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The map label for this gene is pyrG

Identifier: 68535948

GI number: 68535948

Start: 1041131

End: 1042798

Strand: Direct

Name: pyrG

Synonym: jk0871

Alternate gene names: 68535948

Gene position: 1041131-1042798 (Clockwise)

Preceding gene: 68535947

Following gene: 68535949

Centisome position: 42.28

GC content: 62.41

Gene sequence:

>1668_bases
TTGGCCACTAATCGTGCAAAGAGCAGCACTAAATACATCTTCGTCACCGGTGGTGTGGCGTCCTCGCTGGGCAAGGGGCT
CACGGCAGCAAGCCTAGGGCAGCTGCTTTCCTCCCGTGGCCTGCGGGTAACCATGCAAAAGCTGGATCCGTACCTCAACG
TTGATCCGGGCACCATGAACCCCTTCGAGCACGGTGAAGTGTTCGTTACCGAGGACGGTGCGGAGACTGACCTGGATCTA
GGCCACTACGAGCGTTTCCTGGACCGCAACCTCTCCGCCGCTGGCAACGTCACCACCGGCAAGGTGTACTCCAATGTCAT
CGCCAAGGAGCGCCGCGGTGAGTTCCTGGGCAAGACCGTCCAGGTGATCCCTCACATCACTGACGAGATTAAGTCGGCCG
TGTTGGCGATGGGCCAGCCGGATAAGAACGGCCAGGCCCCGGACGTCGTCATTAGCGAGATCGGCGGCACCGTCGGCGAC
ATTGAATCCCAGCCCTTCCTAGAGGCCATCCGCCAGGTCCGCCACGAGGCAGGCCGCGAGAACATTGCCTTCATTCACGT
TTCTCTGGTGCCTTACCTGGCGCCGTCGGGCGAGTTGAAGACTAAGCCGACCCAGCACTCCGTAGCGGAACTGCGCAGCA
TCGGTATCGTCCCGGACGCGATTGTTTTGCGCGCCGACCGTGAGGTCCCGCAGGCTATGAAGTCCAAGATCGCCCTGATG
TGCGACGTGGACGAGGATGGCGTGGTTTCCTGCCCGGATGCGCCTTCCATTTACGACATCCCGAAGGTGCTGCACTCCCA
GCACTTGGATAATTACATCATCCGCCGCCTGAACCTGCCGTTCCGCGACGTGGACTGGACAACCTGGGGCAACCTGTTGG
AGAGCGTCCACAACCCGCAGGGTGAAGTCACCATCGGCATCGTCGGCAAGTACATCGATCTGCCGGATGCTTACCTCTCC
GTCGCGGAAGCGATCCGCGCGGGCGGTTTCGGAGCGAACGTGCGCGCCAACGTGAAGTGGGTCGCCTCCGATGAGTGCGA
GACCGAAAAGGGCGCTGCCGAGGCTCTGAAGGACGTTGACGGTGTAGTCATCCCCGGTGGTTTTGGCAACCGCGGCATCG
AAGGCAAGATTGGCGCCATCACCTACGCGCGTAAGAACAAGCTTCCGCTGCTGGGCATTTGCTTGGGCCTGCAGTGCATC
GTTATCGAGGCCGCGCGCACCGCAGGGCTCACCGATGCTTCCTCTACTGAGTTTGACGCCAACGCCTCCACCCCGGTGAT
CTCCACCATGGAGGAACAGAAGGCAGCTGTGTCGGGCGAGGCGGACCTGGGCGGAACTATGCGTCTGGGCGCTTACCCAG
CGCGCCTGGCTGAAGGCTCCCTGGTCGCTGAGATGTACGGTGCTACCGACGTGTCGGAGCGCCACCGTCACCGCTACGAG
GTGAACAACGCGTACCGCGAGCAGATCACCGAGGGCTCCGGCCTGCAGTTCTCCGGCACCTCTCCGGACGGCACCTTGGT
TGAGTTCGTGGAGTACCCGAAGGACGTACACCCGTACTTCGTGGCCACCCAGGCCCACCCGGAGTACAAGTCCCGCCCGA
CCCGTTCCCACCCGCTGTTCCAGGGACTGGTGGACGCTGCGCTGAAGCACCAGGCTGGGCGCTCCTAA

Upstream 100 bases:

>100_bases
CGCCGCCGCGAACGCGTCGAATGCTACGCCTGAGTAGGCTTGTGTTAGGCTGAAACCCCGTAGATAGCGAAGTTCAAGCG
TCGTTGATTCGGGAGTTACC

Downstream 100 bases:

>100_bases
TTCAGCGCGCCTAGGCTTCCACTCCTAAACTGGGGAGTCATGAGCAACGACAGCACCCCGTACCGCGTTGTAGATAGCGA
ACTGCTGCTGGACGCGCCGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MATNRAKSSTKYIFVTGGVASSLGKGLTAASLGQLLSSRGLRVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDL
GHYERFLDRNLSAAGNVTTGKVYSNVIAKERRGEFLGKTVQVIPHITDEIKSAVLAMGQPDKNGQAPDVVISEIGGTVGD
IESQPFLEAIRQVRHEAGRENIAFIHVSLVPYLAPSGELKTKPTQHSVAELRSIGIVPDAIVLRADREVPQAMKSKIALM
CDVDEDGVVSCPDAPSIYDIPKVLHSQHLDNYIIRRLNLPFRDVDWTTWGNLLESVHNPQGEVTIGIVGKYIDLPDAYLS
VAEAIRAGGFGANVRANVKWVASDECETEKGAAEALKDVDGVVIPGGFGNRGIEGKIGAITYARKNKLPLLGICLGLQCI
VIEAARTAGLTDASSTEFDANASTPVISTMEEQKAAVSGEADLGGTMRLGAYPARLAEGSLVAEMYGATDVSERHRHRYE
VNNAYREQITEGSGLQFSGTSPDGTLVEFVEYPKDVHPYFVATQAHPEYKSRPTRSHPLFQGLVDAALKHQAGRS

Sequences:

>Translated_555_residues
MATNRAKSSTKYIFVTGGVASSLGKGLTAASLGQLLSSRGLRVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDL
GHYERFLDRNLSAAGNVTTGKVYSNVIAKERRGEFLGKTVQVIPHITDEIKSAVLAMGQPDKNGQAPDVVISEIGGTVGD
IESQPFLEAIRQVRHEAGRENIAFIHVSLVPYLAPSGELKTKPTQHSVAELRSIGIVPDAIVLRADREVPQAMKSKIALM
CDVDEDGVVSCPDAPSIYDIPKVLHSQHLDNYIIRRLNLPFRDVDWTTWGNLLESVHNPQGEVTIGIVGKYIDLPDAYLS
VAEAIRAGGFGANVRANVKWVASDECETEKGAAEALKDVDGVVIPGGFGNRGIEGKIGAITYARKNKLPLLGICLGLQCI
VIEAARTAGLTDASSTEFDANASTPVISTMEEQKAAVSGEADLGGTMRLGAYPARLAEGSLVAEMYGATDVSERHRHRYE
VNNAYREQITEGSGLQFSGTSPDGTLVEFVEYPKDVHPYFVATQAHPEYKSRPTRSHPLFQGLVDAALKHQAGRS
>Mature_554_residues
ATNRAKSSTKYIFVTGGVASSLGKGLTAASLGQLLSSRGLRVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDLG
HYERFLDRNLSAAGNVTTGKVYSNVIAKERRGEFLGKTVQVIPHITDEIKSAVLAMGQPDKNGQAPDVVISEIGGTVGDI
ESQPFLEAIRQVRHEAGRENIAFIHVSLVPYLAPSGELKTKPTQHSVAELRSIGIVPDAIVLRADREVPQAMKSKIALMC
DVDEDGVVSCPDAPSIYDIPKVLHSQHLDNYIIRRLNLPFRDVDWTTWGNLLESVHNPQGEVTIGIVGKYIDLPDAYLSV
AEAIRAGGFGANVRANVKWVASDECETEKGAAEALKDVDGVVIPGGFGNRGIEGKIGAITYARKNKLPLLGICLGLQCIV
IEAARTAGLTDASSTEFDANASTPVISTMEEQKAAVSGEADLGGTMRLGAYPARLAEGSLVAEMYGATDVSERHRHRYEV
NNAYREQITEGSGLQFSGTSPDGTLVEFVEYPKDVHPYFVATQAHPEYKSRPTRSHPLFQGLVDAALKHQAGRS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI28559085, Length=554, Percent_Identity=46.028880866426, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI28559083, Length=554, Percent_Identity=46.028880866426, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI221316689, Length=554, Percent_Identity=46.028880866426, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI148491070, Length=555, Percent_Identity=44.6846846846847, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1789142, Length=550, Percent_Identity=54.5454545454545, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25148299, Length=610, Percent_Identity=38.1967213114754, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=570, Percent_Identity=44.2105263157895, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=43.4094903339192, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24664469, Length=555, Percent_Identity=46.6666666666667, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21357815, Length=500, Percent_Identity=45, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CORJK (Q4JVX2)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250653.1
- HSSP:   P17812
- ProteinModelPortal:   Q4JVX2
- SMR:   Q4JVX2
- STRING:   Q4JVX2
- GeneID:   3431919
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0871
- NMPDR:   fig|306537.3.peg.11
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   CJEI306537:JK0871-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59818; Mature: 59687

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 394-394 ACT_SITE 526-526 ACT_SITE 528-528

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNRAKSSTKYIFVTGGVASSLGKGLTAASLGQLLSSRGLRVTMQKLDPYLNVDPGTMN
CCCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCEEEHHHCCCCEECCCCCCC
PFEHGEVFVTEDGAETDLDLGHYERFLDRNLSAAGNVTTGKVYSNVIAKERRGEFLGKTV
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVIPHITDEIKSAVLAMGQPDKNGQAPDVVISEIGGTVGDIESQPFLEAIRQVRHEAGRE
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
NIAFIHVSLVPYLAPSGELKTKPTQHSVAELRSIGIVPDAIVLRADREVPQAMKSKIALM
CEEEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCEEEE
CDVDEDGVVSCPDAPSIYDIPKVLHSQHLDNYIIRRLNLPFRDVDWTTWGNLLESVHNPQ
EECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
GEVTIGIVGKYIDLPDAYLSVAEAIRAGGFGANVRANVKWVASDECETEKGAAEALKDVD
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCC
GVVIPGGFGNRGIEGKIGAITYARKNKLPLLGICLGLQCIVIEAARTAGLTDASSTEFDA
CEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCHHEEEEHHHHCCCCCCCCCCCCC
NASTPVISTMEEQKAAVSGEADLGGTMRLGAYPARLAEGSLVAEMYGATDVSERHRHRYE
CCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCCHHHHHHCCCCHHHHHHHHHH
VNNAYREQITEGSGLQFSGTSPDGTLVEFVEYPKDVHPYFVATQAHPEYKSRPTRSHPLF
HHHHHHHHHCCCCCEEECCCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHCCCCCCCHHH
QGLVDAALKHQAGRS
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATNRAKSSTKYIFVTGGVASSLGKGLTAASLGQLLSSRGLRVTMQKLDPYLNVDPGTMN
CCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCEEEHHHCCCCEECCCCCCC
PFEHGEVFVTEDGAETDLDLGHYERFLDRNLSAAGNVTTGKVYSNVIAKERRGEFLGKTV
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QVIPHITDEIKSAVLAMGQPDKNGQAPDVVISEIGGTVGDIESQPFLEAIRQVRHEAGRE
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
NIAFIHVSLVPYLAPSGELKTKPTQHSVAELRSIGIVPDAIVLRADREVPQAMKSKIALM
CEEEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHCCEEEE
CDVDEDGVVSCPDAPSIYDIPKVLHSQHLDNYIIRRLNLPFRDVDWTTWGNLLESVHNPQ
EECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
GEVTIGIVGKYIDLPDAYLSVAEAIRAGGFGANVRANVKWVASDECETEKGAAEALKDVD
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCC
GVVIPGGFGNRGIEGKIGAITYARKNKLPLLGICLGLQCIVIEAARTAGLTDASSTEFDA
CEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCHHEEEEHHHHCCCCCCCCCCCCC
NASTPVISTMEEQKAAVSGEADLGGTMRLGAYPARLAEGSLVAEMYGATDVSERHRHRYE
CCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCCHHHHHHCCCCHHHHHHHHHH
VNNAYREQITEGSGLQFSGTSPDGTLVEFVEYPKDVHPYFVATQAHPEYKSRPTRSHPLF
HHHHHHHHHCCCCCEEECCCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHCCCCCCCHHH
QGLVDAALKHQAGRS
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA