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The map label for this gene is hemD [H]

Identifier: 71892350

GI number: 71892350

Start: 724900

End: 725649

Strand: Direct

Name: hemD [H]

Synonym: BPEN_602

Alternate gene names: 71892350

Gene position: 724900-725649 (Clockwise)

Preceding gene: 71892349

Following gene: 71892363

Centisome position: 91.57

GC content: 31.33

Gene sequence:

>750_bases
ATGAATATTTTAATTACTCGTCCTTCTCCATATGGAGAACAATTGGTAAATAAATTACTTTCTTTTGGTAAATTTGCATA
TCATTTGCCATTAATTTACTTTTCTACAGGAAAAGAATTATGTTCATTGGAACAGAAATTAAATCTACTTTCTGAAGGAG
ATTTTTTGTGCATTATATCACAACATGCAATTAAATATGCTCATAATCAGTTACTTAACATGGGAATATCCTGGCCTACC
AAATTAGCATATTATTCCATTGGTCATGCGACTAGTGTAATGATGTACAAGTTATCGGGAATATTGGTGAAATATCCTAC
AATCCAGGAAACTAGTGAAAATTTATTACAATTACCTGAACTAATGTATAGTTATGGAAAGCGCGCTCTTATTCTAAGAG
GTAATAATGGACGTACTATTTTAGATGACACTCTTCAAAGAAGAGGAGTATTTGTTGCATCCTGCGAATGTTATACTAGA
CAACCGTTTCGGTATAATAGAGAAAAACAATTATCTAATCTATTAGGATTGAATATTAGAACAGTAGTAGTTACTTCTGG
AGAAATACTACAACACCTATATTATTTAATTCCCGAATCTTATCGCACATCTTGGTTAATACGATGTAAATTAATCGTGG
TAAGTGTACGTCTAGCTAAATTAGCTAGACGTTTAGGTTGGACAAATATTATTATAGCGCAGTCAGCAAACAACGAGATA
CTATTTCATCTTTTGATTAAGAATTCATAA

Upstream 100 bases:

>100_bases
GAAAAATTAGGTTTTATCCTTGCTGAAGATTTATTAATTAAATTTAAACGATAACATGTTTTTATTTGATTTAATTTAAT
CATGTATCGAATTAAAAATT

Downstream 100 bases:

>100_bases
TTTATGAGCACTCCAATCCAAATGCGAACAATCATTTCTATGAACACATAGAAAATTTTAGAAAATGCAATAACAAAAAT
ACTTAATCTTTCTCGATATA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIISQHAIKYAHNQLLNMGISWPT
KLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPELMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTR
QPFRYNREKQLSNLLGLNIRTVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI
LFHLLIKNS

Sequences:

>Translated_249_residues
MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIISQHAIKYAHNQLLNMGISWPT
KLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPELMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTR
QPFRYNREKQLSNLLGLNIRTVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI
LFHLLIKNS
>Mature_249_residues
MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIISQHAIKYAHNQLLNMGISWPT
KLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPELMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTR
QPFRYNREKQLSNLLGLNIRTVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI
LFHLLIKNS

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=245, Percent_Identity=48.1632653061224, Blast_Score=241, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28594; Mature: 28594

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIIS
CEEEEECCCCHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEE
QHAIKYAHNQLLNMGISWPTKLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPE
HHHHHHHHHHHHHCCCCCCHHHHEEECCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHH
LMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTRQPFRYNREKQLSNLLGLNIR
HHHHCCCEEEEEECCCCCEEHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCEE
TVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI
EEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEE
LFHLLIKNS
EEEEEEECC
>Mature Secondary Structure
MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIIS
CEEEEECCCCHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEE
QHAIKYAHNQLLNMGISWPTKLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPE
HHHHHHHHHHHHHCCCCCCHHHHEEECCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHH
LMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTRQPFRYNREKQLSNLLGLNIR
HHHHCCCEEEEEECCCCCEEHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCEE
TVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI
EEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEE
LFHLLIKNS
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]