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The map label for this gene is nuoI

Identifier: 71892259

GI number: 71892259

Start: 600567

End: 601112

Strand: Reverse

Name: nuoI

Synonym: BPEN_502

Alternate gene names: 71892259

Gene position: 601112-600567 (Counterclockwise)

Preceding gene: 71892260

Following gene: 71892258

Centisome position: 75.93

GC content: 33.52

Gene sequence:

>546_bases
ATGATGAAGTTAAAAAAGGTTTTTATAGATATTGGTTCTATATTACGTAGTATTTGGATGATAGGAATGCAAGCATTTAG
TAAACGTGAAACTCGGATGTATCCTGAAGTTCCGTATATTCCATCACCTAGATATCGTGGTCGTATCGTATTGACTCGAG
ACTCTTCAGGTCGAGAACGTTGTGTAGCTTGTAATTTATGCGCTGTAGCTTGTCCAGTAGGGTGTATTTCTTTGAAAAAA
GGAGAATCTACAGATGGTCGGTGGTATCCAAAATTTTTTAGAATCAATTTTTCTAGATGTATTTTTTGTGGTATGTGTGA
AGAGGCATGCCCAACAGCAGCTATTCAATTAACTCCAGATTTTGAAATGAGTGATTTTAAAAGACATGATTTAGTGTATG
AAAAGTCTGATTTATTAATATCGGGTCCTGGAAAATATTTAGAGTATGATTTTTATCAATTTTCTGGTAAGGAAATATTA
GATAAAAAAAAGGGGGACGCGATAAAAGAATCAAAGCCTATAAATGTTAAAAACATATTGCCCTAA

Upstream 100 bases:

>100_bases
GTTGATAGGTTGGAAAATTTGTTTACCAATGACGTTGTTTAATTTATTAAGTACTGCTGTTGTTATTTTATTATAATTAT
TAATATAGGTTAAATATATT

Downstream 100 bases:

>100_bases
TTTTGAAGTGATGGTTAATGAGAGGAGTGTGGTATGACGGCGCTATTTTATATTTCTGGAATCACAGCAATATTGTCTAC
GATATGTGTAATACTGCATT

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MMKLKKVFIDIGSILRSIWMIGMQAFSKRETRMYPEVPYIPSPRYRGRIVLTRDSSGRERCVACNLCAVACPVGCISLKK
GESTDGRWYPKFFRINFSRCIFCGMCEEACPTAAIQLTPDFEMSDFKRHDLVYEKSDLLISGPGKYLEYDFYQFSGKEIL
DKKKGDAIKESKPINVKNILP

Sequences:

>Translated_181_residues
MMKLKKVFIDIGSILRSIWMIGMQAFSKRETRMYPEVPYIPSPRYRGRIVLTRDSSGRERCVACNLCAVACPVGCISLKK
GESTDGRWYPKFFRINFSRCIFCGMCEEACPTAAIQLTPDFEMSDFKRHDLVYEKSDLLISGPGKYLEYDFYQFSGKEIL
DKKKGDAIKESKPINVKNILP
>Mature_181_residues
MMKLKKVFIDIGSILRSIWMIGMQAFSKRETRMYPEVPYIPSPRYRGRIVLTRDSSGRERCVACNLCAVACPVGCISLKK
GESTDGRWYPKFFRINFSRCIFCGMCEEACPTAAIQLTPDFEMSDFKRHDLVYEKSDLLISGPGKYLEYDFYQFSGKEIL
DKKKGDAIKESKPINVKNILP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=129, Percent_Identity=37.984496124031, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1788617, Length=180, Percent_Identity=72.2222222222222, Blast_Score=281, Evalue=2e-77,
Organism=Escherichia coli, GI1789075, Length=104, Percent_Identity=31.7307692307692, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555194, Length=139, Percent_Identity=35.9712230215827, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17864306, Length=132, Percent_Identity=38.6363636363636, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_BLOPB (Q492I3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277993.1
- ProteinModelPortal:   Q492I3
- SMR:   Q492I3
- STRING:   Q492I3
- GeneID:   3563019
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_502
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   RYWSVAG
- ProtClustDB:   PRK05888
- BioCyc:   CBLO291272:BPEN_502-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 20781; Mature: 20781

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
8.8 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
8.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLKKVFIDIGSILRSIWMIGMQAFSKRETRMYPEVPYIPSPRYRGRIVLTRDSSGRER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCE
CVACNLCAVACPVGCISLKKGESTDGRWYPKFFRINFSRCIFCGMCEEACPTAAIQLTPD
EEEHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEEHHHEEEECCCHHCCCCEEEEECCC
FEMSDFKRHDLVYEKSDLLISGPGKYLEYDFYQFSGKEILDKKKGDAIKESKPINVKNIL
CCCCCCHHHCCEEECCCEEEECCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCHHCCC
P
C
>Mature Secondary Structure
MMKLKKVFIDIGSILRSIWMIGMQAFSKRETRMYPEVPYIPSPRYRGRIVLTRDSSGRER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCE
CVACNLCAVACPVGCISLKKGESTDGRWYPKFFRINFSRCIFCGMCEEACPTAAIQLTPD
EEEHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEEHHHEEEECCCHHCCCCEEEEECCC
FEMSDFKRHDLVYEKSDLLISGPGKYLEYDFYQFSGKEILDKKKGDAIKESKPINVKNIL
CCCCCCHHHCCEEECCCEEEECCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCCCHHCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA