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The map label for this gene is mrdA [H]

Identifier: 71892090

GI number: 71892090

Start: 375262

End: 377112

Strand: Reverse

Name: mrdA [H]

Synonym: BPEN_317

Alternate gene names: 71892090

Gene position: 377112-375262 (Counterclockwise)

Preceding gene: 71892091

Following gene: 71892089

Centisome position: 47.64

GC content: 33.55

Gene sequence:

>1851_bases
ATGAAGTCCAATGGTCATCAAATTTTTCATAATTATTCAGCTGAGTCGTTGTTGTTTGCGCGTCGTATAACAATTGCATC
TGTTTTTGTATTATTGATCATTGGCATTTTATTTATTCATCTATATCAGATACAGATAATTCATTTTGATATGTATACTA
CTCGTTCTAATGAAAATCGTATTAAGATTATTCCTATTCCACCTAAAAGAGGAATTATTTACGATCGCAATGGAATTGCT
TTAGCATTAAATCGTACTATTTACCAATTAGAAATAGTTCCAGAGAATACAATTGATTTAAGCCATACGATTCATGAGTT
GAAATTATTACTAAATTTAAGTGATCATGATATAGAATGTTTTGAAAAAAATCGGAAACGTTCTACCCAATTTGTTTCGT
TACCTATTAAAATTGATTTAACGGAAGAACAACAAGCTCGATTTGCTGTTAATAGATTTAGGTTTTCCGGGGTAACAATC
AAAAGTTATCAACGTCGTTACTATCCTTATGGATCCGATGTAACTCATGTTATCGGATACGTCGCTAAAATTAACGGGGA
AGATATAAAAAGATTGAATAAGCAGGGTATTTTGGGTAAGTATGTTGCAGCTCCTAATATAGGAAAATTAGGTATTGAAC
GCTATTACGAAAATATTTTACATGGGACGCCAGGATATGGAGCTGTAGAAATAAATAATCGCGGGAAAGTGATTAGAGAA
TTATATAAAAAATCTCCGATACCAGGAAAAAATATTGTTTTAACATTAGATTTGAATTTACAACAGTATATTATAAAATT
ATTAGTAGGAAATCGGTCTTCTGTAATAGTTGTTGACCCTCGCAACGGAGGAATTCAAGCTTTAATTTCGCATCCTAGTT
ATAATCCAAACTTGTTTGTTGACGGTATCTCCAATACAGAATATAGTATTTTATTAAAGGATAACAATTGTCCTTTACTT
AATCGTGCCACCCAAGGGGTATACCCTCCTGCATCTACAGTAAAACCTTATATTTCTGTATCTGCTTTAACATTGGGGGT
GATTAATCAGAATTTTTTATTTTCTGATCCTGGTTGGTGGCAATTACCTGGTTCAGAAAAACGTTTTCGTGATTGGAAAC
GTTGGGGGCATGGAGAATTAAATATTACGAAAGCTCTTGAAGAATCTTCTGATACTTTTTTTTATCAAATAGCCTACAAA
ATGGGAATAGATAATTTATCAGAATGGATGAATAAATTTGGGTATGGTAGATATACTGGTATCGATCTATTCGAAGAATT
AACTGGCGTGATGCCGACTAAGGCATGGAAAATACAACGTTTTAATCAACCATGGTATCAAGGAGATACGATACCGGTAG
GAATCGGGCAAGGGTATTGGACCGCTACTCCTATACAAATGTCTAAAGCTTTAATTACTTTAATTAATGACGGTAACGTG
CGCATTCCACATTTACTTGATAGTGTTTTATTGGAAAAAAATTGTGTTCCATACCATCAAACGGAATGTGACCAGGTAGG
TGACCCGAAATCAAATGTATGGAAAATAGCTAAAGATGGAATGTTTGGAGCAGCCAATCGTCCAAATGGCACAGTAAGTG
GGAGTTTTTCTGGCACTTCATATAAAGCAGCAGCCAAATCTGGTACAGCACAATTATTTAATTTAAAAAGTAACCAAAAT
TATGATCCAAGTAAGATTTCTGAATCTCTTAGGGATCATAAATTAATGACTGCTTTCGCTCCATACGAAAATCCCACGGT
AGCTGTGGTAGTAATTTTAGAAAACGCTAGAATTGGAGTATCAATAGGATCAATTACAAGAAAAATATTTGATTATGTCT
TATTGCAATAA

Upstream 100 bases:

>100_bases
TAGGACACAGTATTACGCATACATAGCAATGTATCTATTAAATAAGTGTATAATTATTTATATCGATGATTAATATTAGA
TATAAATAAATTTTGATTCA

Downstream 100 bases:

>100_bases
ATAAACATTTAATTGAGTTGTTTTTTATTTATTTTGTCAATCTAACTAGTTATCGTAATGCATCATGAGTCAAATTATTC
GGAAAAATTCATTATGGAAT

Product: cell elongation-specific transpeptidase of penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MKSNGHQIFHNYSAESLLFARRITIASVFVLLIIGILFIHLYQIQIIHFDMYTTRSNENRIKIIPIPPKRGIIYDRNGIA
LALNRTIYQLEIVPENTIDLSHTIHELKLLLNLSDHDIECFEKNRKRSTQFVSLPIKIDLTEEQQARFAVNRFRFSGVTI
KSYQRRYYPYGSDVTHVIGYVAKINGEDIKRLNKQGILGKYVAAPNIGKLGIERYYENILHGTPGYGAVEINNRGKVIRE
LYKKSPIPGKNIVLTLDLNLQQYIIKLLVGNRSSVIVVDPRNGGIQALISHPSYNPNLFVDGISNTEYSILLKDNNCPLL
NRATQGVYPPASTVKPYISVSALTLGVINQNFLFSDPGWWQLPGSEKRFRDWKRWGHGELNITKALEESSDTFFYQIAYK
MGIDNLSEWMNKFGYGRYTGIDLFEELTGVMPTKAWKIQRFNQPWYQGDTIPVGIGQGYWTATPIQMSKALITLINDGNV
RIPHLLDSVLLEKNCVPYHQTECDQVGDPKSNVWKIAKDGMFGAANRPNGTVSGSFSGTSYKAAAKSGTAQLFNLKSNQN
YDPSKISESLRDHKLMTAFAPYENPTVAVVVILENARIGVSIGSITRKIFDYVLLQ

Sequences:

>Translated_616_residues
MKSNGHQIFHNYSAESLLFARRITIASVFVLLIIGILFIHLYQIQIIHFDMYTTRSNENRIKIIPIPPKRGIIYDRNGIA
LALNRTIYQLEIVPENTIDLSHTIHELKLLLNLSDHDIECFEKNRKRSTQFVSLPIKIDLTEEQQARFAVNRFRFSGVTI
KSYQRRYYPYGSDVTHVIGYVAKINGEDIKRLNKQGILGKYVAAPNIGKLGIERYYENILHGTPGYGAVEINNRGKVIRE
LYKKSPIPGKNIVLTLDLNLQQYIIKLLVGNRSSVIVVDPRNGGIQALISHPSYNPNLFVDGISNTEYSILLKDNNCPLL
NRATQGVYPPASTVKPYISVSALTLGVINQNFLFSDPGWWQLPGSEKRFRDWKRWGHGELNITKALEESSDTFFYQIAYK
MGIDNLSEWMNKFGYGRYTGIDLFEELTGVMPTKAWKIQRFNQPWYQGDTIPVGIGQGYWTATPIQMSKALITLINDGNV
RIPHLLDSVLLEKNCVPYHQTECDQVGDPKSNVWKIAKDGMFGAANRPNGTVSGSFSGTSYKAAAKSGTAQLFNLKSNQN
YDPSKISESLRDHKLMTAFAPYENPTVAVVVILENARIGVSIGSITRKIFDYVLLQ
>Mature_616_residues
MKSNGHQIFHNYSAESLLFARRITIASVFVLLIIGILFIHLYQIQIIHFDMYTTRSNENRIKIIPIPPKRGIIYDRNGIA
LALNRTIYQLEIVPENTIDLSHTIHELKLLLNLSDHDIECFEKNRKRSTQFVSLPIKIDLTEEQQARFAVNRFRFSGVTI
KSYQRRYYPYGSDVTHVIGYVAKINGEDIKRLNKQGILGKYVAAPNIGKLGIERYYENILHGTPGYGAVEINNRGKVIRE
LYKKSPIPGKNIVLTLDLNLQQYIIKLLVGNRSSVIVVDPRNGGIQALISHPSYNPNLFVDGISNTEYSILLKDNNCPLL
NRATQGVYPPASTVKPYISVSALTLGVINQNFLFSDPGWWQLPGSEKRFRDWKRWGHGELNITKALEESSDTFFYQIAYK
MGIDNLSEWMNKFGYGRYTGIDLFEELTGVMPTKAWKIQRFNQPWYQGDTIPVGIGQGYWTATPIQMSKALITLINDGNV
RIPHLLDSVLLEKNCVPYHQTECDQVGDPKSNVWKIAKDGMFGAANRPNGTVSGSFSGTSYKAAAKSGTAQLFNLKSNQN
YDPSKISESLRDHKLMTAFAPYENPTVAVVVILENARIGVSIGSITRKIFDYVLLQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=607, Percent_Identity=62.9324546952224, Blast_Score=821, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=614, Percent_Identity=23.2899022801303, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69678; Mature: 69678

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNGHQIFHNYSAESLLFARRITIASVFVLLIIGILFIHLYQIQIIHFDMYTTRSNENR
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCE
IKIIPIPPKRGIIYDRNGIALALNRTIYQLEIVPENTIDLSHTIHELKLLLNLSDHDIEC
EEEEEECCCCCEEECCCCEEEEEECEEEEEEEECCCCCCHHHHHHHHHEEEECCCCCHHH
FEKNRKRSTQFVSLPIKIDLTEEQQARFAVNRFRFSGVTIKSYQRRYYPYGSDVTHVIGY
HHHCCCCCCEEEEEEEEEECCCHHHHHHHHHHEEECCEEHHHHHHHCCCCCCCHHHHHHH
VAKINGEDIKRLNKQGILGKYVAAPNIGKLGIERYYENILHGTPGYGAVEINNRGKVIRE
HHCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHH
LYKKSPIPGKNIVLTLDLNLQQYIIKLLVGNRSSVIVVDPRNGGIQALISHPSYNPNLFV
HHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCEEE
DGISNTEYSILLKDNNCPLLNRATQGVYPPASTVKPYISVSALTLGVINQNFLFSDPGWW
ECCCCCEEEEEEECCCCCCCHHCCCCCCCCHHCCCCCEEEEEEEEEEECCCEEECCCCCE
QLPGSEKRFRDWKRWGHGELNITKALEESSDTFFYQIAYKMGIDNLSEWMNKFGYGRYTG
ECCCCHHHHHHHHHCCCCCEEEEHHHHCCCCEEEEEEEEHHCCHHHHHHHHHHCCCCCCC
IDLFEELTGVMPTKAWKIQRFNQPWYQGDTIPVGIGQGYWTATPIQMSKALITLINDGNV
HHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEECHHHHCCEEEEEECCCCE
RIPHLLDSVLLEKNCVPYHQTECDQVGDPKSNVWKIAKDGMFGAANRPNGTVSGSFSGTS
EHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCEEECCCCCC
YKAAAKSGTAQLFNLKSNQNYDPSKISESLRDHKLMTAFAPYENPTVAVVVILENARIGV
EEHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCEEEEEEEECCEEEE
SIGSITRKIFDYVLLQ
EHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSNGHQIFHNYSAESLLFARRITIASVFVLLIIGILFIHLYQIQIIHFDMYTTRSNENR
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCE
IKIIPIPPKRGIIYDRNGIALALNRTIYQLEIVPENTIDLSHTIHELKLLLNLSDHDIEC
EEEEEECCCCCEEECCCCEEEEEECEEEEEEEECCCCCCHHHHHHHHHEEEECCCCCHHH
FEKNRKRSTQFVSLPIKIDLTEEQQARFAVNRFRFSGVTIKSYQRRYYPYGSDVTHVIGY
HHHCCCCCCEEEEEEEEEECCCHHHHHHHHHHEEECCEEHHHHHHHCCCCCCCHHHHHHH
VAKINGEDIKRLNKQGILGKYVAAPNIGKLGIERYYENILHGTPGYGAVEINNRGKVIRE
HHCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHH
LYKKSPIPGKNIVLTLDLNLQQYIIKLLVGNRSSVIVVDPRNGGIQALISHPSYNPNLFV
HHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCEEE
DGISNTEYSILLKDNNCPLLNRATQGVYPPASTVKPYISVSALTLGVINQNFLFSDPGWW
ECCCCCEEEEEEECCCCCCCHHCCCCCCCCHHCCCCCEEEEEEEEEEECCCEEECCCCCE
QLPGSEKRFRDWKRWGHGELNITKALEESSDTFFYQIAYKMGIDNLSEWMNKFGYGRYTG
ECCCCHHHHHHHHHCCCCCEEEEHHHHCCCCEEEEEEEEHHCCHHHHHHHHHHCCCCCCC
IDLFEELTGVMPTKAWKIQRFNQPWYQGDTIPVGIGQGYWTATPIQMSKALITLINDGNV
HHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEECHHHHCCEEEEEECCCCE
RIPHLLDSVLLEKNCVPYHQTECDQVGDPKSNVWKIAKDGMFGAANRPNGTVSGSFSGTS
EHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCEEECCCCCC
YKAAAKSGTAQLFNLKSNQNYDPSKISESLRDHKLMTAFAPYENPTVAVVVILENARIGV
EEHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCEEEEEEEECCEEEE
SIGSITRKIFDYVLLQ
EHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]