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The map label for this gene is gmk

Identifier: 71892382

GI number: 71892382

Start: 765594

End: 766232

Strand: Direct

Name: gmk

Synonym: BPEN_641

Alternate gene names: 71892382

Gene position: 765594-766232 (Clockwise)

Preceding gene: 71892381

Following gene: 71892383

Centisome position: 96.71

GC content: 30.36

Gene sequence:

>639_bases
ATGAAAAATTCAGGAATATTGTGTATTATATCCGCTCCTAGTGGGACAGGAAAATCTACGTTAATTCATACTGTGATACA
ATGTGATTGCTTTGTTTATCAAACTAAACTATCTATTTCCTATACCACACGTATCAAAAGACCTGGAGAAATACACGGAA
AAGATTATTATTTTATTTCAAAAAAAAAATTTAAATATATGATCGATAAAAATATGTTTTTTGAATATGCGATGATTTTT
AATCATTATTATGGTACCGCAAAAACTGATATTGAAACGATGTTAAATACTGGTATACATATTGTGCTGAATATTGACTG
GAAAGGAGCGCAACAAATTCGCAGTAAAATATCAAAAAACATCTATACTATTTTTATTTTGCCTCCATCAAAGAAAGAAT
TAGCACGTCGATTGTATCTAAGAGGAGAAGACACAGAAAAAGTGATTGTCGCGCGCATGGGCCAAGCAATGGATGAAATT
AGCCATTTTAAAGAATATGATTATATTATCATAAACGATAATTTTAACATTGCTTTGATGCATTTACAGTCAATTATGTT
ATCCGAGCAATTGCGAATAGCGCATCAAAAAATACGCTACGCAACATTAATCAATCATTTGTTATTGCCAGATATATAA

Upstream 100 bases:

>100_bases
ATATATAATTATTCACGACATAAGTACTATGTACGAACGTAATTTATTTTTATAAATATTAGTTATTTATGCAATCAAAT
ATGTATTTAATCATTTTATG

Downstream 100 bases:

>100_bases
ATAATAAATTAATATAAATACATAAATATATATATGTGTTTGCGATCAATATGAATTTAAACTAATAAATAAAATCCACA
TACACGGTAAATGAAAATGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKNSGILCIISAPSGTGKSTLIHTVIQCDCFVYQTKLSISYTTRIKRPGEIHGKDYYFISKKKFKYMIDKNMFFEYAMIF
NHYYGTAKTDIETMLNTGIHIVLNIDWKGAQQIRSKISKNIYTIFILPPSKKELARRLYLRGEDTEKVIVARMGQAMDEI
SHFKEYDYIIINDNFNIALMHLQSIMLSEQLRIAHQKIRYATLINHLLLPDI

Sequences:

>Translated_212_residues
MKNSGILCIISAPSGTGKSTLIHTVIQCDCFVYQTKLSISYTTRIKRPGEIHGKDYYFISKKKFKYMIDKNMFFEYAMIF
NHYYGTAKTDIETMLNTGIHIVLNIDWKGAQQIRSKISKNIYTIFILPPSKKELARRLYLRGEDTEKVIVARMGQAMDEI
SHFKEYDYIIINDNFNIALMHLQSIMLSEQLRIAHQKIRYATLINHLLLPDI
>Mature_212_residues
MKNSGILCIISAPSGTGKSTLIHTVIQCDCFVYQTKLSISYTTRIKRPGEIHGKDYYFISKKKFKYMIDKNMFFEYAMIF
NHYYGTAKTDIETMLNTGIHIVLNIDWKGAQQIRSKISKNIYTIFILPPSKKELARRLYLRGEDTEKVIVARMGQAMDEI
SHFKEYDYIIINDNFNIALMHLQSIMLSEQLRIAHQKIRYATLINHLLLPDI

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=34.375, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=34.375, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=34.375, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI14780902, Length=197, Percent_Identity=25.3807106598985, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI38570142, Length=149, Percent_Identity=26.1744966442953, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=204, Percent_Identity=50.9803921568627, Blast_Score=227, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=35.7954545454545, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=35.7954545454545, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17557440, Length=154, Percent_Identity=29.2207792207792, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71984092, Length=96, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=186, Percent_Identity=36.0215053763441, Blast_Score=128, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21356141, Length=170, Percent_Identity=37.0588235294118, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_BLOPB (Q491W5)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278116.1
- HSSP:   P60546
- ProteinModelPortal:   Q491W5
- SMR:   Q491W5
- STRING:   Q491W5
- GeneID:   3562718
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_641
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   CBLO291272:BPEN_641-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24698; Mature: 24698

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSGILCIISAPSGTGKSTLIHTVIQCDCFVYQTKLSISYTTRIKRPGEIHGKDYYFIS
CCCCCEEEEEECCCCCCCHHHHHHHHHHEEEEEEEEEEEEEEEEECCCCCCCCCEEEEEE
KKKFKYMIDKNMFFEYAMIFNHYYGTAKTDIETMLNTGIHIVLNIDWKGAQQIRSKISKN
CCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCC
IYTIFILPPSKKELARRLYLRGEDTEKVIVARMGQAMDEISHFKEYDYIIINDNFNIALM
EEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEHH
HLQSIMLSEQLRIAHQKIRYATLINHLLLPDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNSGILCIISAPSGTGKSTLIHTVIQCDCFVYQTKLSISYTTRIKRPGEIHGKDYYFIS
CCCCCEEEEEECCCCCCCHHHHHHHHHHEEEEEEEEEEEEEEEEECCCCCCCCCEEEEEE
KKKFKYMIDKNMFFEYAMIFNHYYGTAKTDIETMLNTGIHIVLNIDWKGAQQIRSKISKN
CCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCC
IYTIFILPPSKKELARRLYLRGEDTEKVIVARMGQAMDEISHFKEYDYIIINDNFNIALM
EEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEHH
HLQSIMLSEQLRIAHQKIRYATLINHLLLPDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA