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The map label for this gene is hemC

Identifier: 71892349

GI number: 71892349

Start: 723951

End: 724853

Strand: Direct

Name: hemC

Synonym: BPEN_601

Alternate gene names: 71892349

Gene position: 723951-724853 (Clockwise)

Preceding gene: 71892344

Following gene: 71892350

Centisome position: 91.45

GC content: 32.78

Gene sequence:

>903_bases
ATGAAAAATAAAATTTTAAAAATTGCTACACGAAAAAGTCAACTTGCTATTTGTCAAGCTCAATATGTTCATAATGAATT
GAAACATTATCATCCAACATTAAGCATAGAGTTGATGCCTATTGTAACAACAGGAGATAAATTTTTAAATATTGATGCAA
AAAATAAAATTAAAAAAGGTGCATTTATTAAAGAATTAGAACATGCATTAATAAACTTCCGTGCCGATATTGCTGTTCAT
TCCATGAAAGATATTACAGTGCCTTTACCAGATGAATTAACTCTTCCAGTTCTATGTAAACGCAATGATCCACGTGATGC
TTTTGTTAGTTTAAAATACCCTAACATAGATACGTTACCTATTGGTAGTGTAATAGGTACATCAAGTTTACGCAGACAAT
GTCAAATACGAGCGCATCGTCCAGATCTAGTAGTTAGTAACTTGCGAGGTAATATAGATACTAGATTAAAAAAATTACAA
TATGGACAATATGATGCAATAGTTTTAGCTGTAGCTGGATTACAACGATTACAGTTACATGAGTACATTCGTGTTCATAT
TGATCCGTCTGATCTACTACCAGCAATGGGACAAGGTGTTATAGCCATTGAATGTCGTTCGAATGATGCTGATATTTTAT
CCTTATTATCACCATTATATCATCAAGAAACCTCATTTCGTGTCAGAGCGGAACGCGCTGTTACTACTTATTTGGAAAGT
TATTGTCATTTACCAATTGCTAGTTATGCTGAAATTGAAGAGGATCAAATATGGCTAAGAGCACTTATTGGATTACCTGA
TGGTAGCAAGATTATTCGTACTGAAGGAAGGGCGCCTTTAGATCAAGCAGAAAAATTAGGTTTTATCCTTGCTGAAGATT
TATTAATTAAATTTAAACGATAA

Upstream 100 bases:

>100_bases
ATTTTAAAAATTTTTTAACAAATGTTTTTATAATATAATTATAAAAAACATTCAGATTGATTAAAGATTACAATCATATT
GTCTTAACATAATGATACTG

Downstream 100 bases:

>100_bases
CATGTTTTTATTTGATTTAATTTAATCATGTATCGAATTAAAAATTATGAATATTTTAATTACTCGTCCTTCTCCATATG
GAGAACAATTGGTAAATAAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKNKILKIATRKSQLAICQAQYVHNELKHYHPTLSIELMPIVTTGDKFLNIDAKNKIKKGAFIKELEHALINFRADIAVH
SMKDITVPLPDELTLPVLCKRNDPRDAFVSLKYPNIDTLPIGSVIGTSSLRRQCQIRAHRPDLVVSNLRGNIDTRLKKLQ
YGQYDAIVLAVAGLQRLQLHEYIRVHIDPSDLLPAMGQGVIAIECRSNDADILSLLSPLYHQETSFRVRAERAVTTYLES
YCHLPIASYAEIEEDQIWLRALIGLPDGSKIIRTEGRAPLDQAEKLGFILAEDLLIKFKR

Sequences:

>Translated_300_residues
MKNKILKIATRKSQLAICQAQYVHNELKHYHPTLSIELMPIVTTGDKFLNIDAKNKIKKGAFIKELEHALINFRADIAVH
SMKDITVPLPDELTLPVLCKRNDPRDAFVSLKYPNIDTLPIGSVIGTSSLRRQCQIRAHRPDLVVSNLRGNIDTRLKKLQ
YGQYDAIVLAVAGLQRLQLHEYIRVHIDPSDLLPAMGQGVIAIECRSNDADILSLLSPLYHQETSFRVRAERAVTTYLES
YCHLPIASYAEIEEDQIWLRALIGLPDGSKIIRTEGRAPLDQAEKLGFILAEDLLIKFKR
>Mature_300_residues
MKNKILKIATRKSQLAICQAQYVHNELKHYHPTLSIELMPIVTTGDKFLNIDAKNKIKKGAFIKELEHALINFRADIAVH
SMKDITVPLPDELTLPVLCKRNDPRDAFVSLKYPNIDTLPIGSVIGTSSLRRQCQIRAHRPDLVVSNLRGNIDTRLKKLQ
YGQYDAIVLAVAGLQRLQLHEYIRVHIDPSDLLPAMGQGVIAIECRSNDADILSLLSPLYHQETSFRVRAERAVTTYLES
YCHLPIASYAEIEEDQIWLRALIGLPDGSKIIRTEGRAPLDQAEKLGFILAEDLLIKFKR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=276, Percent_Identity=40.2173913043478, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI66933009, Length=274, Percent_Identity=40.1459854014599, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=54.3333333333333, Blast_Score=328, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6319996, Length=310, Percent_Identity=30.6451612903226, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI20130425, Length=259, Percent_Identity=38.6100386100386, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_BLOPB (Q491Z6)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278083.1
- HSSP:   P06983
- ProteinModelPortal:   Q491Z6
- SMR:   Q491Z6
- STRING:   Q491Z6
- GeneID:   3563074
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_601
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   CBLO291272:BPEN_601-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33932; Mature: 33932

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKILKIATRKSQLAICQAQYVHNELKHYHPTLSIELMPIVTTGDKFLNIDAKNKIKKG
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCEEEECCCHHHHHCC
AFIKELEHALINFRADIAVHSMKDITVPLPDELTLPVLCKRNDPRDAFVSLKYPNIDTLP
HHHHHHHHHHHHHHHHEEEECCCCEEECCCCCCCCCEEECCCCCCCEEEEEECCCCCCCC
IGSVIGTSSLRRQCQIRAHRPDLVVSNLRGNIDTRLKKLQYGQYDAIVLAVAGLQRLQLH
CCHHHCCHHHHHHHHEECCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHE
EYIRVHIDPSDLLPAMGQGVIAIECRSNDADILSLLSPLYHQETSFRVRAERAVTTYLES
EEEEEEECHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
YCHLPIASYAEIEEDQIWLRALIGLPDGSKIIRTEGRAPLDQAEKLGFILAEDLLIKFKR
HHCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKNKILKIATRKSQLAICQAQYVHNELKHYHPTLSIELMPIVTTGDKFLNIDAKNKIKKG
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCEEEECCCHHHHHCC
AFIKELEHALINFRADIAVHSMKDITVPLPDELTLPVLCKRNDPRDAFVSLKYPNIDTLP
HHHHHHHHHHHHHHHHEEEECCCCEEECCCCCCCCCEEECCCCCCCEEEEEECCCCCCCC
IGSVIGTSSLRRQCQIRAHRPDLVVSNLRGNIDTRLKKLQYGQYDAIVLAVAGLQRLQLH
CCHHHCCHHHHHHHHEECCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHE
EYIRVHIDPSDLLPAMGQGVIAIECRSNDADILSLLSPLYHQETSFRVRAERAVTTYLES
EEEEEEECHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHH
YCHLPIASYAEIEEDQIWLRALIGLPDGSKIIRTEGRAPLDQAEKLGFILAEDLLIKFKR
HHCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA