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The map label for this gene is nrdA [H]

Identifier: 71892251

GI number: 71892251

Start: 590814

End: 593096

Strand: Direct

Name: nrdA [H]

Synonym: BPEN_494

Alternate gene names: 71892251

Gene position: 590814-593096 (Clockwise)

Preceding gene: 71892250

Following gene: 71892252

Centisome position: 74.63

GC content: 33.03

Gene sequence:

>2283_bases
ATGAACCAAACTCTACTAGTTACCAAACGAAACGGTCATCACGAACCTATTAATCTTGACAAAATTCACCGAGTTATTAA
TTGGGCCGCCAAAGGATTAGAGCAAGTCTCTGTTTCACAAGTAGAATTGCGTTCCCACATACAATTTTATAATGGAATAA
AAACTTCCGATATTCAAGAAACAATCATAAAAGCAGCAGCAGACTTGATTTCTGAAGAAGAACCAGACTATCAATATTTA
GCAGCACGTTTAGCAGTATTTCATTTACGTAAAAAAGCTTACGGTCAATTTGAACCACCAAAACTGTATAATCATGTGTT
ACGATTAATAAAAATTGGTAAATACGATCAACATTTGCTAGATGATTATAATGCGGAAGAGTTTAATCAAATGGATACAT
TTATTGATCATTGGCGGGACATGAATTTTTCATATGCTGCTGTAAAACAATTAGAAGGTAAATACTTAGTACAAAATAGG
GTAACCGGAGAAATTTATGAAAGTGCTCAGTTTTTATATATATTAACTGCGGCCTGTTTATTTTCTAAATATCCCAAAAA
AACTCGAATGCATTACATTCAACAATTTTATGATGCGATATCAACTTTTAAAATTTCTTTAGCAACACCTATTATGTCTG
GAGTACGCACACCAACACGCCAATTTAGTTCCTGTGTATTAATCGAATGTGATGATAGTCTTGATTCTATCAATGCAACA
TCCAGTTCTATTGTAAAATATGTTGCGCAACGCGCTGGAATAGGTATTAACGCTGGACGTATTAGAGCATTAGGTAGTCC
AATACGTAACGGAGAAGCGTTCCACACCGGATGTATCCCATTCTATAAACATTTTCAAACAGCAGTAAAATCATGCTCTC
AAGGAGGCGTACGTGGAGGAGCGGCCACACTATTTTATCCTATTTGGCATTTAGAAATAGAAAATTTACTTGTTTTAAAA
AATAATCGTGGAATCGATTCTAACCGAATACGTCATTTAGATTATGGTGTACAAATCAATAAATTAATGTACCAACGTCT
TATTGAAGGAAAATATATTACACTATTTAGCCCATCTGATGTGCCAGGACTATATGAAGCTTTTTTTAATAATCAAAATG
AATTCGAACACTTATATAACATATATGAAAATGATCATAATATTAGACATCGAAAAATTAAAGCAATAGAATTGTTTTCT
TTAATGATGCAAGAGCGAGCTTCTACTGGAAGAATCTATATTCAACATACAGATCACTGTAATACTCATAGTGCTTTTGA
TAGTATTGCCGCTCCAGTTCGTCAATCCAATTTATGCTTGGAAATCACTTTACCAACCAAACCTTTAAATAACATTAATG
ACCATAATGGTGAAATTGCTTTATGTACACTATCTGCTTTCAATCTTGGTAACATTGAAAATCTTGATGACTTATCTGAA
CTCTCTATTTTAATAGTAAGAGCTCTCGACGCTTTATTAGATTATCAACATTATCCTATTCCTGCTGCACAACGTAGTGC
TGTAAGAAGACGTTCTTTAGGCATTGGAGTAATTAATTATGCTTATTATCTTGCTAAACATGGGGTACGCTATTCAGATG
GTAGTGCTAATAAACTAACACATCGTACTTTCGAAGCTATTCAATATCATTTATTAAGAGCGTCTAACAATTTGGCTCAA
GAAAAAGGATCTTGCGAGTGGTTCAATGATACTTCATATTCAAAAGGAATCTTACCTATTGATACATATAAAACAGACCT
GAATTCATTTATTAATGAACCATTACATTATAATTGGGAAGATTTGCGTGTAAAGATTAAAAAGTATGGATTACGAAATT
CTACATTATCTGCATTAATGCCATCAGAAACTTCGTCACAAATTTCTAATGCTACTAATGGGATAGAACCTCCCAGAGGT
TACATTAGCATAAAAACTTCAAAAAACGGAATTTTGCGTCAAGTAGTACCTGAATTTATTAAACTAAAATCTGATTATGA
ATTATTATGGCAAATACCGGATAATCGGGGATATCTACAATTAGTAGGGATTATGCAAAAATTCATTGACCAATCCATTT
CAACTAATACTAATTACGATCCCTCTCGATTTCCAGAAAACAAAGTACCTATGAAACAGCTACTTTCAGATTTATTATAC
GCATACAGACTTGGTATTAAAACATTATATTATCATAACACCCGTGATGGAGCTCAAGATGTACAAAAAACACTGCCACA
TAACCAATCAAATATTTGTACAAGTGATGCTTGTACAATTTAG

Upstream 100 bases:

>100_bases
TATTAATTCACCGAATTATCACGAGTCTGATCCATAATTTACTCATCACAAATTACTGTGGTCTAATATTATTATTATTT
CACAACAGGTATACATTTAT

Downstream 100 bases:

>100_bases
AAAAGTAACTACTATTTACTAAAACCTACATATTTATTTTTAAAAAAGGAATAAAAATGATTTATACAACTTTTTCTCAA
AATAAAAATAATCAACTGCT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Protein B1; Ribonucleoside-diphosphate reductase 1 R1 subunit; Ribonucleotide reductase 1 [H]

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MNQTLLVTKRNGHHEPINLDKIHRVINWAAKGLEQVSVSQVELRSHIQFYNGIKTSDIQETIIKAAADLISEEEPDYQYL
AARLAVFHLRKKAYGQFEPPKLYNHVLRLIKIGKYDQHLLDDYNAEEFNQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYILTAACLFSKYPKKTRMHYIQQFYDAISTFKISLATPIMSGVRTPTRQFSSCVLIECDDSLDSINAT
SSSIVKYVAQRAGIGINAGRIRALGSPIRNGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEIENLLVLK
NNRGIDSNRIRHLDYGVQINKLMYQRLIEGKYITLFSPSDVPGLYEAFFNNQNEFEHLYNIYENDHNIRHRKIKAIELFS
LMMQERASTGRIYIQHTDHCNTHSAFDSIAAPVRQSNLCLEITLPTKPLNNINDHNGEIALCTLSAFNLGNIENLDDLSE
LSILIVRALDALLDYQHYPIPAAQRSAVRRRSLGIGVINYAYYLAKHGVRYSDGSANKLTHRTFEAIQYHLLRASNNLAQ
EKGSCEWFNDTSYSKGILPIDTYKTDLNSFINEPLHYNWEDLRVKIKKYGLRNSTLSALMPSETSSQISNATNGIEPPRG
YISIKTSKNGILRQVVPEFIKLKSDYELLWQIPDNRGYLQLVGIMQKFIDQSISTNTNYDPSRFPENKVPMKQLLSDLLY
AYRLGIKTLYYHNTRDGAQDVQKTLPHNQSNICTSDACTI

Sequences:

>Translated_760_residues
MNQTLLVTKRNGHHEPINLDKIHRVINWAAKGLEQVSVSQVELRSHIQFYNGIKTSDIQETIIKAAADLISEEEPDYQYL
AARLAVFHLRKKAYGQFEPPKLYNHVLRLIKIGKYDQHLLDDYNAEEFNQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYILTAACLFSKYPKKTRMHYIQQFYDAISTFKISLATPIMSGVRTPTRQFSSCVLIECDDSLDSINAT
SSSIVKYVAQRAGIGINAGRIRALGSPIRNGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEIENLLVLK
NNRGIDSNRIRHLDYGVQINKLMYQRLIEGKYITLFSPSDVPGLYEAFFNNQNEFEHLYNIYENDHNIRHRKIKAIELFS
LMMQERASTGRIYIQHTDHCNTHSAFDSIAAPVRQSNLCLEITLPTKPLNNINDHNGEIALCTLSAFNLGNIENLDDLSE
LSILIVRALDALLDYQHYPIPAAQRSAVRRRSLGIGVINYAYYLAKHGVRYSDGSANKLTHRTFEAIQYHLLRASNNLAQ
EKGSCEWFNDTSYSKGILPIDTYKTDLNSFINEPLHYNWEDLRVKIKKYGLRNSTLSALMPSETSSQISNATNGIEPPRG
YISIKTSKNGILRQVVPEFIKLKSDYELLWQIPDNRGYLQLVGIMQKFIDQSISTNTNYDPSRFPENKVPMKQLLSDLLY
AYRLGIKTLYYHNTRDGAQDVQKTLPHNQSNICTSDACTI
>Mature_760_residues
MNQTLLVTKRNGHHEPINLDKIHRVINWAAKGLEQVSVSQVELRSHIQFYNGIKTSDIQETIIKAAADLISEEEPDYQYL
AARLAVFHLRKKAYGQFEPPKLYNHVLRLIKIGKYDQHLLDDYNAEEFNQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYILTAACLFSKYPKKTRMHYIQQFYDAISTFKISLATPIMSGVRTPTRQFSSCVLIECDDSLDSINAT
SSSIVKYVAQRAGIGINAGRIRALGSPIRNGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEIENLLVLK
NNRGIDSNRIRHLDYGVQINKLMYQRLIEGKYITLFSPSDVPGLYEAFFNNQNEFEHLYNIYENDHNIRHRKIKAIELFS
LMMQERASTGRIYIQHTDHCNTHSAFDSIAAPVRQSNLCLEITLPTKPLNNINDHNGEIALCTLSAFNLGNIENLDDLSE
LSILIVRALDALLDYQHYPIPAAQRSAVRRRSLGIGVINYAYYLAKHGVRYSDGSANKLTHRTFEAIQYHLLRASNNLAQ
EKGSCEWFNDTSYSKGILPIDTYKTDLNSFINEPLHYNWEDLRVKIKKYGLRNSTLSALMPSETSSQISNATNGIEPPRG
YISIKTSKNGILRQVVPEFIKLKSDYELLWQIPDNRGYLQLVGIMQKFIDQSISTNTNYDPSRFPENKVPMKQLLSDLLY
AYRLGIKTLYYHNTRDGAQDVQKTLPHNQSNICTSDACTI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=791, Percent_Identity=28.5714285714286, Blast_Score=258, Evalue=1e-68,
Organism=Escherichia coli, GI2367133, Length=761, Percent_Identity=79.1064388961892, Blast_Score=1286, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=618, Percent_Identity=25.8899676375405, Blast_Score=165, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17555242, Length=788, Percent_Identity=26.5228426395939, Blast_Score=236, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6322123, Length=794, Percent_Identity=27.8337531486146, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6320914, Length=809, Percent_Identity=27.3176761433869, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17352481, Length=800, Percent_Identity=27, Blast_Score=248, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 86897; Mature: 86897

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTLLVTKRNGHHEPINLDKIHRVINWAAKGLEQVSVSQVELRSHIQFYNGIKTSDIQE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TIIKAAADLISEEEPDYQYLAARLAVFHLRKKAYGQFEPPKLYNHVLRLIKIGKYDQHLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHH
DDYNAEEFNQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILTAACL
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSKYPKKTRMHYIQQFYDAISTFKISLATPIMSGVRTPTRQFSSCVLIECDDSLDSINAT
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCCCCCC
SSSIVKYVAQRAGIGINAGRIRALGSPIRNGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCC
AATLFYPIWHLEIENLLVLKNNRGIDSNRIRHLDYGVQINKLMYQRLIEGKYITLFSPSD
CCEEEEEEEEEEECCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCC
VPGLYEAFFNNQNEFEHLYNIYENDHNIRHRKIKAIELFSLMMQERASTGRIYIQHTDHC
CCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSAFDSIAAPVRQSNLCLEITLPTKPLNNINDHNGEIALCTLSAFNLGNIENLDDLSE
CCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHH
LSILIVRALDALLDYQHYPIPAAQRSAVRRRSLGIGVINYAYYLAKHGVRYSDGSANKLT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHH
HRTFEAIQYHLLRASNNLAQEKGSCEWFNDTSYSKGILPIDTYKTDLNSFINEPLHYNWE
HHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCHH
DLRVKIKKYGLRNSTLSALMPSETSSQISNATNGIEPPRGYISIKTSKNGILRQVVPEFI
HHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
KLKSDYELLWQIPDNRGYLQLVGIMQKFIDQSISTNTNYDPSRFPENKVPMKQLLSDLLY
HCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
AYRLGIKTLYYHNTRDGAQDVQKTLPHNQSNICTSDACTI
HHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNQTLLVTKRNGHHEPINLDKIHRVINWAAKGLEQVSVSQVELRSHIQFYNGIKTSDIQE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TIIKAAADLISEEEPDYQYLAARLAVFHLRKKAYGQFEPPKLYNHVLRLIKIGKYDQHLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHH
DDYNAEEFNQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILTAACL
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSKYPKKTRMHYIQQFYDAISTFKISLATPIMSGVRTPTRQFSSCVLIECDDSLDSINAT
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCCCCCC
SSSIVKYVAQRAGIGINAGRIRALGSPIRNGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCC
AATLFYPIWHLEIENLLVLKNNRGIDSNRIRHLDYGVQINKLMYQRLIEGKYITLFSPSD
CCEEEEEEEEEEECCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCC
VPGLYEAFFNNQNEFEHLYNIYENDHNIRHRKIKAIELFSLMMQERASTGRIYIQHTDHC
CCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSAFDSIAAPVRQSNLCLEITLPTKPLNNINDHNGEIALCTLSAFNLGNIENLDDLSE
CCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHH
LSILIVRALDALLDYQHYPIPAAQRSAVRRRSLGIGVINYAYYLAKHGVRYSDGSANKLT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHH
HRTFEAIQYHLLRASNNLAQEKGSCEWFNDTSYSKGILPIDTYKTDLNSFINEPLHYNWE
HHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCHH
DLRVKIKKYGLRNSTLSALMPSETSSQISNATNGIEPPRGYISIKTSKNGILRQVVPEFI
HHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
KLKSDYELLWQIPDNRGYLQLVGIMQKFIDQSISTNTNYDPSRFPENKVPMKQLLSDLLY
HCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
AYRLGIKTLYYHNTRDGAQDVQKTLPHNQSNICTSDACTI
HHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6087316; 3287341; 9205837; 9278503; 3894026; 2663852; 8702814; 8052308; 9309223; 10493864 [H]