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The map label for this gene is manY [H]

Identifier: 71892222

GI number: 71892222

Start: 547418

End: 548227

Strand: Direct

Name: manY [H]

Synonym: BPEN_460

Alternate gene names: 71892222

Gene position: 547418-548227 (Clockwise)

Preceding gene: 71892221

Following gene: 71892223

Centisome position: 69.15

GC content: 36.67

Gene sequence:

>810_bases
ATGGAAATTAACACACTTCAAATTATTTTATTGTTCATTACATCTTGTGTTATCGGAATGGGCTCAATACTTGACGAATT
TCAATGCCATAGACCGTTAATAGCATGCACGCTAACCGGATTAATTTTAGGAGATATAAAAACTGGAATCATTATTGGAG
GCACGCTAGAAATGATAGCACTAGGATGGATGAATATAGGAGCTGCTGTAGCACCCGATACTGCTTTAGCTTCAATTATC
TCTACTATTTTAGTCATTATGGGGCAACAACCTATCGGAGCAGGAATCGCTTTAGCAATTCCATTAGCCGCTACCGGACA
AGTATTAACCATTATTGTGCGCACTATTACTGTAGCATTTCAACACGCCGCTGACAAAGCAGCTGAACACTGTAATATGA
AAATTTTAAGTTGGATTCATATTACAGCTCTTATGTTGCAAGCTATGCGGGTTTCAATTCCAGCAACTATTGTTGGAGTT
TCCGTTGGAACTGAAACAGTGCACTCTATGCTCCATGCTATTCCAGAAGTGATAACTAATGGTTTAAATATTGCTGGAGG
TATTATTGTTGTAGTTGGTTATGCTATGGTTATAAATATGATGCGCACCGGATATTTAATGCCGTTTTTTTATTTAGGAT
TTGTTATTACAGCCTTTACCGATTTCAATTTAGTCGCATTGGGTATCATTGGTATAATTCTGGCCATCCTGTACATTCAA
TTGTCTCCACGTTATAATCAAGTTAAAAATCAAAATCTTTCTAAACAAACTGTTCAATCCGCAAGTAATCTTGATGACGA
ACTAGATTAA

Upstream 100 bases:

>100_bases
AATAAAAAAAATAAATAATTCTTAATTAATTAGATGTACAATTTTATTTAATAAATTCATGTAAACGCTATATTTTATTT
TCATATATTTAGGAAATGAA

Downstream 100 bases:

>100_bases
TAAGACTAGATTAATAGGTAATCATAATGATTAATAATCCTCAAAAAATCCATACTAAAACAAAAACAATAAAATTAAAG
AAAAATGATATACGTGCGGT

Product: PTS family enzyme IIC, mannose-specific

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EII-P-Man; EIIC-Man; PTS system mannose-specific EIIC component [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MEINTLQIILLFITSCVIGMGSILDEFQCHRPLIACTLTGLILGDIKTGIIIGGTLEMIALGWMNIGAAVAPDTALASII
STILVIMGQQPIGAGIALAIPLAATGQVLTIIVRTITVAFQHAADKAAEHCNMKILSWIHITALMLQAMRVSIPATIVGV
SVGTETVHSMLHAIPEVITNGLNIAGGIIVVVGYAMVINMMRTGYLMPFFYLGFVITAFTDFNLVALGIIGIILAILYIQ
LSPRYNQVKNQNLSKQTVQSASNLDDELD

Sequences:

>Translated_269_residues
MEINTLQIILLFITSCVIGMGSILDEFQCHRPLIACTLTGLILGDIKTGIIIGGTLEMIALGWMNIGAAVAPDTALASII
STILVIMGQQPIGAGIALAIPLAATGQVLTIIVRTITVAFQHAADKAAEHCNMKILSWIHITALMLQAMRVSIPATIVGV
SVGTETVHSMLHAIPEVITNGLNIAGGIIVVVGYAMVINMMRTGYLMPFFYLGFVITAFTDFNLVALGIIGIILAILYIQ
LSPRYNQVKNQNLSKQTVQSASNLDDELD
>Mature_269_residues
MEINTLQIILLFITSCVIGMGSILDEFQCHRPLIACTLTGLILGDIKTGIIIGGTLEMIALGWMNIGAAVAPDTALASII
STILVIMGQQPIGAGIALAIPLAATGQVLTIIVRTITVAFQHAADKAAEHCNMKILSWIHITALMLQAMRVSIPATIVGV
SVGTETVHSMLHAIPEVITNGLNIAGGIIVVVGYAMVINMMRTGYLMPFFYLGFVITAFTDFNLVALGIIGIILAILYIQ
LSPRYNQVKNQNLSKQTVQSASNLDDELD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=271, Percent_Identity=76.0147601476015, Blast_Score=373, Evalue=1e-105,
Organism=Escherichia coli, GI1789528, Length=266, Percent_Identity=25.9398496240602, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: NA

Molecular weight: Translated: 28671; Mature: 28671

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEINTLQIILLFITSCVIGMGSILDEFQCHRPLIACTLTGLILGDIKTGIIIGGTLEMIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCHHHHHH
LGWMNIGAAVAPDTALASIISTILVIMGQQPIGAGIALAIPLAATGQVLTIIVRTITVAF
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHEEECHHCCCHHHHHHHHHHHHHH
QHAADKAAEHCNMKILSWIHITALMLQAMRVSIPATIVGVSVGTETVHSMLHAIPEVITN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCHHHHHHHHHHHHHHHHC
GLNIAGGIIVVVGYAMVINMMRTGYLMPFFYLGFVITAFTDFNLVALGIIGIILAILYIQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LSPRYNQVKNQNLSKQTVQSASNLDDELD
CCCCHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEINTLQIILLFITSCVIGMGSILDEFQCHRPLIACTLTGLILGDIKTGIIIGGTLEMIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCHHHHHH
LGWMNIGAAVAPDTALASIISTILVIMGQQPIGAGIALAIPLAATGQVLTIIVRTITVAF
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHEEECHHCCCHHHHHHHHHHHHHH
QHAADKAAEHCNMKILSWIHITALMLQAMRVSIPATIVGVSVGTETVHSMLHAIPEVITN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCHHHHHHHHHHHHHHHHC
GLNIAGGIIVVVGYAMVINMMRTGYLMPFFYLGFVITAFTDFNLVALGIIGIILAILYIQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LSPRYNQVKNQNLSKQTVQSASNLDDELD
CCCCHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]