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The map label for this gene is hisB

Identifier: 68535863

GI number: 68535863

Start: 942374

End: 942988

Strand: Direct

Name: hisB

Synonym: jk0788

Alternate gene names: 68535863

Gene position: 942374-942988 (Clockwise)

Preceding gene: 68535862

Following gene: 68535864

Centisome position: 38.27

GC content: 66.83

Gene sequence:

>615_bases
GTGGCCACGAACCCCACCCCGCGCATCGGGAAGGCCCAGCGCGCCACCAAAGAATCAGACATTCAGGTCGAGTGGAACCT
GGACGGCACCGGAAAGACCGACATCGATACGGGAGTGCCGTTCTTCGACCATATGCTGACCGCCCTCGGCGCGCACGGTT
CCTTTGACCTGAAGGTGCACGCCCGCGGCGACGTGGAGATCGACGCGCACCACACCGTCGAGGACACCGCCATCGTCATG
GGCCAGGCCCTGGCGCAGGCGTTGGGCGACAAGGCGGGTATCCGCCGCTTCGGCGATGCTTTCATCCCGATGGACGAGAC
GCTGGCGCACGCTGCTGTGGACGTGTCTGGCCGCCCGTACTACGTGGGCGTGGGGGAGCCGGAGCAGATGCTCAGCTCGG
TGATCGGTGGGCACTACGCCACCGTCATCAATCAGCACTTCTTCGAGACGCTGGCGCTGAACTCGCGCATTGCCCTGCAC
GTGCGCTGCCTGTACGGCCGCGACCCGCACCACATCACCGAGGCGGAATTCAAGGCCGTGGCCCGCGCACTGCGCGCCGC
CGTGGAGGACGACCCGCGCGTGGGCGGGGTTCCGTCGACCAAGGGAACACTGTAA

Upstream 100 bases:

>100_bases
TCTTGCCGCCGCCGCCAAGATGATGGACGATTAGACACACCAGACAGACGTTTCAAGAGCTTTTAGAGAACGAGACCAGA
GAGGTAGGTGCAAAGCCACC

Downstream 100 bases:

>100_bases
TGGCGCGCCCGAAGGCGCTGACCATTGAAGAACTAGAAAAGATCGATTCCGTGTGGAAGGCCCCCGGCCTGATCGCCACA
CTGGTGTCGGTCTTCTGTGC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MATNPTPRIGKAQRATKESDIQVEWNLDGTGKTDIDTGVPFFDHMLTALGAHGSFDLKVHARGDVEIDAHHTVEDTAIVM
GQALAQALGDKAGIRRFGDAFIPMDETLAHAAVDVSGRPYYVGVGEPEQMLSSVIGGHYATVINQHFFETLALNSRIALH
VRCLYGRDPHHITEAEFKAVARALRAAVEDDPRVGGVPSTKGTL

Sequences:

>Translated_204_residues
MATNPTPRIGKAQRATKESDIQVEWNLDGTGKTDIDTGVPFFDHMLTALGAHGSFDLKVHARGDVEIDAHHTVEDTAIVM
GQALAQALGDKAGIRRFGDAFIPMDETLAHAAVDVSGRPYYVGVGEPEQMLSSVIGGHYATVINQHFFETLALNSRIALH
VRCLYGRDPHHITEAEFKAVARALRAAVEDDPRVGGVPSTKGTL
>Mature_203_residues
ATNPTPRIGKAQRATKESDIQVEWNLDGTGKTDIDTGVPFFDHMLTALGAHGSFDLKVHARGDVEIDAHHTVEDTAIVMG
QALAQALGDKAGIRRFGDAFIPMDETLAHAAVDVSGRPYYVGVGEPEQMLSSVIGGHYATVINQHFFETLALNSRIALHV
RCLYGRDPHHITEAEFKAVARALRAAVEDDPRVGGVPSTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=199, Percent_Identity=43.7185929648241, Blast_Score=151, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324776, Length=171, Percent_Identity=45.0292397660819, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CORJK (Q4JW57)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250568.1
- HSSP:   P34047
- ProteinModelPortal:   Q4JW57
- SMR:   Q4JW57
- STRING:   Q4JW57
- GeneID:   3433177
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0788
- NMPDR:   fig|306537.3.peg.1762
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   RQAVEYD
- ProtClustDB:   PRK00951
- BioCyc:   CJEI306537:JK0788-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21993; Mature: 21862

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNPTPRIGKAQRATKESDIQVEWNLDGTGKTDIDTGVPFFDHMLTALGAHGSFDLKVH
CCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEE
ARGDVEIDAHHTVEDTAIVMGQALAQALGDKAGIRRFGDAFIPMDETLAHAAVDVSGRPY
ECCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCE
YVGVGEPEQMLSSVIGGHYATVINQHFFETLALNSRIALHVRCLYGRDPHHITEAEFKAV
EEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHH
ARALRAAVEDDPRVGGVPSTKGTL
HHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATNPTPRIGKAQRATKESDIQVEWNLDGTGKTDIDTGVPFFDHMLTALGAHGSFDLKVH
CCCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEE
ARGDVEIDAHHTVEDTAIVMGQALAQALGDKAGIRRFGDAFIPMDETLAHAAVDVSGRPY
ECCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEEECCCCCE
YVGVGEPEQMLSSVIGGHYATVINQHFFETLALNSRIALHVRCLYGRDPHHITEAEFKAV
EEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHH
ARALRAAVEDDPRVGGVPSTKGTL
HHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA