Click here to switch to the map view.

The map label for this gene is trpB

Identifier: 71892204

GI number: 71892204

Start: 523423

End: 524613

Strand: Direct

Name: trpB

Synonym: BPEN_442

Alternate gene names: 71892204

Gene position: 523423-524613 (Clockwise)

Preceding gene: 71892203

Following gene: 71892205

Centisome position: 66.12

GC content: 35.43

Gene sequence:

>1191_bases
ATGATAAAATTAAAATCCTATTTTGGAGAATTTGGAGGTATGTATGTACCGCAAATTCTAATACCAGCCCTAACTCAATT
AGAAGAAGCATTTATATCAGCTCAAGATGATGCTATTTTCCAAAAAGAACTCAAATATCTTTTAAACAACTATGCCGGTC
GTCCTACTCCTTTGACATTATGTAGAAATTTAACAAAAGGAACTCGCGCTAAACTGTATTTAAAACGTGAAGACTTATTG
CATGGAGGATCTCATAAAACCAACCAAGTATTAGGACAAGCTTTATTAGCAAAACGTATGTCTAAAACAGAAATAATCGC
TGAAACTGGTGCCGGACAACATGGAGTGGCTGTCTCCATTGCAGCCTCTCTTTTAGGATTAAAATGTCGTATTTATATGG
GATCTAAAGATATAAAACGTCAAAAACTCAACGTTTTGAGAATGCAATTAATGGGCACACAAGTTATTCCAGTACATCGT
GGATCTGAAACTTTAAAAGATGCTTGTAACGAAGCCATGCGCGAATGGTCGAAAACTTATGAATACACCCATTACATGCT
TGGTACAGCTGCTGGACCTCATCCTTTTCCCACAATCGTTAGAGAATTTCAACGTATTATTGGAAAAGAAACATACAAAC
AAATACAAAAATATGAGCAATGCTTACCAGATGCAATTATTGCTTGCGTAGGAGGAGGATCTAATGCTATTGGCATATTT
TCTGATTTTGTTGACATACCATCAGTGCAGTTATTAGGTGTAGAAGCTGGAGGATTAGGTATAAATACTGAATATCATGG
TGCCGCTCTACAACATGGAAGTATAGGAATTTATTTTGGTATGAAAACTTCAATCTTACAATCTTCGGAAGGACAAGTAA
AAAACTCTTATTCTGTTTCCGCTGGTCTCGATTTTCCGTCTGTCGGTCCAGAGCATGTTTATCTAAAAAATACTGGCCGG
GTACAGTATGTATCTATTAATGATATAGAAGCCATAACAGCTTTTAAGAAATTATCTATTCATGAAGGAATTATTCCAGC
TCTAGAATCCGCTCATGCTTTAGCTCATGCACTAAAAATAATTCAGAAACAACCAGATAAAGCACAAATTTTAGTAGTTA
ATTTGTCTGGACGTGGAGATAAAGACATTTCTACCGTTCATAATGCATTACAAAAAGAAAGAGATAAATAA

Upstream 100 bases:

>100_bases
AGGTATTAAAAATCACCAGAAACTCATCAAAGTCTTCCAAATAATCAGGTCTTATTAAAGGAATATATATTTCAAATAAT
TAAAAAATAAAATAATCAAT

Downstream 100 bases:

>100_bases
CAATGAATCGTTACAAAAAATTATTTACACATTTAAAGAAAAAAAAAATAGGCGCATTTGTTCCTTTTATTGCTGTAGGA
TATCCCGATCCTATTTCTTT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIKLKSYFGEFGGMYVPQILIPALTQLEEAFISAQDDAIFQKELKYLLNNYAGRPTPLTLCRNLTKGTRAKLYLKREDLL
HGGSHKTNQVLGQALLAKRMSKTEIIAETGAGQHGVAVSIAASLLGLKCRIYMGSKDIKRQKLNVLRMQLMGTQVIPVHR
GSETLKDACNEAMREWSKTYEYTHYMLGTAAGPHPFPTIVREFQRIIGKETYKQIQKYEQCLPDAIIACVGGGSNAIGIF
SDFVDIPSVQLLGVEAGGLGINTEYHGAALQHGSIGIYFGMKTSILQSSEGQVKNSYSVSAGLDFPSVGPEHVYLKNTGR
VQYVSINDIEAITAFKKLSIHEGIIPALESAHALAHALKIIQKQPDKAQILVVNLSGRGDKDISTVHNALQKERDK

Sequences:

>Translated_396_residues
MIKLKSYFGEFGGMYVPQILIPALTQLEEAFISAQDDAIFQKELKYLLNNYAGRPTPLTLCRNLTKGTRAKLYLKREDLL
HGGSHKTNQVLGQALLAKRMSKTEIIAETGAGQHGVAVSIAASLLGLKCRIYMGSKDIKRQKLNVLRMQLMGTQVIPVHR
GSETLKDACNEAMREWSKTYEYTHYMLGTAAGPHPFPTIVREFQRIIGKETYKQIQKYEQCLPDAIIACVGGGSNAIGIF
SDFVDIPSVQLLGVEAGGLGINTEYHGAALQHGSIGIYFGMKTSILQSSEGQVKNSYSVSAGLDFPSVGPEHVYLKNTGR
VQYVSINDIEAITAFKKLSIHEGIIPALESAHALAHALKIIQKQPDKAQILVVNLSGRGDKDISTVHNALQKERDK
>Mature_396_residues
MIKLKSYFGEFGGMYVPQILIPALTQLEEAFISAQDDAIFQKELKYLLNNYAGRPTPLTLCRNLTKGTRAKLYLKREDLL
HGGSHKTNQVLGQALLAKRMSKTEIIAETGAGQHGVAVSIAASLLGLKCRIYMGSKDIKRQKLNVLRMQLMGTQVIPVHR
GSETLKDACNEAMREWSKTYEYTHYMLGTAAGPHPFPTIVREFQRIIGKETYKQIQKYEQCLPDAIIACVGGGSNAIGIF
SDFVDIPSVQLLGVEAGGLGINTEYHGAALQHGSIGIYFGMKTSILQSSEGQVKNSYSVSAGLDFPSVGPEHVYLKNTGR
VQYVSINDIEAITAFKKLSIHEGIIPALESAHALAHALKIIQKQPDKAQILVVNLSGRGDKDISTVHNALQKERDK

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=388, Percent_Identity=71.3917525773196, Blast_Score=593, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6321412, Length=388, Percent_Identity=51.2886597938144, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_BLOPB (Q492N6)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277937.1
- HSSP:   P0A2K1
- ProteinModelPortal:   Q492N6
- SMR:   Q492N6
- STRING:   Q492N6
- GeneID:   3562822
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_442
- eggNOG:   COG0133
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- BioCyc:   CBLO291272:BPEN_442-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 43455; Mature: 43455

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLKSYFGEFGGMYVPQILIPALTQLEEAFISAQDDAIFQKELKYLLNNYAGRPTPLTL
CEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHH
CRNLTKGTRAKLYLKREDLLHGGSHKTNQVLGQALLAKRMSKTEIIAETGAGQHGVAVSI
HHHCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AASLLGLKCRIYMGSKDIKRQKLNVLRMQLMGTQVIPVHRGSETLKDACNEAMREWSKTY
HHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHH
EYTHYMLGTAAGPHPFPTIVREFQRIIGKETYKQIQKYEQCLPDAIIACVGGGSNAIGIF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEECCCCCCCHHH
SDFVDIPSVQLLGVEAGGLGINTEYHGAALQHGSIGIYFGMKTSILQSSEGQVKNSYSVS
HHHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCEEEEECCHHHHHCCCCCCCCCCEEEE
AGLDFPSVGPEHVYLKNTGRVQYVSINDIEAITAFKKLSIHEGIIPALESAHALAHALKI
CCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IQKQPDKAQILVVNLSGRGDKDISTVHNALQKERDK
HHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKLKSYFGEFGGMYVPQILIPALTQLEEAFISAQDDAIFQKELKYLLNNYAGRPTPLTL
CEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHH
CRNLTKGTRAKLYLKREDLLHGGSHKTNQVLGQALLAKRMSKTEIIAETGAGQHGVAVSI
HHHCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AASLLGLKCRIYMGSKDIKRQKLNVLRMQLMGTQVIPVHRGSETLKDACNEAMREWSKTY
HHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHH
EYTHYMLGTAAGPHPFPTIVREFQRIIGKETYKQIQKYEQCLPDAIIACVGGGSNAIGIF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEECCCCCCCHHH
SDFVDIPSVQLLGVEAGGLGINTEYHGAALQHGSIGIYFGMKTSILQSSEGQVKNSYSVS
HHHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCEEEEECCHHHHHCCCCCCCCCCEEEE
AGLDFPSVGPEHVYLKNTGRVQYVSINDIEAITAFKKLSIHEGIIPALESAHALAHALKI
CCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IQKQPDKAQILVVNLSGRGDKDISTVHNALQKERDK
HHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA