFTRFLWLQWYKHDQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNYS
AYTLEITPSKLTDTLENTIEALSLLVDIQPRDRRRFKRLMEESRSFESLPIRSQLSDEEVARFSAQRFRFPGVDVRARLF
RQYPLGESASHVIGYLGRISQRDQERIEAMDEANDADGAKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEVEV
SAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEELFGDRRGALVAIEPSTGDILAFVSKPTFDPNLFVEGIDSNTWGEL
NNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTAAWGMHDPGSFTLGNHTFRDDKPGGHGWVDMQTSIVQSCDTY
YYALARDMGVNAIHDFMKPLGFGQITGIDIEGESRGILPSTEWKRKAYRKPEQQKWYDGETISLGIGQGYNSFTILQLAN
AISIIVNNGAAMKPHLVKAVEDSVTRKRTLTVPKESYRLDFKQADIDVIKRAMVAVTHSGTAARVFAGAAYESAGKTGTA
QTYTLGKNEKYNHHALDERKRDHSLYTAFAPADNPKIALALIVENAGFGAAVAAPIARKVMDYYLLGKWPAELEASAPPP
AERPPVDTASVFTTGQTASIASATVMSGGASAVAASAVGASSAMAAASSATAGASMAAALDPAAIAPASAVQTLDERMLQ
ALGHSKPKPVAPGPASAPVAAKAPAPKPRVKPVAATPATGPDVTR

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=651, Percent_Identity=39.63133640553, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786272, Length=622, Percent_Identity=23.4726688102894, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 83051; Mature: 82920

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIRNVELEIGRFRLRVAAAALFTVICFGLLFTRFLWLQWYKHDQYSAKAEDNRISVAP
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
IEPNRGIIMDRNGVVLARNYSAYTLEITPSKLTDTLENTIEALSLLVDIQPRDRRRFKRL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHH
MEESRSFESLPIRSQLSDEEVARFSAQRFRFPGVDVRARLFRQYPLGESASHVIGYLGRI
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
SQRDQERIEAMDEANDADGAKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEVE
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCEEE
VSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEELFGDRRGALVAIEPSTGDILAFVS
ECCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
KPTFDPNLFVEGIDSNTWGELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTA
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AWGMHDPGSFTLGNHTFRDDKPGGHGWVDMQTSIVQSCDTYYYALARDMGVNAIHDFMKP
ECCCCCCCCEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LGFGQITGIDIEGESRGILPSTEWKRKAYRKPEQQKWYDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCHHHHHH
NAISIIVNNGAAMKPHLVKAVEDSVTRKRTLTVPKESYRLDFKQADIDVIKRAMVAVTHS
CEEEEEECCCCCCCHHHHHHHHHHHHHCEEECCCCHHHEECHHHCCHHHHHHHHHHEECC
GTAARVFAGAAYESAGKTGTAQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADNPKIAL
CCEEEEEECHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCEEE
ALIVENAGFGAAVAAPIARKVMDYYLLGKWPAELEASAPPPAERPPVDTASVFTTGQTAS
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCH
IASATVMSGGASAVAASAVGASSAMAAASSATAGASMAAALDPAAIAPASAVQTLDERML
HHHHHHHCCCCHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCHHCCCHHHHHHHHHHHH
QALGHSKPKPVAPGPASAPVAAKAPAPKPRVKPVAATPATGPDVTR
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
TEIRNVELEIGRFRLRVAAAALFTVICFGLLFTRFLWLQWYKHDQYSAKAEDNRISVAP
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
IEPNRGIIMDRNGVVLARNYSAYTLEITPSKLTDTLENTIEALSLLVDIQPRDRRRFKRL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHH
MEESRSFESLPIRSQLSDEEVARFSAQRFRFPGVDVRARLFRQYPLGESASHVIGYLGRI
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
SQRDQERIEAMDEANDADGAKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEVE
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCEEE
VSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEELFGDRRGALVAIEPSTGDILAFVS
ECCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
KPTFDPNLFVEGIDSNTWGELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTA
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AWGMHDPGSFTLGNHTFRDDKPGGHGWVDMQTSIVQSCDTYYYALARDMGVNAIHDFMKP
ECCCCCCCCEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LGFGQITGIDIEGESRGILPSTEWKRKAYRKPEQQKWYDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCHHHHHH
NAISIIVNNGAAMKPHLVKAVEDSVTRKRTLTVPKESYRLDFKQADIDVIKRAMVAVTHS
CEEEEEECCCCCCCHHHHHHHHHHHHHCEEECCCCHHHEECHHHCCHHHHHHHHHHEECC
GTAARVFAGAAYESAGKTGTAQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADNPKIAL
CCEEEEEECHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCEEE
ALIVENAGFGAAVAAPIARKVMDYYLLGKWPAELEASAPPPAERPPVDTASVFTTGQTAS
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCH
IASATVMSGGASAVAASAVGASSAMAAASSATAGASMAAALDPAAIAPASAVQTLDERML
HHHHHHHCCCCHHHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCHHCCCHHHHHHHHHHHH
QALGHSKPKPVAPGPASAPVAAKAPAPKPRVKPVAATPATGPDVTR
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]