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The map label for this gene is mutL [H]

Identifier: 66043837

GI number: 66043837

Start: 647607

End: 649553

Strand: Direct

Name: mutL [H]

Synonym: Psyr_0570

Alternate gene names: 66043837

Gene position: 647607-649553 (Clockwise)

Preceding gene: 66043836

Following gene: 66043838

Centisome position: 10.63

GC content: 63.17

Gene sequence:

>1947_bases
ATGACCGATCTCCTGCTCGACGGCGCCGAAGCCGATAACGCTCAGACTGCCCTGAACGCAGCACGCATCGAACTGCTCAG
TCCGCGTCTGGCCAACCAGATTGCGGCGGGCGAAGTTGTCGAGCGTCCGGCTTCGGTGATCAAGGAGTTGCTGGAAAACA
GCCTCGATTCCGGCGCGCGGCGCATCGATGTCGACGTCGAGCAGGCCGGCATCAAATTGTTGAAAGTGCGTGACGATGGC
AGCGGCATCTCTTCGGACGATCTGCCGTTGGCGCTGGCACGCCACGCTACCAGCAAGATTCGCGACCTGGAAGACCTCGA
GCGGGTCATGAGCCTGGGGTTTCGCGGCGAAGCGCTGGCTTCGATCAGCTCCGTGGCACGCCTGACCCTGACCTCGCGCA
CCCGCGACGCCGATCAGGCATGGCAGGTCGAAACCGAAGGTCGTGACATGGCGCCACGCGTGCAGCCGGCCGCGCATCCG
GTAGGCACCTCCGTTGAAGTACGCGACCTGTTCTTCAATACGCCCGCCCGGCGCAAGTTTCTGAAAGCCGAAAAAACCGA
ATTCGATCATTTGCAGGAAGTCATCAAGCGCATGGCGCTGGCGCGTTTCGACGTGGCCTTCCATCTGCGGCACAACGGCA
AGACCGTGCTGAGCCTGCATGAGGCGCATGACGACACCGCCAGAGCGCGACGTGTCTCGGCAATCTGCGGGCCGGGCTTT
CTGGAGCAGGCGCTGCCCATCGAGATCGAGCGCAACGGCCTGCATTTGTGGGGCTGGGTCGGGCTGCCGACCTTCTCGCG
CAGCCAGGCCGACCTGCAATATTTCTTCGTGAATGGCCGGGCAGTGCGCGACAAGCTGGTCGCCCACGCGGTGCGTCAGG
CGTATCGCGACGTGCTGTTCAATGGCCGTCACCCGACTTTCGTGCTGTTCTTCGAGGTCGACCCGGCTGCTGTGGACGTA
AACGTTCACCCGACCAAGCATGAAGTGCGCTTCCGCGACGGGCGCATGGTGCATGACTTTCTATATGGCACCCTCTACCG
TGCGCTGGGCGATGTGCGCCCTGAAAATCAGTTGGGTGGCAGCGTGCCGGTTGTCGCCGAGGCGCGCCCGAGCGGGCCTG
AAGCGGGCGAATTCGGGCCGCAGGGTGAAATGCGTCTGGCCAACAATGTGCTGGAGCAGCCCCAGGGCGAGCCTTTTGCC
CGGCCTGCTGCCGGTGGCGGCGCTGGCAGCGGTTATCAGTATCAATACACGCCTCGGCCCACCGCTGGCGTGCCGGTCGC
CGAAGCGCAAAGTGCCTACCGGGAATTCTTCGCACCGCTGCCCAGTGCCGCGTCCGCGTCGCTGCCTGAATCGCCCGGTG
ATATTCCGCCGCTGGGTTATGCGCTGGCGCAGCTCAAAGGTATCTACATTCTTGCTGAAAATGCTCACGGCCTGGTGCTG
GTGGACATGCATGCCGCTCACGAGCGGATCATGTACGAGCGCCTTAAAATAGCCATGGCCAACGAAGGCCTGAGCGGCCA
GCCATTGCTGGTGCCCGAATCCATCGCGGTCAGCCAGCGTGAAGCGGACTGCGCCGAAGAACACCTTGCGACCTTCCAGC
GCCTGGGCTTCGAACTGCAGCGGCTCGGCCCGGAAACCCTGGCGATCCGCCAGATCCCTGCGTTGCTCAAGCAGGCCGAG
GCCAACCGGCTGGTCAGCGATGTGCTGGCTGACCTCATGGAATACGGCACCAGCGACCGGGTGCAGGCGCACATGAACGA
GCTGCTCGGCACCATGGCCTGTCACGGCGCGATTCGTGCCAATCGGCGTCTGGCCATCCCGGAAATGAACGGCCTGCTGC
GTGACATGGAAAACACCGAGCGCAGCGGGCAATGCAACCACGGTCGTCCTACCTGGACCCAGATGGGTCTCAATGACCTG
GATAAATTATTCCTGCGCGGTCAATGA

Upstream 100 bases:

>100_bases
TGAACATCGCCACTTTGCGCAGCGCCAACAATCTGAAGTCCGATGAATTGAAGATCGGCCAGGATCTGCGTATTCCAAGT
TCCGAGGTGGCGACTCAGTA

Downstream 100 bases:

>100_bases
ATGAACGCTTTACCTCCGGCCATCTTTCTCATGGGGCCTACCGCTGCAGGCAAGACCGACCTTGCGATAGAACTGACCAA
AGTGCTGCCCTGCGAGTTGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MTDLLLDGAEADNAQTALNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGARRIDVDVEQAGIKLLKVRDDG
SGISSDDLPLALARHATSKIRDLEDLERVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHP
VGTSVEVRDLFFNTPARRKFLKAEKTEFDHLQEVIKRMALARFDVAFHLRHNGKTVLSLHEAHDDTARARRVSAICGPGF
LEQALPIEIERNGLHLWGWVGLPTFSRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFVLFFEVDPAAVDV
NVHPTKHEVRFRDGRMVHDFLYGTLYRALGDVRPENQLGGSVPVVAEARPSGPEAGEFGPQGEMRLANNVLEQPQGEPFA
RPAAGGGAGSGYQYQYTPRPTAGVPVAEAQSAYREFFAPLPSAASASLPESPGDIPPLGYALAQLKGIYILAENAHGLVL
VDMHAAHERIMYERLKIAMANEGLSGQPLLVPESIAVSQREADCAEEHLATFQRLGFELQRLGPETLAIRQIPALLKQAE
ANRLVSDVLADLMEYGTSDRVQAHMNELLGTMACHGAIRANRRLAIPEMNGLLRDMENTERSGQCNHGRPTWTQMGLNDL
DKLFLRGQ

Sequences:

>Translated_648_residues
MTDLLLDGAEADNAQTALNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGARRIDVDVEQAGIKLLKVRDDG
SGISSDDLPLALARHATSKIRDLEDLERVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHP
VGTSVEVRDLFFNTPARRKFLKAEKTEFDHLQEVIKRMALARFDVAFHLRHNGKTVLSLHEAHDDTARARRVSAICGPGF
LEQALPIEIERNGLHLWGWVGLPTFSRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFVLFFEVDPAAVDV
NVHPTKHEVRFRDGRMVHDFLYGTLYRALGDVRPENQLGGSVPVVAEARPSGPEAGEFGPQGEMRLANNVLEQPQGEPFA
RPAAGGGAGSGYQYQYTPRPTAGVPVAEAQSAYREFFAPLPSAASASLPESPGDIPPLGYALAQLKGIYILAENAHGLVL
VDMHAAHERIMYERLKIAMANEGLSGQPLLVPESIAVSQREADCAEEHLATFQRLGFELQRLGPETLAIRQIPALLKQAE
ANRLVSDVLADLMEYGTSDRVQAHMNELLGTMACHGAIRANRRLAIPEMNGLLRDMENTERSGQCNHGRPTWTQMGLNDL
DKLFLRGQ
>Mature_647_residues
TDLLLDGAEADNAQTALNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGARRIDVDVEQAGIKLLKVRDDGS
GISSDDLPLALARHATSKIRDLEDLERVMSLGFRGEALASISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPV
GTSVEVRDLFFNTPARRKFLKAEKTEFDHLQEVIKRMALARFDVAFHLRHNGKTVLSLHEAHDDTARARRVSAICGPGFL
EQALPIEIERNGLHLWGWVGLPTFSRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLFNGRHPTFVLFFEVDPAAVDVN
VHPTKHEVRFRDGRMVHDFLYGTLYRALGDVRPENQLGGSVPVVAEARPSGPEAGEFGPQGEMRLANNVLEQPQGEPFAR
PAAGGGAGSGYQYQYTPRPTAGVPVAEAQSAYREFFAPLPSAASASLPESPGDIPPLGYALAQLKGIYILAENAHGLVLV
DMHAAHERIMYERLKIAMANEGLSGQPLLVPESIAVSQREADCAEEHLATFQRLGFELQRLGPETLAIRQIPALLKQAEA
NRLVSDVLADLMEYGTSDRVQAHMNELLGTMACHGAIRANRRLAIPEMNGLLRDMENTERSGQCNHGRPTWTQMGLNDLD
KLFLRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=315, Percent_Identity=36.1904761904762, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI189458898, Length=335, Percent_Identity=29.5522388059701, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI4505911, Length=319, Percent_Identity=29.153605015674, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI189458896, Length=310, Percent_Identity=30.6451612903226, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4505913, Length=351, Percent_Identity=26.4957264957265, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI310128478, Length=351, Percent_Identity=26.4957264957265, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=32.5688073394495, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI91992162, Length=270, Percent_Identity=28.8888888888889, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992160, Length=270, Percent_Identity=28.8888888888889, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310128480, Length=301, Percent_Identity=24.5847176079734, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1790612, Length=568, Percent_Identity=44.7183098591549, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=36.5325077399381, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=350, Percent_Identity=28, Blast_Score=129, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=316, Percent_Identity=37.0253164556962, Blast_Score=210, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6325093, Length=722, Percent_Identity=23.1301939058172, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324247, Length=344, Percent_Identity=26.453488372093, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323063, Length=348, Percent_Identity=27.5862068965517, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136968, Length=312, Percent_Identity=35.5769230769231, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI17136970, Length=367, Percent_Identity=26.7029972752044, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71232; Mature: 71100

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLLDGAEADNAQTALNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAR
CCCCEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
RIDVDVEQAGIKLLKVRDDGSGISSDDLPLALARHATSKIRDLEDLERVMSLGFRGEALA
EEECCHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFNTPARRKF
HHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHH
LKAEKTEFDHLQEVIKRMALARFDVAFHLRHNGKTVLSLHEAHDDTARARRVSAICGPGF
HHHHCCHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEHHCCHHHHHHHHHHHCCCHH
LEQALPIEIERNGLHLWGWVGLPTFSRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLF
HHHCCCEEEECCCEEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
NGRHPTFVLFFEVDPAAVDVNVHPTKHEVRFRDGRMVHDFLYGTLYRALGDVRPENQLGG
CCCCCEEEEEEEECCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHCCC
SVPVVAEARPSGPEAGEFGPQGEMRLANNVLEQPQGEPFARPAAGGGAGSGYQYQYTPRP
CCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC
TAGVPVAEAQSAYREFFAPLPSAASASLPESPGDIPPLGYALAQLKGIYILAENAHGLVL
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCEEE
VDMHAAHERIMYERLKIAMANEGLSGQPLLVPESIAVSQREADCAEEHLATFQRLGFELQ
EECHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHCHHHHHHHHHHHHHHHHHCHHHH
RLGPETLAIRQIPALLKQAEANRLVSDVLADLMEYGTSDRVQAHMNELLGTMACHGAIRA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
NRRLAIPEMNGLLRDMENTERSGQCNHGRPTWTQMGLNDLDKLFLRGQ
CCEEECHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
TDLLLDGAEADNAQTALNAARIELLSPRLANQIAAGEVVERPASVIKELLENSLDSGAR
CCCEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
RIDVDVEQAGIKLLKVRDDGSGISSDDLPLALARHATSKIRDLEDLERVMSLGFRGEALA
EEECCHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SISSVARLTLTSRTRDADQAWQVETEGRDMAPRVQPAAHPVGTSVEVRDLFFNTPARRKF
HHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHCCHHHHHH
LKAEKTEFDHLQEVIKRMALARFDVAFHLRHNGKTVLSLHEAHDDTARARRVSAICGPGF
HHHHCCHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEHHCCHHHHHHHHHHHCCCHH
LEQALPIEIERNGLHLWGWVGLPTFSRSQADLQYFFVNGRAVRDKLVAHAVRQAYRDVLF
HHHCCCEEEECCCEEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
NGRHPTFVLFFEVDPAAVDVNVHPTKHEVRFRDGRMVHDFLYGTLYRALGDVRPENQLGG
CCCCCEEEEEEEECCEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHCCC
SVPVVAEARPSGPEAGEFGPQGEMRLANNVLEQPQGEPFARPAAGGGAGSGYQYQYTPRP
CCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC
TAGVPVAEAQSAYREFFAPLPSAASASLPESPGDIPPLGYALAQLKGIYILAENAHGLVL
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCEEE
VDMHAAHERIMYERLKIAMANEGLSGQPLLVPESIAVSQREADCAEEHLATFQRLGFELQ
EECHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHCHHHHHHHHHHHHHHHHHCHHHH
RLGPETLAIRQIPALLKQAEANRLVSDVLADLMEYGTSDRVQAHMNELLGTMACHGAIRA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
NRRLAIPEMNGLLRDMENTERSGQCNHGRPTWTQMGLNDLDKLFLRGQ
CCEEECHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]