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The map label for this gene is uppS2 [H]

Identifier: 68535682

GI number: 68535682

Start: 736204

End: 736953

Strand: Direct

Name: uppS2 [H]

Synonym: jk0610

Alternate gene names: 68535682

Gene position: 736204-736953 (Clockwise)

Preceding gene: 68535681

Following gene: 68535683

Centisome position: 29.9

GC content: 65.07

Gene sequence:

>750_bases
GTGAGTAGCACTGATTATCCGCACGTGGACCGTTCCGAGATTCCGCCGGAGCTCCGCCCGAAGCACATCGCACTGGTGAT
GGATGGCAACGGGCGCTGGGCCAAGGAGCGCGGCATGGTCCGCACCGAGGGGCACCGCCGTGGCGAGGCTGTGCTGATGT
CTTTGGTGGAGGAGTGCATCGAGCTGGGCGTGGATTACCTTTCCGCCTATGCGTTCTCCACCGAGAACTGGCGCCGCTCG
GCGGACGAGGTGCGCTTCCTGATGGGCTTTAACCGCGACGTATTGCGCAGGCAGCGCGACTACTTGAACAGCCTGGGCGT
GCGGATCCGCTGGGTGGGGCGCCGCCCGCGCCTGTGGCGTAGCGTGATTGCGGAACTGGAACAGGCCGAGGAGCTGACGA
AGAACAACACGACCATGACCTTGGGCATGTGCGTGAACTACGGCGGCCGGGCGGAGATCGCGGACGCGGCGCGTTGGATC
GCCGAGGACGTGAAGGCCGGTCGGCTGAAGCCCCGGCAGGTGAACGAGAAGACGTTCGCCCGCTACCTGGACGAGCCGGA
CATGCCGGACGTGGATCTGTTCCTGCGGCCGTCGGGCGAGATGCGAACCTCGAACTTCCTGCCGTGGCAGTCCACCTACG
CGGAGATGGTGTACCAGGATGTGCTGTTCCCGGATTACACGCCGAACCACCTGCGGGCGGCGGTGCTGGAGTTTGCGAAG
CGCGATAGGCGCTTTGGAGGTGTGAAGTGA

Upstream 100 bases:

>100_bases
TCGCCTGCTGTTGGCACACGTGCGGCAGCAGCTGGAGGTAGGCTGCCCGGCTTACGCAGCGCTATAGGGTTAGTGGTGCG
CGTGTGGCAATATAGTACGG

Downstream 100 bases:

>100_bases
GCGACGTGACCGGTGCAAACGGGGCGGATGCCGCCGAGCAGGTCGAGCAGCCGCAGCCGACGAAGCGCCAAATCGCGCGC
TGGCAGCAGTACCTGGCCAA

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2 [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSSTDYPHVDRSEIPPELRPKHIALVMDGNGRWAKERGMVRTEGHRRGEAVLMSLVEECIELGVDYLSAYAFSTENWRRS
ADEVRFLMGFNRDVLRRQRDYLNSLGVRIRWVGRRPRLWRSVIAELEQAEELTKNNTTMTLGMCVNYGGRAEIADAARWI
AEDVKAGRLKPRQVNEKTFARYLDEPDMPDVDLFLRPSGEMRTSNFLPWQSTYAEMVYQDVLFPDYTPNHLRAAVLEFAK
RDRRFGGVK

Sequences:

>Translated_249_residues
MSSTDYPHVDRSEIPPELRPKHIALVMDGNGRWAKERGMVRTEGHRRGEAVLMSLVEECIELGVDYLSAYAFSTENWRRS
ADEVRFLMGFNRDVLRRQRDYLNSLGVRIRWVGRRPRLWRSVIAELEQAEELTKNNTTMTLGMCVNYGGRAEIADAARWI
AEDVKAGRLKPRQVNEKTFARYLDEPDMPDVDLFLRPSGEMRTSNFLPWQSTYAEMVYQDVLFPDYTPNHLRAAVLEFAK
RDRRFGGVK
>Mature_248_residues
SSTDYPHVDRSEIPPELRPKHIALVMDGNGRWAKERGMVRTEGHRRGEAVLMSLVEECIELGVDYLSAYAFSTENWRRSA
DEVRFLMGFNRDVLRRQRDYLNSLGVRIRWVGRRPRLWRSVIAELEQAEELTKNNTTMTLGMCVNYGGRAEIADAARWIA
EDVKAGRLKPRQVNEKTFARYLDEPDMPDVDLFLRPSGEMRTSNFLPWQSTYAEMVYQDVLFPDYTPNHLRAAVLEFAKR
DRRFGGVK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=38.2882882882883, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=38.2882882882883, Blast_Score=148, Evalue=4e-36,
Organism=Escherichia coli, GI1786371, Length=238, Percent_Identity=39.4957983193277, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=224, Percent_Identity=32.1428571428571, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=225, Percent_Identity=34.2222222222222, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=30.5676855895196, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=32.034632034632, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28948; Mature: 28817

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTDYPHVDRSEIPPELRPKHIALVMDGNGRWAKERGMVRTEGHRRGEAVLMSLVEECI
CCCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCHHHCCCEECCCCCHHHHHHHHHHHHHH
ELGVDYLSAYAFSTENWRRSADEVRFLMGFNRDVLRRQRDYLNSLGVRIRWVGRRPRLWR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHH
SVIAELEQAEELTKNNTTMTLGMCVNYGGRAEIADAARWIAEDVKAGRLKPRQVNEKTFA
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RYLDEPDMPDVDLFLRPSGEMRTSNFLPWQSTYAEMVYQDVLFPDYTPNHLRAAVLEFAK
HHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RDRRFGGVK
HHHHCCCCC
>Mature Secondary Structure 
SSTDYPHVDRSEIPPELRPKHIALVMDGNGRWAKERGMVRTEGHRRGEAVLMSLVEECI
CCCCCCCCCHHCCCCCCCCCEEEEEECCCCCCHHHCCCEECCCCCHHHHHHHHHHHHHH
ELGVDYLSAYAFSTENWRRSADEVRFLMGFNRDVLRRQRDYLNSLGVRIRWVGRRPRLWR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHH
SVIAELEQAEELTKNNTTMTLGMCVNYGGRAEIADAARWIAEDVKAGRLKPRQVNEKTFA
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RYLDEPDMPDVDLFLRPSGEMRTSNFLPWQSTYAEMVYQDVLFPDYTPNHLRAAVLEFAK
HHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RDRRFGGVK
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]