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The map label for this gene is hisA

Identifier: 71892240

GI number: 71892240

Start: 574691

End: 575431

Strand: Direct

Name: hisA

Synonym: BPEN_482

Alternate gene names: 71892240

Gene position: 574691-575431 (Clockwise)

Preceding gene: 71892401

Following gene: 71892241

Centisome position: 72.59

GC content: 31.44

Gene sequence:

>741_bases
GTGATTATTCCTGCGCTAGATATTATTAACGGAAATATAGTTAGACTATATCAAGGATCTTATTGCATGCAAACTAATTA
CGGCGAACCTATATCATTATTAAAGGAATACATACGACAAGGAGCAAAAATGATACATCTAGTTGATCTAGATGGAGCAA
AAAATCCATTAAAAAGACAAAGTTTATTAATTAGTCAACTAATAAAAGAAGCCAATCCTTTATCTAAGATACAAATAGGA
GGAGGTATACGTAACGCTTCAGATGTAGAAATTCTGTTAGAATCAGGAGCAACACGTATAGTATTAGGTTCTATAGCAGT
TACACAACCAAAGATAGTAAAAAAATGGTTTGAATATTTTGATCCAAATACTTTAGTTTTAGCGGTAGATATACACGTTT
ATTCTGAAGAAAATCGAAAAGTTGCTATTTACGGTTGGCAAAAAGAAACTGATTTGCAATTAGAACAAATAATAGAAGAA
TATTATACTGTAGGCTTAAAACATGTTATTTGCACAGATATCTCCAAAGATGGAACTTTGTTAGGTAGCAATATATCTTT
ATATCGATCAATATGTCATGCTTGGCCACGAATAGCATTTCAATCGTCTGGAGGTGTTAATAAATTATCAGAAATATCTA
AATTACGTTCTTCTGGAGTGGCAGGAATCATTATTGGTCGTGCTTTTTTAGAAAATACATTTACTATCAATGAGGCTATA
TCATGTTGGCAAAACGAATAA

Upstream 100 bases:

>100_bases
GGTTATAAAATATAAAAATTTTTTTGGTGTACAATTTCATCCAGAAAAATCAGGAATGCCCGGTCAACAATTAGTAAAAA
ATTTTTTGGAGATATAATTT

Downstream 100 bases:

>100_bases
TTCCTTGTCTTGATGTAGGTAATAACAAAGTAATTAAAGGAATACAATTTAAAGATCATAAAATTGTAGGAGATATCTTA
GAATTAGCAAATAGATATGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MIIPALDIINGNIVRLYQGSYCMQTNYGEPISLLKEYIRQGAKMIHLVDLDGAKNPLKRQSLLISQLIKEANPLSKIQIG
GGIRNASDVEILLESGATRIVLGSIAVTQPKIVKKWFEYFDPNTLVLAVDIHVYSEENRKVAIYGWQKETDLQLEQIIEE
YYTVGLKHVICTDISKDGTLLGSNISLYRSICHAWPRIAFQSSGGVNKLSEISKLRSSGVAGIIIGRAFLENTFTINEAI
SCWQNE

Sequences:

>Translated_246_residues
MIIPALDIINGNIVRLYQGSYCMQTNYGEPISLLKEYIRQGAKMIHLVDLDGAKNPLKRQSLLISQLIKEANPLSKIQIG
GGIRNASDVEILLESGATRIVLGSIAVTQPKIVKKWFEYFDPNTLVLAVDIHVYSEENRKVAIYGWQKETDLQLEQIIEE
YYTVGLKHVICTDISKDGTLLGSNISLYRSICHAWPRIAFQSSGGVNKLSEISKLRSSGVAGIIIGRAFLENTFTINEAI
SCWQNE
>Mature_246_residues
MIIPALDIINGNIVRLYQGSYCMQTNYGEPISLLKEYIRQGAKMIHLVDLDGAKNPLKRQSLLISQLIKEANPLSKIQIG
GGIRNASDVEILLESGATRIVLGSIAVTQPKIVKKWFEYFDPNTLVLAVDIHVYSEENRKVAIYGWQKETDLQLEQIIEE
YYTVGLKHVICTDISKDGTLLGSNISLYRSICHAWPRIAFQSSGGVNKLSEISKLRSSGVAGIIIGRAFLENTFTINEAI
SCWQNE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=246, Percent_Identity=52.4390243902439, Blast_Score=286, Evalue=7e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_BLOPB (Q494D7)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277974.1
- ProteinModelPortal:   Q494D7
- STRING:   Q494D7
- GeneID:   3562989
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_482
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   CBLO291272:BPEN_482-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 27442; Mature: 27442

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: ACT_SITE 7-7 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPALDIINGNIVRLYQGSYCMQTNYGEPISLLKEYIRQGAKMIHLVDLDGAKNPLKRQ
CCCCCEEECCCCEEEEEECCEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
SLLISQLIKEANPLSKIQIGGGIRNASDVEILLESGATRIVLGSIAVTQPKIVKKWFEYF
HHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECEECCCCHHHHHHHHHC
DPNTLVLAVDIHVYSEENRKVAIYGWQKETDLQLEQIIEEYYTVGLKHVICTDISKDGTL
CCCEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCEE
LGSNISLYRSICHAWPRIAFQSSGGVNKLSEISKLRSSGVAGIIIGRAFLENTFTINEAI
ECCCHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCHHHHH
SCWQNE
HHHCCC
>Mature Secondary Structure
MIIPALDIINGNIVRLYQGSYCMQTNYGEPISLLKEYIRQGAKMIHLVDLDGAKNPLKRQ
CCCCCEEECCCCEEEEEECCEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
SLLISQLIKEANPLSKIQIGGGIRNASDVEILLESGATRIVLGSIAVTQPKIVKKWFEYF
HHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECEECCCCHHHHHHHHHC
DPNTLVLAVDIHVYSEENRKVAIYGWQKETDLQLEQIIEEYYTVGLKHVICTDISKDGTL
CCCEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCEE
LGSNISLYRSICHAWPRIAFQSSGGVNKLSEISKLRSSGVAGIIIGRAFLENTFTINEAI
ECCCHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCHHHHH
SCWQNE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA