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The map label for this gene is parE [H]

Identifier: 66043818

GI number: 66043818

Start: 622501

End: 624405

Strand: Direct

Name: parE [H]

Synonym: Psyr_0551

Alternate gene names: 66043818

Gene position: 622501-624405 (Clockwise)

Preceding gene: 66043817

Following gene: 66043819

Centisome position: 10.22

GC content: 62.15

Gene sequence:

>1905_bases
ATGGCCAATCCCAGCGCTAGCTCTTATAACGCAGACGCCATCGAAGTCCTCTCGGGCCTCGATCCGGTTCGTAAACGTCC
GGGCATGTACACCGACACCTCGCGGCCCAACCACCTGGCTCAGGAAGTCATCGACAACAGCGTCGACGAAGCCTTGGCCG
GCCACGCGCGTTCGGTACAAGTCATCCTTCATGCCGACAATTCGCTCGAGGTGTCCGACGACGGCCGCGGCATGCCGGTG
GACATCCACCCGGAAGAAGGCGTGTCCGGCGTCGAGCTGATCCTCACCAAGCTTCACGCAGGCGGCAAGTTTTCCAACAA
GAACTATCAGTTCTCCGGCGGCCTGCACGGCGTGGGCATTTCCGTGGTCAACGCGCTGTCCACTCAGGTCCGGGTGCGGG
TCAAGCGTGATGGCAACGAATATGAGATGACCTTCGCTGACGGCTACAAGGCCACCGAACTGGCGGTCGTCGGCACCGTC
GGCAAGCGCAACACCGGGACCAGCGTCTATTTCGCCCCCGATCCGAAGTATTTCGATACACCGAAGTTTTCCGTCAGCCG
TCTCAAGCACGTCCTCAAGGCCAAGGCGGTTCTGTGCCCGGGCCTGCTGGTCAGCTTCGAAGACAAATCCAGCGGCGAGA
AAGTCGAGTGGCATTACGAAGACGGCCTGCGCTCCTACCTGCAGGACTCGGTCACCGAATTCCTGCGCCTGCCGGACGAG
CCGTTCTGCGGCAGCTTCACCGGTAACAAGGAAGCGGTCGACTGGGCGTTGCTGTGGCTGCCCGAGGGTGGCGACAGCGT
TCAGGAAAGCTACGTCAACCTGATCCCGACCGCGCAGGGCGGCACCCACGTGAACGGCTTGCGCCAGGGTTTGCTGGATG
CCATGCGCGAGTTCTGCGAGTTCCGCAACCTGTTGCCGCGTGGTGTGAAGCTGGCCCCGGAAGACGTCTGGGAACGCATT
GCCTTCGTCCTGTCGATGAAAATGCAGGAGCCGCAGTTCTCCGGGCAGACCAAGGAACGTCTGTCGTCCCGTGAAGCGGC
GGCGTTCGTCTCCGGCGTGGTCAAGGATGCGTTCAGCCTGTGGCTCAACACGCACTCCGAGCTGGGCCTGCAGCTGGCCG
ATCTGGCGATCAACAACGCCGGTCGGCGCCTCAAGGCGAGCAAAAAGGTCGAGCGCAAGCGCATCACCCAAGGGCCGGCG
TTGCCGGGCAAGCTGGCTGACTGTGCCGGACAGGACCCGGCGCGCTCCGAACTGTTTCTGGTCGAGGGTGACTCTGCCGG
CGGTTCCGCCAAGCAGGCTCGCGACAAGGAATTCCAGGCGATCCTGCCGCTGCGCGGCAAAATCCTCAACACCTGGGAAG
TCGATGGCGGCGAAGTGCTTGCCAGTCAGGAAGTCCACAACATTGCCGTGGCCATCGGGGTTGACCCCGGCGCAGCCGAT
ATCAGCCAGTTGCGTTACGGCAAGATCTGCATCCTGGCTGACGCCGACTCGGACGGTCTGCACATTGCGACGCTGCTGTG
TGCGTTATTCGTGCAGCACTTCCGCCCGTTGGTTGACGCCGGGCATGTGTACGTCGCCATGCCGCCGCTGTACCGGATCG
ACCTGGGCAAGGAAATCTACTACGCGCTGGACGAAGCCGAGCGTGACGGGATCCTTGACCGTCTGGTCGCTGAAAAGAAA
CGTGGCAAGCCGCAGGTCACCCGATTCAAGGGCCTGGGTGAAATGAACCCGCCGCAGTTGCGCGAAACCACCATGGACCC
GAACACCCGGCGCCTGGTGCAGCTCACGCTGGATGATTTCGCAGCCACGTCGGAAATGATGGACATGTTGCTGGCTAAGA
AGCGTGCAGGTGATCGCAAGTCCTGGCTCGAATCCAAGGGCAACCTTGCCGAGGTCCTGACTTGA

Upstream 100 bases:

>100_bases
AAGATCGATCTGTCGGCGCTGTAGGTGATCGATGCCCGGTCACATGAATGCAAGAACATTGAACCCCCGAAATTCCATGA
AAGATTGATATCGAGAACCC

Downstream 100 bases:

>100_bases
TACGAGCCTGGCTCGCCGCCCTGATCCTGATTGCCGCGCCGGTTGTCGCTGCGCCACTCGAGGCCCTGAAGCTGCAATCC
GAGCATCCGGTGGACGACAT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MANPSASSYNADAIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHARSVQVILHADNSLEVSDDGRGMPV
DIHPEEGVSGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTQVRVRVKRDGNEYEMTFADGYKATELAVVGTV
GKRNTGTSVYFAPDPKYFDTPKFSVSRLKHVLKAKAVLCPGLLVSFEDKSSGEKVEWHYEDGLRSYLQDSVTEFLRLPDE
PFCGSFTGNKEAVDWALLWLPEGGDSVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLAPEDVWERI
AFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNTHSELGLQLADLAINNAGRRLKASKKVERKRITQGPA
LPGKLADCAGQDPARSELFLVEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGGEVLASQEVHNIAVAIGVDPGAAD
ISQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPPLYRIDLGKEIYYALDEAERDGILDRLVAEKK
RGKPQVTRFKGLGEMNPPQLRETTMDPNTRRLVQLTLDDFAATSEMMDMLLAKKRAGDRKSWLESKGNLAEVLT

Sequences:

>Translated_634_residues
MANPSASSYNADAIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHARSVQVILHADNSLEVSDDGRGMPV
DIHPEEGVSGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTQVRVRVKRDGNEYEMTFADGYKATELAVVGTV
GKRNTGTSVYFAPDPKYFDTPKFSVSRLKHVLKAKAVLCPGLLVSFEDKSSGEKVEWHYEDGLRSYLQDSVTEFLRLPDE
PFCGSFTGNKEAVDWALLWLPEGGDSVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLAPEDVWERI
AFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNTHSELGLQLADLAINNAGRRLKASKKVERKRITQGPA
LPGKLADCAGQDPARSELFLVEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGGEVLASQEVHNIAVAIGVDPGAAD
ISQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPPLYRIDLGKEIYYALDEAERDGILDRLVAEKK
RGKPQVTRFKGLGEMNPPQLRETTMDPNTRRLVQLTLDDFAATSEMMDMLLAKKRAGDRKSWLESKGNLAEVLT
>Mature_633_residues
ANPSASSYNADAIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHARSVQVILHADNSLEVSDDGRGMPVD
IHPEEGVSGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTQVRVRVKRDGNEYEMTFADGYKATELAVVGTVG
KRNTGTSVYFAPDPKYFDTPKFSVSRLKHVLKAKAVLCPGLLVSFEDKSSGEKVEWHYEDGLRSYLQDSVTEFLRLPDEP
FCGSFTGNKEAVDWALLWLPEGGDSVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLAPEDVWERIA
FVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNTHSELGLQLADLAINNAGRRLKASKKVERKRITQGPAL
PGKLADCAGQDPARSELFLVEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGGEVLASQEVHNIAVAIGVDPGAADI
SQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPPLYRIDLGKEIYYALDEAERDGILDRLVAEKKR
GKPQVTRFKGLGEMNPPQLRETTMDPNTRRLVQLTLDDFAATSEMMDMLLAKKRAGDRKSWLESKGNLAEVLT

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=624, Percent_Identity=25, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI19913406, Length=644, Percent_Identity=24.3788819875776, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1789408, Length=629, Percent_Identity=72.6550079491256, Blast_Score=966, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=563, Percent_Identity=39.9644760213144, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17535065, Length=628, Percent_Identity=24.3630573248408, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=595, Percent_Identity=25.2100840336134, Blast_Score=119, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324241, Length=675, Percent_Identity=23.4074074074074, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17136538, Length=631, Percent_Identity=22.9793977812995, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69476; Mature: 69344

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPSASSYNADAIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHARSVQ
CCCCCCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCEEE
VILHADNSLEVSDDGRGMPVDIHPEEGVSGVELILTKLHAGGKFSNKNYQFSGGLHGVGI
EEEECCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH
SVVNALSTQVRVRVKRDGNEYEMTFADGYKATELAVVGTVGKRNTGTSVYFAPDPKYFDT
HHHHHHHHEEEEEEEECCCEEEEEEECCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCC
PKFSVSRLKHVLKAKAVLCPGLLVSFEDKSSGEKVEWHYEDGLRSYLQDSVTEFLRLPDE
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCC
PFCGSFTGNKEAVDWALLWLPEGGDSVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCE
CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHH
FRNLLPRGVKLAPEDVWERIAFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSL
HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WLNTHSELGLQLADLAINNAGRRLKASKKVERKRITQGPALPGKLADCAGQDPARSELFL
HHCCHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEE
VEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGGEVLASQEVHNIAVAIGVDPGAAD
EECCCCCCCHHHHHCCHHHEECCCCCEEEEEEECCCCCEEECCCCCEEEEEEECCCCHHH
ISQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPPLYRIDLGKEIY
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCHHH
YALDEAERDGILDRLVAEKKRGKPQVTRFKGLGEMNPPQLRETTMDPNTRRLVQLTLDDF
HHHHHHHHCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCEEEEEEHHHH
AATSEMMDMLLAKKRAGDRKSWLESKGNLAEVLT
HHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
ANPSASSYNADAIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHARSVQ
CCCCCCCCCCHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCEEE
VILHADNSLEVSDDGRGMPVDIHPEEGVSGVELILTKLHAGGKFSNKNYQFSGGLHGVGI
EEEECCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH
SVVNALSTQVRVRVKRDGNEYEMTFADGYKATELAVVGTVGKRNTGTSVYFAPDPKYFDT
HHHHHHHHEEEEEEEECCCEEEEEEECCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCC
PKFSVSRLKHVLKAKAVLCPGLLVSFEDKSSGEKVEWHYEDGLRSYLQDSVTEFLRLPDE
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCC
PFCGSFTGNKEAVDWALLWLPEGGDSVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCE
CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHH
FRNLLPRGVKLAPEDVWERIAFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSL
HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WLNTHSELGLQLADLAINNAGRRLKASKKVERKRITQGPALPGKLADCAGQDPARSELFL
HHCCHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEE
VEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGGEVLASQEVHNIAVAIGVDPGAAD
EECCCCCCCHHHHHCCHHHEECCCCCEEEEEEECCCCCEEECCCCCEEEEEEECCCCHHH
ISQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPPLYRIDLGKEIY
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCHHH
YALDEAERDGILDRLVAEKKRGKPQVTRFKGLGEMNPPQLRETTMDPNTRRLVQLTLDDF
HHHHHHHHCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCEEEEEEHHHH
AATSEMMDMLLAKKRAGDRKSWLESKGNLAEVLT
HHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]