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The map label for this gene is cyoE

Identifier: 71892022

GI number: 71892022

Start: 280494

End: 281378

Strand: Reverse

Name: cyoE

Synonym: BPEN_248

Alternate gene names: 71892022

Gene position: 281378-280494 (Counterclockwise)

Preceding gene: 71892023

Following gene: 71892021

Centisome position: 35.54

GC content: 28.02

Gene sequence:

>885_bases
ATGATTAAATATTATTTATACTTAACAAAACCAGGAATTGTTTTAGGTAATTTAATGTCATCTGCAGGAGGATTTTTAAT
CGCATCGCGAGGTGCTATATCTTATTCTTTATTTATCACAATGATTGTAGGAACAGCCTTAGTAATAGCTTCTGGCTGTG
TGTTAAATAACATTATTGATCGAGATATTGATGCAGTTATGGAAAGAACTAAACATAGAGTCTTGGTGCAACACGGTCAA
ATTTTTTTAAATCAAAGTATCTTTTATGCAGTAATATTAAGTATATTTGGATTTTTGTTTTTAAGTTTTACTAAGAATGT
TTTGACAATATATTTATCGGCAATAGGTTTATTTATATATGTCGGTGTGTATAGTTTATGGATGAAACGTAGATCTATTT
ATAGTATAATGGTGGGTAGTATATCAGGAGCGATGCCGCCAGTCATTGGATATTGTGCTGCTGCAAATCAATTTGATGCA
GGGGCTTTGATGTTATTAATAATTTTTAGTTTATGGCAAATCCCACATTCTCATTCCATTGCTATTTTACGATTAAATGA
TTATAAAGTAGCTTTTATTCCAACTTTCCCTATTAAAAAGGGAGTGGAGTCAACTAAGAATCATATGGTTGTTTATATAA
TTGGATTTATTATAGCAACTATATTATTTACTGTTATGGGGTACACTAGTTATATATTTTTAATAATAATTAGCATTATG
AATTTATGGTGGTTACATATGGGATTTTATGGTTATAGAATAATTAATCACGATAGTTTGTGGGCAAAAAAAATGTTTTT
ATTATCTCTTATCATTATAATATCATTAAATTTGCTTTTATCCTTAGATCATATTTTATTCTCTACAAAAAATATATTAC
TGTAA

Upstream 100 bases:

>100_bases
TTCACAATATTTATTGTTTTTATCCTTGTGTTAGGAAGTGTATGGATTATGACACATTTACATCATAATTTGATGATTTA
AATAAGATAGTTTAATTGTT

Downstream 100 bases:

>100_bases
TTATGACATATGCAAAATATTATTAATTTAAATGAATAAATAATATAATATTTCTCAATATTTATAAAATTTTTATTTTG
AATATTTCATATAATATATT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MIKYYLYLTKPGIVLGNLMSSAGGFLIASRGAISYSLFITMIVGTALVIASGCVLNNIIDRDIDAVMERTKHRVLVQHGQ
IFLNQSIFYAVILSIFGFLFLSFTKNVLTIYLSAIGLFIYVGVYSLWMKRRSIYSIMVGSISGAMPPVIGYCAAANQFDA
GALMLLIIFSLWQIPHSHSIAILRLNDYKVAFIPTFPIKKGVESTKNHMVVYIIGFIIATILFTVMGYTSYIFLIIISIM
NLWWLHMGFYGYRIINHDSLWAKKMFLLSLIIIISLNLLLSLDHILFSTKNILL

Sequences:

>Translated_294_residues
MIKYYLYLTKPGIVLGNLMSSAGGFLIASRGAISYSLFITMIVGTALVIASGCVLNNIIDRDIDAVMERTKHRVLVQHGQ
IFLNQSIFYAVILSIFGFLFLSFTKNVLTIYLSAIGLFIYVGVYSLWMKRRSIYSIMVGSISGAMPPVIGYCAAANQFDA
GALMLLIIFSLWQIPHSHSIAILRLNDYKVAFIPTFPIKKGVESTKNHMVVYIIGFIIATILFTVMGYTSYIFLIIISIM
NLWWLHMGFYGYRIINHDSLWAKKMFLLSLIIIISLNLLLSLDHILFSTKNILL
>Mature_294_residues
MIKYYLYLTKPGIVLGNLMSSAGGFLIASRGAISYSLFITMIVGTALVIASGCVLNNIIDRDIDAVMERTKHRVLVQHGQ
IFLNQSIFYAVILSIFGFLFLSFTKNVLTIYLSAIGLFIYVGVYSLWMKRRSIYSIMVGSISGAMPPVIGYCAAANQFDA
GALMLLIIFSLWQIPHSHSIAILRLNDYKVAFIPTFPIKKGVESTKNHMVVYIIGFIIATILFTVMGYTSYIFLIIISIM
NLWWLHMGFYGYRIINHDSLWAKKMFLLSLIIIISLNLLLSLDHILFSTKNILL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=169, Percent_Identity=34.3195266272189, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786631, Length=293, Percent_Identity=50.8532423208191, Blast_Score=311, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71998235, Length=187, Percent_Identity=34.7593582887701, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=187, Percent_Identity=28.3422459893048, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921064, Length=258, Percent_Identity=30.6201550387597, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_BLOPB (Q493G3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277752.1
- STRING:   Q493G3
- GeneID:   3562797
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_248
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- ProtClustDB:   PRK04375
- BioCyc:   CBLO291272:BPEN_248-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33110; Mature: 33110

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x106dcb1c)-; HASH(0x1198ba60)-; HASH(0x11989880)-; HASH(0x11989694)-; HASH(0x10c7ed2c)-; HASH(0x11684094)-; HASH(0x11978dd8)-; HASH(0x117c9ef0)-; HASH(0x1198b9c4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKYYLYLTKPGIVLGNLMSSAGGFLIASRGAISYSLFITMIVGTALVIASGCVLNNIID
CEEEEEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDIDAVMERTKHRVLVQHGQIFLNQSIFYAVILSIFGFLFLSFTKNVLTIYLSAIGLFIY
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVYSLWMKRRSIYSIMVGSISGAMPPVIGYCAAANQFDAGALMLLIIFSLWQIPHSHSI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
AILRLNDYKVAFIPTFPIKKGVESTKNHMVVYIIGFIIATILFTVMGYTSYIFLIIISIM
EEEEECCEEEEEEECCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLWWLHMGFYGYRIINHDSLWAKKMFLLSLIIIISLNLLLSLDHILFSTKNILL
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MIKYYLYLTKPGIVLGNLMSSAGGFLIASRGAISYSLFITMIVGTALVIASGCVLNNIID
CEEEEEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDIDAVMERTKHRVLVQHGQIFLNQSIFYAVILSIFGFLFLSFTKNVLTIYLSAIGLFIY
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVYSLWMKRRSIYSIMVGSISGAMPPVIGYCAAANQFDAGALMLLIIFSLWQIPHSHSI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
AILRLNDYKVAFIPTFPIKKGVESTKNHMVVYIIGFIIATILFTVMGYTSYIFLIIISIM
EEEEECCEEEEEEECCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLWWLHMGFYGYRIINHDSLWAKKMFLLSLIIIISLNLLLSLDHILFSTKNILL
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA