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The map label for this gene is hlyB [H]

Identifier: 66045349

GI number: 66045349

Start: 2462935

End: 2464554

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_2109

Alternate gene names: 66045349

Gene position: 2462935-2464554 (Clockwise)

Preceding gene: 66045348

Following gene: 66045350

Centisome position: 40.42

GC content: 56.17

Gene sequence:

>1620_bases
ATGAGAAACGTCAAGGTCGCTGTTCGTGCCGGGATGAGCTTTATGCTGATCACCTGCCTGCTCATCGCGCTGGGAGGGAT
CGCGCTATGGAAAATGGGCGAGTTACGGGCCAGCATGGAATCGCTGGAAAAGGACGCGATGGCCAGCATCATACAGGCTA
ACAAAATAAGCAGCGCCACGCTGCGTTTGCGACTGGATGCCCGGCGATTGATTGCACAGACTGACCCGCAGGCTCAGACA
ATTACCGTGACTCGATTGAAAGCTGCGCGAGAAGACATGCTCAAACAATCTGCTGCATATGCGCCGCTGGCAAGCGCTGC
CGATGAGGCAAGTCTCTATCAAACCGTCACTGCGTCCGCCCAGAAGTTTGCGTCACTTCTGGATACGGTGCTCGAATTGA
TTCAGAAAGGTGCCAACGCTGATGCGGTGACGTTTACCGACACCAATATAGTGCCCGTCACCGGTGAGTTGCAGACCGCC
ATCGATGCGTTGGTGCAGATGAATATTGATCAGGCCGATCAACTGAGTGTGCGTGCAGAAGCCGCCTATGAAAGTGGTTT
TATGTTCACAGTGGTTATTATTATAGTGTCATTGATTATTACCATATTTCTCGCGATTCTGTTGACGCGCAGTATTGTCA
CGCCTTTGAAATCATTGTTGTCGGTCAATGAGCGTATTGCCAGCGGTGATCTTCGTGGTGATATTCCGGTCACCGGTGAC
GATGAGTTTTCCGAACTGCAACGCGCGACACTGGCCATGCAGAAGAACCTGCGACAAACCATTGGCCTGATCGGCAACTC
GTCACAGCAACTGGCTTCCGCTGCCGAAGAAATGAACTGCATCACCGTGCAGTCCAGCACCGGGTTGGGGCGTCAGAATC
AGGAGATCGAGCAGGCCGCCACGGCGGTCAACGAAATGACCGCAGCGGTCGATGAGGTCGCACGCAACGCAGCAGCTGCG
TCTGACGCAGCGAAAGAATCCAACGCCTCCACCGTGCGCGGGGCTGAGCGAGTGGCCAGTACCGTCACCGCGATCGAAAA
ACTGAGCGCCACGGTGCTTGCCACCAGTGCTGACGTGCAGCGTCTGGCCGGACAATCCAACGACATCAGCAAAGTCCTCG
CGGTGATTCGTACCATCGCCGAGCAAACCAACCTGCTTGCTCTCAACGCCGCTATTGAAGCCGCTCGTGCCGGCGAGCAG
GGGCGCGGTTTTGCGGTGGTGGCGGATGAGGTCCGGGCACTGGCGCATCGCACCCAGCAGTCCACCCAGGAAATCGAGCA
AATGATCGGCGCCGTTCTAGAGGGCTCCGAACAAGCCACCCGGTCGATGCAGGAAAGTTGCATGGGCGCGCAGGATACTC
TGGGGGTTGCACATGAGGCCGGTGCAGCGCTTGACGATATTGCCCGGCGTATCGAAGAAATCAATGACATGAACACGCTG
ATCGCCACAGCTTCCGAAGAGCAGGCGCAGGTGGCTCGTTCCATCGACCACAATCTGATCAGTATTCGCGACCTGTCCGT
GCAGAGTACCGAGGGCGCCAATCAGACTTCCCTTGCCAGTGGCGAACTGTCGAGACTGGCCATTGAAATGAATGGCGTCG
TTACACGATTCAAGATGTAA

Upstream 100 bases:

>100_bases
TGTCGACCTCTTGAGTGACGTCCCTGTTCAATCGGGCGACTGAAGGTATCGACTGTGTTCCGAGATTGTCCACGCCGTAC
CCACCTCCGAAGGTAACAAG

Downstream 100 bases:

>100_bases
CTTGATTGGCTGTCCGCAAGGCGAGGCCATGTCTTCAAGCTTGCGGACAGACCAACGGATCGTCCTGAAACAGGCATAAG
CCTATGAAAATTATTGGCGA

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MRNVKVAVRAGMSFMLITCLLIALGGIALWKMGELRASMESLEKDAMASIIQANKISSATLRLRLDARRLIAQTDPQAQT
ITVTRLKAAREDMLKQSAAYAPLASAADEASLYQTVTASAQKFASLLDTVLELIQKGANADAVTFTDTNIVPVTGELQTA
IDALVQMNIDQADQLSVRAEAAYESGFMFTVVIIIVSLIITIFLAILLTRSIVTPLKSLLSVNERIASGDLRGDIPVTGD
DEFSELQRATLAMQKNLRQTIGLIGNSSQQLASAAEEMNCITVQSSTGLGRQNQEIEQAATAVNEMTAAVDEVARNAAAA
SDAAKESNASTVRGAERVASTVTAIEKLSATVLATSADVQRLAGQSNDISKVLAVIRTIAEQTNLLALNAAIEAARAGEQ
GRGFAVVADEVRALAHRTQQSTQEIEQMIGAVLEGSEQATRSMQESCMGAQDTLGVAHEAGAALDDIARRIEEINDMNTL
IATASEEQAQVARSIDHNLISIRDLSVQSTEGANQTSLASGELSRLAIEMNGVVTRFKM

Sequences:

>Translated_539_residues
MRNVKVAVRAGMSFMLITCLLIALGGIALWKMGELRASMESLEKDAMASIIQANKISSATLRLRLDARRLIAQTDPQAQT
ITVTRLKAAREDMLKQSAAYAPLASAADEASLYQTVTASAQKFASLLDTVLELIQKGANADAVTFTDTNIVPVTGELQTA
IDALVQMNIDQADQLSVRAEAAYESGFMFTVVIIIVSLIITIFLAILLTRSIVTPLKSLLSVNERIASGDLRGDIPVTGD
DEFSELQRATLAMQKNLRQTIGLIGNSSQQLASAAEEMNCITVQSSTGLGRQNQEIEQAATAVNEMTAAVDEVARNAAAA
SDAAKESNASTVRGAERVASTVTAIEKLSATVLATSADVQRLAGQSNDISKVLAVIRTIAEQTNLLALNAAIEAARAGEQ
GRGFAVVADEVRALAHRTQQSTQEIEQMIGAVLEGSEQATRSMQESCMGAQDTLGVAHEAGAALDDIARRIEEINDMNTL
IATASEEQAQVARSIDHNLISIRDLSVQSTEGANQTSLASGELSRLAIEMNGVVTRFKM
>Mature_539_residues
MRNVKVAVRAGMSFMLITCLLIALGGIALWKMGELRASMESLEKDAMASIIQANKISSATLRLRLDARRLIAQTDPQAQT
ITVTRLKAAREDMLKQSAAYAPLASAADEASLYQTVTASAQKFASLLDTVLELIQKGANADAVTFTDTNIVPVTGELQTA
IDALVQMNIDQADQLSVRAEAAYESGFMFTVVIIIVSLIITIFLAILLTRSIVTPLKSLLSVNERIASGDLRGDIPVTGD
DEFSELQRATLAMQKNLRQTIGLIGNSSQQLASAAEEMNCITVQSSTGLGRQNQEIEQAATAVNEMTAAVDEVARNAAAA
SDAAKESNASTVRGAERVASTVTAIEKLSATVLATSADVQRLAGQSNDISKVLAVIRTIAEQTNLLALNAAIEAARAGEQ
GRGFAVVADEVRALAHRTQQSTQEIEQMIGAVLEGSEQATRSMQESCMGAQDTLGVAHEAGAALDDIARRIEEINDMNTL
IATASEEQAQVARSIDHNLISIRDLSVQSTEGANQTSLASGELSRLAIEMNGVVTRFKM

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=328, Percent_Identity=32.3170731707317, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI2367378, Length=318, Percent_Identity=32.7044025157233, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788194, Length=350, Percent_Identity=33.7142857142857, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1788195, Length=299, Percent_Identity=31.1036789297659, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1789453, Length=335, Percent_Identity=28.6567164179104, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57293; Mature: 57293

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNVKVAVRAGMSFMLITCLLIALGGIALWKMGELRASMESLEKDAMASIIQANKISSAT
CCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LRLRLDARRLIAQTDPQAQTITVTRLKAAREDMLKQSAAYAPLASAADEASLYQTVTASA
EEEEEHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHH
QKFASLLDTVLELIQKGANADAVTFTDTNIVPVTGELQTAIDALVQMNIDQADQLSVRAE
HHHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCHHHHHHHHHHHCCCCCCHHHHHHHH
AAYESGFMFTVVIIIVSLIITIFLAILLTRSIVTPLKSLLSVNERIASGDLRGDIPVTGD
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEFSELQRATLAMQKNLRQTIGLIGNSSQQLASAAEEMNCITVQSSTGLGRQNQEIEQAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHH
TAVNEMTAAVDEVARNAAAASDAAKESNASTVRGAERVASTVTAIEKLSATVLATSADVQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAGQSNDISKVLAVIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQQ
HHCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHH
STQEIEQMIGAVLEGSEQATRSMQESCMGAQDTLGVAHEAGAALDDIARRIEEINDMNTL
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IATASEEQAQVARSIDHNLISIRDLSVQSTEGANQTSLASGELSRLAIEMNGVVTRFKM
HHCCCHHHHHHHHHHCCCEEEEEECCEECCCCCCCCCCCCCHHHHHEEECCCCCHHCCC
>Mature Secondary Structure
MRNVKVAVRAGMSFMLITCLLIALGGIALWKMGELRASMESLEKDAMASIIQANKISSAT
CCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LRLRLDARRLIAQTDPQAQTITVTRLKAAREDMLKQSAAYAPLASAADEASLYQTVTASA
EEEEEHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHH
QKFASLLDTVLELIQKGANADAVTFTDTNIVPVTGELQTAIDALVQMNIDQADQLSVRAE
HHHHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCHHHHHHHHHHHCCCCCCHHHHHHHH
AAYESGFMFTVVIIIVSLIITIFLAILLTRSIVTPLKSLLSVNERIASGDLRGDIPVTGD
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEFSELQRATLAMQKNLRQTIGLIGNSSQQLASAAEEMNCITVQSSTGLGRQNQEIEQAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHH
TAVNEMTAAVDEVARNAAAASDAAKESNASTVRGAERVASTVTAIEKLSATVLATSADVQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAGQSNDISKVLAVIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQQ
HHCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHH
STQEIEQMIGAVLEGSEQATRSMQESCMGAQDTLGVAHEAGAALDDIARRIEEINDMNTL
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IATASEEQAQVARSIDHNLISIRDLSVQSTEGANQTSLASGELSRLAIEMNGVVTRFKM
HHCCCHHHHHHHHHHCCCEEEEEECCEECCCCCCCCCCCCCHHHHHEEECCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]