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The map label for this gene is fabB [H]

Identifier: 71892271

GI number: 71892271

Start: 615721

End: 616935

Strand: Reverse

Name: fabB [H]

Synonym: BPEN_514

Alternate gene names: 71892271

Gene position: 616935-615721 (Counterclockwise)

Preceding gene: 71892274

Following gene: 71892270

Centisome position: 77.93

GC content: 36.46

Gene sequence:

>1215_bases
ATGAAACGCGCTGTTATCACTGGTTTAGGGATTATATCAAGTATTGGAAATAATCAGAATGAAGTTTTGGTTTCTTTAAA
AAATGGTAGATCTGGAGTCACTTTTTCTCAAGAATTAAAAGAATCTGGCATGCGCAGTCATGTTTGGGGTAATATTAAAC
TGAATACATCTGGATTAATTGATCGTAAGATTGCTCGTTTTATGAGCGATGCATCTATTTATACTTATTTATCTATGGAA
CAGGCCATAATAGATTCTGGATTATCTACAGGTATGGTTTCTAATGATCAAACAGGATTGATTGTCGGGTCCGGAGGGGG
ATCTCCACGTAATCAAGTTTCTGGATCTAATGGAATGCGTTTGCGTGGTTTGAGAGGAGTGGGTCCTTATATGGTAACTA
AATCTATGGCTTCAGGCGTATCAGCATGTTTGGCTACTTCTTTTAAAATTCGCGGGGTCAGTTATTCTATCAGTTCCGCT
TGTTCTACATCTACACATTGTATCGGAAATGCGGTTGAATTAATTCAATCAGGAAAACAATCTATTATTTTTGCTGGAGG
CGGAGAGGAATTATGTTGGGAAATGGCTTGTGAATTTGATGCTATGGGTGCATTATCTACGAAGTATAATACGACACCAG
AGAGAGCATCTCGTCCTTATGACATTAATAGAGATGGATTCGTAATTGCGGGAGGTGGAGGGATAGTTGTAATAGAAGAG
TTAACGCATGCTTTAAGTCGTGGAGCTTATATTTATGCAGAAATTGTTGGGTATGGAGCTACGTCTGATGGATGTGATAT
GGTTGCTCCTTCTGGAGAAGGAGCAATTCGATGTATGAAAATGGCATTAAGAAATGTTGGCGGTTCGATAGATTATCTTA
ATGTGCACGGTACATCAACTCAAATAGGTGATATTAAAGAAATTTGGGCTATCCGTGAAATTTTTGGTGATCAACATCCT
TCTTTTTCTTCTACTAAGTCAATGACTGGGCATTCATTAGGAGCCGCTGGAGTTCATGAAACTATTTTTACTTTATTAAT
GTTAAAACATAATTTTATCGCTCCGAGTATTAATATTGATCATTTAGATCCATATATGAAAAATATGAGAATTATTATTA
ATAATCCTGTTTATCGTAAATTGAAAACAGCCATGACTAATAGTTTTGGGTTCGGGGGAACAAATGCTACATTAATTATG
AGTAAATATTCCTGA

Upstream 100 bases:

>100_bases
TAATTTTTACCGTACGATTTAACATTTTAAGTAGATATGTTTAAGGTTTAGTACGATTTTGGTATTGCAAAACATTATTA
TCATGAGGTATATAAAAAAA

Downstream 100 bases:

>100_bases
ATGTTTTGTTAATATTTTGGTTATATAAGGTTTTAGTGTCATACATTGTATTTTATGCGTATAAAATACAATGTATAGTT
TTAAATGTGTATATTCAGGG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKRAVITGLGIISSIGNNQNEVLVSLKNGRSGVTFSQELKESGMRSHVWGNIKLNTSGLIDRKIARFMSDASIYTYLSME
QAIIDSGLSTGMVSNDQTGLIVGSGGGSPRNQVSGSNGMRLRGLRGVGPYMVTKSMASGVSACLATSFKIRGVSYSISSA
CSTSTHCIGNAVELIQSGKQSIIFAGGGEELCWEMACEFDAMGALSTKYNTTPERASRPYDINRDGFVIAGGGGIVVIEE
LTHALSRGAYIYAEIVGYGATSDGCDMVAPSGEGAIRCMKMALRNVGGSIDYLNVHGTSTQIGDIKEIWAIREIFGDQHP
SFSSTKSMTGHSLGAAGVHETIFTLLMLKHNFIAPSINIDHLDPYMKNMRIIINNPVYRKLKTAMTNSFGFGGTNATLIM
SKYS

Sequences:

>Translated_404_residues
MKRAVITGLGIISSIGNNQNEVLVSLKNGRSGVTFSQELKESGMRSHVWGNIKLNTSGLIDRKIARFMSDASIYTYLSME
QAIIDSGLSTGMVSNDQTGLIVGSGGGSPRNQVSGSNGMRLRGLRGVGPYMVTKSMASGVSACLATSFKIRGVSYSISSA
CSTSTHCIGNAVELIQSGKQSIIFAGGGEELCWEMACEFDAMGALSTKYNTTPERASRPYDINRDGFVIAGGGGIVVIEE
LTHALSRGAYIYAEIVGYGATSDGCDMVAPSGEGAIRCMKMALRNVGGSIDYLNVHGTSTQIGDIKEIWAIREIFGDQHP
SFSSTKSMTGHSLGAAGVHETIFTLLMLKHNFIAPSINIDHLDPYMKNMRIIINNPVYRKLKTAMTNSFGFGGTNATLIM
SKYS
>Mature_404_residues
MKRAVITGLGIISSIGNNQNEVLVSLKNGRSGVTFSQELKESGMRSHVWGNIKLNTSGLIDRKIARFMSDASIYTYLSME
QAIIDSGLSTGMVSNDQTGLIVGSGGGSPRNQVSGSNGMRLRGLRGVGPYMVTKSMASGVSACLATSFKIRGVSYSISSA
CSTSTHCIGNAVELIQSGKQSIIFAGGGEELCWEMACEFDAMGALSTKYNTTPERASRPYDINRDGFVIAGGGGIVVIEE
LTHALSRGAYIYAEIVGYGATSDGCDMVAPSGEGAIRCMKMALRNVGGSIDYLNVHGTSTQIGDIKEIWAIREIFGDQHP
SFSSTKSMTGHSLGAAGVHETIFTLLMLKHNFIAPSINIDHLDPYMKNMRIIINNPVYRKLKTAMTNSFGFGGTNATLIM
SKYS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=33.1742243436754, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=38.9221556886228, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI41872631, Length=334, Percent_Identity=27.2455089820359, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=74.009900990099, Blast_Score=620, Evalue=1e-179,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=37.6811594202899, Blast_Score=221, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=33.0143540669856, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=37.218045112782, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=352, Percent_Identity=26.4204545454545, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=368, Percent_Identity=23.6413043478261, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=32.7313769751693, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=35.0119904076739, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=25.8928571428571, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=25.8928571428571, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=21.7289719626168, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43089; Mature: 43089

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGLGIISSIGNNQNEVLVSLKNGRSGVTFSQELKESGMRSHVWGNIKLNTSGLI
CCCEEEEHHHHHHHCCCCCCEEEEEEECCCCCCEEHHHHHHCCCCHHEEEEEEECCCCCH
DRKIARFMSDASIYTYLSMEQAIIDSGLSTGMVSNDQTGLIVGSGGGSPRNQVSGSNGMR
HHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCE
LRGLRGVGPYMVTKSMASGVSACLATSFKIRGVSYSISSACSTSTHCIGNAVELIQSGKQ
EEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEEHHHHCCCCHHHHHHHHHHHHCCCC
SIIFAGGGEELCWEMACEFDAMGALSTKYNTTPERASRPYDINRDGFVIAGGGGIVVIEE
EEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEECCCCEEEHHH
LTHALSRGAYIYAEIVGYGATSDGCDMVAPSGEGAIRCMKMALRNVGGSIDYLNVHGTST
HHHHHHCCCEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
QIGDIKEIWAIREIFGDQHPSFSSTKSMTGHSLGAAGVHETIFTLLMLKHNFIAPSINID
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCH
HLDPYMKNMRIIINNPVYRKLKTAMTNSFGFGGTNATLIMSKYS
HCCHHHHCCEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKRAVITGLGIISSIGNNQNEVLVSLKNGRSGVTFSQELKESGMRSHVWGNIKLNTSGLI
CCCEEEEHHHHHHHCCCCCCEEEEEEECCCCCCEEHHHHHHCCCCHHEEEEEEECCCCCH
DRKIARFMSDASIYTYLSMEQAIIDSGLSTGMVSNDQTGLIVGSGGGSPRNQVSGSNGMR
HHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCE
LRGLRGVGPYMVTKSMASGVSACLATSFKIRGVSYSISSACSTSTHCIGNAVELIQSGKQ
EEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEEHHHHCCCCHHHHHHHHHHHHCCCC
SIIFAGGGEELCWEMACEFDAMGALSTKYNTTPERASRPYDINRDGFVIAGGGGIVVIEE
EEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEECCCCEEEHHH
LTHALSRGAYIYAEIVGYGATSDGCDMVAPSGEGAIRCMKMALRNVGGSIDYLNVHGTST
HHHHHHCCCEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
QIGDIKEIWAIREIFGDQHPSFSSTKSMTGHSLGAAGVHETIFTLLMLKHNFIAPSINID
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCH
HLDPYMKNMRIIINNPVYRKLKTAMTNSFGFGGTNATLIMSKYS
HCCHHHHCCEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]