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The map label for this gene is trpE [H]

Identifier: 68535870

GI number: 68535870

Start: 948060

End: 949631

Strand: Direct

Name: trpE [H]

Synonym: jk0795

Alternate gene names: 68535870

Gene position: 948060-949631 (Clockwise)

Preceding gene: 68535869

Following gene: 68535871

Centisome position: 38.5

GC content: 64.69

Gene sequence:

>1572_bases
ATGTCAGACATGGGTGACAACACTTCCAGCAAGTCCATCGGCGACCTGACAAGCCTTGAGACCTTCCGCGAACTCGCGGC
AAAGCACCGCGTGGTGCCCGTAGTTCGCAAGGTCCTCGCCGACGGAGAGACCGCCCTGTCCGCCTACCGGAAACTCGCCG
ACGGCCGCCCCGGCACGTTCCTGCTGGAATCGGCGGCGCACGGCCAGTCGTGGGATCGCTACTCCTTCATCGGCACCGGA
GCCCGCTGCGCCCTGACGGCCAAGGACAGCGTGGACGGCGGCGCGGCACGCTGGATCGGCCAGCCTCCGGTGGACATCCC
GGCAGGCACCGACCCGCTGGATGCAATCCGCAACACGCTGGAACACCTGCAGACCGCGCCGATGCCAGGGCTGCCGCCGC
TGACCAGCGGCCTGGTTGGCTACATGGGCTACGACATGATCCGCTACATCGAATCCGTGCCGGATACCTGCACCGACGAC
CTGAACATTCCCGACATGGTGCAGCTGTTGGTGGAAGACATGGCCGTCGTCGACCACTACGAGGGCACCATCTGGCTGAT
CGCCAGCGTGATCAACTGGGATAACTCCGACGAGCGGGTGGACGAGGCATACGCCGAGGCAGTGGACCGGCTAGACACCA
TGGTGGAACGGCTGGCCGCGGGCGCGGCAGGGGGCGTCACTACCTTTGCAACCCCCACGCCTAAGTACCGTAGGCAGCGC
ACCTACGACGACCACCGCGAGCGCATCGGCAAGGTCAAGGAGCACATCAAGGCCGGCGATGCGTTCCAGGTGGTGCTCTC
GCAGCGCTTCGAAATGGAGACCGACGTCGACCCGATCGACATCTATCGCATGCTGCGGGTATCGAACCCTTCGCCCTACA
TGTTCCTGGTTAACGTGCCTACCGAGGGTTTTGACGCCACCGCGTTCCACATCATTGGCTCCTCCCCGGAATCACTGGTG
CAGGTCCGTGACGGCAATGTCACGACGTTCCCCATCGCGGGATCCAGGCCGCGCGGAGAGACGGTGGAACAGGACTTCGC
CTTCGAACGCGAGCTGGTCAACGACGAGAAGGAAAACTCCGAACACCTGATGCTGGTGGACCTGGGGCGCAACGACCTCG
GAAGAGTCAGCGAGCCCGGCACGGTGGAGGTGCACGACTTCCGCCACGTGGAGCGCTACTCGGCGGTGATGCACCTGGTA
TCCGGTGTCAGCGGCAAGCTGGCCGCGGGGAAGACGGCAGTGGATGCGTTCAACGCTACGTTCCCGGCCGGAACCCTGTC
GGGCGCGCCGAAACCCTCGGCACTGAAGATCATCGACACGCTGGAGGACACACGCCGCGGAGTCTACGGCGGCACAGTCG
GCTACTTCGACTTTTCCGGCAACACCGACCAGTCCATTGCCATCCGCACCGGGCTGTACAAGGACGGCACCGTGTACGTC
CAGGCCGGTGGCGGAATCGTCGCGGACTCCGACCCGGAGGCTGAAGACCTGGAGACCCGCAACAAGGCCGCGGCAGTGCT
GCGGGCAGTAGCTGCGGCGGAAACCATGAAGAACGCAGGGGAGAAGCAGTGA

Upstream 100 bases:

>100_bases
GACTGCGACGGCGATACGGTGCTGCTGAAGATTGAGCAGACTGGCGCGGCTTGCCACACCGGCAACCGCACTTGTTTTGA
CGCCGACCGCTTGGCCTAAC

Downstream 100 bases:

>100_bases
GCAAGAGCACGGCGAGCGCAGCGAACGCAGTGAGCGCGGAAGAGGACGTAACAGCGGACGCAACCCAAAAGGCCAAGCGC
ATCCGACAGATCGCGCTGCT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSDMGDNTSSKSIGDLTSLETFRELAAKHRVVPVVRKVLADGETALSAYRKLADGRPGTFLLESAAHGQSWDRYSFIGTG
ARCALTAKDSVDGGAARWIGQPPVDIPAGTDPLDAIRNTLEHLQTAPMPGLPPLTSGLVGYMGYDMIRYIESVPDTCTDD
LNIPDMVQLLVEDMAVVDHYEGTIWLIASVINWDNSDERVDEAYAEAVDRLDTMVERLAAGAAGGVTTFATPTPKYRRQR
TYDDHRERIGKVKEHIKAGDAFQVVLSQRFEMETDVDPIDIYRMLRVSNPSPYMFLVNVPTEGFDATAFHIIGSSPESLV
QVRDGNVTTFPIAGSRPRGETVEQDFAFERELVNDEKENSEHLMLVDLGRNDLGRVSEPGTVEVHDFRHVERYSAVMHLV
SGVSGKLAAGKTAVDAFNATFPAGTLSGAPKPSALKIIDTLEDTRRGVYGGTVGYFDFSGNTDQSIAIRTGLYKDGTVYV
QAGGGIVADSDPEAEDLETRNKAAAVLRAVAAAETMKNAGEKQ

Sequences:

>Translated_523_residues
MSDMGDNTSSKSIGDLTSLETFRELAAKHRVVPVVRKVLADGETALSAYRKLADGRPGTFLLESAAHGQSWDRYSFIGTG
ARCALTAKDSVDGGAARWIGQPPVDIPAGTDPLDAIRNTLEHLQTAPMPGLPPLTSGLVGYMGYDMIRYIESVPDTCTDD
LNIPDMVQLLVEDMAVVDHYEGTIWLIASVINWDNSDERVDEAYAEAVDRLDTMVERLAAGAAGGVTTFATPTPKYRRQR
TYDDHRERIGKVKEHIKAGDAFQVVLSQRFEMETDVDPIDIYRMLRVSNPSPYMFLVNVPTEGFDATAFHIIGSSPESLV
QVRDGNVTTFPIAGSRPRGETVEQDFAFERELVNDEKENSEHLMLVDLGRNDLGRVSEPGTVEVHDFRHVERYSAVMHLV
SGVSGKLAAGKTAVDAFNATFPAGTLSGAPKPSALKIIDTLEDTRRGVYGGTVGYFDFSGNTDQSIAIRTGLYKDGTVYV
QAGGGIVADSDPEAEDLETRNKAAAVLRAVAAAETMKNAGEKQ
>Mature_522_residues
SDMGDNTSSKSIGDLTSLETFRELAAKHRVVPVVRKVLADGETALSAYRKLADGRPGTFLLESAAHGQSWDRYSFIGTGA
RCALTAKDSVDGGAARWIGQPPVDIPAGTDPLDAIRNTLEHLQTAPMPGLPPLTSGLVGYMGYDMIRYIESVPDTCTDDL
NIPDMVQLLVEDMAVVDHYEGTIWLIASVINWDNSDERVDEAYAEAVDRLDTMVERLAAGAAGGVTTFATPTPKYRRQRT
YDDHRERIGKVKEHIKAGDAFQVVLSQRFEMETDVDPIDIYRMLRVSNPSPYMFLVNVPTEGFDATAFHIIGSSPESLVQ
VRDGNVTTFPIAGSRPRGETVEQDFAFERELVNDEKENSEHLMLVDLGRNDLGRVSEPGTVEVHDFRHVERYSAVMHLVS
GVSGKLAAGKTAVDAFNATFPAGTLSGAPKPSALKIIDTLEDTRRGVYGGTVGYFDFSGNTDQSIAIRTGLYKDGTVYVQ
AGGGIVADSDPEAEDLETRNKAAAVLRAVAAAETMKNAGEKQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=516, Percent_Identity=34.4961240310078, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788114, Length=481, Percent_Identity=29.9376299376299, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI1786809, Length=252, Percent_Identity=29.3650793650794, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=486, Percent_Identity=38.2716049382716, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6324361, Length=411, Percent_Identity=25.3041362530414, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56784; Mature: 56653

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMGDNTSSKSIGDLTSLETFRELAAKHRVVPVVRKVLADGETALSAYRKLADGRPGTF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEE
LLESAAHGQSWDRYSFIGTGARCALTAKDSVDGGAARWIGQPPVDIPAGTDPLDAIRNTL
EEECCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHH
EHLQTAPMPGLPPLTSGLVGYMGYDMIRYIESVPDTCTDDLNIPDMVQLLVEDMAVVDHY
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCC
EGTIWLIASVINWDNSDERVDEAYAEAVDRLDTMVERLAAGAAGGVTTFATPTPKYRRQR
CCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHC
TYDDHRERIGKVKEHIKAGDAFQVVLSQRFEMETDVDPIDIYRMLRVSNPSPYMFLVNVP
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEECC
TEGFDATAFHIIGSSPESLVQVRDGNVTTFPIAGSRPRGETVEQDFAFERELVNDEKENS
CCCCCCEEEEEECCCHHHHEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
EHLMLVDLGRNDLGRVSEPGTVEVHDFRHVERYSAVMHLVSGVSGKLAAGKTAVDAFNAT
CEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCC
FPAGTLSGAPKPSALKIIDTLEDTRRGVYGGTVGYFDFSGNTDQSIAIRTGLYKDGTVYV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEE
QAGGGIVADSDPEAEDLETRNKAAAVLRAVAAAETMKNAGEKQ
EECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDMGDNTSSKSIGDLTSLETFRELAAKHRVVPVVRKVLADGETALSAYRKLADGRPGTF
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEE
LLESAAHGQSWDRYSFIGTGARCALTAKDSVDGGAARWIGQPPVDIPAGTDPLDAIRNTL
EEECCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHH
EHLQTAPMPGLPPLTSGLVGYMGYDMIRYIESVPDTCTDDLNIPDMVQLLVEDMAVVDHY
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCC
EGTIWLIASVINWDNSDERVDEAYAEAVDRLDTMVERLAAGAAGGVTTFATPTPKYRRQR
CCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHC
TYDDHRERIGKVKEHIKAGDAFQVVLSQRFEMETDVDPIDIYRMLRVSNPSPYMFLVNVP
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEECC
TEGFDATAFHIIGSSPESLVQVRDGNVTTFPIAGSRPRGETVEQDFAFERELVNDEKENS
CCCCCCEEEEEECCCHHHHEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
EHLMLVDLGRNDLGRVSEPGTVEVHDFRHVERYSAVMHLVSGVSGKLAAGKTAVDAFNAT
CEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCC
FPAGTLSGAPKPSALKIIDTLEDTRRGVYGGTVGYFDFSGNTDQSIAIRTGLYKDGTVYV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEE
QAGGGIVADSDPEAEDLETRNKAAAVLRAVAAAETMKNAGEKQ
EECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]