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The map label for this gene is mrdB [H]

Identifier: 71892089

GI number: 71892089

Start: 374085

End: 375197

Strand: Reverse

Name: mrdB [H]

Synonym: BPEN_316

Alternate gene names: 71892089

Gene position: 375197-374085 (Counterclockwise)

Preceding gene: 71892090

Following gene: 71892087

Centisome position: 47.39

GC content: 32.08

Gene sequence:

>1113_bases
ATGAGTCAAATTATTCGGAAAAATTCATTATGGAATAGGTACCATATTGATTTAACATTATTTCTATTAATTATTTGTTT
ATTATTATACGGAATTTTCATAATGTGGAGCGCGTGTGGTCAAAATTTTGAAATGATGCGACTCAAAGTGTTTCAAATTA
TAGGAGGGTTATTGTTGATGTTTTTTTTAGCACAAGTTCCACCCAGAACTTATGAATTTTGGACACCGTATATATATTTT
TTATGTCTTATATTATTAATCTCAGTCAATATGATTGGTCAAATTAGCAAAGGAGCTCAACGTTGGTTAGATTTTGGTAT
TATAAGATTTCAGCCATCAGAAATAGTTAAGATTTCTGTTTTGCTCATGGTAGCGCGTTATATTGATAGGGAGCAGCATC
CTCCATCCTTAAAAAATGTTGGTATTGTACTATTATTAATTATGATTCCTACCATATTTATGTTGTTACAACCAGATTTA
GGCACAGCAATTTTAACAGTTAGTTCTGGATTTTTTGCACTATTTTTATCTGGAATTAGCTGGAAATTAATTGTATTTAC
ATTATTACTCATGGTTTTATTTGCTCCTATATTTTGGTTTTTTTGTATGCACGATTACCAGCGATCTAGAATAGAGATTC
TATTACATCCAGAAATCGATCCGCAAGGCGCCGGGTATCATATTATTCAATCAAAAATTGCTATCGGTTCAGGTGGTTTT
ACTGGAAAAGGATGGCTACATGGGACACAATCACAGTTAGAATTTTTACCAGAACGTCATACTGACTTTATTTTTTCAGT
GATAGGAGAAGAACTAGGATTTTTTGGGATATTAATATTATTGTCGTTATATTTAGGGATTATACTGCGCGGACTCTTTA
TCGCTATCAACACGCAGCATATGTTTGGGCGATTAATTATTGGAAGTTTTATGTTAGTATTGTTTATGTATATATTCGTA
AATGTTGGTATGGTTAGCGGTCTACTACCAATAGTAGGCATTCCATTGCCATTAATAAGTTACGGTGGTTCATCTTTATT
AGTATTAATGGCAGGATTTGGCATTGTTATGTCAATAAACGGGCACAGAAAAATGATTTCTAAAATTTTATGA

Upstream 100 bases:

>100_bases
ACAAGAAAAATATTTGATTATGTCTTATTGCAATAAATAAACATTTAATTGAGTTGTTTTTTATTTATTTTGTCAATCTA
ACTAGTTATCGTAATGCATC

Downstream 100 bases:

>100_bases
ATTAGAAAACTCTATATAATATGTTATCAACGTTATTATAAATATCATTAATTTTGTGAAAAATTTAAAAATCTAAAAAA
AATACAGGTGTATACACCAC

Product: rod shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSQIIRKNSLWNRYHIDLTLFLLIICLLLYGIFIMWSACGQNFEMMRLKVFQIIGGLLLMFFLAQVPPRTYEFWTPYIYF
LCLILLISVNMIGQISKGAQRWLDFGIIRFQPSEIVKISVLLMVARYIDREQHPPSLKNVGIVLLLIMIPTIFMLLQPDL
GTAILTVSSGFFALFLSGISWKLIVFTLLLMVLFAPIFWFFCMHDYQRSRIEILLHPEIDPQGAGYHIIQSKIAIGSGGF
TGKGWLHGTQSQLEFLPERHTDFIFSVIGEELGFFGILILLSLYLGIILRGLFIAINTQHMFGRLIIGSFMLVLFMYIFV
NVGMVSGLLPIVGIPLPLISYGGSSLLVLMAGFGIVMSINGHRKMISKIL

Sequences:

>Translated_370_residues
MSQIIRKNSLWNRYHIDLTLFLLIICLLLYGIFIMWSACGQNFEMMRLKVFQIIGGLLLMFFLAQVPPRTYEFWTPYIYF
LCLILLISVNMIGQISKGAQRWLDFGIIRFQPSEIVKISVLLMVARYIDREQHPPSLKNVGIVLLLIMIPTIFMLLQPDL
GTAILTVSSGFFALFLSGISWKLIVFTLLLMVLFAPIFWFFCMHDYQRSRIEILLHPEIDPQGAGYHIIQSKIAIGSGGF
TGKGWLHGTQSQLEFLPERHTDFIFSVIGEELGFFGILILLSLYLGIILRGLFIAINTQHMFGRLIIGSFMLVLFMYIFV
NVGMVSGLLPIVGIPLPLISYGGSSLLVLMAGFGIVMSINGHRKMISKIL
>Mature_369_residues
SQIIRKNSLWNRYHIDLTLFLLIICLLLYGIFIMWSACGQNFEMMRLKVFQIIGGLLLMFFLAQVPPRTYEFWTPYIYFL
CLILLISVNMIGQISKGAQRWLDFGIIRFQPSEIVKISVLLMVARYIDREQHPPSLKNVGIVLLLIMIPTIFMLLQPDLG
TAILTVSSGFFALFLSGISWKLIVFTLLLMVLFAPIFWFFCMHDYQRSRIEILLHPEIDPQGAGYHIIQSKIAIGSGGFT
GKGWLHGTQSQLEFLPERHTDFIFSVIGEELGFFGILILLSLYLGIILRGLFIAINTQHMFGRLIIGSFMLVLFMYIFVN
VGMVSGLLPIVGIPLPLISYGGSSLLVLMAGFGIVMSINGHRKMISKIL

Specific function: This is one of the proteins responsible for the rod shape of E.coli. Is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=368, Percent_Identity=63.0434782608696, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1786277, Length=318, Percent_Identity=34.5911949685535, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 42000; Mature: 41869

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIIRKNSLWNRYHIDLTLFLLIICLLLYGIFIMWSACGQNFEMMRLKVFQIIGGLLLM
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FFLAQVPPRTYEFWTPYIYFLCLILLISVNMIGQISKGAQRWLDFGIIRFQPSEIVKISV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHH
LLMVARYIDREQHPPSLKNVGIVLLLIMIPTIFMLLQPDLGTAILTVSSGFFALFLSGIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCC
WKLIVFTLLLMVLFAPIFWFFCMHDYQRSRIEILLHPEIDPQGAGYHIIQSKIAIGSGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHEECCCCC
TGKGWLHGTQSQLEFLPERHTDFIFSVIGEELGFFGILILLSLYLGIILRGLFIAINTQH
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MFGRLIIGSFMLVLFMYIFVNVGMVSGLLPIVGIPLPLISYGGSSLLVLMAGFGIVMSIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCEEEEC
GHRKMISKIL
CHHHHHHHCC
>Mature Secondary Structure 
SQIIRKNSLWNRYHIDLTLFLLIICLLLYGIFIMWSACGQNFEMMRLKVFQIIGGLLLM
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FFLAQVPPRTYEFWTPYIYFLCLILLISVNMIGQISKGAQRWLDFGIIRFQPSEIVKISV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHH
LLMVARYIDREQHPPSLKNVGIVLLLIMIPTIFMLLQPDLGTAILTVSSGFFALFLSGIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCC
WKLIVFTLLLMVLFAPIFWFFCMHDYQRSRIEILLHPEIDPQGAGYHIIQSKIAIGSGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHEECCCCC
TGKGWLHGTQSQLEFLPERHTDFIFSVIGEELGFFGILILLSLYLGIILRGLFIAINTQH
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MFGRLIIGSFMLVLFMYIFVNVGMVSGLLPIVGIPLPLISYGGSSLLVLMAGFGIVMSIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCEEEEC
GHRKMISKIL
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]