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The map label for this gene is trpC [H]

Identifier: 71892203

GI number: 71892203

Start: 522007

End: 523380

Strand: Direct

Name: trpC [H]

Synonym: BPEN_441

Alternate gene names: 71892203

Gene position: 522007-523380 (Clockwise)

Preceding gene: 71892202

Following gene: 71892204

Centisome position: 65.94

GC content: 31.0

Gene sequence:

>1374_bases
ATGCAACACACAATACTCGATAAAATTTTATCATATAAAAAAATGTGGATAGCTGATCAAAAAAAACAACATTCATTACA
TTTTTTAAAAAGTAAAATACAAGCAAGCAATCGTGATTTTTATAGCGCTGTGTCTCGCAATAAATATCAAAAAACAATAT
TTATATTAGAATGTAAGAAAGCGTCTCCTTCTAAAGGTATTATTTGTAATGATTTTGATCCTATCAAAATAGCACAGACT
TATAAAAATTACTCCTCAGTGATATCAGTATTAACTGATAATAAATACTTTCATGGGAATTTTAATATTTTACACCAAGT
GAGCAACATCGTAAAACAACCAATATTATGTAAAGATTTCTTTATTTCAGAATGGCAAATTTATTTTGCGCGCTTACATA
AAGCTGATGCTATTTTACTAATGCTATCAATTCTAGATGATGCATCCTATCAAAAATTGGTCAAAATAGCTCATACATTA
TGTATGGGGGTACTAACAGAAATCGCAAACGAAGATGAATTAAAGCGCGCTAAATATTTAGGAGCTAAAGTTATCGGTAT
AAATAATCGTAATCTGAATGATTTGTCCGTTGATTTAAATCGCACTATTACTCTAAGTAAAGATATACCTAATACAATCA
CTGTAATCAGCGAGTCTGGTATTAGCAATTATTGTCATATAAGAAAACTTAGACGATATGTTAATGGATTTTTAATAGGT
ACAATATTAATGTCTCAACCAAAGCTTAATGCAGCCATTAAAAAATTAATTTTAGGAGAAAATAAAATATGTGGACTAAC
TCGAGTGAGAGACGCTGATATTGCATACAAATCAGGCGCAATATATGGAGGGCTAATTTTTGTTCCCACTTCACCTCGCT
ACATAAATATCACAATTGCGCAACGTATTGTTTCTTGTGTAAAATATTTAAGTTATGTTGGTGTATTTTGTAATGCTCCA
ATTTCTTATATTGTTACCATAGTTAACATATTAGGACTAGCAGCAGTTCAACTTCATGGCGTAGAAGATCAAGATTATAT
TAATATTTTACGGACACGATTACCCATAACATGTCATATATGGAAAAGTATTAATATGAATCACAGACCATTGTCGAAAT
GTAATATACTGAACGTAGACCGCTATTTAGCAGACAGTGGAGGGGGTAGTGGAAAAACTTTTGATTGGTCACTGCTTTCT
AGCATGCAATTAGATAAAGTAATTTTAGCCGGAGGATTGACAATAAACAATTGTAATAAAGCGGCGGGCATAGGTTGTTT
AGGTTTAGATTTTAATTCTGGAGTTGAAATTAAACCAGGTATTAAAAATCACCAGAAACTCATCAAAGTCTTCCAAATAA
TCAGGTCTTATTAA

Upstream 100 bases:

>100_bases
ACCGATCTACGCGCTAATGCACAACTAGCTTTAGAAAAAATACATTATGGCATACCTTACACTCTTTTGAGTTCTTTATC
AGAAACTAAGATACAAAACC

Downstream 100 bases:

>100_bases
AGGAATATATATTTCAAATAATTAAAAAATAAAATAATCAATATGATAAAATTAAAATCCTATTTTGGAGAATTTGGAGG
TATGTATGTACCGCAAATTC

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MQHTILDKILSYKKMWIADQKKQHSLHFLKSKIQASNRDFYSAVSRNKYQKTIFILECKKASPSKGIICNDFDPIKIAQT
YKNYSSVISVLTDNKYFHGNFNILHQVSNIVKQPILCKDFFISEWQIYFARLHKADAILLMLSILDDASYQKLVKIAHTL
CMGVLTEIANEDELKRAKYLGAKVIGINNRNLNDLSVDLNRTITLSKDIPNTITVISESGISNYCHIRKLRRYVNGFLIG
TILMSQPKLNAAIKKLILGENKICGLTRVRDADIAYKSGAIYGGLIFVPTSPRYINITIAQRIVSCVKYLSYVGVFCNAP
ISYIVTIVNILGLAAVQLHGVEDQDYINILRTRLPITCHIWKSINMNHRPLSKCNILNVDRYLADSGGGSGKTFDWSLLS
SMQLDKVILAGGLTINNCNKAAGIGCLGLDFNSGVEIKPGIKNHQKLIKVFQIIRSY

Sequences:

>Translated_457_residues
MQHTILDKILSYKKMWIADQKKQHSLHFLKSKIQASNRDFYSAVSRNKYQKTIFILECKKASPSKGIICNDFDPIKIAQT
YKNYSSVISVLTDNKYFHGNFNILHQVSNIVKQPILCKDFFISEWQIYFARLHKADAILLMLSILDDASYQKLVKIAHTL
CMGVLTEIANEDELKRAKYLGAKVIGINNRNLNDLSVDLNRTITLSKDIPNTITVISESGISNYCHIRKLRRYVNGFLIG
TILMSQPKLNAAIKKLILGENKICGLTRVRDADIAYKSGAIYGGLIFVPTSPRYINITIAQRIVSCVKYLSYVGVFCNAP
ISYIVTIVNILGLAAVQLHGVEDQDYINILRTRLPITCHIWKSINMNHRPLSKCNILNVDRYLADSGGGSGKTFDWSLLS
SMQLDKVILAGGLTINNCNKAAGIGCLGLDFNSGVEIKPGIKNHQKLIKVFQIIRSY
>Mature_457_residues
MQHTILDKILSYKKMWIADQKKQHSLHFLKSKIQASNRDFYSAVSRNKYQKTIFILECKKASPSKGIICNDFDPIKIAQT
YKNYSSVISVLTDNKYFHGNFNILHQVSNIVKQPILCKDFFISEWQIYFARLHKADAILLMLSILDDASYQKLVKIAHTL
CMGVLTEIANEDELKRAKYLGAKVIGINNRNLNDLSVDLNRTITLSKDIPNTITVISESGISNYCHIRKLRRYVNGFLIG
TILMSQPKLNAAIKKLILGENKICGLTRVRDADIAYKSGAIYGGLIFVPTSPRYINITIAQRIVSCVKYLSYVGVFCNAP
ISYIVTIVNILGLAAVQLHGVEDQDYINILRTRLPITCHIWKSINMNHRPLSKCNILNVDRYLADSGGGSGKTFDWSLLS
SMQLDKVILAGGLTINNCNKAAGIGCLGLDFNSGVEIKPGIKNHQKLIKVFQIIRSY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=456, Percent_Identity=53.9473684210526, Blast_Score=501, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=34.4444444444444, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320210, Length=211, Percent_Identity=33.6492890995261, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 51399; Mature: 51399

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHTILDKILSYKKMWIADQKKQHSLHFLKSKIQASNRDFYSAVSRNKYQKTIFILECKK
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEECC
ASPSKGIICNDFDPIKIAQTYKNYSSVISVLTDNKYFHGNFNILHQVSNIVKQPILCKDF
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCHHHH
FISEWQIYFARLHKADAILLMLSILDDASYQKLVKIAHTLCMGVLTEIANEDELKRAKYL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GAKVIGINNRNLNDLSVDLNRTITLSKDIPNTITVISESGISNYCHIRKLRRYVNGFLIG
CEEEEEECCCCCCCEEEECCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
TILMSQPKLNAAIKKLILGENKICGLTRVRDADIAYKSGAIYGGLIFVPTSPRYINITIA
HHHHCCCCHHHHHHHHHCCCCCEECCEEECCCCCEEECCCEEEEEEEEECCCCEEEEHHH
QRIVSCVKYLSYVGVFCNAPISYIVTIVNILGLAAVQLHGVEDQDYINILRTRLPITCHI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCEEEEE
WKSINMNHRPLSKCNILNVDRYLADSGGGSGKTFDWSLLSSMQLDKVILAGGLTINNCNK
EECCCCCCCCCCCCCEECHHHHHHCCCCCCCCEEEHHHHHHCCHHHEEEECCEEEECCCC
AAGIGCLGLDFNSGVEIKPGIKNHQKLIKVFQIIRSY
CCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHTILDKILSYKKMWIADQKKQHSLHFLKSKIQASNRDFYSAVSRNKYQKTIFILECKK
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEECC
ASPSKGIICNDFDPIKIAQTYKNYSSVISVLTDNKYFHGNFNILHQVSNIVKQPILCKDF
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCHHHH
FISEWQIYFARLHKADAILLMLSILDDASYQKLVKIAHTLCMGVLTEIANEDELKRAKYL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
GAKVIGINNRNLNDLSVDLNRTITLSKDIPNTITVISESGISNYCHIRKLRRYVNGFLIG
CEEEEEECCCCCCCEEEECCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
TILMSQPKLNAAIKKLILGENKICGLTRVRDADIAYKSGAIYGGLIFVPTSPRYINITIA
HHHHCCCCHHHHHHHHHCCCCCEECCEEECCCCCEEECCCEEEEEEEEECCCCEEEEHHH
QRIVSCVKYLSYVGVFCNAPISYIVTIVNILGLAAVQLHGVEDQDYINILRTRLPITCHI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCEEEEE
WKSINMNHRPLSKCNILNVDRYLADSGGGSGKTFDWSLLSSMQLDKVILAGGLTINNCNK
EECCCCCCCCCCCCCEECHHHHHHCCCCCCCCEEEHHHHHHCCHHHEEEECCEEEECCCC
AAGIGCLGLDFNSGVEIKPGIKNHQKLIKVFQIIRSY
CCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]