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The map label for this gene is mutY [H]

Identifier: 71892030

GI number: 71892030

Start: 289949

End: 290998

Strand: Reverse

Name: mutY [H]

Synonym: BPEN_256

Alternate gene names: 71892030

Gene position: 290998-289949 (Counterclockwise)

Preceding gene: 71892031

Following gene: 71892029

Centisome position: 36.76

GC content: 29.71

Gene sequence:

>1050_bases
ATGGCTCAAGATATTATTTTTTCAAAAAAAATGTTACTGTGGTATCATAAATATAGAACGCAGGATTTTCCATGGCAATT
GAATAAAACAATGTATAAGACTTGGTTATCTGAAATCATGCTGCAACAAACACAAGTGAAAACTGTAATTTTTTATTATG
AACGATTTATTTCAAAATTTCCAACTATTAAACAATTGGCGACAGCAGAATTAGATGAAGTATTATTTTTATGGAGCGGA
TTAGGGTATTATGTGCGAGCTAGGAATTTACATAAAACAGCTAAAATTATTGTTAATCATTATCACGGCAATTTTCCAAA
AGATTTCGACACGCTTGTTTCTTTTCCTGGTATCGGAAAATCTACCGCAGGAGCTATATTATCGTTAACATTAGATCAGC
ATTATCCTATTCTTGATAGTAATGTAAAACGAATACTAATTAGATATTATGCTCTCGATTATTCTTTATCAAGAAATAGC
TCTGAAGTAAATAATAAACTATGGTTGTTAATTAAGCAATTACTTCCTAATATAGGAGTTGCAGATTTTAATCAAGCCAT
GATGGATCTCGGGAGATTAATATGTACTAGTACGTATCCACTTTGCAATGATTGCCCTCTTCGAGAAGGTTGTCGATCTT
TTCTAAATCACTGTGTTGATCAATATCCCAGAAAGAAACTTAAAAAAAAATTAATTAAGAAAACTATCTGGTTTTTATTG
TTATTGTCACAACAGTATCAAATGAAAATGATATGGCTCGAAAAGCGATCATATCAAGGAATATGGGGAGGATTATTTTG
TTTTCCTGAATTTTCCACCCTTAAAATATTAAATACGTGGTTGTTACACTATAATCTTCATAATAATCAACGTATGAATC
TGGATATTCTAAAACACAAATTAAGCAATATTGATTTAGAAATAAAACCAATATTGCTTAATACACATAAAAAATTAAAT
TATAAAAAAGATGGGATTTGGTATGATTTGATGCATCCTCCAGTCATTGGATTACCTAAACCAATTTCTATAATACTGCA
GAAATTGTAA

Upstream 100 bases:

>100_bases
GCAAAATTGTTTTAAATTTTTAACAATACCTTTTAATAAAAGTTTTAGTTGATTGCGTAAGCATGTGATTACATTTGATT
TTTATATAGCACAAAAACGT

Downstream 100 bases:

>100_bases
TCATAACGCAGTAAAGATATTGAATTTCCAATTCTCATACAAATGATTGTTGCAATGTGAGACTTCTAATAATGTCCAAA
ATAATTTATTGTGTTTTTTT

Product: adenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAQDIIFSKKMLLWYHKYRTQDFPWQLNKTMYKTWLSEIMLQQTQVKTVIFYYERFISKFPTIKQLATAELDEVLFLWSG
LGYYVRARNLHKTAKIIVNHYHGNFPKDFDTLVSFPGIGKSTAGAILSLTLDQHYPILDSNVKRILIRYYALDYSLSRNS
SEVNNKLWLLIKQLLPNIGVADFNQAMMDLGRLICTSTYPLCNDCPLREGCRSFLNHCVDQYPRKKLKKKLIKKTIWFLL
LLSQQYQMKMIWLEKRSYQGIWGGLFCFPEFSTLKILNTWLLHYNLHNNQRMNLDILKHKLSNIDLEIKPILLNTHKKLN
YKKDGIWYDLMHPPVIGLPKPISIILQKL

Sequences:

>Translated_349_residues
MAQDIIFSKKMLLWYHKYRTQDFPWQLNKTMYKTWLSEIMLQQTQVKTVIFYYERFISKFPTIKQLATAELDEVLFLWSG
LGYYVRARNLHKTAKIIVNHYHGNFPKDFDTLVSFPGIGKSTAGAILSLTLDQHYPILDSNVKRILIRYYALDYSLSRNS
SEVNNKLWLLIKQLLPNIGVADFNQAMMDLGRLICTSTYPLCNDCPLREGCRSFLNHCVDQYPRKKLKKKLIKKTIWFLL
LLSQQYQMKMIWLEKRSYQGIWGGLFCFPEFSTLKILNTWLLHYNLHNNQRMNLDILKHKLSNIDLEIKPILLNTHKKLN
YKKDGIWYDLMHPPVIGLPKPISIILQKL
>Mature_348_residues
AQDIIFSKKMLLWYHKYRTQDFPWQLNKTMYKTWLSEIMLQQTQVKTVIFYYERFISKFPTIKQLATAELDEVLFLWSGL
GYYVRARNLHKTAKIIVNHYHGNFPKDFDTLVSFPGIGKSTAGAILSLTLDQHYPILDSNVKRILIRYYALDYSLSRNSS
EVNNKLWLLIKQLLPNIGVADFNQAMMDLGRLICTSTYPLCNDCPLREGCRSFLNHCVDQYPRKKLKKKLIKKTIWFLLL
LSQQYQMKMIWLEKRSYQGIWGGLFCFPEFSTLKILNTWLLHYNLHNNQRMNLDILKHKLSNIDLEIKPILLNTHKKLNY
KKDGIWYDLMHPPVIGLPKPISIILQKL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=222, Percent_Identity=41.4414414414414, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI190358497, Length=222, Percent_Identity=41.4414414414414, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI115298648, Length=222, Percent_Identity=41.4414414414414, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI115298654, Length=222, Percent_Identity=41.4414414414414, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI115298652, Length=222, Percent_Identity=41.4414414414414, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI115298650, Length=222, Percent_Identity=41.4414414414414, Blast_Score=185, Evalue=5e-47,
Organism=Escherichia coli, GI1789331, Length=349, Percent_Identity=47.5644699140401, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41302; Mature: 41171

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDIIFSKKMLLWYHKYRTQDFPWQLNKTMYKTWLSEIMLQQTQVKTVIFYYERFISKF
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PTIKQLATAELDEVLFLWSGLGYYVRARNLHKTAKIIVNHYHGNFPKDFDTLVSFPGIGK
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
STAGAILSLTLDQHYPILDSNVKRILIRYYALDYSLSRNSSEVNNKLWLLIKQLLPNIGV
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
ADFNQAMMDLGRLICTSTYPLCNDCPLREGCRSFLNHCVDQYPRKKLKKKLIKKTIWFLL
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSQQYQMKMIWLEKRSYQGIWGGLFCFPEFSTLKILNTWLLHYNLHNNQRMNLDILKHK
HHHCHHHEEEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHH
LSNIDLEIKPILLNTHKKLNYKKDGIWYDLMHPPVIGLPKPISIILQKL
HHCCCEEEEEEEEECCHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
AQDIIFSKKMLLWYHKYRTQDFPWQLNKTMYKTWLSEIMLQQTQVKTVIFYYERFISKF
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PTIKQLATAELDEVLFLWSGLGYYVRARNLHKTAKIIVNHYHGNFPKDFDTLVSFPGIGK
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
STAGAILSLTLDQHYPILDSNVKRILIRYYALDYSLSRNSSEVNNKLWLLIKQLLPNIGV
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
ADFNQAMMDLGRLICTSTYPLCNDCPLREGCRSFLNHCVDQYPRKKLKKKLIKKTIWFLL
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSQQYQMKMIWLEKRSYQGIWGGLFCFPEFSTLKILNTWLLHYNLHNNQRMNLDILKHK
HHHCHHHEEEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHH
LSNIDLEIKPILLNTHKKLNYKKDGIWYDLMHPPVIGLPKPISIILQKL
HHCCCEEEEEEEEECCHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]