Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 71892300

GI number: 71892300

Start: 652578

End: 654047

Strand: Reverse

Name: guaB [H]

Synonym: BPEN_547

Alternate gene names: 71892300

Gene position: 654047-652578 (Counterclockwise)

Preceding gene: 71892302

Following gene: 71892299

Centisome position: 82.62

GC content: 39.32

Gene sequence:

>1470_bases
ATGTTGACTTTTGTTAAAGAGGCTTTGACTTTTGATGATGTGTTGATCGTTCCGTCTCGTTCGAGGGTGCTTCCTGCGGA
GACGGTTTTAAAAAGTTTTTTGACTAGTGCTGTTTCTTTGAACATTCCTGTTGTATCATCGGCGATGGATACAGTGACTG
AGTCGAGTCTAGCTATCGCTTTAGCGCAAGAAGGCGGAGTGGGTTTTATTCATAAAAATATGTCTTTGGATCACCAGATT
AATGAGGTACGTCGGGTTAAACGTTATGAAAGCGGAATAGTAACGAATCCTCAATGTGTTACTCCTGATACGACTCTATT
GCAAGTGAAGGGGTTGACCTCTCGCAATGGATTTGCTGGCTATCCAGTTGTGATGAACACAAATGAGTTAGTTGGAATTG
TTACGAGTCGTGATGTACGGTTTGTCAGTGATTTATCAAATTTTGTTTTTTCTGTTATGACTCCTAAAGAACGTTTAATT
ACAGTGTTGGAAAAGGAAAATAGAGAAGTAGTATTAAGTAAAATGCATGATAAAAGAGTAGAAAAAATTTTGTTGATTGA
TGCTGCATTTCGTCTTAAAGGTATGATCACTGCAAAGGATTTTGAAAAAGCAGAACGTAAACCGTATGCGTGCAAAGATA
ATTATGGAAGGTTATGTGTTGGAGCTGCTATTGGAGTAGGAGAGGATTATAAAGAGCGTGTTGAAGGGTTGGTTGATGCT
GGTTTAGATGTATTACTTGTTGATTCTTCTCATGGGCATTCAGAGAGAGTATTAGATTGTATTGCAACAGTTCGAAATAT
GTATCCTAATTTATCAATTATAGGGGGCAATGTTGTTACAAAAGAAGGTGCATTAGAATTGGTTAAATCTGGTGCTAGCG
CAGTGAAAGTTGGTATTGGGCCTGGTTCTATTTGTACAACTCGTATTGTTACTGGTGTAGGGATTCCGCAAATTACAGCC
ATTTCTGATGTAGCGGAAGCCTTAAAAAATACGAATGTCCCGGTTATCGCGGATGGCGGTATTCGTTTTTCTGGTGATAT
TGCTAAAGCAATAGCGGCTGGTGCACATTGTGTAATGATTGGTTCGTTATTAGCGGGTACAGAGGAATCACCAGGAGATA
TAGAATTTTATCAGGGCAGATCTTTTAAAACTTATAGAGGTATGGGTTCTTTAGGAGCTATGTCTCAAGGCTCTGCTGAT
AGATATTTTCAACAACAGGATCCCGTCATTACTCATAAATTGGTTCCGGAAGGGATAGAAGGACGTGTTCCTTATAAAGG
AAAATTAGAAACGATTATACATCAATTAATGGGTGGATTGCGCTCTTGTATGGGATTGACAGGCTGCGTTACTATTAATG
ATTTGAGGACGCACGCTAGGTTTGTACGTGTCAGTTATTCGGGCATGCAGGAAAGTCATGTGCATGATGTAATGATAACA
AAGGAATCGCCTAATTATCGGTTACGATGA

Upstream 100 bases:

>100_bases
ATGCGTTGTTTAAATTTTGGTTTTAGAGGACATGGTGATGAAAAGAAATTGCAGTCGTAGCAGTGTCGTTACTGTAGTAT
AGGGTATACTGATAATTGTA

Downstream 100 bases:

>100_bases
TTATTAATAACTAGTTAAGTTTATGTGTGTATTATACTGCGTTATTTTTGCAGTTTGTGCGGCGTGGTGTCACGAACGTT
GTTGATCATTAATATGTGGT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLTFVKEALTFDDVLIVPSRSRVLPAETVLKSFLTSAVSLNIPVVSSAMDTVTESSLAIALAQEGGVGFIHKNMSLDHQI
NEVRRVKRYESGIVTNPQCVTPDTTLLQVKGLTSRNGFAGYPVVMNTNELVGIVTSRDVRFVSDLSNFVFSVMTPKERLI
TVLEKENREVVLSKMHDKRVEKILLIDAAFRLKGMITAKDFEKAERKPYACKDNYGRLCVGAAIGVGEDYKERVEGLVDA
GLDVLLVDSSHGHSERVLDCIATVRNMYPNLSIIGGNVVTKEGALELVKSGASAVKVGIGPGSICTTRIVTGVGIPQITA
ISDVAEALKNTNVPVIADGGIRFSGDIAKAIAAGAHCVMIGSLLAGTEESPGDIEFYQGRSFKTYRGMGSLGAMSQGSAD
RYFQQQDPVITHKLVPEGIEGRVPYKGKLETIIHQLMGGLRSCMGLTGCVTINDLRTHARFVRVSYSGMQESHVHDVMIT
KESPNYRLR

Sequences:

>Translated_489_residues
MLTFVKEALTFDDVLIVPSRSRVLPAETVLKSFLTSAVSLNIPVVSSAMDTVTESSLAIALAQEGGVGFIHKNMSLDHQI
NEVRRVKRYESGIVTNPQCVTPDTTLLQVKGLTSRNGFAGYPVVMNTNELVGIVTSRDVRFVSDLSNFVFSVMTPKERLI
TVLEKENREVVLSKMHDKRVEKILLIDAAFRLKGMITAKDFEKAERKPYACKDNYGRLCVGAAIGVGEDYKERVEGLVDA
GLDVLLVDSSHGHSERVLDCIATVRNMYPNLSIIGGNVVTKEGALELVKSGASAVKVGIGPGSICTTRIVTGVGIPQITA
ISDVAEALKNTNVPVIADGGIRFSGDIAKAIAAGAHCVMIGSLLAGTEESPGDIEFYQGRSFKTYRGMGSLGAMSQGSAD
RYFQQQDPVITHKLVPEGIEGRVPYKGKLETIIHQLMGGLRSCMGLTGCVTINDLRTHARFVRVSYSGMQESHVHDVMIT
KESPNYRLR
>Mature_489_residues
MLTFVKEALTFDDVLIVPSRSRVLPAETVLKSFLTSAVSLNIPVVSSAMDTVTESSLAIALAQEGGVGFIHKNMSLDHQI
NEVRRVKRYESGIVTNPQCVTPDTTLLQVKGLTSRNGFAGYPVVMNTNELVGIVTSRDVRFVSDLSNFVFSVMTPKERLI
TVLEKENREVVLSKMHDKRVEKILLIDAAFRLKGMITAKDFEKAERKPYACKDNYGRLCVGAAIGVGEDYKERVEGLVDA
GLDVLLVDSSHGHSERVLDCIATVRNMYPNLSIIGGNVVTKEGALELVKSGASAVKVGIGPGSICTTRIVTGVGIPQITA
ISDVAEALKNTNVPVIADGGIRFSGDIAKAIAAGAHCVMIGSLLAGTEESPGDIEFYQGRSFKTYRGMGSLGAMSQGSAD
RYFQQQDPVITHKLVPEGIEGRVPYKGKLETIIHQLMGGLRSCMGLTGCVTINDLRTHARFVRVSYSGMQESHVHDVMIT
KESPNYRLR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=487, Percent_Identity=38.6036960985626, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI217035146, Length=485, Percent_Identity=38.5567010309278, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI34328930, Length=485, Percent_Identity=38.5567010309278, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI156616279, Length=485, Percent_Identity=38.5567010309278, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI34328928, Length=485, Percent_Identity=38.5567010309278, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI217035152, Length=479, Percent_Identity=38.6221294363257, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI217035148, Length=485, Percent_Identity=37.7319587628866, Blast_Score=299, Evalue=5e-81,
Organism=Homo sapiens, GI217035150, Length=485, Percent_Identity=35.6701030927835, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=36.6935483870968, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=36.6935483870968, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=36.6935483870968, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=36.6935483870968, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=35.8870967741936, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=70.6967213114754, Blast_Score=656, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=229, Percent_Identity=37.9912663755458, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=505, Percent_Identity=33.6633663366337, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=35.9154929577465, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=226, Percent_Identity=40.7079646017699, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=496, Percent_Identity=39.3145161290323, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6323585, Length=494, Percent_Identity=37.8542510121458, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=39.0143737166324, Blast_Score=307, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=40.4624277456647, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=126, Percent_Identity=37.3015873015873, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=39.2116182572614, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=39.2116182572614, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.0909090909091, Blast_Score=282, Evalue=3e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52979; Mature: 52979

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFVKEALTFDDVLIVPSRSRVLPAETVLKSFLTSAVSLNIPVVSSAMDTVTESSLAIA
CCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCEEEE
LAQEGGVGFIHKNMSLDHQINEVRRVKRYESGIVTNPQCVTPDTTLLQVKGLTSRNGFAG
EECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCCCCC
YPVVMNTNELVGIVTSRDVRFVSDLSNFVFSVMTPKERLITVLEKENREVVLSKMHDKRV
CCEEECCCCEEEEEECCCHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHHH
EKILLIDAAFRLKGMITAKDFEKAERKPYACKDNYGRLCVGAAIGVGEDYKERVEGLVDA
HEEEEEEHHHHHCCEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHC
GLDVLLVDSSHGHSERVLDCIATVRNMYPNLSIIGGNVVTKEGALELVKSGASAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGIPQITAISDVAEALKNTNVPVIADGGIRFSGDIAKAIAAGAHCVMI
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHH
GSLLAGTEESPGDIEFYQGRSFKTYRGMGSLGAMSQGSADRYFQQQDPVITHKLVPEGIE
HHHHCCCCCCCCCEEEECCCCEEHHCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCC
GRVPYKGKLETIIHQLMGGLRSCMGLTGCVTINDLRTHARFVRVSYSGMQESHVHDVMIT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCEEEEEEECCCCCCCCEEEEEE
KESPNYRLR
ECCCCCCCC
>Mature Secondary Structure
MLTFVKEALTFDDVLIVPSRSRVLPAETVLKSFLTSAVSLNIPVVSSAMDTVTESSLAIA
CCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCEEEE
LAQEGGVGFIHKNMSLDHQINEVRRVKRYESGIVTNPQCVTPDTTLLQVKGLTSRNGFAG
EECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCCCCC
YPVVMNTNELVGIVTSRDVRFVSDLSNFVFSVMTPKERLITVLEKENREVVLSKMHDKRV
CCEEECCCCEEEEEECCCHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHHH
EKILLIDAAFRLKGMITAKDFEKAERKPYACKDNYGRLCVGAAIGVGEDYKERVEGLVDA
HEEEEEEHHHHHCCEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHC
GLDVLLVDSSHGHSERVLDCIATVRNMYPNLSIIGGNVVTKEGALELVKSGASAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGIPQITAISDVAEALKNTNVPVIADGGIRFSGDIAKAIAAGAHCVMI
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHH
GSLLAGTEESPGDIEFYQGRSFKTYRGMGSLGAMSQGSADRYFQQQDPVITHKLVPEGIE
HHHHCCCCCCCCCEEEECCCCEEHHCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCC
GRVPYKGKLETIIHQLMGGLRSCMGLTGCVTINDLRTHARFVRVSYSGMQESHVHDVMIT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCEEEEEEECCCCCCCCEEEEEE
KESPNYRLR
ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]