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The map label for this gene is hisI

Identifier: 68535869

GI number: 68535869

Start: 947675

End: 948058

Strand: Direct

Name: hisI

Synonym: jk0794

Alternate gene names: 68535869

Gene position: 947675-948058 (Clockwise)

Preceding gene: 68535868

Following gene: 68535870

Centisome position: 38.48

GC content: 63.02

Gene sequence:

>384_bases
GTGAGCAACACAGACTCCAAGACAGGCCCCAACACAGACCCGGCAACCTGCGAGCTAGACCCCGCCATCGCCGAACGCGT
CCGCTTCAACGCTGACGGCTTAGTCCCCGCCATCGTCCAAGACATCACCAACGGCGACGTGCTGATGATGGCGTGGATGA
ACGATCACGCCCTGGCCCACACTCTGGCCACCAAGAAGGGCACCTACTGGTCCCGGTCGCGCCAGTCCTACTGGATCAAG
GGCGAGACCAGCGGCCATACCCAGCGCGTCGAAGAGGTGCGTCTGGACTGCGACGGCGATACGGTGCTGCTGAAGATTGA
GCAGACTGGCGCGGCTTGCCACACCGGCAACCGCACTTGTTTTGACGCCGACCGCTTGGCCTAA

Upstream 100 bases:

>100_bases
GCGCGGATGCCGTGCTGGCGGCCTCCATCTTCCACTTCGGCGAGGTCGAGATCCGCGAGGTCAAGCAGGCTCTGGCCGAT
GCGGGCTACGAGGTACGACT

Downstream 100 bases:

>100_bases
CATGTCAGACATGGGTGACAACACTTCCAGCAAGTCCATCGGCGACCTGACAAGCCTTGAGACCTTCCGCGAACTCGCGG
CAAAGCACCGCGTGGTGCCC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MSNTDSKTGPNTDPATCELDPAIAERVRFNADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIK
GETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADRLA

Sequences:

>Translated_127_residues
MSNTDSKTGPNTDPATCELDPAIAERVRFNADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIK
GETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADRLA
>Mature_126_residues
SNTDSKTGPNTDPATCELDPAIAERVRFNADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIKG
ETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADRLA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=46.6666666666667, Blast_Score=92, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=35.1648351648352, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_CORJK (Q4JW51)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250574.1
- ProteinModelPortal:   Q4JW51
- SMR:   Q4JW51
- STRING:   Q4JW51
- GeneID:   3433184
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0794
- NMPDR:   fig|306537.3.peg.1767
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   CJEI306537:JK0794-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13969; Mature: 13837

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTDSKTGPNTDPATCELDPAIAERVRFNADGLVPAIVQDITNGDVLMMAWMNDHALAH
CCCCCCCCCCCCCCCEEEECHHHHHHEECCCCCCHHHHHHHCCCCCEEEEEECCCCHHHH
TLATKKGTYWSRSRQSYWIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTC
HHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHEEECCCCCEEEEEEECCCCEEECCCCCC
FDADRLA
CCCCCCC
>Mature Secondary Structure 
SNTDSKTGPNTDPATCELDPAIAERVRFNADGLVPAIVQDITNGDVLMMAWMNDHALAH
CCCCCCCCCCCCCCEEEECHHHHHHEECCCCCCHHHHHHHCCCCCEEEEEECCCCHHHH
TLATKKGTYWSRSRQSYWIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTC
HHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHEEECCCCCEEEEEEECCCCEEECCCCCC
FDADRLA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA