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The map label for this gene is ilvI [H]

Identifier: 66044101

GI number: 66044101

Start: 958172

End: 959896

Strand: Direct

Name: ilvI [H]

Synonym: Psyr_0846

Alternate gene names: 66044101

Gene position: 958172-959896 (Clockwise)

Preceding gene: 66044099

Following gene: 66044102

Centisome position: 15.72

GC content: 59.13

Gene sequence:

>1725_bases
GTGGAGCTTTTATCTGGCGCTGAAATGGTCGTCCGCTTTTTGCGTGACGAAGGCGTTGAGCATATCTATGGGTACCCTGG
TGGTGCCCTCCTGCATGTCTACGATGCCCTGTTCAAAGAACCGGCGGTGAGCCACATCCTTGTTCGCCACGAGCAGGCTG
CCACGCACATGGCCGATGGCTATGCGCGGGCTACCGGCAAGGCAGGCGTGGTGCTGGTGACCTCGGGTCCTGGTGCAACC
AATGCCATTACCGGTATCGCCACGGCGTACATGGACTCCATTCCGATGGTGGTCCTGTCCGGTCAGGTAGCCAGTACGCT
GGTGGGCACCGATGCGTTCCAGGAGACCGACATGATCGGTATCTCCCGGCCGATCGTGAAGCACAGCTTCATGATCAAGC
ACCCGTCGGAAATCCCGGACGTCCTGAAAAAGGCTTTCTACCTGGCACAGTCCGGTCGTCCGGGCCCGGTGGTCGTCGAT
ATTCCGAAGGACATGACCAACCCGGCCGAAAAATTCGAATACGTCTTCCCGAAAAAAGCCAAGCTGCGCTCCTACAGCCC
GGCGGTTCGTGGCCATTCCGGTCAGATCCGCAAGGCCGTCGAGATGCTGCTGGCGGCCAAGCGTCCTATCGTCTACGCCG
GTGGCGGGGTGATCATGGGCAATGCTTCGGCGCAACTGACCGAGCTGGCGCAACTGCTCGATGCACCGGTAACCAATACC
CTGATGGGGCTTGGGTGCTATCCGGGCACGGATCGCCAGTTCGTCGGCATGCTCGGGATGCACGGCAGCTACACCGCTAA
CCTCGCGATGCACCACACCGATGTGATCCTGGCCGTCGGCGCGCGCTTCGACGACCGAGTCATCAACGGCGCCAGCAAGT
TCTGCCCGAACGCCAAGATTATCCACATCGATATCGACCCGGCTTCGATCTCCAAGACCATCAAGGCCGATGTGCCTATC
GTCGGTCCTGTCGAAAGCGTGCTGACCGAAATGGTTGCCACCTTGAAAGAGATCGGTGAGACACCCGACAAGGCATCCGT
TGCTGCGTGGTGGAAGCAGATTGACGAGTGGCGCGGTACGGGGGATCTGTTCCCGTACAACCGTGGCGATGGCACAGTCA
TCAAGCCGCAGGCCGTTATCGAAACGCTGTGCGAAGTCACCAAGGGCGACGCTTATGTCACCTCGGACGTCGGTCAGCAT
CAGATGTTCGCTGCGCAGTACTACCGCTTCAACAAGCCGAACCGCTGGATCAACTCGGGCGGCCTGGGCACCATGGGCTT
TGGTTTTCCGGCAGCAATGGGCGTGAAACTGAGTTTCCCGGACGAGCACGTGGCCTGCGTGACCGGCGAAGGCAGTATCC
AGATGAACATTCAGGAGCTGTCGACCTGCCTGCAGTACGGCCTGCCGGTGAAGATCATTCTGCTCAACAACGGTGTGCTG
GGCATGGTCCGCCAATGGCAGGACATGAGCTACGGCGCGCGTCACTCGCATTCCTACATGGAGTCGCTGCCTGATTTCGT
CAAGCTGGTCGAGGCCTATGGTCACGTCGGCATGCGTATCACTGACCTGAAGGATCTGAAGCCGAAGATGGAAGAAGCCT
TTGCCATGACTGACCGGCTGGTGTTCATGGATATTCAGGTCGATGTGACCGAGCACGTCTATCCGATGCAAATCAAGGAC
GGCTCCATGCGCGATATGTGGTTGAGCAAGACGGAGCGGACATAA

Upstream 100 bases:

>100_bases
ACGTAGTCGGCGACCACCGTCGCTCATGCTCTGCTGGCAGTAAACCTATTAAGACCCGTCCCGGAGTGGGCGGTATTCTG
GCGTTTTAGAGGTGAACAAC

Downstream 100 bases:

>100_bases
TCATGCGCCATATCATTTCCCTGCTGCTGGAAAACGAACCGGGTGCACTGTCGCGCGTCGTTGGTCTGTTCTCCCAGCGT
AACTACAACATCGAAAGTCT

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS-III; ALS-III; Acetohydroxy-acid synthase III large subunit [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MELLSGAEMVVRFLRDEGVEHIYGYPGGALLHVYDALFKEPAVSHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT
NAITGIATAYMDSIPMVVLSGQVASTLVGTDAFQETDMIGISRPIVKHSFMIKHPSEIPDVLKKAFYLAQSGRPGPVVVD
IPKDMTNPAEKFEYVFPKKAKLRSYSPAVRGHSGQIRKAVEMLLAAKRPIVYAGGGVIMGNASAQLTELAQLLDAPVTNT
LMGLGCYPGTDRQFVGMLGMHGSYTANLAMHHTDVILAVGARFDDRVINGASKFCPNAKIIHIDIDPASISKTIKADVPI
VGPVESVLTEMVATLKEIGETPDKASVAAWWKQIDEWRGTGDLFPYNRGDGTVIKPQAVIETLCEVTKGDAYVTSDVGQH
QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGVKLSFPDEHVACVTGEGSIQMNIQELSTCLQYGLPVKIILLNNGVL
GMVRQWQDMSYGARHSHSYMESLPDFVKLVEAYGHVGMRITDLKDLKPKMEEAFAMTDRLVFMDIQVDVTEHVYPMQIKD
GSMRDMWLSKTERT

Sequences:

>Translated_574_residues
MELLSGAEMVVRFLRDEGVEHIYGYPGGALLHVYDALFKEPAVSHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT
NAITGIATAYMDSIPMVVLSGQVASTLVGTDAFQETDMIGISRPIVKHSFMIKHPSEIPDVLKKAFYLAQSGRPGPVVVD
IPKDMTNPAEKFEYVFPKKAKLRSYSPAVRGHSGQIRKAVEMLLAAKRPIVYAGGGVIMGNASAQLTELAQLLDAPVTNT
LMGLGCYPGTDRQFVGMLGMHGSYTANLAMHHTDVILAVGARFDDRVINGASKFCPNAKIIHIDIDPASISKTIKADVPI
VGPVESVLTEMVATLKEIGETPDKASVAAWWKQIDEWRGTGDLFPYNRGDGTVIKPQAVIETLCEVTKGDAYVTSDVGQH
QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGVKLSFPDEHVACVTGEGSIQMNIQELSTCLQYGLPVKIILLNNGVL
GMVRQWQDMSYGARHSHSYMESLPDFVKLVEAYGHVGMRITDLKDLKPKMEEAFAMTDRLVFMDIQVDVTEHVYPMQIKD
GSMRDMWLSKTERT
>Mature_574_residues
MELLSGAEMVVRFLRDEGVEHIYGYPGGALLHVYDALFKEPAVSHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT
NAITGIATAYMDSIPMVVLSGQVASTLVGTDAFQETDMIGISRPIVKHSFMIKHPSEIPDVLKKAFYLAQSGRPGPVVVD
IPKDMTNPAEKFEYVFPKKAKLRSYSPAVRGHSGQIRKAVEMLLAAKRPIVYAGGGVIMGNASAQLTELAQLLDAPVTNT
LMGLGCYPGTDRQFVGMLGMHGSYTANLAMHHTDVILAVGARFDDRVINGASKFCPNAKIIHIDIDPASISKTIKADVPI
VGPVESVLTEMVATLKEIGETPDKASVAAWWKQIDEWRGTGDLFPYNRGDGTVIKPQAVIETLCEVTKGDAYVTSDVGQH
QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGVKLSFPDEHVACVTGEGSIQMNIQELSTCLQYGLPVKIILLNNGVL
GMVRQWQDMSYGARHSHSYMESLPDFVKLVEAYGHVGMRITDLKDLKPKMEEAFAMTDRLVFMDIQVDVTEHVYPMQIKD
GSMRDMWLSKTERT

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=563, Percent_Identity=25.044404973357, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI21361361, Length=532, Percent_Identity=26.8796992481203, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI87081685, Length=576, Percent_Identity=63.5416666666667, Blast_Score=774, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=559, Percent_Identity=40.9660107334526, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1786717, Length=547, Percent_Identity=34.0036563071298, Blast_Score=318, Evalue=8e-88,
Organism=Escherichia coli, GI1787096, Length=561, Percent_Identity=27.6292335115865, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI1788716, Length=535, Percent_Identity=24.4859813084112, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17531299, Length=585, Percent_Identity=25.982905982906, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17531301, Length=585, Percent_Identity=25.982905982906, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17542570, Length=520, Percent_Identity=25.7692307692308, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323755, Length=589, Percent_Identity=41.5959252971138, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320816, Length=491, Percent_Identity=22.6069246435845, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922626, Length=595, Percent_Identity=25.8823529411765, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62661; Mature: 62661

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLSGAEMVVRFLRDEGVEHIYGYPGGALLHVYDALFKEPAVSHILVRHEQAATHMADG
CCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
YARATGKAGVVLVTSGPGATNAITGIATAYMDSIPMVVLSGQVASTLVGTDAFQETDMIG
HHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCHHHCCCCC
ISRPIVKHSFMIKHPSEIPDVLKKAFYLAQSGRPGPVVVDIPKDMTNPAEKFEYVFPKKA
CCCCHHHHEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHCCCCCHH
KLRSYSPAVRGHSGQIRKAVEMLLAAKRPIVYAGGGVIMGNASAQLTELAQLLDAPVTNT
HHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCEEEEECCCHHHHHHHHHHCCCHHHH
LMGLGCYPGTDRQFVGMLGMHGSYTANLAMHHTDVILAVGARFDDRVINGASKFCPNAKI
HHHCCCCCCCCHHHHHHHCCCCCEEEEEEEEECEEEEEECCCCCHHHHCCHHHHCCCCEE
IHIDIDPASISKTIKADVPIVGPVESVLTEMVATLKEIGETPDKASVAAWWKQIDEWRGT
EEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GDLFPYNRGDGTVIKPQAVIETLCEVTKGDAYVTSDVGQHQMFAAQYYRFNKPNRWINSG
CCCCCCCCCCCCEECHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCEECCC
GLGTMGFGFPAAMGVKLSFPDEHVACVTGEGSIQMNIQELSTCLQYGLPVKIILLNNGVL
CCCCCCCCCHHHCCEEEECCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCHH
GMVRQWQDMSYGARHSHSYMESLPDFVKLVEAYGHVGMRITDLKDLKPKMEEAFAMTDRL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCHHHHHHHHHHCEE
VFMDIQVDVTEHVYPMQIKDGSMRDMWLSKTERT
EEEEEEEECCCCEEEEEECCCCCHHHHHHCCCCC
>Mature Secondary Structure
MELLSGAEMVVRFLRDEGVEHIYGYPGGALLHVYDALFKEPAVSHILVRHEQAATHMADG
CCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
YARATGKAGVVLVTSGPGATNAITGIATAYMDSIPMVVLSGQVASTLVGTDAFQETDMIG
HHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCHHHCCCCC
ISRPIVKHSFMIKHPSEIPDVLKKAFYLAQSGRPGPVVVDIPKDMTNPAEKFEYVFPKKA
CCCCHHHHEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHCCCCCHH
KLRSYSPAVRGHSGQIRKAVEMLLAAKRPIVYAGGGVIMGNASAQLTELAQLLDAPVTNT
HHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCEEEEECCCHHHHHHHHHHCCCHHHH
LMGLGCYPGTDRQFVGMLGMHGSYTANLAMHHTDVILAVGARFDDRVINGASKFCPNAKI
HHHCCCCCCCCHHHHHHHCCCCCEEEEEEEEECEEEEEECCCCCHHHHCCHHHHCCCCEE
IHIDIDPASISKTIKADVPIVGPVESVLTEMVATLKEIGETPDKASVAAWWKQIDEWRGT
EEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GDLFPYNRGDGTVIKPQAVIETLCEVTKGDAYVTSDVGQHQMFAAQYYRFNKPNRWINSG
CCCCCCCCCCCCEECHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCEECCC
GLGTMGFGFPAAMGVKLSFPDEHVACVTGEGSIQMNIQELSTCLQYGLPVKIILLNNGVL
CCCCCCCCCHHHCCEEEECCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCHH
GMVRQWQDMSYGARHSHSYMESLPDFVKLVEAYGHVGMRITDLKDLKPKMEEAFAMTDRL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCHHHHHHHHHHCEE
VFMDIQVDVTEHVYPMQIKDGSMRDMWLSKTERT
EEEEEEEECCCCEEEEEECCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6308579; 1630901; 9278503; 3891724; 9298646 [H]