Click here to switch to the map view.

The map label for this gene is pyrD1 [H]

Identifier: 68536036

GI number: 68536036

Start: 1135423

End: 1136532

Strand: Direct

Name: pyrD1 [H]

Synonym: jk0959

Alternate gene names: 68536036

Gene position: 1135423-1136532 (Clockwise)

Preceding gene: 68536035

Following gene: 68536038

Centisome position: 46.11

GC content: 66.31

Gene sequence:

>1110_bases
ATGCTGAAGAAGTTTCGCCACGGCGCCTATCAGATGGCGCTGAAGGGGATGTTTACCCTGCGCCCAGAGCGCATCCACGG
ACTAATGTCCCGCGGCTTGCAGCAGGTGGCGGGATCCAGGGCTGCCCTCTCCGCTATGGATGGCGCGCTGGCCGTGCACG
ATGAGGCGCTGAGCCAGCAGATCGCCGGGATCACCTTCCCGCGTCCGCTCGGCCTAGCCGCGGGATTCGACAAGGACGCC
AAAGAGGTCGACGCCTGGGGCCCGCTAGGATTCGGTTTCGCAGAGATCGGCACCGTCACAGCCCTGGCGCAGCCGGGCAA
CCCCACCCCGCGACTGTTCCGCCTGCCGCAGGATAAGGCGATCCTCAACCGCATGGGCTTCAACAATGAGGGGTCGCGCG
CGGCGGCGATGCGCCTGGAGAAGCGCAGCACGGACATTCCGGTGGGCGCGAACCTCGGTAAGTCCAAGCTGGTGGCCGCC
GAGATTGCGGACCGCGACTACCGAGAGTCCGCCAAGGCCATCGGCGGGGTGGCCGACTACCTGGTTATCAACGTCTCCTC
CCCCAACACCCCGGGGTTGCGTGACCTGCAGGCCGTGGAATCCCTGCGTCCGATCATCCGCGCGGTGCAGGAAGAAAGTG
CCCGTCCGCTGTTTGTGAAGATCGCCCCGGACCTGAGCGACGAGGATATCGACAAGGTCTGCGACCTGGCCATCGAGATG
GGGGTTACGGGCTTGATCGCCACGAACACCACCATCAGTCGCGAAGGCCTGAAGACCCCGGCCCACGAGGTGAAGGCAAT
GGGTGCGGGCGGCATTTCAGGCGCCCCGGTGGCAGCCCGTGCGCTGGAGGTGCTGCGTCGCCTAGCGGGCCGTGCTGACG
GGAAGCTAGTTCTGATTGGCGTGGGCGGCATCGACTCCCCGCAAGCGGCGTGGGAGCGCATCGCCGCCGGCGCCAGCTTG
ATCCAGGGCTACACGCCGTTCATCTACGGCGGCCCGGACTGGATCCGCGAGATCCACCAAGGCTTGGCCGCACAGCTGAA
GGCCCACGGCCTGGAGAATATCTCGCAGGCCGTGGGCAGCGGGTTGCCGTGGGTGGAGGCTAAAAACTAG

Upstream 100 bases:

>100_bases
AATGTGTACAGCGCACAGAGTGTGGATGACGCGGTGAAGGATAAGCAGACGACGCCGGATGAAGAGTATCCGGTGAAGAA
GGGATAAAAGGGGATCAGAA

Downstream 100 bases:

>100_bases
TTTTCTGCCCATCCCCAGATGATGCCGCGGGCGGTCGCCTTGAAGTTCAGGTTAAAGCCCAGGACGGTCGGGGTTTGGCG
GTCATCGATGTCCAGCTCCT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLKKFRHGAYQMALKGMFTLRPERIHGLMSRGLQQVAGSRAALSAMDGALAVHDEALSQQIAGITFPRPLGLAAGFDKDA
KEVDAWGPLGFGFAEIGTVTALAQPGNPTPRLFRLPQDKAILNRMGFNNEGSRAAAMRLEKRSTDIPVGANLGKSKLVAA
EIADRDYRESAKAIGGVADYLVINVSSPNTPGLRDLQAVESLRPIIRAVQEESARPLFVKIAPDLSDEDIDKVCDLAIEM
GVTGLIATNTTISREGLKTPAHEVKAMGAGGISGAPVAARALEVLRRLAGRADGKLVLIGVGGIDSPQAAWERIAAGASL
IQGYTPFIYGGPDWIREIHQGLAAQLKAHGLENISQAVGSGLPWVEAKN

Sequences:

>Translated_369_residues
MLKKFRHGAYQMALKGMFTLRPERIHGLMSRGLQQVAGSRAALSAMDGALAVHDEALSQQIAGITFPRPLGLAAGFDKDA
KEVDAWGPLGFGFAEIGTVTALAQPGNPTPRLFRLPQDKAILNRMGFNNEGSRAAAMRLEKRSTDIPVGANLGKSKLVAA
EIADRDYRESAKAIGGVADYLVINVSSPNTPGLRDLQAVESLRPIIRAVQEESARPLFVKIAPDLSDEDIDKVCDLAIEM
GVTGLIATNTTISREGLKTPAHEVKAMGAGGISGAPVAARALEVLRRLAGRADGKLVLIGVGGIDSPQAAWERIAAGASL
IQGYTPFIYGGPDWIREIHQGLAAQLKAHGLENISQAVGSGLPWVEAKN
>Mature_369_residues
MLKKFRHGAYQMALKGMFTLRPERIHGLMSRGLQQVAGSRAALSAMDGALAVHDEALSQQIAGITFPRPLGLAAGFDKDA
KEVDAWGPLGFGFAEIGTVTALAQPGNPTPRLFRLPQDKAILNRMGFNNEGSRAAAMRLEKRSTDIPVGANLGKSKLVAA
EIADRDYRESAKAIGGVADYLVINVSSPNTPGLRDLQAVESLRPIIRAVQEESARPLFVKIAPDLSDEDIDKVCDLAIEM
GVTGLIATNTTISREGLKTPAHEVKAMGAGGISGAPVAARALEVLRRLAGRADGKLVLIGVGGIDSPQAAWERIAAGASL
IQGYTPFIYGGPDWIREIHQGLAAQLKAHGLENISQAVGSGLPWVEAKN

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=323, Percent_Identity=41.4860681114551, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI119943098, Length=320, Percent_Identity=25.9375, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787177, Length=341, Percent_Identity=41.9354838709677, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17509475, Length=320, Percent_Identity=37.5, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322633, Length=322, Percent_Identity=23.6024844720497, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281361352, Length=321, Percent_Identity=42.6791277258567, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17137316, Length=321, Percent_Identity=42.6791277258567, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39060; Mature: 39060

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKFRHGAYQMALKGMFTLRPERIHGLMSRGLQQVAGSRAALSAMDGALAVHDEALSQQ
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHH
IAGITFPRPLGLAAGFDKDAKEVDAWGPLGFGFAEIGTVTALAQPGNPTPRLFRLPQDKA
HHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHEECCCCCCCCCEEECCCHHH
ILNRMGFNNEGSRAAAMRLEKRSTDIPVGANLGKSKLVAAEIADRDYRESAKAIGGVADY
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEE
LVINVSSPNTPGLRDLQAVESLRPIIRAVQEESARPLFVKIAPDLSDEDIDKVCDLAIEM
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
GVTGLIATNTTISREGLKTPAHEVKAMGAGGISGAPVAARALEVLRRLAGRADGKLVLIG
CCCEEEEECCEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
VGGIDSPQAAWERIAAGASLIQGYTPFIYGGPDWIREIHQGLAAQLKAHGLENISQAVGS
CCCCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
GLPWVEAKN
CCCCEECCC
>Mature Secondary Structure
MLKKFRHGAYQMALKGMFTLRPERIHGLMSRGLQQVAGSRAALSAMDGALAVHDEALSQQ
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHH
IAGITFPRPLGLAAGFDKDAKEVDAWGPLGFGFAEIGTVTALAQPGNPTPRLFRLPQDKA
HHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHEECCCCCCCCCEEECCCHHH
ILNRMGFNNEGSRAAAMRLEKRSTDIPVGANLGKSKLVAAEIADRDYRESAKAIGGVADY
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCEEE
LVINVSSPNTPGLRDLQAVESLRPIIRAVQEESARPLFVKIAPDLSDEDIDKVCDLAIEM
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
GVTGLIATNTTISREGLKTPAHEVKAMGAGGISGAPVAARALEVLRRLAGRADGKLVLIG
CCCEEEEECCEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
VGGIDSPQAAWERIAAGASLIQGYTPFIYGGPDWIREIHQGLAAQLKAHGLENISQAVGS
CCCCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
GLPWVEAKN
CCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA