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The map label for this gene is emrA [H]

Identifier: 77761103

GI number: 77761103

Start: 804911

End: 806002

Strand: Reverse

Name: emrA [H]

Synonym: XC_0672

Alternate gene names: 77761103

Gene position: 806002-804911 (Counterclockwise)

Preceding gene: 77761104

Following gene: 66767008

Centisome position: 15.65

GC content: 67.49

Gene sequence:

>1092_bases
ATGAATACACCTGCCGACACCGCTCCAACCGCCGCACAGAGACGGCGTCGCCGTCGCCGCCGTCTGTATGGCGTGCTCGG
GTTCGGTGGGCTTGCGCTGATCGGCGTGGCGTTGGTGCTGTATGCGTGGCGGCTGCCGCCGTTCACCAGCGCGGTGGAGC
GCACCGAAAACGCGATGGTGCATGGCCAGGTCACGGTGATCGCGCCACAGGTCAGTGGCTATGTCACGCAGGTGCCGGTG
CAGGATTTTGCGCATGTGCGCCGCGGCCAGCTGTTGGCAAAGATCGACGACCGCATCTATGCGCAGCATTTGGAACAGGC
CAAGGCGCAACTGCAGACCACGCAGGCCAACCTGGCCAACTGGGAACAGCAGCGCCACAGCGCCGAGGCCACCATCGCCG
AGCAACGCGCCACCCTGAGCAGCAACCAGGCCCAGCGCGATCGCACGCGCTCGGCGTATGCACGCGCGCAGCAACTGGCC
AACCAGAAACTGGTGTCCGAGCAGGACCGCGACACCGCATTTGCCGCGCGCGCACAGGCCGACGCCGGCGTGGCTCAGGC
GCGCGCCGCAGTGCAGGCCGCCGAAGAGAACGCGCGCAGTGTCACCGTCAATCGTGCAGCGCTGGAAGCGGCGGTAGCCA
ATGCGCAGGCAGCCGTGCAGCTGGCACAAATCAACCTGGACAACACGCGCATCCTCGCGCCGCGCGACGGCCAGCTGGGT
CAGCTCGGCGTGCGCCAGGGCGCCTATGTCACCAACGGCACGCAGTTGATGGCCTTGGTGCCGGACACCTTGTGGGTGGT
GGCCAACTTCAAGGAAACCCAAATGGCCAATGTGCGTGTGGGCCAGCGCGCCAGCTTCACCGTGGATGCGCTGGCCAATG
CGCGCCTGCAGGGCCGCGTGCAGGAGATCTCGCCAGCGGCCGGCTCCGAGTTCAGCGTGTTACGCGCGGACAACGCCACC
GGCAACTTCGTCAAGATTGCCCAGCGCATTCCGCTGCGCATCAGTGTCGATCCCGGCCAGCCGCAGGCCGCGCGGCTGCG
TCCGGGCATGTCGGTGGTGGTGGCCATCGACACCGCCCAGCGCGCCGAGTAA

Upstream 100 bases:

>100_bases
TTGCCATTGCCACCGGGTTGTGGATTCTCTCCGTGCTGGTGTGGCGCCGTTATCTGCGCCCGCCGGTTGCCCCCTCTCCT
TCTGTTCCGACTGCGCGCCC

Downstream 100 bases:

>100_bases
GCAACGCAGCCGTTATGATGCGGCGATGACTGTTTTGGCCCCCTTTCCTGTGCACTGGCGCGCACTGCGCTTTGCCGAGC
TGGACACGCCCCAGCTCTAC

Product: multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNTPADTAPTAAQRRRRRRRRLYGVLGFGGLALIGVALVLYAWRLPPFTSAVERTENAMVHGQVTVIAPQVSGYVTQVPV
QDFAHVRRGQLLAKIDDRIYAQHLEQAKAQLQTTQANLANWEQQRHSAEATIAEQRATLSSNQAQRDRTRSAYARAQQLA
NQKLVSEQDRDTAFAARAQADAGVAQARAAVQAAEENARSVTVNRAALEAAVANAQAAVQLAQINLDNTRILAPRDGQLG
QLGVRQGAYVTNGTQLMALVPDTLWVVANFKETQMANVRVGQRASFTVDALANARLQGRVQEISPAAGSEFSVLRADNAT
GNFVKIAQRIPLRISVDPGQPQAARLRPGMSVVVAIDTAQRAE

Sequences:

>Translated_363_residues
MNTPADTAPTAAQRRRRRRRRLYGVLGFGGLALIGVALVLYAWRLPPFTSAVERTENAMVHGQVTVIAPQVSGYVTQVPV
QDFAHVRRGQLLAKIDDRIYAQHLEQAKAQLQTTQANLANWEQQRHSAEATIAEQRATLSSNQAQRDRTRSAYARAQQLA
NQKLVSEQDRDTAFAARAQADAGVAQARAAVQAAEENARSVTVNRAALEAAVANAQAAVQLAQINLDNTRILAPRDGQLG
QLGVRQGAYVTNGTQLMALVPDTLWVVANFKETQMANVRVGQRASFTVDALANARLQGRVQEISPAAGSEFSVLRADNAT
GNFVKIAQRIPLRISVDPGQPQAARLRPGMSVVVAIDTAQRAE
>Mature_363_residues
MNTPADTAPTAAQRRRRRRRRLYGVLGFGGLALIGVALVLYAWRLPPFTSAVERTENAMVHGQVTVIAPQVSGYVTQVPV
QDFAHVRRGQLLAKIDDRIYAQHLEQAKAQLQTTQANLANWEQQRHSAEATIAEQRATLSSNQAQRDRTRSAYARAQQLA
NQKLVSEQDRDTAFAARAQADAGVAQARAAVQAAEENARSVTVNRAALEAAVANAQAAVQLAQINLDNTRILAPRDGQLG
QLGVRQGAYVTNGTQLMALVPDTLWVVANFKETQMANVRVGQRASFTVDALANARLQGRVQEISPAAGSEFSVLRADNAT
GNFVKIAQRIPLRISVDPGQPQAARLRPGMSVVVAIDTAQRAE

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=339, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1788711, Length=353, Percent_Identity=32.0113314447592, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1790519, Length=327, Percent_Identity=27.82874617737, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081951, Length=337, Percent_Identity=26.1127596439169, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789637, Length=319, Percent_Identity=28.8401253918495, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081796, Length=243, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790012, Length=245, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790024, Length=283, Percent_Identity=24.7349823321555, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39320; Mature: 39320

Theoretical pI: Translated: 11.35; Mature: 11.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPADTAPTAAQRRRRRRRRLYGVLGFGGLALIGVALVLYAWRLPPFTSAVERTENAMV
CCCCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEE
HGQVTVIAPQVSGYVTQVPVQDFAHVRRGQLLAKIDDRIYAQHLEQAKAQLQTTQANLAN
EEEEEEEEECCCCEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WEQQRHSAEATIAEQRATLSSNQAQRDRTRSAYARAQQLANQKLVSEQDRDTAFAARAQA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
DAGVAQARAAVQAAEENARSVTVNRAALEAAVANAQAAVQLAQINLDNTRILAPRDGQLG
HCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHEEEEEEECCCCEEECCCCCCCC
QLGVRQGAYVTNGTQLMALVPDTLWVVANFKETQMANVRVGQRASFTVDALANARLQGRV
CCCCCCCCEEECCCEEEEECCCEEEEEECCCHHHEHHCCCCCCCCEEHHHHHCCHHHCHH
QEISPAAGSEFSVLRADNATGNFVKIAQRIPLRISVDPGQPQAARLRPGMSVVVAIDTAQ
HHCCCCCCCCEEEEEECCCCCCHHHHHHHCCEEEEECCCCCCHHHCCCCCEEEEEECCCC
RAE
CCC
>Mature Secondary Structure
MNTPADTAPTAAQRRRRRRRRLYGVLGFGGLALIGVALVLYAWRLPPFTSAVERTENAMV
CCCCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEE
HGQVTVIAPQVSGYVTQVPVQDFAHVRRGQLLAKIDDRIYAQHLEQAKAQLQTTQANLAN
EEEEEEEEECCCCEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WEQQRHSAEATIAEQRATLSSNQAQRDRTRSAYARAQQLANQKLVSEQDRDTAFAARAQA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
DAGVAQARAAVQAAEENARSVTVNRAALEAAVANAQAAVQLAQINLDNTRILAPRDGQLG
HCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHEEEEEEECCCCEEECCCCCCCC
QLGVRQGAYVTNGTQLMALVPDTLWVVANFKETQMANVRVGQRASFTVDALANARLQGRV
CCCCCCCCEEECCCEEEEECCCEEEEEECCCHHHEHHCCCCCCCCEEHHHHHCCHHHCHH
QEISPAAGSEFSVLRADNATGNFVKIAQRIPLRISVDPGQPQAARLRPGMSVVVAIDTAQ
HHCCCCCCCCEEEEEECCCCCCHHHHHHHCCEEEEECCCCCCHHHCCCCCEEEEEECCCC
RAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]