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The map label for this gene is hisC

Identifier: 68535862

GI number: 68535862

Start: 941186

End: 942307

Strand: Direct

Name: hisC

Synonym: jk0787

Alternate gene names: 68535862

Gene position: 941186-942307 (Clockwise)

Preceding gene: 68535861

Following gene: 68535863

Centisome position: 38.22

GC content: 65.86

Gene sequence:

>1122_bases
ATGGCCGAGCAGAACAACCAGATCTCCCTGGCCGACCTGCCACTGCGCGAGGAGCTGCGCGGCAAGTCCGCCTATGGAGC
CCCGCAGCTTTCCGTAGCCAACCAGCTGAACACCAACGAAAACCCCTATCCGCCGTCGCCGGAGATTGTTGAGGGCATCG
CCCGCCGCGTGGCGGAGCTGGGCAAGCAGCTGAACCGTTATCCCGACCGCGACGCAGTGGGGTTGCGCGAGGCCCTAGCG
GCGTACGTGAGCCAGCAGACGGGTGTGGGCGTCACTAAAGAACAGGTATGGGCAGCCAACGGTTCCAACGAGGTATTGCA
GCAGCTCCTGCAGGCTTTCGGTGGGCCCGGGCGCAGCGCGATGGGCTTCGTGCCGAGCTACTCCATGCACCCGATCCTGG
CGGCGGGCACGCAGACGGAGTTTGTTACGGTCGAGCGCCGCGCCGAGAACCGCTTCGACATCGACGTGGACGAGGCACTC
GCCGCCATCGACGAGCGCCAGCCGAACGTCATCTTTATTACGACGCCCAACAACCCCACGGGCAACAGCACACCGTTGGC
CGACATCGAGCGGATCCTGCAGGCAGCCCCCGGCATTGTGATTGTGGACGAGGCCTACGCGGAGTTCTCCGACGAGCCGA
GCGCGGTGGGGCTGCTGGAGCAGTACCCGACGAAGCTGGTGGTTTCCCGCACCATGTCCAAGGCCTTCGACTTCGCCGGC
GGGCGGCTGGGCTACTTCGTGGCCCACCCGGCGTTTATCGAGGCCGTGATGCTGGTGCGCCTGCCGTACCACCTGGCGAC
CCTGTCGCAGGCAGCGGCGGAAGTGGCGCTGGAACACTCCGCGGCCACGCTGCAGACGGTGGCGAAACTGCGCCAGGAGC
GCGACCGAGTGGTTGCCCGCCTGCGCGAGCTGGGCTACGACGTGATCGACTCGCACTCGAACTTCGTGTTCTTTGGCGGC
TTTGCCCACGTCGGCGATTCGGCCGCGGTGTGGCAGCGATTCCTGGACCAAGAGGTGCTGATCCGCGACGTCGGTGTGGC
AGGCTGGCTGCGCGCGACGATTGGACTGCCGGAGGAAAACGATGCGTTTCTTGCCGCCGCCGCCAAGATGATGGACGATT
AG

Upstream 100 bases:

>100_bases
GGTAATCACCCTGTCGAAGTCCGAGGGGCTGCCCGCCCACGGTGAAGCCATCAGTGCACGCACCAGCACCGCAAACACCA
ACGGAACGGAGGTCTAGACC

Downstream 100 bases:

>100_bases
ACACACCAGACAGACGTTTCAAGAGCTTTTAGAGAACGAGACCAGAGAGGTAGGTGCAAAGCCACCGTGGCCACGAACCC
CACCCCGCGCATCGGGAAGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MAEQNNQISLADLPLREELRGKSAYGAPQLSVANQLNTNENPYPPSPEIVEGIARRVAELGKQLNRYPDRDAVGLREALA
AYVSQQTGVGVTKEQVWAANGSNEVLQQLLQAFGGPGRSAMGFVPSYSMHPILAAGTQTEFVTVERRAENRFDIDVDEAL
AAIDERQPNVIFITTPNNPTGNSTPLADIERILQAAPGIVIVDEAYAEFSDEPSAVGLLEQYPTKLVVSRTMSKAFDFAG
GRLGYFVAHPAFIEAVMLVRLPYHLATLSQAAAEVALEHSAATLQTVAKLRQERDRVVARLRELGYDVIDSHSNFVFFGG
FAHVGDSAAVWQRFLDQEVLIRDVGVAGWLRATIGLPEENDAFLAAAAKMMDD

Sequences:

>Translated_373_residues
MAEQNNQISLADLPLREELRGKSAYGAPQLSVANQLNTNENPYPPSPEIVEGIARRVAELGKQLNRYPDRDAVGLREALA
AYVSQQTGVGVTKEQVWAANGSNEVLQQLLQAFGGPGRSAMGFVPSYSMHPILAAGTQTEFVTVERRAENRFDIDVDEAL
AAIDERQPNVIFITTPNNPTGNSTPLADIERILQAAPGIVIVDEAYAEFSDEPSAVGLLEQYPTKLVVSRTMSKAFDFAG
GRLGYFVAHPAFIEAVMLVRLPYHLATLSQAAAEVALEHSAATLQTVAKLRQERDRVVARLRELGYDVIDSHSNFVFFGG
FAHVGDSAAVWQRFLDQEVLIRDVGVAGWLRATIGLPEENDAFLAAAAKMMDD
>Mature_372_residues
AEQNNQISLADLPLREELRGKSAYGAPQLSVANQLNTNENPYPPSPEIVEGIARRVAELGKQLNRYPDRDAVGLREALAA
YVSQQTGVGVTKEQVWAANGSNEVLQQLLQAFGGPGRSAMGFVPSYSMHPILAAGTQTEFVTVERRAENRFDIDVDEALA
AIDERQPNVIFITTPNNPTGNSTPLADIERILQAAPGIVIVDEAYAEFSDEPSAVGLLEQYPTKLVVSRTMSKAFDFAGG
RLGYFVAHPAFIEAVMLVRLPYHLATLSQAAAEVALEHSAATLQTVAKLRQERDRVVARLRELGYDVIDSHSNFVFFGGF
AHVGDSAAVWQRFLDQEVLIRDVGVAGWLRATIGLPEENDAFLAAAAKMMDD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=373, Percent_Identity=31.3672922252011, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322075, Length=350, Percent_Identity=27.7142857142857, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_CORJK (Q4JW58)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250567.1
- ProteinModelPortal:   Q4JW58
- SMR:   Q4JW58
- STRING:   Q4JW58
- GeneID:   3433178
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0787
- NMPDR:   fig|306537.3.peg.1761
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   GRTAIGF
- ProtClustDB:   PRK03317
- BioCyc:   CJEI306537:JK0787-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40621; Mature: 40490

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQNNQISLADLPLREELRGKSAYGAPQLSVANQLNTNENPYPPSPEIVEGIARRVAEL
CCCCCCCEEEECCCHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GKQLNRYPDRDAVGLREALAAYVSQQTGVGVTKEQVWAANGSNEVLQQLLQAFGGPGRSA
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCHHHHHHHHHHHCCCCCCC
MGFVPSYSMHPILAAGTQTEFVTVERRAENRFDIDVDEALAAIDERQPNVIFITTPNNPT
CCCCCCCCCCCEEECCCCCEEEEEEHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCC
GNSTPLADIERILQAAPGIVIVDEAYAEFSDEPSAVGLLEQYPTKLVVSRTMSKAFDFAG
CCCCCHHHHHHHHHHCCCEEEEECHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCC
GRLGYFVAHPAFIEAVMLVRLPYHLATLSQAAAEVALEHSAATLQTVAKLRQERDRVVAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRELGYDVIDSHSNFVFFGGFAHVGDSAAVWQRFLDQEVLIRDVGVAGWLRATIGLPEEN
HHHCCCHHHCCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
DAFLAAAAKMMDD
CHHHHHHHHHHCC
>Mature Secondary Structure 
AEQNNQISLADLPLREELRGKSAYGAPQLSVANQLNTNENPYPPSPEIVEGIARRVAEL
CCCCCCEEEECCCHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GKQLNRYPDRDAVGLREALAAYVSQQTGVGVTKEQVWAANGSNEVLQQLLQAFGGPGRSA
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCHHHHHHHHHHHCCCCCCC
MGFVPSYSMHPILAAGTQTEFVTVERRAENRFDIDVDEALAAIDERQPNVIFITTPNNPT
CCCCCCCCCCCEEECCCCCEEEEEEHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCC
GNSTPLADIERILQAAPGIVIVDEAYAEFSDEPSAVGLLEQYPTKLVVSRTMSKAFDFAG
CCCCCHHHHHHHHHHCCCEEEEECHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCC
GRLGYFVAHPAFIEAVMLVRLPYHLATLSQAAAEVALEHSAATLQTVAKLRQERDRVVAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRELGYDVIDSHSNFVFFGGFAHVGDSAAVWQRFLDQEVLIRDVGVAGWLRATIGLPEEN
HHHCCCHHHCCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
DAFLAAAAKMMDD
CHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA