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The map label for this gene is hisH

Identifier: 71892401

GI number: 71892401

Start: 574098

End: 574274

Strand: Direct

Name: hisH

Synonym: BPEN_481

Alternate gene names: 71892401

Gene position: 574098-574274 (Clockwise)

Preceding gene: 71892239

Following gene: 71892240

Centisome position: 72.52

GC content: 35.59

Gene sequence:

>590_bases
ATGAATATAGTTATCATAGACACCAACTGCTCTAATTTATTATCTGTAAAAACCATGCTACATAGATTAGGACACAACCC
AATAATAAGTGACAGAGCTGATGTTATATCTCAGGCGGACAAACTGTTTTTACCAGGAGTAGGCACTGCTTCATCCGCGA
TGAAACAATTAAAAAAAAAAATCTAATTACATTGATACAAAATTGTACTAAACCAATATTGGGTATTTGCTTAGGAATGC
AGTTATTTGGATCTATAAGTTCTGAAAATAATGGTGTAAACACTTTAAATATTATTCATACACCTGTCAAACGTATGCAA
TACCACGGTTTTCCCTTGCCACATATGGGATGGAATACTATTACTATTCCAAAAAAACATTTTTTATTTTATGGCATAAA
AGAAAATGATTATTTTTATTTTGCACATAGTTATTGCATAAAAGTATGTTCTGTAACAATTTCTCAAACAAATTACGGAC
AATTATTTAGTTCGGTTATAAAATATAAAAATTTTTTTGGTGTACAATTTCATCCAGAAAAATCAGGAATGCCCGGTCAA
CAATTAGTAAAAAATTTTTTGGAGATATAA

Upstream 100 bases:

>100_bases
ATCATAAAGCAGAAAGTTTATTTAAATCTTTCGGGCGATCGTTACGTCAAGCCATTTACATAGACAATAACAATATACCA
AGCTCTAAAGGAACATTGCT

Downstream 100 bases:

>100_bases
TTTGTGATTATTCCTGCGCTAGATATTATTAACGGAAATATAGTTAGACTATATCAAGGATCTTATTGCATGCAAACTAA
TTACGGCGAACCTATATCAT

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH

Number of amino acids: Translated: 59; Mature: 59

Protein sequence:

>196_residues
MNIVIIDTNCSNLLSVKTMLHRLGHNPIISDRADVISQADKLFLPGVGTASSAMKQLKKKNLITLIQNCTKPILGICLGM
QLFGSISSENNGVNTLNIIHTPVKRMQYHGFPLPHMGWNTITIPKKHFLFYGIKENDYFYFAHSYCIKVCSVTISQTNYG
QLFSSVIKYKNFFGVQFHPEKSGMPGQQLVKNFLEI

Sequences:

>Translated_59_residues
MNIVIIDTNCSNLLSVKTMLHRLGHNPIISDRADVISQADKLFLPGVGTASSAMKQLKK
>Mature_59_residues
MNIVIIDTNCSNLLSVKTMLHRLGHNPIISDRADVISQADKLFLPGVGTASSAMKQLKK

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI1788334, Length=59, Percent_Identity=55.9322033898305, Blast_Score=73, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS5_BLOPB (Q492K0)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277973.1
- ProteinModelPortal:   Q492K0
- SMR:   Q492K0
- STRING:   Q492K0
- GeneID:   3562988
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_481
- eggNOG:   COG0118
- HOGENOM:   HBG292341
- OMA:   YSEEDDI
- ProtClustDB:   PRK13170
- GO:   GO:0005737
- HAMAP:   MF_00278
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226
- PIRSF:   PIRSF000495
- TIGRFAMs:   TIGR01855

Pfam domain/function: PF00117 GATase

EC number: 2.4.2.-

Molecular weight: Translated: 6406; Mature: 6406

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 77-77 ACT_SITE 178-178 ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVIIDTNCSNLLSVKTMLHRLGHNPIISDRADVISQADKLFLPGVGTASSAMKQLKK
CEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNIVIIDTNCSNLLSVKTMLHRLGHNPIISDRADVISQADKLFLPGVGTASSAMKQLKK
CEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA